Are you experiencing neuropathy symptoms like numbness, muscle weakness, and pain? Read more about the benefits of CBD oil for neuropathy to find out how the compound may help improve your quality of life

How CBD May Help With Neuropathy

Neuropathy is a medical condition also known as peripheral neuropathy. This nerve dysfunction is caused by issues within the peripheral nervous system, including the brain, spinal cord, and nerves(1).

Individuals with neuropathy may experience numbness, pain, and weakness in the hands and feet(2).

Cannabidiol (CBD) may have health benefits that may help relieve these symptoms.

CBD may possess analgesic properties that may alleviate different types of chronic pain, such as neuropathic pain(3).

Cannabidiol, more commonly known as CBD, is an active compound derived from the cannabis plant.

This compound interacts with the endocannabinoid system or ECS(4), which is a system that is present in most parts of the body(5).

The ECS also contains cannabinoid receptors 1 and 2(CB1 and CB2)(6).

CB1 receptors regulate pain sensation, while CB2 receptors help with inflammatory responses(7-8).

Vomiting, nausea, and anxiety are common symptoms associated with peripheral neuropathies(9).

Meanwhile, CBD may also contain anti-anxiety (anxiolytic)(10) and anti-vomiting (anti-emetic) therapeutic benefits(11).

Studies have suggested that CBD may indirectly activate the serotonin receptors 5-HT1A, producing anxiolytic effects(12).

Serotonin is a hormone that induces feelings of happiness and stabilizes mood.

Therefore, CBD may improve the regulation of serotonin and help with mood stabilization and anxiety reduction(13).

Certain neuropathy cases may be easily treated and sometimes cured. If neuropathy cannot be cured, the treatment aims to prevent further nerve damage and control and manage symptoms(14).

Fortunately, CBD has been shown to contain therapeutic benefits that may be effective in helping with symptoms linked to neuropathy.

Benefits and Uses of Using CBD for Neuropathy

A 2020 study from the journal Current Pharmaceutical Biotechnology investigated the efficacy of topical CBD oil to relieve symptoms of peripheral neuropathy of the lower extremities(15).

Twenty-nine participants suffering from symptoms of peripheral neuropathy were examined.

The participants’ pain scale was measured biweekly using the neuropathic pain scale (NPS). Results indicated that CBD oil may have reduced pain and other intolerable sensations in individuals with peripheral neuropathy(16).

An animal study has also suggested that cannabidiol may also contain therapeutic benefits for chemotherapy-related neuropathy(17).

Researchers examined THC (tetrahydrocannabinol) and CBD’s effects on neuropathic pain caused by chemotherapy(18).

The results showed that CBD may aid in preventing the development of chemotherapy-induced peripheral neuropathy.

Additionally, CBD’s efficacy may be improved by administering low doses of THC(19).

THC, or tetrahydrocannabinol, which contains psychoactive properties, is another major compound found in the cannabis plant(20).

Due to the findings on the animal subjects, CBD’s indicated benefits may be a potential subject for future research on humans.

A British Journal of Pharmacology study also discussed that CBD may have properties in reducing vomiting and nausea in individuals undergoing chemotherapy(21).

Nausea and vomiting are both common symptoms associated with neuropathy(22).

Meanwhile, a 2018 study discussed that CBD may aid in the improvement of mobility of people who have multiple sclerosis(23).

Multiple sclerosis is defined as a debilitating disease of the central nervous system, including the brain and spinal cord(24).

Neuropathy is a medical condition that results from damaged nerves on the brain and spine or the peripheral nerves(25).

Furthermore, anxiety and depression are commonly experienced by individuals suffering from neuropathic pain(26).

A study on CBD has shown that the compound may have antidepressant and anxiolytic benefits(27).

However, according to a 2020 study, the potential pain-relieving effects of CBD may not be used for universal pain management as the compound may not be able to provide analgesic effects for every type of pain(28).

How to Use CBD Oil for Neuropathy

For neuropathy, individuals may use CBD oil products in different ways. Such formats include CBD tinctures, CBD edibles like gummies, CBD topicals, and vapes.

The effectiveness of the types of CBD formats may depend on the individual’s weight, metabolism, and diet.

CBD Tinctures

CBD tinctures, also known as CBD oil, are created through hemp concentrates or cannabis infused into carrier oils like coconut, olive, or MCT oil(29).

