Does CBD Help With Surgery Recovery?

  • A study archived in Transplantation Proceedings showed that cannabidiol (CBD) might help treat chronic pain in kidney transplant patients(1)
  • A clinical study in 2019 found that CBD and other phytocannabinoids were as effective as antibiotics in the post-surgery healing process(2).
  • A 2019 survey was presented during the 2019 Society of Anesthesia and Sleep Medicine Annual Meeting. It stated that the surveyed surgeons expressed interest in using CBD as a potential medication for post-surgical pain management(3).
  • Still, CBD should not be used with other medications, like anesthesia or over-the-counter painkillers, because it might have drug interactions with these medicines(4).
  • More research is warranted on CBD’s effects on humans and its health benefits on the post-surgery recovery process

Best CBD Oils for Surgery Recovery

Editor's Pick

Spruce 750mg Lab Grade CBD Oil

Specifically formulated to be more palatable to CBD users
Spruce 750mg Lab Grade CBD Oil Bottle
  • Overall Clinical Score
    99%
    Editor's Pick
  • Score breakdown
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
  • Summary

    Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

    Pro's
    Cons's
    •  Mid-strength
    •  Natural peppermint flavor
    •  Made from 100% organic and natural ingredients
    •  No other flavors
  • Features
    Discount pricing available? 20% Off Coupon Code: CBDCLINICALS
    Source
    Source of Hemp
    Kentucky, USA & North Carolina, USA
    Form Oil Tincture
    Ingredients Organic Hemp Seed Oil, Full Spectrum CBD Oil
    Type
    Type of CBD
    Full Spectrum
    Extraction
    Extraction Method
    Moonshine extraction method
    How to take it Under tongue
    Potency
    Potency - CBD Per Bottle
    750 mg per bottle
    Carrier Oil Organic Hemp Seed Oil
    Concentration
    CBD Concentration Per Serving
    25mg of CBD per dropper full (1ml)
    Drug Test Contains 0.3% THC but there is a chance you may test positive for marijuana
    Flavours Peppermint
    Price Range $89 ($75.65 for subscriptions, 15% discount from regular price)
    $/mg CBD
    Price ($/mg)
    $0.12/mg ($0.10/mg with subscription)
    Shipping
    Shipping/Time to delivery
    2-4 business days (first class USPS)
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants Organic, Non-GMO, no pesticides, no herbicides, no solvents or chemical fertilizers, No preservatives or sweeteners
    Allergens Vegan, Gluten free
    Refund policy Within 30 days
    Recommended for New CBD users
    Countries served USA only (all 50 states)
Check Latest Prices

Best Organic

NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil

Perfect for anyone who are looking for CBD products that promote a healthy body and mind.
NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
  • Overall Clinical Score
    99%
    Best Organic
  • Score breakdown
    Value
    Quality
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    Lab Testing Transparency
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  • Summary

    Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

    Pro's
    Cons's
    •  Pure CBD hemp
    •  All natural
    •  Approximately 300 drops total
    •  No other flavors
  • Features
    Discount pricing available? 20% Off Coupon Code: CBDCLINICALS20
    Source
    Source of Hemp
    Colorado, USA
    Form Oil Tincture
    Ingredients Full Spectrum Hemp Extract, Organic Virgin Hemp Seed Oil
    Type
    Type of CBD
    Full Spectrum CBD
    Extraction
    Extraction Method
    CO2 Method
    How to take it Under the tongue for approximately 30 seconds before swallowing
    Potency
    Potency - CBD Per Bottle
    900mg per bottle
    Carrier Oil Organic Hemp Oil
    Concentration
    CBD Concentration Per Serving
    60mg per dropper full (1ml)
    Drug Test Contains 0.3% THC but there is a chance you may test positive for marijuana
    Flavours Natural
    Price Range $99 - $434
    $/mg CBD
    Price ($/mg)
    $0.08 - $0.13
    Shipping
    Shipping/Time to delivery
    2-3 Days via USPS
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants No additives or preservatives, Non-GMO, NO herbicides, pesticides, or chemical fertilizers
    Allergens Not specified
    Refund policy Within 30 days
    Recommended for Health-conscious persons
    Countries served USA (all 50 states) and over 40 countries including Australia, Azerbaijan, Beliza, Bosnia & Herzegovina, Brazil, Chile, China, Croatia, Czech Republic, Estonia, France, Hong Kong, Hungary, Ireland, Israel, Japan, Latvia, Lebanon, Lithuania, Macao, Malaysia, Malta, Netherlands, New Zealand, Oman, Paraguay, Poland, Portugal, Saudi Arabia, Serbia, Singapore, South Korea, Sweden, Switzerland, United Arab Emirates, United Kingdom, Uruguay, and many more.
Check Latest Prices

