Best CBD Cream for Tendonitis - April 2024

How CBD Creams May Help With Tendonitis

Tendonitis (sometimes called tendinitis) is an inflammation of the tendon, a thick fibrous connective tissue that attaches muscles to bones⁽¹⁾.

The condition causes tenderness and pain outside joints⁽²⁾. Although tendonitis occurs in any of the body’s tendons, it usually affects the shoulders, heels, knees, wrists, and elbows.

Cannabidiol, popularly known as CBD, is one of the numerous chemical compounds present in the cannabis plant.

Compared to THC (tetrahydrocannabinol), which is the primary psychoactive compound of cannabis (sometimes called marijuana), CBD is non-intoxicating and does not present psychoactive activities⁽³⁾.

Clinical studies suggest that CBD has potential pain-relieving effects and anti-inflammatory properties^(4-5). Tendonitis is associated with pain and inflammation⁽⁶⁾. Hence, CBD may help with tendonitis.

Additionally, CBD and other cannabinoids work with the human body’s ECS (endocannabinoid system) to maintain homeostasis, a process by which living organisms maintain stability while adapting to environmental changes⁽⁷⁾.

The ECS comprises cannabinoid receptors 1 and 2 (CB1 and CB2), endocannabinoids, and enzymes⁽⁸⁾. The most prominent cannabinoid receptor is CB1, abundant in the CNS (central nervous system).

The CB1 receptors bind with THC and mediate most of the CNS effects of THC⁽⁹⁾.

Meanwhile, CB2 receptors are found predominantly in cells and tissues of the immune system. The expression of these receptors is associated with inflammation⁽¹⁰⁾.

Although cannabidiol has low-affinity binding for both cannabinoid receptors, CBD agonist activity at CB2 receptors may account for the compound’s anti-inflammatory properties and influence on pain⁽¹¹⁾.

To date, there is no specific study regarding CBD cream and how it may help with tendonitis. However, CBD’s purported health benefits and its activity in the ECS may help with such a condition.

Still, more studies are warranted to elucidate CBD’s efficacy on tendonitis.

Benefits of Using CBD Creams for Tendonitis

Corticosteroids are common medications for tendonitis to help with pain management⁽¹²⁾. However, frequent corticosteroid injections may weaken the tendon and cause it to rupture⁽¹³⁾.

In contrast, a study from the journal Current Drug Safety mentioned that controlled CBD administration may be safe in humans and animals⁽¹⁴⁾.

Although there is no specific research examining the benefits of using CBD creams for tendonitis, CBD’s potential therapeutic effects may help manage symptoms of tendonitis, including pain and inflammation.

CBD for Chronic Pain 

A study from the European Journal of Pain that uses a rat model suggested that topical CBD application may have the potential to relieve arthritis pain-related behaviors and inflammation without detrimental side effects⁽¹⁵⁾.

A 2018 case report from Pediatric Dermatology reported that self-initiated use of topical CBD in patients with epidermolysis bullosa resulted in less pain, less blistering, and rapid wound healing⁽¹⁶⁾.

Epidermolysis bullosa is a rare form of blistering skin disorder.

Meanwhile, a 2018 research article from Molecules mentioned that a few researchers had proposed a topical administration of cannabidiol with silicon fluids and hyaluronic acid⁽¹⁷⁾. They believed that this system could potentially enhance application methods and improve absorption into the skin to help ease pain.

CBD for Inflammation 

One study mentioned that oxidative stress and apoptosis are involved in tendon degeneration⁽¹⁸⁾.

Oxidative stress is caused by an imbalance between the production and accumulation of ROS (reactive oxygen species) in tissues and cells and the ability of the biological system to detoxify reactive products⁽¹⁹⁾.

Meanwhile, apoptosis allows cells to self-destruct when stimulated by an appropriate target⁽²⁰⁾.

CBD is an agonist of A2A (adenosine) receptors, G-protein coupled receptors that regulate inflammatory processes⁽²¹⁾. When CBD activates A2A receptors, the non-psychoactive compound may prevent oxidative stress.

