Can CBD help with neuropathy?

  • Anxiety, vomiting, nausea, and pain are typical neuropathic symptoms, as reiterated in a study on painful peripheral neuropathies, which was published in Current Neuropharmacology(1).
  • CBD may possess some anti-anxiety and anti-emetic (anti-vomiting) characteristics, according to a report in the Journal of Psychopharmacology(2). Meanwhile, a study published in the Journal of Experimental Medicine demonstrated one mechanism by which CBD inhibits inflammatory and neuropathic pain(3).
  • Muscle spasms can be symptoms of neuropathic damage, which often manifests in painful, uncontrolled muscle twitches(4). A study has demonstrated that medicine containing CBD and THC in a 1:1 ratio may help with pain management in people with spasticity, chronic neuropathic pain, severe pain due to nerve damage, and peripheral neuropathic pain(5).
  • It is essential to conduct research into the safety and effectiveness of cannabis products and consult with a doctor experienced in cannabis use before consuming or using these products as treatment options or part of a health regimen.

Best CBD Oils For Neuropathy

  1. Editor’s Pick: Spruce 750mg Lab Grade CBD Oil
  2. Best Organic: NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
  3. Most Pure: CBDistillery Full Spectrum CBD Oil
  4. Best Natural Alternative: cbdMD CBD Oil Tincture Natural 1500mg
  5. Best Customer Service: Sabaidee Super Good Vibes CBD Oil
Editor's Pick

Spruce 750mg Lab Grade CBD Oil

Specifically formulated to be more palatable to CBD users
Spruce 750mg Lab Grade CBD Oil Bottle
  • Overall Clinical Score
    99%
    Editor's Pick
  • Score breakdown
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
  • Summary

    Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

    Pro's
    Cons's
    •  Mid-strength
    •  Natural peppermint flavor
    •  Made from 100% organic and natural ingredients
    •  No other flavors
  • Features
    Discount pricing available? 20% Off Coupon Code: CBDCLINICALS
    Source
    Source of Hemp
    Kentucky, USA & North Carolina, USA
    Form Oil Tincture
    Ingredients Organic Hemp Seed Oil, Full Spectrum CBD Oil
    Type
    Type of CBD
    Full Spectrum
    Extraction
    Extraction Method
    Moonshine extraction method
    How to take it Under tongue
    Potency
    Potency - CBD Per Bottle
    750 mg per bottle
    Carrier Oil Organic Hemp Seed Oil
    Concentration
    CBD Concentration Per Serving
    25mg of CBD per dropper full (1ml)
    Drug Test Contains 0.3% THC but there is a chance you may test positive for marijuana
    Flavours Peppermint
    Price Range $89 ($75.65 for subscriptions, 15% discount from regular price)
    $/mg CBD
    Price ($/mg)
    $0.12/mg ($0.10/mg with subscription)
    Shipping
    Shipping/Time to delivery
    2-4 business days (first class USPS)
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants Organic, Non-GMO, no pesticides, no herbicides, no solvents or chemical fertilizers, No preservatives or sweeteners
    Allergens Vegan, Gluten free
    Refund policy Within 30 days
    Recommended for New CBD users
    Countries served USA only (all 50 states)
Check Latest Prices
Best Organic

NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil

Perfect for anyone who are looking for CBD products that promote a healthy body and mind.
NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
  • Overall Clinical Score
    99%
    Best Organic
  • Score breakdown
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
  • Summary

    Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

    Pro's
    Cons's
    •  Pure CBD hemp
    •  All natural
    •  Approximately 300 drops total
    •  No other flavors
  • Features
    Discount pricing available? 20% Off Coupon Code: CBDCLINICALS20
    Source
    Source of Hemp
    Colorado, USA
    Form Oil Tincture
    Ingredients Full Spectrum Hemp Extract, Organic Virgin Hemp Seed Oil
    Type
    Type of CBD
    Full Spectrum CBD
    Extraction
    Extraction Method
    CO2 Method
    How to take it Under the tongue for approximately 30 seconds before swallowing
    Potency
    Potency - CBD Per Bottle
    900mg per bottle
    Carrier Oil Organic Hemp Oil
    Concentration
    CBD Concentration Per Serving
    60mg per dropper full (1ml)
    Drug Test Contains 0.3% THC but there is a chance you may test positive for marijuana
    Flavours Natural
    Price Range $99 - $434
    $/mg CBD
    Price ($/mg)
    $0.08 - $0.13
    Shipping
    Shipping/Time to delivery
    2-3 Days via USPS
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants No additives or preservatives, Non-GMO, NO herbicides, pesticides, or chemical fertilizers
    Allergens Not specified
    Refund policy Within 30 days
    Recommended for Health-conscious persons
    Countries served USA (all 50 states) and over 40 countries including Australia, Azerbaijan, Beliza, Bosnia & Herzegovina, Brazil, Chile, China, Croatia, Czech Republic, Estonia, France, Hong Kong, Hungary, Ireland, Israel, Japan, Latvia, Lebanon, Lithuania, Macao, Malaysia, Malta, Netherlands, New Zealand, Oman, Paraguay, Poland, Portugal, Saudi Arabia, Serbia, Singapore, South Korea, Sweden, Switzerland, United Arab Emirates, United Kingdom, Uruguay, and many more.
Check Latest Prices
Most Pure