Best Value

Sabaidee Super Good Vibes CBD Oil

4x the strength of a regular cbd oil
Sabaidee Super Good Vibes CBD Oil
  • Overall Clinical Score
    99%
    Best Value
  • Score breakdown
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
  • Summary

    Super Good Vibes CBD Oil provides the purest and highest quality Cannabidiol (CBD) on the market as well as other high quality phytocannabinoids, terpenes, vitamins, omega fatty acids, trace minerals, and other beneficial for your health elements, which all work together to provide benefits.

    Pro's
    Cons's
    •  Extra strong
    •  Significant benefits with just a few drops
    •  100% Natural ingredients
    •  No other flavors
  • Features
    Discount pricing available? 15% Off Coupon Code: CBDCLINICALS15
    Source
    Source of Hemp
    Colorado, USA
    Form Oil Tincture
    Ingredients Cannabidiol (CBD), Coconut Medium-chain triglycerides (MCT) Oil, Peppermint oil
    Type
    Type of CBD
    Broad Spectrum
    Extraction
    Extraction Method
    CO2-extraction
    How to take it Using 1-3 servings per day as needed is a good start to determine how much you need
    Potency
    Potency - CBD Per Bottle
    1000 mg per bottle
    Carrier Oil Coconut MCT Oil
    Concentration
    CBD Concentration Per Serving
    33.5 mg per dropper (1ml)
    Drug Test Contains 0.3% THC but there is a chance you may test positive for marijuana
    Flavours Peppermint
    Price Range Single Bottle - $119.95, 2-Pack - $109.97 each, 3-Pack - $98.31 each, 6-Pack - $79.99 each
    $/mg CBD
    Price ($/mg)
    Single bottle - $0.010, 2-Pack - $0.011, 3-Pack - $0.009, 6-Pack - $0.007
    Shipping
    Shipping/Time to delivery
    3-5 Business days
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants Contaminant-free
    Allergens Vegan and Gluten-free
    Refund policy Within 30 days
    Recommended for Patients who are looking for serious CBD oil support
    Countries served USA only (all 50 states)
Check Latest Prices

Best Natural Alternative

cbdMD CBD Oil Tincture Natural 1500mg

Uses USA hemp that is grown on non-GMO farms, and is both vegan and gluten-free
cbdMD CBD Oil Tincture Natural 1500mg
  • Overall Clinical Score
    99%
    Best Natural Alternative
  • Score breakdown
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
  • Summary

    cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

    Pro's
    Cons's
    •  Various delicious flavors to choose from
    •  Has vegan, organic, and gluten-free ingredients
    •  Free shipping for this particular product within USA
    •  World-class customer service team
    •  cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
  • Features
    Discount pricing available? 15% Off Coupon Code: cbdMD15
    Source
    Source of Hemp
    Kentucky, USA
    Form Oil Tincture
    Ingredients Cannabidiol (CBD), MCT Oil, and Flavoring
    Type
    Type of CBD
    Broad Spectrum
    Extraction
    Extraction Method
    CO2 extraction method
    How to take it Under tongue
    Potency
    Potency - CBD Per Bottle
    1500mg per bottle
    Carrier Oil Organic Coconut MCT Oil
    Concentration
    CBD Concentration Per Serving
    50mg per dropper full (1ml)
    Drug Test Containing less than 0.3% THC, there are still trace amounts
    Flavours Natural, Berry, Orange and Mint
    Price Range $99.99
    $/mg CBD
    Price ($/mg)
    $0.07
    Shipping
    Shipping/Time to delivery
    2-5 Business days (via Fedex)
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants 100% organic, non-GMO, and vegan-certified
    Allergens Vegan, Gluten free
    Refund policy Within 30 days
    Recommended for Daily CBD oil users
    Countries served USA only (all 50 states)
Check Latest Prices

Why People Are Turning to CBD for Surgery Recovery

To manage post-surgical pain in patients, doctors typically prescribe analgesics, such as opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), and other painkillers(5)

While these medications offer pain relief, they may also have side effects that may be detrimental to patients. 

NSAID use may result in bloatedness, gas, stomach pain, nausea, vomiting, heartburn, diarrhea, increased blood pressure, and constipation(6).

Meanwhile, the use of opioids may cause vomiting, nausea, urinary retention, constipation, impaired thinking skills, drowsiness, and reduced respiratory function(7)

Opioid misuse among users is also a concern. Findings from the National Institute on Drug Abuse state that one of the most commonly misused prescription medications are opioids(8).

According to a survey conducted at the Hospital for Special Surgery (HSS), surgeons expressed an interest in using CBD as a potential pain management medication after surgery(9).

The survey results were also presented during the 2019 Society of Anesthesia and Sleep Medicine (SASM) Annual Meeting.

Clinicians and researchers have been seeking ways of relieving post-operative pain without resorting to opioid use because of the supposed harmful side effects of these anti-pain medications(10).

HSS researcher Alexandra Sideris, PhD, said, “We found that the surveyed surgeons expressed generally positive attitudes toward the use of CBD and expressed a desire for further study to address safety and efficacy of CBD in their patients.”

In a 2019 clinical study, six patients with third-molar extraction were given antibiotics, CBD, and other phytocannabinoids(11).

The researchers observed pain, swelling, and tolerance in the test subjects. They concluded that phytocannabinoids, like CBD, had the potential to be used in dental clinic practices for oral diseases and wound-healing prophylaxis (a preventive measure against diseases).

They also compared the use of antibiotics and phytocannabinoids, like CBD, and noted that the treatments had no significant differences.

A 2018 study archived in the journal Transplantation Proceedings showed that CBD might help with the treatment of chronic pain(12)

The researchers gave 50mg of CBD to seven kidney transplant patients twice a day for three weeks. During the study, the dosage was gradually increased to 150mg of CBD. 

They also acknowledged that NSAID use in kidney transplant patients might result in kidney toxicity. 

Two participants reported pain improvement, four had a partial positive response to CBD treatment in the first 15 days, while one test subject said there was no change after the use of CBD.

The authors observed that CBD had side effects, including dry mouth, dizziness, nausea, drowsiness, and intermittent heat episodes. Still, they acknowledged the benefits of CBD and concluded that CBD was well-tolerated by users.

A 2019 study investigated CBD’s effects on 131 chronic pain patients who were using opioids(13).

Over half of the study sample reported that they were able to reduce the use of or eliminate opioids after eight weeks of adding CBD to their medication regimen. Almost all CBD users reported improvements in their quality of life.

The authors concluded that CBD could significantly reduce opioid use and improve chronic pain and sleep quality in individuals using opioids for pain management.

According to Johns Hopkins Medicine, individuals who have undergone surgery may experience nausea and vomiting due to the anesthesia. They may also report soreness, pain, and swelling around the incision site, and restlessness or sleeplessness(14).