Tinctures are usually administered sublingually or under the tongue, offering a faster onset time.

However, you may also ingest CBD oil tinctures by mixing them with food like yogurt or drinks like coffee and smoothies(30).

CBD Vapes

Vaping or inhaling CBD through vape pens may be the quickest way for individuals to feel the effects of the compound(31).

However, be warned that vaping and smoking may cause severe pulmonary diseases or lung injury(32).

CBD Topicals

CBD topicals such as lotions, CBD creams, and salves are used to reduce inflammation and offer localized pain relief(33).

Individuals with neuropathy may use topical CBD if they feel sharp pains on parts of the body like hands and feet(34).

The contents of CBD topicals are not absorbed into the system compared to other forms(35).

Thus, topically applied CBD may be a safer option considering there is little information about the long-term safety of cannabidiol(36).

CBD Edibles

Edibles like CBD gummies, supplements, and pills take effect by going through the gastrointestinal tract and entering the bloodstream.

How Long Does CBD Take to Help With Neuropathy?

There is no official research regarding the time it takes for CBD to help with neuropathy.

CBD tinctures may take effect after 15 to 30 minutes due to the compound’s direct entry into the bloodstream(37).

CBD edibles like gummies and pills may begin working within 30 to 90 minutes after you ingest them(38).

Consuming CBD through vaping or smoking may offer the quickest onset time, taking effect within 2 to 15 minutes(39).

However, caution should be exercised when smoking or vaping CBD. The method may cause potential health risks, such as lung irritation and severe pulmonary disease(40).

Lastly, CBD topicals such as CBD creams, lotions, and balms have an onset time of 10 to 15 minutes(41).

Consult an experienced medical professional or physician before taking any CBD oil products for neuropathy.

How Long Will CBD Help With Neuropathy?

No clinical trials have indicated how long the effects of CBD in the body may last to help with neuropathy.

The compound’s effects may remain in the system depending on the dosage of CBD, the frequency of its consumption, and the method of administration(42).

CBD Oil for Neuropathy Dosage

Currently, the Food and Drug Administration (FDA) does not consider CBD as an official medical treatment for neuropathy(43).

So, there is no standard dosage in taking CBD or CBD products.

However, in general, people with no prior experience with using CBD should initially start by taking low doses and then slowly increasing their intake if no major side effects are observed(44).

Additionally, a study from Current Drug Safety stated that humans may tolerate 1mg to 1,500 mg of CBD per day(45).

Still, consulting with your doctor about the best CBD oil dosage for your medical condition is highly encouraged.

CBD Oil for Neuropathy: Buying Guide

Before buying CBD oil for neuropathy, it is important to note several factors to ensure that you get high-quality products.

Considerations such as the type of CBD extracts, extraction methods, hemp source, ingredients, and individual preferences should be considered.

Below are some factors you may also consider when choosing CBD oil for neuropathy:

Types of CBD Extracts

The types of CBD oil extracts are:

Full-spectrum CBD oil has all the extracts and compounds of the cannabis plant, including terpenes, flavonoids, cannabinoids, and a THC concentration of less than 0.3%(46).

Terpenes produce the plant’s unique fragrance, whereas flavonoids refer to plant compounds with antioxidant and anti-inflammatory properties.

These compounds may produce an “entourage effect” when combined in one product.

The entourage effect is defined as the phenomenon where the integration of different cannabis compounds may enhance their medicinal properties(47).

A study from Frontiers in Plant Science suggested that the entourage effect in full-spectrum hemp extracts may produce better health benefits compared to pure CBD(48).

Meanwhile, broad-spectrum CBD oil is almost the same as full-spectrum, as it contains identical compounds and cannabinoids.

The only difference is that broad-spectrum CBD has trace amounts of THC only or is completely THC-free.

Lastly, CBD isolates, harvested from Cannabis sativa, are a pure form of cannabidiol and do not contain any other cannabinoids or compounds.

Individuals who may want to experience CBD’s benefits without the psychoactive effects of THC may choose broad-spectrum CBD.

Extraction Methods

There are many extraction methods used when obtaining hemp extracts. Steam distillation, ethanol, natural solvent, and carbon dioxide (CO2) extraction are such techniques.

CO2 extraction is the most utilized extraction process. In this technique, compressed CO2 is used as the extraction solvent(49).

