How Does CBD Oil Help With Sleep?

  • A 2019 experiment demonstrated how adults experienced sedative effects after taking cannabidiol (CBD) (1).   
  • ADAA (Anxiety and Depression Association of America) mentioned how anxiety could lead to sleeping problems (2). A study has shown how CBD reduced the anxiety of 79% of human subjects (3)
  • A 2019 study has shown that CBD was reported to improve sleep issues among 71.4% of patients with autism spectrum disorder (ASD) (4)The Journal of Clinical Pharmacy and Therapeutics shared a study that described how four patients treated with CBD has reduced the frequency of  REM sleep behavior disorder (RBD) events (5).
  • A study published in FEBS Letters has found that CBD modulated sleep cycles among animal subjects. The authors mentioned how CBD might have therapeutic value in daytime sleepiness (6).

Best CBD Oil for Sleep

Editor's Pick

Spruce 750mg Lab Grade CBD Oil

Specifically formulated to be more palatable to CBD users
Spruce 750mg Lab Grade CBD Oil Bottle
  • Overall Clinical Score
    99%
    Editor's Pick
  • Score breakdown
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
  • Summary

    Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

    Pro's
    Cons's
    •  Mid-strength
    •  Natural peppermint flavor
    •  Made from 100% organic and natural ingredients
    •  No other flavors
  • Features
    Discount pricing available? 20% Off Coupon Code: CBDCLINICALS
    Source
    Source of Hemp
    Kentucky, USA & North Carolina, USA
    Form Oil Tincture
    Ingredients Organic Hemp Seed Oil, Full Spectrum CBD Oil
    Type
    Type of CBD
    Full Spectrum
    Extraction
    Extraction Method
    Moonshine extraction method
    How to take it Under tongue
    Potency
    Potency - CBD Per Bottle
    750 mg per bottle
    Carrier Oil Organic Hemp Seed Oil
    Concentration
    CBD Concentration Per Serving
    25mg of CBD per dropper full (1ml)
    Drug Test Contains 0.3% THC but there is a chance you may test positive for marijuana
    Flavours Peppermint
    Price Range $89 ($75.65 for subscriptions, 15% discount from regular price)
    $/mg CBD
    Price ($/mg)
    $0.12/mg ($0.10/mg with subscription)
    Shipping
    Shipping/Time to delivery
    2-4 business days (first class USPS)
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants Organic, Non-GMO, no pesticides, no herbicides, no solvents or chemical fertilizers, No preservatives or sweeteners
    Allergens Vegan, Gluten free
    Refund policy Within 30 days
    Recommended for New CBD users
    Countries served USA only (all 50 states)
Check Latest Prices

Best Organic

NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil

Perfect for anyone who are looking for CBD products that promote a healthy body and mind.
NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
  • Overall Clinical Score
    99%
    Best Organic
  • Score breakdown
    Value
    Quality
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    Customer Service
    Lab Testing Transparency
    Effectiveness
  • Summary

    Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

    Pro's
    Cons's
    •  Pure CBD hemp
    •  All natural
    •  Approximately 300 drops total
    •  No other flavors
  • Features
    Discount pricing available? 20% Off Coupon Code: CBDCLINICALS20
    Source
    Source of Hemp
    Colorado, USA
    Form Oil Tincture
    Ingredients Full Spectrum Hemp Extract, Organic Virgin Hemp Seed Oil
    Type
    Type of CBD
    Full Spectrum CBD
    Extraction
    Extraction Method
    CO2 Method
    How to take it Under the tongue for approximately 30 seconds before swallowing
    Potency
    Potency - CBD Per Bottle
    900mg per bottle
    Carrier Oil Organic Hemp Oil
    Concentration
    CBD Concentration Per Serving
    60mg per dropper full (1ml)
    Drug Test Contains 0.3% THC but there is a chance you may test positive for marijuana
    Flavours Natural
    Price Range $99 - $434
    $/mg CBD
    Price ($/mg)
    $0.08 - $0.13
    Shipping
    Shipping/Time to delivery
    2-3 Days via USPS
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants No additives or preservatives, Non-GMO, NO herbicides, pesticides, or chemical fertilizers
    Allergens Not specified
    Refund policy Within 30 days
    Recommended for Health-conscious persons
    Countries served USA (all 50 states) and over 40 countries including Australia, Azerbaijan, Beliza, Bosnia & Herzegovina, Brazil, Chile, China, Croatia, Czech Republic, Estonia, France, Hong Kong, Hungary, Ireland, Israel, Japan, Latvia, Lebanon, Lithuania, Macao, Malaysia, Malta, Netherlands, New Zealand, Oman, Paraguay, Poland, Portugal, Saudi Arabia, Serbia, Singapore, South Korea, Sweden, Switzerland, United Arab Emirates, United Kingdom, Uruguay, and many more.
Check Latest Prices