CBDistillery Full Spectrum CBD Oil

Reap all of the benefits of cannabis plant without any potentially intoxicating effects.
CBDistillery Full Spectrum CBD Oil Tincture
  • Overall Clinical Score
    99%
    Most Pure
  • Score breakdown
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
  • Summary

    CBDistillery’s Full Spectrum Oil Tinctures combine the powers of CBD oil and other naturally occurring plant proteins, minerals, vitamins, and more so that you can get all of the benefits of the cannabis plant without any potentially intoxicating effects.

    Pro's
    Cons's
    •  60-Day Satisfaction Guarantee
    •  Various strengths
    •  Oil extracted from aerial plant parts of US grown industrial hemp
    •  Sourced from non-GMO industrial hemp grown in the USA through natural farming practices
    •  Dropper is a bit shaky
  • Features
    Discount pricing available? CBDCLINICALS15
    Source
    Source of Hemp
    Colorado, USA
    Form Oil Tincture
    Ingredients Fractionated Coconut Oil (MCT) and Full Spectrum CBD Hemp Extract (Aerial Parts)
    Type
    Type of CBD
    Full-spectrum
    Extraction
    Extraction Method
    CO2 extraction
    How to take it Apply your desired dosage and hold under the tongue for 10-20 seconds before swallowing.
    Potency
    Potency - CBD Per Bottle
    500mg - 5000mg
    Carrier Oil Coconut Oil (MCT)
    Concentration
    CBD Concentration Per Serving
    16.6mg to 166.6mg
    Drug Test May contain trace amounts of hemp derived THC <0.3%
    Flavours None
    Price Range $35 - $240
    $/mg CBD
    Price ($/mg)
    $0.04 - $0.07
    Shipping
    Shipping/Time to delivery
    Standard UPS Shipping, ships up to 5 business days
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants Contaminant-free
    Allergens Allergen-free
    Recommended for Different CBD users with different needs
Check Latest Prices
Best Natural Alternative

cbdMD CBD Oil Tincture Natural 1500mg

Uses USA hemp that is grown on non-GMO farms, and is both vegan and gluten-free
cbdMD CBD Oil Tincture Natural 1500mg
  • Overall Clinical Score
    99%
    Best Natural Alternative
  • Score breakdown
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
  • Summary

    cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

    Pro's
    Cons's
    •  Various delicious flavors to choose from
    •  Has vegan, organic, and gluten-free ingredients
    •  Free shipping for this particular product within USA
    •  World-class customer service team
    •  cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
  • Features
    Discount pricing available? 15% Off Coupon Code: cbdMD15
    Source
    Source of Hemp
    Kentucky, USA
    Form Oil Tincture
    Ingredients Cannabidiol (CBD), MCT Oil, and Flavoring
    Type
    Type of CBD
    Broad Spectrum
    Extraction
    Extraction Method
    CO2 extraction method
    How to take it Under tongue
    Potency
    Potency - CBD Per Bottle
    1500mg per bottle
    Carrier Oil Organic Coconut MCT Oil
    Concentration
    CBD Concentration Per Serving
    50mg per dropper full (1ml)
    Drug Test Containing less than 0.3% THC, there are still trace amounts
    Flavours Natural, Berry, Orange and Mint
    Price Range $99.99
    $/mg CBD
    Price ($/mg)
    $0.07
    Shipping
    Shipping/Time to delivery
    2-5 Business days (via Fedex)
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants 100% organic, non-GMO, and vegan-certified
    Allergens Vegan, Gluten free
    Refund policy Within 30 days
    Recommended for Daily CBD oil users
    Countries served USA only (all 50 states)
Check Latest Prices
Best Customer Service

Sabaidee Super Good Vibes CBD Oil

4x the strength of a regular cbd oil
Sabaidee Super Good Vibes CBD Oil
  • Overall Clinical Score
    99%
    Best Customer Service
  • Score breakdown
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
  • Summary

    Super Good Vibes CBD Oil provides the purest and highest quality Cannabidiol (CBD) on the market as well as other high quality phytocannabinoids, terpenes, vitamins, omega fatty acids, trace minerals, and other beneficial for your health elements, which all work together to provide benefits.