If butane or hexane is used for extraction, such substances may leave behind harmful residues(50).

Carrier Oils 

Upon extraction from the hemp plant, cannabidiol is infused into carrier oils, enhancing the CBD product’s bioavailability.

These carrier oils can be coconut, hemp seed, or MCT oil.

People often confuse hemp oil and hemp seed oil. Note that they are different.

Hempseed oil does not have cannabinoids. However, it is rich in nutrients and fatty acids(51).

Third-party Lab Testing

Trusted CBD brands undergo thorough evaluation through third-party testing.

CBD products are screened by third-party labs for harmful contaminants such as pesticides or heavy metals that may be dangerous to consumers.

Brands should outwardly show their certificate of analysis (COA) on their websites.

It is advisable to check the COA and ensure that the results match the CBD product label. This practice allows buyers to verify its concentration, potency, and efficacy.

The CBD Brand’s Reputation

The CBD brand’s reputation should be thoroughly appraised to see if the company is authorized to distribute and produce CBD products.

It is preferable to opt for CBD products produced by trusted companies that manufacture non-GMO, cruelty-free CBD products made from organic hemp.

Brands should also be certified by the U.S. Department of Agriculture (USDA) and have an exemplary standing with the Better Business Bureau (BBB) to verify their credibility.

In the United States, Colorado Botanicals, CBDistillery, and MedTerra are some brands that sell a wide range of CBD products.


It is highly encouraged to use CBD oil made from organic and natural ingredients.

Research has noted that natural ingredients may have numerous benefits like inflammatory properties for skincare(52).

Ensure that the carrier oils are derived from organic, food-grade vegetable glycerin or fats. Other glycerin products have GMOs or byproducts of industrial processing(53).

Risks and Side Effects of Using CBD for Neuropathy

CBD is reported to be safe and well tolerated by humans(54). However, the compound may cause some minor side effects such as(55):

Furthermore, taking CBD alongside certain prescription medications for neuropathy, such as opioids and antidepressants, may cause increased sleepiness, fatigue, and possible accidents when driving(56).

It is of the utmost importance to talk with your doctor or healthcare provider before taking CBD with any mentioned medications.

Legality of CBD

Currently, Epidolex is the only pharmaceutical-grade cannabidiol oil medication approved by the Food and Drug Administration (FDA).

Epidolex is used to treat seizures caused by Dravet syndrome, Lennox-Gastaut syndrome, and tuberous sclerosis complex(57).

Due to the Farm Bill of 2018, medical cannabis or medical marijuana with less than 0.3% THC is legal in the federal United States(58).

Regardless, individuals who plan to use CBD products must first verify their state laws and check product labels to determine if CBD is legal in their area.

What Is Neuropathy?

Neuropathy or peripheral neuropathy may be defined as a dysfunction of the nerves that may result in tingling, numbness, muscle weakness, and pain. This condition may start in the hands and feet. However, the rest of the body is also at risk of being affected(59).

Some cases of peripheral neuropathy may be easily treated. However, if the condition is too severe, medication or surgery is required to manage neuropathy symptoms.

Causes of Neuropathy

Neuropathy is not due to a single disease. Medical conditions which impact health may cause neuropathy in individuals, including(60):

  • Trauma: Traumatic injuries caused by falls, car accidents, or sports activities may result in neuropathy. Repetitive stress and compression of the nerves’ space may also cause neuropathy.
  • Diabetes: Sixty to seventy percent of people who have diabetes may experience neuropathy. Diabetes may also cause small fiber neuropathy, which produces a painful burning feeling in the hands and feet.
  • Autoimmune disorders and infections: Lupus, rheumatoid arthritis, and Sjogren’s syndrome are chronic autoimmune disorders that may cause neuropathy.

Infections such as shingles, Lyme disease, chickenpox, leprosy, herpes, and hepatitis C may also induce neuropathy.

  • Other health conditions: Kidney and liver disorders, tumors, hypothyroidism, and lymphoma may cause neuropathy.
  • Medications: Some antibiotics, antiseizure medications, and HIV medications  can cause neuropathy. Some treatments, including cancer chemotherapy and radiation, can damage peripheral nerves.
  • Poisons: Exposure to toxic substances such as heavy metals (including lead and mercury) and industrial chemicals, especially solvents, may also affect nerve function.