How to Take CBD Creams for Tendonitis

Cannabidiol has been shown to help with inflammation and muscle tightness when applied topically⁽²²⁾.

You may take CBD cream for tendonitis by directly applying this pain relief cream to the affected area.

Aside from creams, topical CBD products are also available in salves and lotions. Other CBD forms include edibles like gummies, CBD tinctures, and CBD vapes.

How Long Does CBD Take to Help With Tendonitis?

How long CBD takes to help with tendonitis depends on the administration method used or several other factors like CBD potency and the user’s body weight.

For CBD topicals like CBD cream, it usually takes 15 to 30 minutes for you to feel the effects of CBD⁽²³⁾.

How Long Will CBD Help With Tendonitis?

How long CBD lasts after it starts to help usually depends on its pharmacokinetics, the movement of a substance or drug into, through, and out of the body.

Pharmacokinetics includes the time course of drug absorption, distribution, metabolism, excretion, and bioavailability.

Bioavailability is the amount of a specific substance that reaches circulation in the body and provides an active effect.

However, CBD topicals like CBD creams are not absorbed into the entire body⁽²⁴⁾. Therefore, CBD’s bioavailability via the topical route is zero⁽²⁵⁾.

The CB2 receptors in the skin are the ones that take CBD to be absorbed locally⁽²⁶⁾.

How to Choose the Right CBD Creams for Tendonitis

There are various CBD brands in the market promising to offer the best CBD cream for pain and specific conditions like tendonitis.

Below are a few pertinent factors to consider that may help you sort through products to find the best CBD cream for you:

CBD Extracts

CBD extracts can be categorized as full-spectrum CBD, broad-spectrum CBD, and CBD isolates⁽²⁷⁾.

A full-spectrum CBD product contains all compounds of the cannabis plant, including CBD and other cannabinoids, essential oils, flavonoids, and terpenes.

Full-spectrum CBD also has 0.3% of THC. Additionally, it is known to provide the entourage effect due to the presence of all cannabis compounds.

The entourage effect is a concept wherein the biologically active compounds of cannabis work better when administered together.

Flavonoids are active compounds found in cannabis that are believed to have antioxidant, anti-inflammatory, and antiviral actions⁽²⁸⁾.

Meanwhile, terpenes are the components of essential oils responsible for the aroma of cannabis⁽²⁹⁾.

Broad-spectrum CBD also contains all of the natural compounds of cannabis except for THC⁽³⁰⁾. Lastly, CBD isolates refer to the type of CBD that only contains pure cannabidiol.

Ingredients 

If possible, always opt for CBD creams made from U.S.-grown hemp. Make sure to choose CBD formats made with natural, organic ingredients or non-GMO products because you will be applying the content to your skin.

Clinical studies have identified numerous benefits of natural ingredients, including anti-inflammatory properties for skincare⁽³¹⁾.

Most CBD topicals like CBD creams, CBD salves, and lotions may also contain aloe vera, peppermint, eucalyptus, arnica, beeswax, menthol, and botanical extracts.

If you are to use CBD topicals for the first time, make sure to consult your doctor first to know whether you are allergic to some of the ingredients listed.

Extraction Method 

The extraction method is the process wherein CBD oil is derived from cannabis.

Carbon dioxide, ethanol, or solvent extraction is preferred to create a safe CBD product⁽³²⁾. The CBD extract may then be diluted with oil, such as olive oil. Extraction techniques utilizing hexane or butane may leave harmful residues, like heavy metals and pesticides.

Third-Party Lab Testing

The best way to check whether a CBD product contains what the brand says it does is to look at the lab reports and COAs (certificates of analysis).

The COAs or lab test results must be up-to-date and come from a trusted third-party laboratory. Hence, ensure that the information on the COA matches the claims on the product label.

Brand Reputation

Many CBD brands like CBDistillery and Medterra are dedicated to offering only high-quality CBD products to their customers.