    Pro's
    Cons's
    •  Extra strong
    •  Significant benefits with just a few drops
    •  100% Natural ingredients
    •  No other flavors
  • Features
    Discount pricing available? 15% Off Coupon Code: CBDCLINICALS15
    Source
    Source of Hemp
    Colorado, USA
    Form Oil Tincture
    Ingredients Cannabidiol (CBD), Coconut Medium-chain triglycerides (MCT) Oil, Peppermint oil
    Type
    Type of CBD
    Broad Spectrum
    Extraction
    Extraction Method
    CO2-extraction
    How to take it Using 1-3 servings per day as needed is a good start to determine how much you need
    Potency
    Potency - CBD Per Bottle
    1000 mg per bottle
    Carrier Oil Coconut MCT Oil
    Concentration
    CBD Concentration Per Serving
    33.5 mg per dropper (1ml)
    Drug Test Contains 0.3% THC but there is a chance you may test positive for marijuana
    Flavours Peppermint
    Price Range Single Bottle - $119.95, 2-Pack - $109.97 each, 3-Pack - $98.31 each, 6-Pack - $79.99 each
    $/mg CBD
    Price ($/mg)
    Single bottle - $0.010, 2-Pack - $0.011, 3-Pack - $0.009, 6-Pack - $0.007
    Shipping
    Shipping/Time to delivery
    3-5 Business days
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants Contaminant-free
    Allergens Vegan and Gluten-free
    Refund policy Within 30 days
    Recommended for Patients who are looking for serious CBD oil support
    Countries served USA only (all 50 states)
Check Latest Prices

Why Some People are Turning to CBD for Neuropathy

Neuropathy, often called peripheral neuropathy, is a medical condition characterized by a problem in the peripheral nervous system, which is found outside the spinal cord and the brain(6)

Some cases of neuropathy can be easily treated and sometimes cured. If neuropathy cannot be cured, the treatment is aimed at preventing further nerve damage and controlling and managing symptoms(7)

Fortunately, CBD has been shown to possess some therapeutic characteristics that might help with symptoms linked to neuropathy. 

CBD vs. Chronic Pain, Anxiety, and Vomiting

The American Chronic Pain Association describes neuropathic pain (also known as nerve pain) as chronic pain that occurs when the nerves in the peripheral nervous system are injured or damaged(8)

Anxiety, vomiting, nausea, and pain are typical neuropathic symptoms, as described in a study on painful peripheral neuropathies, which was published in Current Neuropharmacology(9)

CBD has been shown to possess health benefits that may alleviate these symptoms.

CBD may be useful in treating different types of chronic pain(10). Chronic pain, particularly neuropathic pain, is a major clinical problem that is difficult to treat, according to the author of a study on neuronal mechanisms for neuropathic pain(11).

CBD may also possess other therapeutic elements, including some anti-anxiety and anti-emetic (anti-vomiting) characteristics(12)

CBD vs. Inflammation and Muscle Spasms

There are many causes of neuropathy, and diabetes (an inflammatory disease) is the number one cause in the United States(13). 

Neuropathy can also be caused by autoimmune diseases, such as lupus and rheumatoid arthritis(14). Autoimmune diseases are linked to an increased risk of high blood pressure and cardiovascular disease(15).

A study showed one mechanism by which CBD inhibits inflammatory and neuropathic pain(16).  These types of chronic pain are two of the most challenging types of pain to treat(17).

A 2016 animal study from the European Journal of Pain showed that CBD applied on the skin might help reduce pain and inflammation due to arthritis(18). 

CBD’s potent anti-inflammatory properties were also demonstrated in an in vitro 2018 study published in the Journal of Pharmacology and Experimental Therapeutics(19)

In addition, CBD may help reduce muscle spasms, which can be a feature of neuropathic damage, often manifesting in painful, uncontrolled muscle twitches(20)

Another clinical study, which was published by Neuropsychiatric Disease and Treatment, examined Sativex, a combined cannabinoid medicine constituted by THC and CBD in a 1:1 ratio(21)

Sativex mouth spray has demonstrated some efficacy not only for helping with pain management in patients with chronic neuropathic pain, pain due to nerve damage, peripheral neuropathic pain, advanced cancer pain, and rheumatoid arthritis but also for spasticity due to multiple sclerosis (MS)(22)

Similar results were obtained from another review published in The Cochrane Database of Systematic Reviews in 2018(23)

The said review of hundreds of studies looked at marijuana-based medicines on neuropathic pain in adults. While not all of them were positive results, there was evidence that cannabinoids could reduce the symptoms of neuropathy.

How CBD Oil Works to Help with Neuropathy

To understand how CBD works to help with neuropathy, it is essential that one understands how the endocannabinoid system (ECS) works. 

The therapeutic effects of cannabinoids, such as CBD, are realized by their interaction with the body’s ECS and its specialized cannabinoid receptors. 

The ECS, integral to the body’s physiologies, is responsible for regulating a wide range of body functions, including pain sensation, immune response, anxiety, sleep, mood, appetite, metabolism, and memory.

CB1 and CB2 are the two main types of receptors found in specific parts of the human body. These receptors each have particular roles in the ECS.