Alternative Treatments for Neuropathy

Neuropathy is treated by identifying and treating the underlying medical issues that may cause the condition.

Treatment options include the following(61):

  • Medication: Individuals may be prescribed antidepressants, antiseizure pills, and topical patches and creams containing capsaicin.

Note that opioids or any common painkiller may not provide effective analgesic effects for every individual experiencing neuropathic pain(62).

  • Physical therapy: Doing a combination of exercises and massages may help increase your strength, range of motion, and balance.
  • Surgery: Individuals may develop neuropathies caused by nerve strain, like pressure from tumors. Doctors may require surgery to reduce the tension.
  • Proper nutrition and healthy habits: Adapting healthy practices such as eating a nutritious diet, exercising, quitting smoking, and regulating alcohol intake may reduce the risk of developing neuropathy.


  1. How can CBD help with neuropathy?

Neuropathic pain, anxiety, nausea, and vomiting are common symptoms of peripheral neuropathy(63).

CBD contains various therapeutical benefits such as pain-relieving(64), anti-anxiety(65), and anti-vomiting properties(66) that may alleviate symptoms associated with neuropathy.

  1. What evidence or research exists to say that CBD helps with neuropathy?

According to a 2020 study, individuals were given topical CBD oil to manage symptoms of peripheral neuropathy of the lower extremities(67).

Results showed that CBD oil may have lessened the pain sensations that the individuals experienced.

Another study noted that CBD may possess properties that reduce vomiting and nausea in individuals undergoing chemotherapy(68).

Nausea and vomiting are prevailing symptoms of neuropathy(69).

  1. Is there any evidence that CBD can make neuropathy worse?

No studies have suggested that CBD can make neuropathy worse.

According to the World Health Organization’s (WHO) review, CBD is well tolerated by the body, safe, and non-addictive(7071).

  1. Will CBD interact with any current medication I may be taking for neuropathy?

Using CBD with prescription medications like opioids and antidepressants may cause increased drowsiness and fatigue that may result in driving accidents(72).

It is encouraged to consult with your physician before taking CBD alongside any prescription medications.

  1. Are there other treatments I should consider alongside CBD to help with neuropathy?

Treatment options for neuropathy may include antidepressants, antiseizure medications, and topicals containing capsaicin(73).

Maintaining a healthy lifestyle like avoiding smoking and alcohol may also reduce the risk of neuropathy(74).

Some cases may require surgery, such as neuropathy caused by pressure from tumors.

  1. Can I fail a drug test if I use CBD for neuropathy?

CBD oil or any CBD products that may contain small amounts of THC may build up in the system when taken over a prolonged time.

This increased THC level in the bloodstream may cause a positive drug test(75).

  1. What is the dosage for neuropathy?

There is no set dosage in taking CBD for neuropathy.

However, you may start with low doses of CBD then gradually increase into a higher dose if you do not feel any significant side effects(76).

It is best to consult your physician on the best CBD dosage for you.

  1. Will CBD for neuropathy make me high?

CBD is a non-psychoactive compound (77). Therefore, it will not cause a euphoric high(78).

  1. Can I use CBD oil for diabetic neuropathy or nerve pain?

Diabetic neuropathy is defined as nerve damage caused by diabetes(79). A study discussed that topical CBD oil may aid with neuropathic pain(80).

However, it is best to talk to your physician before taking CBD for diabetic neuropathy.

  1. Can I mix CBD oil for neuropathy with drinks or food?

CBD tinctures are usually administered under the tongue. However, individuals may also take CBD oil tinctures by mixing them with food and drinks(81).

  1. How do I make my experience with CBD oil better?

To maximize CBD’s potential benefits and for a better user experience, it is encouraged to follow the instructions indicated on the CBD product’s label.

Depending on your preferences, you may also try different routes of administration, such as tinctures, edibles, and vapes.

Consult your doctor on the best CBD form that will fit your needs.