Still, make sure to research the CBD company to verify if it is a trusted brand. Read customer feedback to get more insight into the manufacturer and its products.

Carrier Oils 

After extracting CBD from the hemp plant, CBD manufacturers infuse cannabidiol into a carrier oil.

The most commonly utilized carrier oils are coconut oil and hempseed oil⁽³³⁾. Although most people interchangeably use’ hempseed oil’ and ‘hemp oil,’ they have significant variations.

Hemp oil (CBD oil) is an essential oil that comes from the flowers and leaves of hemp plants, while hempseed oil is made from the pressed seeds of hemp.

Hempseed oil is sufficient in nutrients and fatty acids, although it does not contain CBD⁽³⁴⁾.

Safety of CBD Creams for Tendonitis

According to the WHO (World Health Organization), cannabidiol is generally well tolerated. The compound also has a good safety profile⁽³⁵⁾.

Topical products like CBD cream are applied to the skin for localized relief. It is believed that CBD may decrease sunburn, itchiness, muscle tightness, and inflammation when applied topically⁽³⁶⁾.

When cannabinoids like CBD are applied to the skin, they neither enter the bloodstream nor become available to the entire body⁽³⁷⁾.

Hence, topical CBD products like CBD creams may be safer to use, considering how little is known about the long-term safety of cannabidiol⁽³⁸⁾.

The Potential Side Effects and Risks of Using CBD for Tendonitis

Like other substances, CBD may also carry some risks and produce minor side effects, including⁽³⁹⁾:

• Dry mouth
• Diarrhea
• Reduced appetite
• Drowsiness
• Fatigue 

CBD may also cause drug interactions with other medications a person may be taking for tendonitis.

At high doses, CBD may inhibit the activity of cytochrome P450⁽⁴⁰⁾. Cytochrome P450 is a family of liver enzymes that metabolize approximately 60% of the pharmaceutical drugs people consume.

Over-the-counter pain relievers, including aspirin and ibuprofen, may relieve discomfort associated with tendonitis⁽⁴¹⁾. Topical creams with anti-inflammatory effects may also be effective in reducing pain.

Doctors may also inject corticosteroids (steroids) medication around a tendon for pain relief. A cortisone injection may also reduce inflammation⁽⁴²⁾.

NSAIDs (nonsteroidal inflammatory drugs), like ibuprofen and steroids, use the cytochrome P450 enzyme system and may interact with CBD⁽⁴³⁾.

For this reason, ensure to talk with your healthcare provider first if you are considering using CBD alongside other medications for tendonitis.

NOTE: The risks and side effects discussed in this section are for oral CBD. If you are to use CBD creams for tendonitis, it would be better to consult a dermatologist.

Remember that some CBD topicals may include other ingredients like beeswax and peppermint, which may trigger an allergic reaction in some people.

CBD Dosage

The FDA (Food and Drug Administration) has not approved CBD as a medical treatment for tendonitis. Thus, there is no standard CBD dosage for such a condition.

Meanwhile, it has been shown that mid-range doses between 10mg and 100mg of CBD daily may be effective for pain and inflammation⁽⁴⁴⁾.

Tendonitis is associated with pain and inflammation⁽⁴⁵⁾. Hence, mid-range doses of CBD may help with tendonitis. Still, it is best to talk with a healthcare professional experienced in cannabis use for accurate dosing.

Legality of CBD

The U.S. Congress ratified the 2018 Farm Bill, legalizing the commercial use of industrial hemp and products obtained from hemp plants⁽⁴⁶⁾.

The Farm Bill states that Cannabis sativa L. and other derivatives of cannabis with no more than 0.3% THC content on a dry weight basis are deemed legal under federal law⁽⁴⁷⁾.

The Federal Comprehensive Drug Abuse Prevention and Control Act of 1970 established a drug schedule to classify substances into five categories based on their potential for drug abuse and possible medical usage⁽⁴⁸⁾.