CB1 receptors are mostly located in the brain and central nervous system. However, they are also found in the reproductive organs, gastrointestinal and urinary tracts, liver, lungs, and retina(24)

 CB1 receptors play a role in motor regulation, memory processing,  appetite, pain sensation, mood, and sleep(25)

The activation of CB1 receptors has also been related to neuroprotective responses. This activity suggests the cannabinoids with a higher affinity for CB1 receptors could help in the treatment and prevention of neurodegenerative conditions, such as Parkinson’s disease, Alzheimer’s disease, and multiple sclerosis.

Meanwhile, CB2 receptors are primarily situated on cells in the immune system and its associated structures.

When CB2 receptors are triggered, they stimulate a response that fights inflammation, reducing pain, and minimizing damage to tissues.

These anti-inflammatory responses have been found to be potentially useful for treating inflammation-related conditions, such as chronic inflammatory demyelinating polyneuropathy (CIDP), Crohn’s disease, arthritis, and inflammatory bowel syndrome(26).  

CBD acts indirectly against cannabinoid agonists, which are substances that bind to a receptor and cause the same action as the substances that typically attach to the receptor.

CBD also interacts with several other receptors in the body, such as the 5-HT1A receptor, which is linked to serotonin, a neurotransmitter found to be a contributor to feelings of well-being. It is through this interaction that these cannabinoids promote healing and balance(27).  

The Pros and Cons of CBD Oil for Neuropathy 

The Pros 

  • Studies mentioned previously demonstrate CBD’s therapeutic benefits in helping alleviate neuropathic symptoms, such as inflammation, spasm, anxiety, pain, nausea, and vomiting.  
  • CBD has been well-received by several health agencies, like the World Health Organization (WHO), which states that CBD “is generally well-tolerated with a good safety profile.”(28). CBD oil may be safer than most over-the-counter and prescription drugs that may have many side effects.
  • CBD is non-addictive, says Nora Volkow, director of the National Institute on Drug Abuse (NIDA) in a 2015 article (26). This characteristic makes CBD safe for daily intake(29)
  • CBD oil may be purchased without a prescription in locations where they are legally available.

The Cons

  • Studies are too limited to determine whether or not CBD is an effective treatment for conditions other than the ones approved by the U.S. Food and Drug Administration (FDA).
  • As with the use of any natural chemical compound, there are risks involved in using CBD. According to the Mayo Clinic, possible side effects include drowsiness, dry mouth, diarrhea, fatigue, and reduced appetite(30)
  • CBD has been shown to interact with other drugs and alter how the body metabolizes certain medications, as a 2017 research revealed(31). Consult with a doctor experienced in cannabis use before starting a CBD regimen or combining it with current prescription medications.
  • Dr. Doris Trauner, professor of neurosciences and pediatrics at the University of California San Diego School of Medicine and a physician at San Diego’s Rady Children’s Hospital, cautions that CBD products marketed online and in dispensaries are mostly unregulated(32)

The lack of regulation makes it difficult to determine whether the CBD gummies, tinctures, patches, balms, and gelcaps contain what the product label claims.

A 2107 review published in the Journal of the American Medical Association revealed labeling inaccuracies among CBD products. Some products had less CBD than stated, while others had more(33)

How CBD Oil Compares to Alternative Treatments for Neuropathy

Alternative treatments for neuropathy include the use of capsaicin, amino acids, and primrose oil(34). 

  • Capsaicin is a substance found in hot peppers. A study looked into the use of an 8% capsaicin dermal patch and found that almost 71% of those who had cancer-associated neuropathic pain experienced 90% pain relief(35)
  • Amino acids, such as acetyl-L-carnitine, may benefit people who have undergone chemotherapy and people with diabetes, says Mayo Clinic(36)
  • Primrose oil may help reduce neuropathic pain in people with diabetes, according to Mayo Clinic, in an article on peripheral neuropathy diagnosis and treatment(37)

Meanwhile, CBD has been shown to possess some characteristics that may help with neuropathy.

  • Some CBD products come in the form of creams and transdermal patches infused with capsaicin. The capsaicin in these CBD creams and patches combine with CBD’s natural pain-relieving benefits to target specific areas in the body.
  • Hemp oil produced from cannabis seed is an excellent source of essential amino acids and fatty acids(38)
  • CBD’s anti-inflammatory properties have been shown to potentially help with Type 1 Diabetes, according to a 2016 study published in Clinical Hemorheology and Microcirculation(39). Some CBD topicals also come infused with primrose oil. 

How to Choose the Right CBD for Neuropathy

Studies cited previously show that CBD is not the only cannabinoid found in cannabis that can help alleviate neuropathic symptoms, such as inflammation, spasm, anxiety, pain, nausea, and vomiting. Hence, when choosing a CBD product, it may be best to opt for one that contains full-spectrum CBD oil.

Full-spectrum CBD oil contains all phytonutrients from hemp, including trace amounts of THC, terpenes, flavonoids, amino acids, and essential oils. These compounds work together to intensify the therapeutic benefits of each cannabinoid, resulting in the “entourage effect”.