Best Value

Sabaidee Super Good Vibes CBD Oil

4x the strength of a regular cbd oil
Sabaidee Super Good Vibes CBD Oil
  • Overall Clinical Score
    99%
    Best Value
  • Score breakdown
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
  • Summary

    Super Good Vibes CBD Oil provides the purest and highest quality Cannabidiol (CBD) on the market as well as other high quality phytocannabinoids, terpenes, vitamins, omega fatty acids, trace minerals, and other beneficial for your health elements, which all work together to provide benefits.

    Pro's
    Cons's
    •  Extra strong
    •  Significant benefits with just a few drops
    •  100% Natural ingredients
    •  No other flavors
  • Features
    Discount pricing available? 15% Off Coupon Code: CBDCLINICALS15
    Source
    Source of Hemp
    Colorado, USA
    Form Oil Tincture
    Ingredients Cannabidiol (CBD), Coconut Medium-chain triglycerides (MCT) Oil, Peppermint oil
    Type
    Type of CBD
    Broad Spectrum
    Extraction
    Extraction Method
    CO2-extraction
    How to take it Using 1-3 servings per day as needed is a good start to determine how much you need
    Potency
    Potency - CBD Per Bottle
    1000 mg per bottle
    Carrier Oil Coconut MCT Oil
    Concentration
    CBD Concentration Per Serving
    33.5 mg per dropper (1ml)
    Drug Test Contains 0.3% THC but there is a chance you may test positive for marijuana
    Flavours Peppermint
    Price Range Single Bottle - $119.95, 2-Pack - $109.97 each, 3-Pack - $98.31 each, 6-Pack - $79.99 each
    $/mg CBD
    Price ($/mg)
    Single bottle - $0.010, 2-Pack - $0.011, 3-Pack - $0.009, 6-Pack - $0.007
    Shipping
    Shipping/Time to delivery
    3-5 Business days
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants Contaminant-free
    Allergens Vegan and Gluten-free
    Refund policy Within 30 days
    Recommended for Patients who are looking for serious CBD oil support
    Countries served USA only (all 50 states)
Check Latest Prices

Best Natural Alternative

cbdMD CBD Oil Tincture Natural 1500mg

Uses USA hemp that is grown on non-GMO farms, and is both vegan and gluten-free
cbdMD CBD Oil Tincture Natural 1500mg
  • Overall Clinical Score
    99%
    Best Natural Alternative
  • Score breakdown
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
  • Summary

    cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

    Pro's
    Cons's
    •  Various delicious flavors to choose from
    •  Has vegan, organic, and gluten-free ingredients
    •  Free shipping for this particular product within USA
    •  World-class customer service team
    •  cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
  • Features
    Discount pricing available? 15% Off Coupon Code: cbdMD15
    Source
    Source of Hemp
    Kentucky, USA
    Form Oil Tincture
    Ingredients Cannabidiol (CBD), MCT Oil, and Flavoring
    Type
    Type of CBD
    Broad Spectrum
    Extraction
    Extraction Method
    CO2 extraction method
    How to take it Under tongue
    Potency
    Potency - CBD Per Bottle
    1500mg per bottle
    Carrier Oil Organic Coconut MCT Oil
    Concentration
    CBD Concentration Per Serving
    50mg per dropper full (1ml)
    Drug Test Containing less than 0.3% THC, there are still trace amounts
    Flavours Natural, Berry, Orange and Mint
    Price Range $99.99
    $/mg CBD
    Price ($/mg)
    $0.07
    Shipping
    Shipping/Time to delivery
    2-5 Business days (via Fedex)
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants 100% organic, non-GMO, and vegan-certified
    Allergens Vegan, Gluten free
    Refund policy Within 30 days
    Recommended for Daily CBD oil users
    Countries served USA only (all 50 states)
Check Latest Prices

Why People Are Turning to CBD for Sleep

Sleep Disorders published a 2015 study that discussed the residual side effects of sleep medication. Prescription hypnotic drugs, such as benzodiazepine, chronobiotic agents, and low-dose hydrochloride, produce adverse effects that may interfere in the quality of life (7).  