Some states have passed laws allowing the use of recreational and medical marijuana. Nevertheless, these state laws do not change that, under federal law, marijuana is still included in the Schedule I drug category⁽⁴⁹⁾.

Substances listed as Schedule I drugs have a high abuse potential with no accepted medical use⁽⁵⁰⁾. For this reason, medications under this category may not be dispensed, prescribed, or administered under federal law.

Rules and regulations regarding medical cannabis may be confusing. Hence, consumers should familiarize themselves with various state laws.

In Texas, for instance, the local government passed laws in June of 2019, creating a state industrial hemp program⁽⁵¹⁾.

Under House Bill 1325, the Texas Department of State Health Services is in charge of issuing licenses for people who want to manufacture or sell consumable hemp-derived products in the Lone Star State.

Meanwhile, in October 2021, California Governor Gavin Newsom signed Assembly Bill No. 45 into law⁽⁵²⁾.

The bill allows the inclusion of hemp and cannabinoids, extracts, or hemp derivatives in dietary supplements, food and beverages, cosmetics, and processed pet food provided that they contain less than 0.3% THC⁽⁵³⁾.

Colorado is another state that permits recreational and medical marijuana use. The local government decriminalized the use of marijuana by passing Amendment 64 to the Colorado Constitution in November 2012⁽⁵⁴⁾.

Remember that even if a specific state law indicates that CBD is legal, the only FDA-approved CBD drug is Epidiolex, used to treat rare and severe forms of epilepsy.

FAQs

1. How can CBD help with tendonitis?

CBD has potential anti-inflammatory and pain-relieving properties^(55-56). These purported health benefits may help with tendonitis.

Tendonitis is a tendon irritation that causes pain⁽⁵⁷⁾. Common names for various tendonitis problems include the golfer’s elbow, swimmer’s shoulder, tennis elbow, and jumper’s knee.

2. What evidence or research exists to say that CBD helps with tendonitis?

There is no direct evidence suggesting that CBD can help with tendonitis. However, a study showed that oxidative stress may cause tendon degeneration⁽⁵⁸⁾.

CBD is an agonist of A2A receptors, G-protein coupled receptors that regulate inflammatory processes. When CBD activates these receptors, the compound may prevent oxidative stress⁽⁵⁹⁾.

Oxidative stress takes place when there is a disparity between antioxidants and oxidants.

Cannabidiol has been shown to affect redox balance by modifying the activity level of antioxidants and oxidants⁽⁶⁰⁾. CBD may also interrupt free radical chain reactions by capturing these free radicals or transforming them into less active forms.

3. Is there any evidence that CBD can make tendonitis worse?

There is no evidence suggesting that CBD can make tendonitis worse.

Still, it is best to make an appointment with a healthcare professional experienced in cannabis use. This way, they can advise you regarding possible risks, drug interactions, and allergic reactions.

4. Will CBD interact with any current medication I may be taking for tendonitis?

Yes. CBD may interact with painkillers, like NSAIDs and corticosteroids⁽⁶¹⁾. Most doctors recommend these medications for tendonitis to help with pain management⁽⁶²⁾.

Nevertheless, if you want to use CBD topicals, like CBD creams, for tendonitis, you should talk with a dermatologist first.

Most CBD topical products contain extracts mixed into fat, such as coconut oil and beeswax. These ingredients make it easier to spread the content on your skin and allow the compound to penetrate it⁽⁶³⁾.

However, a 2019 study from the journal Contact Dermatitis showed that a few patients with lip inflammation and facial eczema had positive allergic reactions to beeswax⁽⁶⁴⁾.

For this reason, consumers need to consult a dermatologist to determine if certain ingredients in CBD topicals can cause them an allergic reaction.

5. Are there other treatments I should consider alongside CBD to help with tendonitis?

Some people suffering from tendonitis may benefit from physical therapy to strengthen the affected muscle tendon⁽⁶⁵⁾.