CBD for Nausea and Vomiting

A study found in the British Journal of Pharmacology stated that CBD reduced vomiting and nausea in rats and shrew test subjects(15).

Another study suggested that CBD and other cannabinoids might be useful in treating nausea and vomiting that result from chemotherapy and other treatments(16).

Cannabinoids are substances that may come from the Cannabis sativa plant. The cannabinoid tetrahydrocannabinol (THC) mainly comes from a variant of the cannabis plant, known as the marijuana plant.

Meanwhile, CBD primarily comes from the hemp plant, which is also from cannabis plants. Unlike CBD, THC has psychoactive effects that could get users high.

Cannabinoids help the endocannabinoid system (ECS) maintain homeostasis (natural balance) in the body(17). They interact with the ECS through endocannabinoid receptors, which are found throughout the body.

CBD for Pain

Authors of a study in the journal Therapeutics and Clinical Risk Management suggested that cannabinoids, like CBD, had analgesic and anti-inflammatory properties that might be useful in treating intractable (hard to control) pain(18).

Another study published in the journal Clinical Rehabilitation reported that CBD and THC helped improve the intractable pain of patients with medical conditions related to the central nervous system(19).

The patients had multiple sclerosis, brachial plexus damage, spinal cord injury, and limb amputation because of neurofibromatosis.

Brachial plexus refers to the nerve network responsible for sending signals from the spinal cord to the arms, shoulders, and hands(20). Meanwhile, neurofibromatosis is a genetic disorder of the nervous system that affects how nerve cells form and grow(21).

CBD for Sleep

Research done in 2019 investigated CBD’s effects on 103 adults and found that the substance reduced the participants’ anxiety and improved their sleep(22).

A 2017 systematic review in the journal Current Psychiatry Reports suggested that CBD might be useful in treating sleep disorders, like insomnia and rapid eye movement (REM) sleep behavior disorder(23).

REM sleep behavior disorder is characterized by acting out vivid and unpleasant dreams during REM sleep(24)

How CBD Oil Works to Alleviate Symptoms of Surgery Recovery

According to research, CBD’s purported antiemetic (vomit-reducing) and anti-nausea effects are due to the substance’s indirect activation of the 5-HT1A receptors in the dorsal raphe nucleus(25).

The dorsal raphe nucleus is one of the most sensitive sites in the brain that is responsible for processing rewards or pleasures(26).

5-HT1A receptors are serotonin receptor subtypes. Meanwhile, serotonin is a hormone that helps regulate happiness, anxiety, and mood(27)

Clinical studies in animal models suggested that CBD’s analgesic and anxiety-reducing effects result from its interaction with the serotonin receptor 5-HT1A(28)

The Pros and Cons of CBD Oil for Surgery Recovery

The Pros

  • Human and animal studies previously mentioned reported the therapeutic effects of CBD on individuals undergoing surgery recovery and the associated symptoms.
  • Compared to NSAIDs and other analgesic drugs, CBD’s safety profile is more favorable(29).
  • Dependence on CBD is unlikely in humans and animals(30). Hence, individuals recovering from surgery should not worry about developing a CBD addiction. 

The Cons

  • More research is needed on CBD’s direct effects on post-operative recovery and related conditions. 
  • Despite CBD’s promise as an effective treatment for post-surgery conditions, the substance has reported side effects, including changes in weight or appetite, diarrhea, and tiredness(31)
  • The United States Food and Drug Administration (US FDA) does not support CBD use for conditions other than epilepsy.
  • Using CBD oil before a surgical procedure is not recommended. Similar to blood thinners, CBD has purported anticoagulant (blood clot-preventing) effects(32). Prevention of blood-clotting may result in increased bleeding.
  • CBD should also not be used with anesthesia and other pain medications. CBD inhibits the enzyme family cytochrome P450(33). These are the same enzymes that metabolize most anesthesia and pain medications(34)

Hence, CBD and these medications may have drug interactions that would affect these medicines’ efficacy.