Also, access to prescribed sleep medications may be challenging for some, while others may have treatment-resistant insomnia. 

These difficulties are why CBD is increasingly popular among individuals looking for alternative approaches to better sleep. 

A study posted in the Neuropsychiatric Diseases and Treatment shared that the prevalence of sleep disorders has risen due to increased work hours, night shifts, and lifestyle conditions. Prolonged wakefulness can lead to a decline in cognitive function and the impairment of the immune system (8)

A study has shown that 33% of adults worldwide suffer from sleep disorders every year (9)

Sleep problems may be caused by factors, like sleep apnea, restless leg syndrome, insomnia, chronic pain, and narcolepsy (a condition that causes an individual to fall asleep during the day) (10)

Many studies have shown how CBD might potentially affect some of these conditions. 

CBD Oil vs. Sleep Disorders

The human sleep cycle comprises four stages of non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep. The first three stages are NREM sleep, followed by the fourth stage, REM sleep

A healthy sleep cycle experiences all four stages of sleep. NREM stages account for 75-80% of sleep time, while 20-25% is spent on REM sleep (11)

An individual with insomnia will have trouble maintaining the sleep cycle. Some may even have difficulty getting to the first two stages of sleep. 

The disruption of this cycle can lead to many health issues, such as hypoxemia (low oxygen) and dyspnea (shortness of breath), pain conditions, and neurodegenerative diseases (12).

A 2017 study published in Current Psychiatry Reports mentioned that CBD might have therapeutic potential for treating insomnia. The study continued by acknowledging that CBD may hold promise for excessive daytime sleepiness and REM-sleep behavior disorder (13)

A crossover study compared CBD with nitrazepam (a hypnotic drug). The authors found that a CBD dose of 160 mg increased the duration of sleep among human subjects (14)

REM-sleep behavior disorder (RBD), a parasomnia, is defined by undesired events during sleep. Parasomnias are disruptive sleep disorders.

An individual may suddenly wake between stages 2 to 4 in the sleep cycle. This condition often involves confusional arousal (disorientation of time and place), sleep terrors, loss of muscle atonia, and sleepwalking (15)

RBD is prevalent among men over 50 years old and among patients with Parkinson’s disease (PD). A study has described the beneficial effects of CBD in reducing RBD symptoms among PD patients (16)

During the study, four patients with PD were treated with CBD. The clinical trial resulted in the reduced frequency of RBD-related events. Upon discontinuation of the treatment, RBD complex movements and symptoms returned (17)

The study stated that although positive results have been observed among patients, the mechanism of therapeutic action remains a hypothesis. More research is needed to confirm the efficacy and implications of CBD.

For more information on how CBD helps with insomnia, click here.

Psychiatrist and cannabis researcher, Scott Shannon, M.D., led a clinical study on 71 adult patients with anxiety and sleep disorders. The study entitled Cannabidiol in Anxiety and Sleep: A Large Case Series was published in The Permanente Journal in 2019.

After conducting the 12-week study, they have found that 57 out of the 72 of the patients who had anxiety experienced improvements during the first month of taking CBD (18)

Post-traumatic stress disorder (PTSD) develops after a traumatic event. PTSD is frequently associated with night terrors and disturbed sleep (19)

A study posted in the Journal of Alternative and Complementary Medicine has demonstrated how CBD treatment (of over two months) decreased the severity of PTSD symptoms in healthy human subjects (20)

The study showed examples of how CBD dosings of 12mg (oral) and 32 mg (inhalation) have decreased the anxiety symptoms and sleep disturbances on patients. 

Also, the Frontiers of Pharmacology published a recent study that experimented on how CBD affects children with autism spectrum disorder (ASD). Children with ASD often suffer from comorbidity of symptoms, including anxiety and sleep disorder

Parents have reported that CBD may have improved ASD symptoms. Among the 53 children (ages 4-22 years old), sleep problems improved in 71.4% and worsened in 4.7%, while anxiety improved in 47.1% and worsened in 23.5% (21).  