For example, eccentric strengthening, or applying tension to a muscle as it lengthens, may effectively treat chronic tendon conditions⁽⁶⁶⁾.

CBD topicals like creams could be a safer form of CBD, considering how little is known about the compound’s long-term safety⁽⁶⁷⁾.

Still, it is vital to consult a healthcare professional, especially if you are to use CBD for the first time alongside any other treatments for tendonitis. This way, these experts can advise you about potential allergic reactions.

6. Can I fail a drug test if I use CBD for tendonitis?

No. You will not get a positive drug test if you use CBD topicals like creams for tendonitis. CBD topicals do not enter the bloodstream⁽⁶⁸⁾.

Furthermore, CBD does not cause a euphoric effect⁽⁶⁹⁾. However, some CBD products have traces of THC that may build up in your body when taken frequently via ingestion or inhalation⁽⁷⁰⁾.

An increased THC level in the bloodstream may result in a positive drug test.

7. What is the dosage for tendonitis?

The FDA does not recognize CBD as a medical treatment for tendonitis. Hence, there is no standard CBD dosage for such a condition.

However, doses between 10mg and 100mg of CBD daily may be effective for pain and inflammation⁽⁷¹⁾. Pain and inflammation are associated with tendonitis⁽⁷²⁾.

8. What are the benefits of CBD creams or oils for tendonitis?

It is believed that CBD applied topically may help with muscle tightness and inflammation⁽⁷³⁾. CBD topicals are available in creams, oils, salves, and lotions.

Tendonitis involves inflammation⁽⁷⁴⁾. Therefore, applying CBD topicals like cream may benefit individuals with such a condition.

9. Are there any side effects when CBD creams or oils are used for tendonitis?

Some people may be allergic to a particular ingredient in CBD creams, like beeswax. For this reason, consult your healthcare provider first.

10. Is CBD legal to use for tendonitis? 

CBD and other derivatives of cannabis with no more than 0.3% THC content on a dry weight basis are considered legal under federal law⁽⁷⁵⁾.

Still, state laws vary, so familiarize yourself with various rules and regulations regarding CBD use for tendonitis and other medical conditions.