  1. Neuropathy (Peripheral Neuropathy)
  2. Peripheral neuropathy
  3. Cannabidiol (CBD)-what we know and what we don’t
  4. The Endocannabinoid System, Our Universal Regulator
  5. ibid.
  6. The Endocannabinoid System and Cannabidiol’s Promise for the Treatment of Substance Use Disorder
  7. Cannabinoids and Pain: New Insights From Old Molecules
  8. The role of CB1 in immune modulation by cannabinoids
  9. Neuropathy (Peripheral Neuropathy)
  10. Cannabidiol as a Potential Treatment for Anxiety Disorders
  11. Regulation of nausea and vomiting by cannabinoids
  12. Cannabidiol as a Potential Treatment for Anxiety Disorders
  13. Agonistic properties of cannabidiol at 5-HT1a receptors
  14. Neuropathy (Peripheral Neuropathy)
  15. The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities
  16. ibid.
  17. Single and combined effects of Δ9‐tetrahydrocannabinol and cannabidiol in a mouse model of chemotherapy‐induced neuropathic pain
  18. Single and combined effects of Δ9‐tetrahydrocannabinol and cannabidiol in a mouse model of chemotherapy‐induced neuropathic pain
  19. Single and combined effects of Δ9‐tetrahydrocannabinol and cannabidiol in a mouse model of chemotherapy‐induced neuropathic pain
  20. Cannabidiol (CBD)
  21. Regulation of nausea and vomiting by cannabinoids
  22. Neuropathy (Peripheral Neuropathy)
  23. Cannabidiol to Improve Mobility in People with Multiple Sclerosis
  24. ibid.
  25. Peripheral neuropathy
  26. Anxiety- and Depression-Like Behavior and Impaired Neurogenesis Evoked by Peripheral Neuropathy Persist following Resolution of Prolonged Tactile Hypersensitivity
  27. Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa
  28. A Balanced Approach for Cannabidiol Use in Chronic Pain
  29. Healing with CBD page 205
  30. ibid.
  31. Best way to take CBD
  32. Outbreak of Lung Injury Associated with the Use of E-Cigarette, or Vaping, Products
  33. Healing with CBD. page. 210.
  34. Peripheral neuropathy
  35. How to Safely Use CBD: Should You Inhale, Spray, Apply, or Eat It?
  36. ibid.
  37. Healing with CBD. page. 192.
  38. ibid. page. 191
  39. ibid. page. 197
  40. Can vaping damage your lungs? What we do (and don’t) know
  41. Healing With CBD. page. 210
  42. Healing with CBD. page. 195.
  43. FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD)
  44. Healing with CBD. page. 227.
  45. Safety and side effects of cannabidiol, a Cannabis sativa constituent
  46. Cannabidiol Primer for Healthcare Professionals
  47. The “Entourage Effect”: Terpenes Coupled with Cannabinoids for the Treatment of Mood Disorders and Anxiety Disorders
  48. The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No “Strain,” No Gain
  49. Understanding Dabs: Contamination Concerns of Cannabis Concentrates and Cannabinoid Transfer During the Act of Dabbing
  50. Cannabidiol Primer for Healthcare Professionals
  51. Hemp Seed Oil Properties
  52. Innovations in natural ingredients and their use in skin care
  53. Healing with CBD. page. 208.
  54. Cannabidiol (CBD), page 5.
  55. What are the benefits of CBD — and is it safe to use?
  56. CBD and other medications: Proceed with caution
  57. FDA Approves New Indication for Drug Containing an Active Ingredient Derived from Cannabis to Treat Seizures in Rare Genetic Disease
  58. Industrial hemp
  59. Neuropathy (Peripheral Neuropathy)
  60. ibid.
  61. Peripheral neuropathy
  62. Opioids and neuropathic pain
  63. Neuropathy (Peripheral Neuropathy)
  64. Cannabidiol (CBD)-what we know and what we don’t
  65. Cannabidiol as a Potential Treatment for Anxiety Disorders
  66. Regulation of nausea and vomiting by cannabinoids
  67. The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities
  68. Regulation of nausea and vomiting by cannabinoids
  69. Neuropathy (Peripheral Neuropathy)
  70. Cannabinoid (CBD) Pre-Review Report, page 14.
  71. Cannabidiol (CBD), page 5.
  72. CBD and other medications: Proceed with caution
  73. Peripheral neuropathy
  74. ibid.
  75. Can You Take CBD and Pass a Drug Test?
  76. Healing with CBD. page. 227.
  77. Cannabidiol and Other Non-Psychoactive Cannabinoids for Prevention and Treatment of Gastrointestinal Disorders: Useful Nutraceuticals?
  78. Cannabidiol (CBD)-what we know and what we don’t
  79. Diabetic neuropathy
  80. The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities
  81. Healing with CBD page 205

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