Based on the previous studies mentioned, CBD might have the potential to improve sleep quality and reduce anxiety among human subjects. However, more studies are needed to verify the observations and hypotheses presented. 

CBD Oil vs. Daytime Sleepiness

The circadian rhythm involves an individual’s physical, mental, and behavioral changes. These changes respond to light and dark environments, thus influencing one’s sleep-wake cycle

There are several challenges in maintaining circadian rhythms, such as night shift work, improper eating behavior, prolonged wakefulness, and other lifestyle disorders (22)

The Journal of Clinical Psychology released a study demonstrating how  CBD (15 mg) increased wakefulness among healthy young adults (23). The dose used in the clinical trial also contained tetrahydrocannabinol (THC). 

Moreover, a study posted in Current Neuropharmacology demonstrated how CBD acted as a wake-inducing agent to mice during the “lights-on” period. The hypothesis was that CBD might influence the increase of dopamines in the brain of animal subjects (24).  

Dopamines are neurotransmitters in the body that regulates bodily functions. Dopamines are also in charge of the reward system in the brain and promote wakefulness. The study also found that an increase in dopamine in rat models led to alertness (25)

The study hypothesized that since CBD induced alertness among animal and human subjects, it might hold a therapeutic value in sleep disorders caused by daytime sleepiness (26).

CBD Oil vs. Sleep Apnea

For individuals experiencing treatment-resistant insomnia, they may be experiencing an underlying condition called sleep apnea. 

Sleep apnea is a disorder wherein throat muscles block the airway, making it difficult to breathe while sleeping.

There are currently three types of sleep apnea. Obstructive sleep apnea involves the throat muscles blocking the airway, while central sleep apnea occurs when the brain does not send proper signals to the muscles. Complex sleep apnea is when an individual experiences both central sleep and obstructive sleep apneas (27).  

Obstructive sleep apnea (OSA) is the most common among the three types of sleep apneas. A study had mentioned that sleep-disordered breathing is common among patients with treatment-resistant insomnia (28)

Currently, there is a lack of study on how CBD affects individuals who have sleep apneas. 

A 2018 study posted in the Journal of Clinical Sleep Medicine mentioned that early animal studies have demonstrated that cannabinoid agonists, such as dronabinol (a synthetic form of the psychoactive-causing cannabinoid, THC), provided respiratory stability. The authors of the study acknowledge that this might hold therapeutic value for OSA (29)

The authors also called for “increased funding and further research on the use of synthetic medical cannabis extracts to treat OSA.”

However, the American Academy of Sleep Medicine (AASM) holds a strong position against the use of medical cannabis, cannabinoids, and its synthetic extracts in treating OSA. AASM stated the opposition is due to unreliable delivery methods, insufficient evidence, and safety (30).

This statement from AASM came after the Minnesota Department of Health announced in 2017 that they are adding OSA into the qualifying conditions for their medical cannabis program (31)

Individuals with sleep apneas are strongly advised to consult with a licensed medical practitioner at accredited sleep facilities before taking any treatment. 

CBD Oil vs. Restless Leg Syndrome

Restless Leg Syndrome (RLS) is a neurological disorder wherein the individual feels pain or discomfort when the legs are at rest. Moving the legs or walking can temporarily relieve the pain. 

There are not enough scientific studies that directly address how CBD may affect individuals with RLS. However, some studies have linked the improvement of RLS symptoms with cannabis use. 

A recent study posted in Sleeping & Breathing discussed the potential benefit of cannabis use among patients presenting with refractory RLS. The study added that patients had reported total remission of RLS symptoms following cannabis use (32)

The author continued by proposing more clinical trials to study the effect and implications of cannabis use for RLS symptoms. 

CBD Oil vs. Chronic Pain

Chronic pain can be associated with insomnia in some individuals. A review published in the Journal of American Pain Society mentioned that individuals with chronic headaches, migraine, and arthritis had reported poor sleep quality or sleep disturbances (33).  

A 2017 study published in the Physiological Reviews showed that migraine headaches might partially be caused by intense sensory nerve stimulation. The stimulation is caused by the release of inflammatory agents, creating a migraine attack (34).

CBD is becoming a popular alternative approach in treating chronic pain. Many studies have recognized the pain-relieving effects of phytocannabinoids, such as CBD and THC.