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1. Tendinitis
   https://www.mayoclinic.org/diseases-conditions/tendinitis/symptoms-causes/syc-20378243#:~:text=Tendinitis%20is%20inflammation%20or%20irritation,%2C%20wrists%2C%20knees%20and%20heels.
2. Ibid.
3. Cannabidiol (CBD)
   https://www.ncbi.nlm.nih.gov/books/NBK556048/
4. Research Shows Pain-Relieving Effects of CBD
   https://www.sciencedaily.com/releases/2021/04/210423130221.htm#:~:text=Summary%3A,it’s%20certainly%20creating%20wonder%20profits.
5. Antioxidative and Anti-Inflammatory Properties of Cannabidiol
   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023045/
6. Tendinitis
   https://www.mayoclinic.org/diseases-conditions/tendinitis/symptoms-causes/syc-20378243#:~:text=Tendinitis%20is%20inflammation%20or%20irritation,%2C%20wrists%2C%20knees%20and%20heels.
7. The Endocannabinoid System, Our Universal Regulator
   https://www.jyi.org/2018-june/2018/6/1/the-endocannabinoid-system-our-universal-regulator
8. An Introduction to the Endogenous Cannabinoid System
   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789136/#:~:text=The%20ECS%20is%20comprised%20of,and%20degradation%20of%20the%20endocannabinoids.&text=Exogenous%20cannabinoids%2C%20such%20as%20tetrahydrocannabinol,their%20interactions%20with%20cannabinoid%20receptors.
9. Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in Disease
   https://www.frontiersin.org/articles/10.3389/fncel.2016.00294/full
10. Ibid.
11. The Endocannabinoid System, Cannabinoids, and Pain
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820295/
12. Tendinitis
    https://www.mayoclinic.org/diseases-conditions/tendinitis/diagnosis-treatment/drc-20378248
13. Complications Associated With the Use of Corticosteroids in the Treatment of Athletic Injuries
    https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.465.5381&rep=rep1&type=pdf
14. Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent
    https://pubmed.ncbi.nlm.nih.gov/22129319/#:~:text=Also%2C%20chronic%20use%20and%20high,reportedly%20well%20tolerated%20in%20humans.&text=Based%20on%20recent%20advances%20in,and%20in%20vivo%20side%20effects.
15. Transdermal Cannabidiol Reduces Inflammation and Pain-Related Behaviours in a Rat Model of Arthritis
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851925/
16. Self-Initiated Use of Topical Cannabidiol Oil for Epidermolysis Bullosa
    https://pubmed.ncbi.nlm.nih.gov/29786144/
17. Cannabinoid Delivery Systems for Pain and Inflammation Treatment
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222489/#B30-molecules-23-02478
18. Overexpression of Antioxidant Enzyme Peroxiredoxin 5 Protects Human Tendon Cells Against Apoptosis and Loss of Cellular Function During Oxidative Stress
    https://pubmed.ncbi.nlm.nih.gov/15276323/#:~:text=Oxidative%20stress%20and%20apoptosis%20are%20implicated%20in%20tendon%20degeneration.&text=Results%20from%20our%20study%20indicate,apoptosis%20and%20maintaining%20collagen%20synthesis.
19. Oxidative Stress: Harms and Benefits for Human Health
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551541/#:~:text=Oxidative%20stress%20is%20a%20phenomenon,to%20detoxify%20these%20reactive%20products.
20. Apoptosis: A Review of Programmed Cell Death
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2117903/
21. Antioxidative and Anti-Inflammatory Properties of Cannabidiol
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023045/#:~:text=Therefore%2C%20it%20has%20been%20suggested,of%20immune%20cells%20%5B66%5D.
22. Healing With CBD, page. 210.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
23. Healing With CBD, page. 193
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
24. How to Safely Use CBD: Should You Inhale, Spray, Apply, or Eat It?
    https://www.consumerreports.org/cbd/how-to-use-cbd-inhale-spray-apply-eat/
25. Healing With CBD, page 210.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
26. Ibid.
27. Cannabidiol Primer for Healthcare Professionals
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340472/
28. Flavonoids As Antioxidants
    https://pubmed.ncbi.nlm.nih.gov/10924197/
29. The Cannabis Terpenes
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763918/
30. Cannabidiol Primer for Healthcare Professionals
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340472/
31. Innovations in Natural Ingredients and Their Use in Skin Care
    https://pubmed.ncbi.nlm.nih.gov/20626172/
32. Cannabidiol Primer for Healthcare Professionals
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340472/
33. Healing With CBD, page 205.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
34. Hemp Seed Oil Properties
    https://extension.okstate.edu/fact-sheets/hemp-seed-oil-properties.html