Those with allergies to THC may opt to use broad-spectrum CBD oil, which is like full-spectrum CBD but without the THC that makes the user high.

However, regardless of the form of CBD product of choice, careful consideration must still be employed in selecting the best CBD oil to help with the immune system, inflammation, pain, and anxiety.

The following factors are essential to ensure the safety and reliability of the CBD products purchased:

  1. Research on the exact legal stipulations applicable to CBD in the area where it would be bought and used.
  2. Purchase only high-quality CBD products from legitimate and reliable brands. The majority of companies that manufacture the best CBD oil products grow their hemp from their own farm, or they purchase from licensed hemp producers.
  3. Research product reviews before buying from an online store. When purchasing from a physical store or dispensary, check whether the store is authorized by the government to sell CBD.
  4. One important thing to look for in CBD products is certification codes. Several certification authorities approve certain products only after some thorough screening tests. 
  5. Compare company claims about their products’ potency with that of the third-party lab reports. Look for a certificate of analysis for every product purchased.
  6. Consulting with a trusted medical professional experienced in CBD use is ideal before one purchases his or her first bottle of CBD. 

Best CBD Creams For Neuropathy

1. Most Popular: Spruce Topical CBD Cream
2. Best Skin Relief: Sabaidee Comfort Cream
3. Athlete’s Top Choice: cbdMD CBD Recover Inflammation Cream

Most Popular

Spruce Topical CBD Cream

Maximum Strength Formula, Great For Pain Relief
Spruce Topical CBD Cream Jar
  • Overall Clinical Score
    99%
    Most Popular
  • Score breakdown
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
  • Summary

    Each of Spruce’s two-ounce containers of cream contains a total of 300mg of CBD. Users can apply this cream to painful areas as many times as needed. The cream is completely plant-based with moisturizing ingredients such as paraffin and mineral oil.

    One thing that users may want to watch out for is that this cream does contain some THC. At 0.3 percent THC, it is a very small amount and unlikely to be absorbed in the body for long. However, users who must go through routine drug tests may want to avoid this product.

    Pro's
    Cons's
    •  Made with all-natural plant-derived scents
    •  Pleasant scent
    •  Very affordable
    •  Made from 100% organic and natural ingredients
    •  Available in single size only
  • Features
    Discount pricing available? 20% Off Coupon Code: CBDCLINICALS
    Source
    Source of Hemp
    Kentucky, USA & North Carolina, USA
    Form Cream
    Ingredients Water, Mineral Oil, Petrolatum, Glycerin, Microcrystalline Wax, Lanolin Alcohol, Paraffin, Panthenol, Magnesium Sulfate, Decyl Oleate, Octyldodecanol, Aluminum Stearates, Fragrance, Citric Acid, Magnesium Stearate, Methylchloroisothiazolinone, Methylisothiazolinone, Hemp Extracted CBD
    Type
    Type of CBD
    Full Spectrum
    Extraction
    Extraction Method
    Moonshine extraction method
    How to take it Topical/Transdermal
    Potency
    Potency - CBD Per Bottle
    300 mg per jar
    Carrier Oil Not specified
    Concentration
    CBD Concentration Per Serving
    5.17 mg per gram
    Drug Test Contains 0.3% THC but there is a chance you may test positive for marijuana
    Flavours all-natural plant-derived scents
    Price Range $39 ($33.15 for subscriptions, 15% discount from regular price)
    $/mg CBD
    Price ($/mg)
    $0.13 ($0.11/mg with subscription)
    Shipping
    Shipping/Time to delivery
    2-4 business days (first class USPS)
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants Organic, Non-GMO, no pesticides, no herbicides, no solvents or chemical fertilizers, No preservatives or sweeteners
    Allergens Vegan, Gluten free
    Refund policy Within 30 days
    Recommended for Aches and pains
    Countries served USA only (all 50 states)
Check Latest Prices
Best Skin Relief

Sabaidee Comfort Cream

For skin restoration and daily relief
Sabaidee Comfort Cream
  • Overall Clinical Score
    99%
    Best Skin Relief
  • Score breakdown
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
  • Summary

    Comfort Cream is a silky and soothing lotion formulated with natural skin relief botanicals and infused with over 500mg of sustainably grown broad spectrum CBD from Hemp Extract. It leaves the skin moisturized with a slight shine, and no greasy residue after.