A study posted in Proceedings of the National Academy of Sciences of the United States of America acknowledged the inflammatory and analgesic effects of CBD (35). The research discussed CBD’s ability to enhance adenosine signaling leading to decreased inflammation. 

Another study published in the Journal of Experimental Medicine also reported how CBD has potentially suppressed neuropathic pain and inflammation on animal subjects (36).

Moreover, a 2015 experiment published in the European Journal of Pain demonstrated how rats with induced-arthritis displayed reduced joint swelling and improved limb postures following transdermal CBD absorption (37).     

How CBD Oil Works to Help With Sleep

The endocannabinoid system is made of G-protein receptors located throughout the human body, such as cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2). 

These receptors can be found mostly in the central nervous system, the immune system, and the peripheral nervous system (38).

It has been mentioned in a study from Pharmacological Reviews that modulating the ECS might lead to therapeutic promises in a wide range of conditions and diseases (39)

A review posted in Elsevier discussed the role of the CB1 receptor in the regulation of sleep. The author mentioned how the localization of the CB1 receptor in sleep-inducing areas might be a potential mechanism for sleep promotion (40)

According to a study, the activity of CBD on G-protein receptors might drive its neuroprotective, antidepressive, and anxiolytic benefits (41).  

Moreover, a study released in Current Neuropharmacology discussed how microinjections of CBD into the lateral hypothalamus (next to the pituitary gland) led to the enhancement of dopamine to increase wakefulness during daylight hours (42)

The endocannabinoid system modulates pain signals in the body. The cannabinoid receptors may be found in pain circuits (from sensory nerve endings to the brain) (43).

Clinical trials seemed to indicate that the compounds of hemp plants (Cannabis sativa), such as CBD and THC, may be promising treatments for difficult to treat painful conditions (44).

Pros and Cons of CBD Oil for Sleep

The Pros

  • CBD may be beneficial in treating insomnia (45)
  • The beneficial effects of CBD may include reducing REM-sleep behavior disorder symptoms among PD patients (46)
  • CBD may potentially help in reducing anxiety and improve the quality of sleep among individuals with anxiety-related insomnia (47).
  • CBD, in low doses, might help improve wakefulness during daylight. The reduction of daytime sleepiness may lead to healthy circadian rhythms (48)
  • CBD may help alleviate inflammation and block neuropathic pain, such as headaches and migraines (49)
  • Transdermal CBD application might help in alleviating joint inflammation and pain (50)
  • CBD, unlike THC, does not induce psychoactive effects. 
  • The World Health Organization (WHO) has acknowledged that CBD is non-addictive and safe for daily use (51)

The Cons

  • Although legal in the United States, CBD remains highly unregulated. Individuals are encouraged to thoroughly research which brands are safe and legitimate. 
  • CBD may present a few side effects, such as dry mouth, diarrhea, sleepiness, and reduced appetite (52).
  • It is not advisable to take CBD in conjunction with other medications. Individuals must first consult with a licensed physician before taking CBD, as this might create an interaction with pharmaceutical drugs. 
  • There are many different hypotheses on CBD’s potential effects on sleep. Some studies said that CBD might induce wakefulness (53), while other studies suggested CBD might cause sleepiness (54)
  • A recent study published in Molecules has found that extremely high doses of CBD may cause liver injury (55)

How Does CBD Compare to Other Alternative Treatments?

Melatonin is a popular sleep aid that is marketed as a dietary supplement. Melatonin is a natural hormone in the brain responsible for the body’s sleep response to darkness. The body’s ability to produce melatonin is crucial in maintaining the circadian rhythm. 

Although highly marketed, melatonin has produced conflicting results in clinical studies (56)

The American Academy of Sleep Medicine did not include melatonin in the list of treatments for insomnia, although they’ve acknowledged that the dietary supplement produced better results compared to placebo (57).

CBD is considered a natural alternative approach in treating insomnia. Like melatonin, CBD’s health benefits with regards to insomnia remain a hypothesis. 

Around 40-80% of individuals with autism spectrum disorder (ASD) may present with sleep problems. In 2019, doctors conducted an experiment on children and adolescents with ASD. They have found that melatonin improved sleep problems in 60% of the patients (58), while CBD improved sleep in 71.4% of the patients (59).

Chamomile tea is another alternative treatment for insomnia. The traditional herb has been a staple among wellness enthusiasts. However, there is a lack of study on chamomile’s effectiveness in treating insomnia. 