35. Cannabidiol (CBD)
    https://www.who.int/medicines/access/controlled-substances/CannabidiolCriticalReview.pdf
36. Healing With CBD, page 210.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
37. Ibid.
38. How to Safely Use CBD: Should You Inhale, Spray, Apply, or Eat It?
    https://www.consumerreports.org/cbd/how-to-use-cbd-inhale-spray-apply-eat/
39. What Are the Benefits of CBD — And Is It Safe to Use?
    https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/is-cbd-safe-and-effective/faq-20446700#:~:text=CBD%20use%20also%20carries%20some,taking%2C%20such%20as%20blood%20thinners.
40. Healing With CBD, page 114.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
41. Tendinitis
    https://www.mayoclinic.org/diseases-conditions/tendinitis/diagnosis-treatment/drc-20378248
42. Ibid.
43. Healing With CBD, pages 115-116
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
44. CBD: A Patient’s Guide to Medicinal Cannabis, page 129.
    https://drive.google.com/file/d/1MILU_6ZjYkII-XMUPHLFPiPQbrz__5Sh/view
45. Tendinitis
    https://www.mayoclinic.org/diseases-conditions/tendinitis/symptoms-causes/syc-20378243
46. H.R.2 – Agriculture Improvement Act of 2018
    https://www.congress.gov/bill/115th-congress/house-bill/2/text
47. FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD)
    https://www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbd
48. The Federal Controlled Substances Act: Schedules and Pharmacy Registration
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839489/#:~:text=The%20Federal%20Comprehensive%20Drug%20Abuse,effective%20on%20May%201%2C%201971.&text=The%20goal%20of%20the%20Controlled,and%20dispensing%20of%20controlled%20substances.
49. Ibid.
50. Ibid.
51. Cannabis and the Law
    https://guides.sll.texas.gov/cannabis/cbd
52. Assembly Bill No. 45
    https://leginfo.legislature.ca.gov/faces/billTextClient.xhtml?bill_id=202120220AB45
53. Ibid.
54. Legal Marijuana Use in Colorado
    https://cannabis.colorado.gov/legal-marijuana-use-in-colorado
55. Antioxidative and Anti-Inflammatory Properties of Cannabidiol
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023045/
56. Research Shows Pain-Relieving Effects of CBD
    https://www.sciencedaily.com/releases/2021/04/210423130221.htm
57. Tendinitis
    https://www.mayoclinic.org/diseases-conditions/tendinitis/symptoms-causes/syc-20378243#:~:text=Tendinitis%20is%20inflammation%20or%20irritation,%2C%20wrists%2C%20knees%20and%20heels.
58. Overexpression of Antioxidant Enzyme Peroxiredoxin 5 Protects Human Tendon Cells Against Apoptosis and Loss of Cellular Function During Oxidative Stress
    https://pubmed.ncbi.nlm.nih.gov/15276323/#:~:text=Oxidative%20stress%20and%20apoptosis%20are%20implicated%20in%20tendon%20degeneration.&text=Results%20from%20our%20study%20indicate,apoptosis%20and%20maintaining%20collagen%20synthesis.
59. Antioxidative and Anti-Inflammatory Properties of Cannabidiol
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023045/#:~:text=Therefore%2C%20it%20has%20been%20suggested,of%20immune%20cells%20%5B66%5D.
60. Ibid.
61. Healing With CBD, pages 115-116
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
62. Tendinitis
    https://www.mayoclinic.org/diseases-conditions/tendinitis/diagnosis-treatment/drc-20378248
63. How to Safely Use CBD: Should You Inhale, Spray, Apply, or Eat It?
    https://www.consumerreports.org/cbd/how-to-use-cbd-inhale-spray-apply-eat/
64. Contact Allergy to Beeswax and Propolis Among Patients With Cheilitis or Facial Dermatitis
    https://pubmed.ncbi.nlm.nih.gov/31066083/
65. Tendinitis
    https://www.mayoclinic.org/diseases-conditions/tendinitis/diagnosis-treatment/drc-20378248
66. Ibid.
67. How to Safely Use CBD: Should You Inhale, Spray, Apply, or Eat It?
    https://www.consumerreports.org/cbd/how-to-use-cbd-inhale-spray-apply-eat/
68. Healing With CBD, page 210.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
69. Cannabidiol (CBD)-What We Know and What We Don’t
    https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476
70. Can You Take CBD and Pass a Drug Test?
    https://www.consumerreports.org/cbd/can-you-take-cbd-and-pass-a-drug-test/
71. CBD: A Patient’s Guide to Medicinal Cannabis, page 129.
    https://drive.google.com/file/d/1MILU_6ZjYkII-XMUPHLFPiPQbrz__5Sh/view
72. Tendinitis
    https://www.mayoclinic.org/diseases-conditions/tendinitis/diagnosis-treatment/drc-20378248
73. Healing With CBD, page 210.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
74. Tendinitis
    https://my.clevelandclinic.org/health/diseases/10919-tendinitis
75. FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD)
    https://www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbd

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