    Pro's
    Cons's
    •  Non-greasy
    •  Better version of Sabaidee Relief Rub
    •  More portable
    •  Not intended for facial application
  • Features
    Discount pricing available? 15% Off Coupon Code: CBDCLINICALS15
    Source
    Source of Hemp
    Colorado, USA
    Form Cream
    Ingredients Water, Olive Oil Glycereth-8 Esters, Sunflower Oil, Vinyl Crosspolymer, PEG-6, Jojoba Oil, Peppermint Oil, Camphor Oil, Menthol, Wintergreen Oil, Lavander Oil, Bergamot Oil, Shea Butter, Broad Spectrum Hemp Extract, Caprlyl Glycol, Glycerine, Citrus Reticulata Fruit Extract, Citrus Aurantium Amara Fruit Extract, Citrus Aurantium Sinensis Peel Extract, Absorbic Acid, Citric Acid, Lactic Acid
    Type
    Type of CBD
    Broad Spectrum
    Extraction
    Extraction Method
    CO2-extraction
    How to take it Massage the cream into skin and use as needed for desired relief. Store at room temperature. Do not eat. Not intended for facial application. Avoid contact with eyes.
    Potency
    Potency - CBD Per Bottle
    500 mg per tube
    Carrier Oil Not specified
    Concentration
    CBD Concentration Per Serving
    10 mg to 11.04 mg per ml
    Drug Test Contains 0.3% THC but there is a chance you may test positive for marijuana
    Flavours Sweet mint
    Price Range 1 Tube - $59 each, 2 Tubes - $54 each, 3 Tubes - $49 each, 6 Tubes - $40 each
    $/mg CBD
    Price ($/mg)
    1 Tube - $1.18, 2 Tubes - $1.08, 3 Tubes - $0.98, 6 Tubes - $0.80
    Shipping
    Shipping/Time to delivery
    3-5 Business days
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants Contaminant-free
    Allergens Vegan and Gluten-free
    Recommended for Skin maintenance
Check Latest Prices
Athlete's Top Choice

cbdMD CBD Recover Inflammation Cream

Enriched with CBD, arnica, vitamin B6, and MSM for a full profile of topical properties, this product was designed with one goal in mind: recovery.
cbdMD CBD Recover Inflammation Cream Bottle
  • Overall Clinical Score
    99%
    Athlete's Top Choice
  • Score breakdown
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
  • Summary

    This product features a broad-spectrum cannabinoid extract which contains other natural phytocannabinoids, such as cannabidivarin (CBDV) and cannabigerol (CBG).

    This cream contains 1500 mg of USA Grade-A premium CBD, together with some supplemental natural compounds that have pain-relieving and anti-inflammatory characteristics.

    cbdMD products are THC-free and sourced from USA hemp. They are also third-party, ISO-certified lab-tested to ensure safety and effectiveness.

    Pro's
    Cons's
    •  Quick-acting relief
    •  Specifically designed to ease inflammation caused by muscles, ligaments, tendons, and nerves
    •  Not thick and greasy
    •  Ideal for athletic recovery
    •  Made from premium CBD from non-GMO USA hemp
    •  A little bit pricey compared to other brands
  • Features
    Discount pricing available? 15% Off Coupon Code: cbdMD15
    Source
    Source of Hemp
    Kentucky, USA
    Form Topical
    Ingredients Organic Aloe Leaf Juice, Organic Coconut Oil, Cannabidiol (CBD), Organic Arnica Flower Extract, Vitamin B6, Methylsulfonylmethane (MSM), Histamine Dihydrochloride, Emulsifying Wax, Stearic Acid, Cetyl Alcohol, Hydroxyethylcellulose, Glycerin, Sweet Basil Leaf Oil, Black Pepper Oil, Roman Chamomile Flower Oil, German Chamomile Flower Oil, Cinnamon Leaf Oil, Citronella Oil, Eucalyptus Leaf Oil, Helichrysum Flower Oil, Ginger Root Oil, Pink Grapefruit Peel Oil, Juniper Berry Oil, Lemongrass Oil, Peppermint Oil, Pine Needle Oil, Ravensara Oil, Rosemary Leaf Oil, Spearmint Oil, Wild Oregano Oil, Organic Cypress Oil, Sweet Fennel Oil, Lemon Peel Oil, Lavender Flower Oil, Organic Alcohol, Phenoxyethanol, Caprylyl Glycol, and Sorbic Acid
    Type
    Type of CBD
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CBD Dosage for Neuropathy

There is no prescribed CBD dose specific for neuropathy. However, there was a review on the use of Sativex for treating neuropathic pains of different origin(40)

According to the U.S. National Library of Medicine, through its ClinicalTrials.gov website, Sativex may be used in both cases as pain medication(41):

  1. For palliative care (an approach that improves the quality of life of individuals with a life-threatening illness, such as cancer), Sativex may be administered at low doses, with a range of 1 to 4 sprays per day. Each actuation of the spray delivers 2.7mg delta-9-tetrahydrocannabinol (THC) and 2.5mg cannabidiol (CBD). The maximum daily dose is 10.8mg THC and 10mg CBD.
  2. For pain, Sativex may be administered at medium doses, with a range of 6 to 10 sprays per day. Each actuation of the spray delivers 2.7mg delta-9-tetrahydrocannabinol (THC) and 2.5mg cannabidiol (CBD). The maximum daily dose is 27mg THC and 25mg CBD.