CBD teas are also available for individuals who wish to widen their options and achieve overall wellness. 

How to Choose the Right CBD Oil for Sleep

Before taking CBD, one must need to know the different types of CBD concentrations available. Full-spectrum CBD oil is a concentration that includes all the compounds present in the hemp plant

These cannabinoids are CBD, THC, cannabinol (CBN), cannabigerol (CBG), and cannabichromene (CBC). When taken together, all these compounds produce the “entourage effect.” 

The entourage effect means that an individual takes in all the supposed benefits of the cannabinoids. 

The full-spectrum CBD oil may be a good option for individuals who suffer from sleep disruptions without the presence of anxiety. 

Although THC content in full-spectrum CBD oil must be 0.3% or below, it is advised that one opts for a concentration without any traces of THC

A 2018 study published in Lancet shared that high doses of THC have been linked to increased anxiety and paranoia among patients in a clinical study (60)

Broad-spectrum CBD oil is an ideal choice for individuals who do not want THC in their system. 

Like the full-spectrum, the broad-spectrum may also produce the entourage effect without the presence of THC. This concentration usually contains only CBD, CBG, CBN, and CBC. 

Lastly, CBD isolate is a concentration that contains 99% pure CBD extracts. This concentration is recommended to individuals who do not have the tolerance for other cannabinoids.

When choosing CBD brands, individuals must always look for a certificate of analysis (COA). The COA is a third-party laboratory result that verifies how much cannabinoids are present in the product. The COA is also crucial in determining if the product is free from heavy metals, pesticides, fungicides, and other harmful substances.

Additional tips on shopping for the best CBD oil

  • One must be particular with their brand’s source of hemp. One must always choose brands that use organic and non-GMO hemp. Some brands also have gluten-free or vegan options.
  • One must be particular with carrier oil due to possible allergies. Many brands use MCT oil (unrefined coconut oil), hemp oil, extra-virgin olive oil, and grapeseed oil. Carrier oils are always specified in the product description.
  • Read testimonials and brand reviews from other customers. Check the rating of each product. 
  • Avoid toxic substances like propylene glycol and polyethylene glycol when buying CBD vape pens and CBD vape cartridges. 
  • Always research the extraction process of the CBD brand. The CO2 extraction process does not add any heat or solvents.
  • Choose CBD brands that have a money-back guarantee.

CBD Dosage for Sleep

More studies are needed to determine the proper dosing of CBD. Many studies have produced conflicting results when researching the effects of CBD

Studies have shown that low doses (10mg/kg) produced anxiolytic effects on rats compared to higher doses (100mg/kg) (61).  

In a crossover study, researchers comparing CBD with nitrazepam (a hypnotic pharmaceutical drug used for insomnia) have found that a high single dose of CBD (160mg) on rats increased the duration of sleep (62)

The doses mentioned are considered high doses and not economically viable since CBD can be quite expensive. 

However, a study has found that 25 mg to 75 mg of CBD per day would be enough to produce effects on human adults who presented with insomnia and anxiety (63)

A contrasting study demonstrated how CBD might work as a wake-promoting agent. The researchers gave 15 mg CBD (combined with 15 mg THC) dose, which resulted in increased wakefulness in young human adults (64)

Individuals who are taking CBD for the first time are advised to start with a low dose between  1 milligram per kilogram to 50 milligrams per kilogram of CBD per day (< 1 mg/kg to 50 mg/kg per day) (65)

They can gradually increase the dosage when the body gets used to the CBD in their system.  

How to Take CBD Oil for Sleep

First time CBD users may take CBD products that have lower concentrations of cannabinoids in a single serving. These products may be in the form of sprays, capsules, oil drops, or edibles (gummies). 

When using CBD gummies for sleep, one can take a serving around 30 minutes before bedtime.

For individuals who are used to taking CBD, they may opt for CBD oil tinctures or drops. These can be taken by using a dropper to put CBD oil under the tongue. For better sleep, it is recommended to take the CBD tincture before bedtime.

CBD companies have come up with ways to improve their tincture formulas by adding terpenes (for flavoring) or natural and artificial sweeteners.

Individuals looking for joint or muscle pain relief may opt for a transdermal approach, such as CBD balms, CBD creams, CBD lotions, or CBD patches.