How to Take CBD Oil for Neuropathy

A topical CBD cream or CBD patch is ideal when dealing with inflammation or pain in a specific area of the body. When applied on the skin, the CBD cream or patch can interact with local clusters of cannabinoid receptors, instead of the ECS as a whole.

Many CBD creams and patches are also infused with other elements, such as essential oils, that may supplement CBD’s therapeutic benefits.

Neuropathic pain also disrupts sleep, as the pain is sometimes worse at night. When orally consumed before bedtime, through a tincture or a capsule, CBD may help influence physiological functions throughout the whole body through an interaction with the ECS.

CBD oil capsules and edibles, such as brownies, gummies, and lozenges, are a convenient and straightforward way to take CBD oil, especially for beginners.

Meanwhile, CBD oil tinctures or drops may be a practical option for those who seek fast results and maximum dosage control. 

Sublingual application allows for results to be experienced within 30 to 60 minutes after its use, and the effects can be felt for 4 to 6 hours.

Understanding CBD 

Medical cannabis (also called medical marijuana) is defined as a herbal drug derived from the cannabis plant that is used as part of the treatment for a specific symptom or disease(42).  

Cannabis sativa L. (Cannabaceae) is a type of cannabis that is one of the most recognized ancient plants. Sativa is Latin for “useful”, and it is a term that is commonly used in plant names. 

CBD oil may be derived from either a hemp plant or marijuana plant, although most CBD oil products in the market are hemp-derived. 

CBD is non-psychoactive, making it favorable to those who want to experience its health benefits without the ‘high’ induced by tetrahydrocannabinol (THC). In general, a level of about 1% THC is considered the threshold for cannabis to have an intoxicating effect(43).

Conclusion

There has been an intensive search for new pain-relieving remedies in the last several decades. However, every successful drug for the treatment of chronic pain produces aversive side effects(44)

CBD is not a cure-all. However, CBD has been shown to possess great potential to help with symptoms of peripheral neuropathy. 

Further studies on CBD could help provide individuals with a way to manage their pain more effectively. Participating in clinical trials in the pursuit of a cure for peripheral neuropathy is an invaluable way to get actively involved. For those interested to find and take part in a clinical trial on peripheral neuropathy, click here(45).