Lastly, vaping is the fastest way to bring CBD into the system, but it is not as long-lasting compared to CBD tinctures. Individuals must be aware of the side effects of vaping before choosing this method to take CBD (66)

Derived from agricultural or industrial hemp, cannabidiol (CBD) is now a legal compound In the U.S., Canada, and some countries in Europe. 

The United States 2018 Farm Bill legalized hemp extraction, making CBD legal in the USA (67)

Manufacturers are allowed to transport, produce, and sell CBD as long as the concentration contains 0.3% or lower THC levels. Unlike THC, CBD does have any psychoactive effects. 

Although CBD is currently unregulated, the U.S. Food and Drug Administration remains watchful. CBD companies are not allowed to make health claims or sell CBD as a food supplement. 

CBD companies rely on third-party lab results to gain the confidence of customers.

Currently, there is only one pharmaceutical drug that contains CBD. Epidiolex is the first FDA-approved CBD drug used to treat rare forms of epilepsy  (68)

Conclusion

Studies have shown that CBD might hold therapeutic benefits in achieving better sleep by improving mental health, such as reducing anxiety (69) and PTSD symptoms (70) among human subjects. 

Moreover, a clinical experiment has demonstrated how CBD has improved the anxiety and sleep disturbances of children with ASD (71).

CBD has also been shown to reduce REM-sleep behavior disorder (RBD) events in patients with neurodegenerative diseases (72)

Lastly, a contrasting study has shown that CBD might help reduce daytime sleepiness, which may contribute to maintaining a healthy circadian rhythm (73).

Existing studies have shown promising results. However, more studies are needed to confirm CBD’s effectiveness in achieving better sleep.

Experts advise that whatever treatments or medications have been chosen, a good sleeping habit is still essential in achieving a healthy circadian rhythm. 

  • Maintain a healthy sleep schedule.
  • Stay active by exercising, doing yoga, hiking, or bicycling.
  • Avoid or limit caffeine, alcohol, and nicotine use.
  • Avoid large meals before bedtime.
  • Do not drink too much before bedtime.
  • Avoid naps
  • If one is experiencing pain, do not put up with it. Consult a medical professional about getting proper medication for the pain.

Individuals are advised to consult with a licensed physician before taking CBD into their daily regimen. 


  1. Shannon, S., Lewis, N., Lee, H., & Hughes, S. (2019). Cannabidiol in Anxiety and Sleep: A Large Case Series. The Permanente journal, 23, 18–041. https://doi.org/10.7812/TPP/18-041
  2. Anxiety and Depression Association of America. Retrieved from https://adaa.org/understanding-anxiety/related-illnesses/sleep-disorders#:~:text=Anxiety%20causes%20sleeping%20problems%2C%20and,of%20developing%20an%20anxiety%20disorder.
  3. Shannon, S (2019)., Op cit. 
  4. Barchel, D., Stolar, O., De-Haan, T., Ziv-Baran, T., Saban, N., Fuchs, D. O., Koren, G., & Berkovitch, M. (2019). Oral Cannabidiol Use in Children With Autism Spectrum Disorder to Treat Related Symptoms and Co-morbidities. Frontiers in pharmacology, 9, 1521. https://doi.org/10.3389/fphar.2018.01521
  5. M. H. N. Chagas MD PhD, A. L. Eckeli MD PhD, A. W. Zuardi MD PhD, M. A. Pena-Pereira MD, M. A. Sobreira-Neto MD, E. T. Sobreira PhD, M. R. Camilo MD, M. M. Bergamaschi PhD, C. H. Schenck MD, J. E. C. Hallak MD PhD, V. Tumas MD PhD and J. A. S. Crippa MD PhD., (2014)., Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson’s disease patients: a case series., Journal of Clinical Pharmacy and Therapeutics. https://doi.org/10.1111/jcpt.12179
  6. Murillo-Rodríguez, E., Millán-Aldaco, D., Palomero-Rivero, M., Mechoulam, R., & Drucker-Colín, R. (2006). Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats. FEBS letters, 580(18), 4337–4345. https://doi.org/10.1016/j.febslet.2006.04.102
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  16. M. H. N. Chagas (2014).,Op cit
  17. Ibid
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  19. Vandrey, R., Babson, K. A., Herrmann, E. S., & Bonn-Miller, M. O. (2014). Interactions between disordered sleep, post-traumatic stress disorder, and substance use disorders. International review of psychiatry (Abingdon, England), 26(2), 237–247. https://doi.org/10.3109/09540261.2014.901300
  20. Elms, L., Shannon, S., Hughes, S., & Lewis, N. (2019). Cannabidiol in the Treatment of Post-Traumatic Stress Disorder: A Case Series. Journal of alternative and complementary medicine (New York, N.Y.), 25(4), 392–397. https://doi.org/10.1089/acm.2018.0437
  21. Barchel Dana, Stolar Orit, De-Haan Tal, Ziv-Baran Tomer, Saban Naama, Fuchs Danny Or, Koren Gideon, Berkovitch Matitiahu., (2019) Frontiers in Pharmacology .,Oral Cannabidiol Use in Children With Autism Spectrum Disorder to Treat Related Symptoms and Co-morbidities., https://doi.org/10.3389/fphar.2018.01521
  22. National Institute of General Medical Sciences. Circadian Rhythms. Retrieved from https://www.nigms.nih.gov/education/fact-sheets/Pages/circadian-rhythms.aspx#:~:text=Circadian%20rhythms%20are%20physical%2C%20mental,a%20light%2Drelated%20circadian%20rhythm.
  23. Nicholson, A. N., Turner, C., Stone, B. M., & Robson, P. J. (2004). Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults. Journal of clinical psychopharmacology, 24(3), 305–313. https://doi.org/10.1097/01.jcp.0000125688.05091.8f
  24. Murillo-Rodríguez, E., Sarro-Ramírez, A., Sánchez, D., Mijangos-Moreno, S., Tejeda-Padrón, A., Poot-Aké, A., Guzmán, K., Pacheco-Pantoja, E., & Arias-Carrión, O. (2014). Potential effects of cannabidiol as a wake-promoting agent. Current neuropharmacology, 12(3), 269–272. https://doi.org/10.2174/1570159X11666131204235805
  25. Ibid.
  26. Ibid.
  27. The Mayo Clinic. Sleep Apnea Symptoms. Retrieved from https://www.mayoclinic.org/diseases-conditions/sleep-apnea/symptoms-causes/syc-20377631
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  29. Ramar, K., Rosen, I. M., Kirsch, D. B., Chervin, R. D., Carden, K. A., Aurora, R. N., Kristo, D. A., Malhotra, R. K., Martin, J. L., Olson, E. J., Rosen, C. L., Rowley, J. A., & American Academy of Sleep Medicine Board of Directors (2018). Medical Cannabis and the Treatment of Obstructive Sleep Apnea: An American Academy of Sleep Medicine Position Statement. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 14(4), 679–681. https://doi.org/10.5664/jcsm.7070
  30. American Academy of Sleep Medicine. Position Statement Against Medical Cannabis. Retrieved from https://aasm.org/medical-marijuana-position-statement/
  31. Minnesota Department of Health. (2017) Medical Cannabis Program to Add Autism and Obstructive Sleep Apnea as Qualifying Conditions. Retrieved from https://www.health.state.mn.us/news/pressrel/2017/cannabis113017.html
  32. Ghorayeb I. (2020). More evidence of cannabis efficacy in restless legs syndrome. Sleep & breathing = Schlaf & Atmung, 24(1), 277–279. https://doi.org/10.1007/s11325-019-01978-1
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  36. Xiong, W., Cui, T., Cheng, K., Yang, F., Chen, S. R., Willenbring, D., Guan, Y., Pan, H. L., Ren, K., Xu, Y., & Zhang, L. (2012). Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. The Journal of experimental medicine, 209(6), 1121–1134. https://doi.org/10.1084/jem.20120242
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  38. Blessing, E. M., Steenkamp, M. M., Manzanares, J., & Marmar, C. R. (2015). Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 12(4), 825–836. https://doi.org/10.1007/s13311-015-0387-1
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  46. M. H. N. Chagas (2014).,Op cit
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  68. FDA Approves First Drug Comprised of an Active Ingredient Derived from Marijuana to Treat Rare, Severe Forms of Epilepsy.  Retrieved from https://www.fda.gov/news-events/press-announcements/fda-approves-first-drug-comprised-active-ingredient-derived-marijuana-treat-rare-severe-forms#:~:text=The%20U.S.%20Food%20and%20Drug,years%20of%20age%20and%20older.
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