  1. Marchettini P, Lacerenza M, Mauri E, Marangoni C. Painful peripheral neuropathies. Curr Neuropharmacol. 2006;4(3):175–181. doi:10.2174/157015906778019536.
  2. Crippa, J. A. S., Derenusson, G. N., Ferrari, T. B., Wichert-Ana, L., Duran, F. L., Martin-Santos, R., … Hallak, J. E. C. (2011). Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. Journal of Psychopharmacology, 25(1), 121–130. https://doi.org/10.1177/0269881110379283; Parker LA, Rock EM, Limebeer CL. Regulation of nausea and vomiting by cannabinoids. Br J Pharmacol. 2011;163(7):1411–1422. doi:10.1111/j.1476-5381.2010.01176.x.
  3. Xiong W, Cui T, Cheng K, et al. Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. J Exp Med. 2012;209(6):1121–1134. doi:10.1084/jem.20120242.
  4. NINDS. (2018, Aug). Peripheral Neuropathy Fact Sheet. Retrieved from https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Peripheral-Neuropathy-Fact-Sheet.
  5. Perez J. Combined cannabinoid therapy via an oromucosal spray. Drugs Today (Barc) 2006;42:495–503.DOI: 10.1358/dot.2006.42.8.1021517.  
  6. Cleveland Clinic. (2019, Dec 16). Neuropathy (Peripheral Neuropathy). Retrieved from https://my.clevelandclinic.org/health/diseases/14737-neuropathy.
  7. ibid.
  8. The American Chronic Pain Association. Neuropathic Pain. Retrieved from https://www.theacpa.org/conditions-treatments/conditions-a-z/neuropathic-pain/.
  9. Marchettini P et al. op. cit.
  10. Grinspoon, P. (2019, Aug 27). Cannabidiol (CBD) — what we know and what we don’t. Retrieved from https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476.
  11. Zhuo M. Neuronal mechanism for neuropathic pain. Mol Pain. 2007;3:14. Published 2007 Jun 6. doi:10.1186/1744-8069-3-14.
  12. Crippa et al. op. cit.
  13. Cleveland Clinic. op. cit.
  14. Mayo Clinic. (2019, May 22). Peripheral neuropathy. Retrieved from https://www.mayoclinic.org/diseases-conditions/peripheral-neuropathy/symptoms-causes/syc-20352061.
  15. Wolf VL, Ryan MJ. Autoimmune Disease-Associated Hypertension. Curr Hypertens Rep. 2019;21(1):10. Published 2019 Feb 2. doi:10.1007/s11906-019-0914-2. 
  16. Xiong W et al. op. cit.
  17. Grinspoon, P. op. cit.
  18. Hammell DC, Zhang LP, Ma F, et al. Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. Eur J Pain. 2016;20(6):936–948. doi:10.1002/ejp.818.
  19. Petrosino S et al. Anti-inflammatory Properties of Cannabidiol, a Nonpsychotropic Cannabinoid, in Experimental Allergic Contact Dermatitis. Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 652-663; DOI: https://doi.org/10.1124/jpet.117.244368.
  20. NINDS. op. cit.
  21. Malfitano AM, Proto MC, Bifulco M. Cannabinoids in the management of spasticity associated with multiple sclerosis. Neuropsychiatr Dis Treat. 2008;4(5):847–853. doi:10.2147/ndt.s3208.
  22. Perez J. op.cit.
  23. Mücke M, Phillips T, Radbruch L, Petzke F, Häuser W. Cannabis-based medicines for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2018;3(3):CD012182. Published 2018 Mar 7. doi:10.1002/14651858.CD012182.pub2.
  24. Reggio PH. Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown. Curr Med Chem. 2010;17(14):1468–1486. doi:10.2174/092986710790980005.
  25. ECHO. (2017, April 18). Retrieved from https://echoconnection.org/look-endocannabinoid-systems-cb1-cb2-receptors/.
  26. Turcotte C, Blanchet MR, Laviolette M, Flamand N. The CB2 receptor and its role as a regulator of inflammation. Cell Mol Life Sci. 2016;73(23):4449–4470. doi:10.1007/s00018-016-2300-4.
  27. ECHO. (2017, March 29). Retrieved from https://echoconnection.org/differences-cbd-thc/.
  28. WHO. Expert Committee on Drug Dependence. (2017, Nov 6-10). Cannabidiol (CBD). Retrieved from https://www.who.int/medicines/access/controlled-substances/5.2_CBD.pdf.
  29. Nora Volkow. NIDA. Researching Marijuana for Therapeutic Purposes: The Potential Promise of Cannabidiol (CBD). National Institute on Drug Abuse website. https://www.drugabuse.gov/about-nida/noras-blog/2015/07/researching-marijuana-therapeutic-purposes-potential-promise-cannabidiol-cbd. July 20, 2015. Accessed January 31, 2020.
  30. Bauer, B. (2018, Dec 20). What are the benefits of CBD — and is it safe to use? Retrieved from https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/is-cbd-safe-and-effective/faq-20446700.
  31. Iffland K, Grotenhermen F. An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis Cannabinoid Res. 2017;2(1):139–154. Published 2017 Jun 1.
  32. Peachman, RB. (2019, Feb 26). Can CBD Help Your Child? Retrieved from https://www.consumerreports.org/cbd/can-cbd-help-your-child/.
  33. Bonn-Miller MO, Loflin MJE, Thomas BF, Marcu JP, Hyke T, Vandrey R. Labeling Accuracy of Cannabidiol Extracts Sold Online. JAMA. 2017;318(17):1708–1709. doi:10.1001/jama.2017.11909.
  34. Mayo Clinic. (2019, May 22). Peripheral neuropathy. Retrieved from https://www.mayoclinic.org/diseases-conditions/peripheral-neuropathy/diagnosis-treatment/drc-20352067.
  35. Baranidharan G, Das S, Bhaskar A. A review of the high-concentration capsaicin patch and experience in its use in the management of neuropathic pain. Ther Adv Neurol Disord. 2013;6(5):287–297. doi:10.1177/1756285613496862.
  36. Mayo Clinic. op. cit.
  37. ibid.
  38. Huestis MA. Human cannabinoid pharmacokinetics. Chem Biodivers. 2007;4(8):1770–1804. doi:10.1002/cbdv.200790152.
  39. Lehmann C et al. Experimental cannabidiol treatment reduces early pancreatic inflammation in type 1 diabetes.Clin Hemorheol Microcirc. 2016;64(4):655-662. doi: 10.3233/CH-168021. DOI: 10.3233/CH-168021.
  40. Jordi Perez & Mª Victoria Ribera (2008) Managing neuropathic pain with Sativex®: a review of its pros and cons, Expert Opinion on Pharmacotherapy, 9:7, 1189-1195, DOI: 10.1517/14656566.9.7.1189.
  41. NIH. (2013, June). A Study of Sativex® for Pain Relief in Patients With Advanced Malignancy. Retrieved from https://clinicaltrials.gov/ct2/show/NCT00530764.
  42. Ware M. (2020, Jan 23). Medical cannabis.https://www.britannica.com/science/medical-cannabis.
  43. E. Small and D. Marcus, “Hemp: A New Crop with New Uses for North America,” in Trends in New Crops and New Uses, ed. J. Janick and A. Whipkey (Alexandria, VA: American Society for Horticultural Science Press, 2002.
  44. Mogil, J. Animal models of pain: progress and challenges. Nat Rev Neurosci 10, 283–294 (2009). https://doi.org/10.1038/nrn2606.
  45. The Foundation for Peripheral Neuropathy. (2016). Peripheral Neuropathy Clinical Trials. Retrieved from https://www.foundationforpn.org/research/peripheral-neuropathy-clinical-trials/
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