How CBD Oil Compares to Alternative Treatments for Surgery Recovery

Curcumin may help with post-surgery symptoms. A 2014 study reported that curcumin alleviated post-operative pain and helped promote recovery from surgery(35).

The researchers also supported the use of curcumin alone or as an adjunct therapy to surgery recovery.

Like curcumin, CBD also has benefits that may help with post-operative pain and recovery. These properties are outlined in the studies previously mentioned.

How to Choose the Right CBD for Surgery Recovery

As previously mentioned, THC may help alleviate pain. However, cannabis use, even medical cannabis or medical marijuana, is not allowed in all US states(36)

A full-spectrum CBD oil contains trace amounts of THC and other parts of the cannabis plant, such as terpenes, flavonoids, fatty acids, and essential oils.

It is believed that these ingredients synergize to generate the Cannabis sativa plant’s full therapeutic potential. This synergy is called the entourage effect.

However, THC from full-spectrum oils may still be detected by some drug exams. Some individuals may also experience mild mind-alterations because of the THC content. 

Those who want to ensure that their CBD is non-psychoactive may use broad-spectrum CBD products. This type of CBD contains all the ingredients of full-spectrum products, except for THC.

For pure, isolated cannabidiol, individuals may purchase CBD isolates.

Full-spectrum CBD oil is recommended for post-operative recovery. However, even consumers buying products online should choose only high-quality products sourced from credible manufacturers and dispensaries

More importantly, before taking CBD, consult with a doctor first.

CBD Dosage for Surgery Recovery

There is no standard CBD dosage chart for individuals undergoing surgery recovery. 

Individuals are encouraged to begin with small amounts or doses. If no adverse effects are observed, the dosage may be gradually increased.

However, before using CBD, consult with a healthcare professional first. 

How to Take CBD for Surgery Recovery

CBD may be ingested via CBD gummies, gelcaps, and pills. They may also be applied under the tongue via CBD oil and CBD tinctures.

Individuals may add CBD oil to their food or drinks to mask CBD’s naturally grassy taste. 

CBD topicals, such as creams, balms, and lotions, may also be used. These CBD products may be applied to the painful areas. 

Some balms and lotions have menthol and other soothing ingredients, such as peppermint, which may bring additional relief for post-operative pain.

CBD oil may be massaged into the affected areas for added pain relief. However, caution should be exercised when applying CBD directly to the incision areas.

For instantaneous effects, CBD may be taken via vape pens. 

However, vaping CBD makes it challenging to determine how much of the substance has been taken. Vaping is also known to cause lung problems in some individuals(37)

Conclusion

CBD has many purported health benefits. Previous studies showed that CBD might help with surgery recovery.

The use of NSAIDs, opioids, and other pain killers, whether short-term or long-term, may also have detrimental side effects on individuals.

CBD is generally safe to use. Some surgeons have expressed their interest in prescribing CBD as a pain management medication for individuals recovering from surgeries and other procedures.

These surgeons have also voiced concerns regarding opioid use, hence their search for alternative approaches, like CBD use.

Previous research cited showed that CBD might be useful post-surgery. It also has properties that might help with conditions that occur after surgical procedures, such as nausea, vomiting, pain, and difficulty sleeping.

The effects of cannabis on individuals experiencing pain are positive. However, the use of cannabis is illegal in the US.

Meanwhile, CBD use is safe and legal. However, it is essential to note that CBD should not be used before a surgical procedure.

Studies have shown that CBD might have anticoagulant effects, which could prevent blood-clotting and result in increased bleeding.

There are several ways to take CBD post-surgery. The choice of format and administration method depends on an individual’s lifestyle and preferences.

CBD is available in formats, like gummies, pills, tinctures, oils, lotions, balms, salves, and ointments.

When using CBD for post-surgical recovery, seek the advice of medical professionals first. 


  1. Cuñetti, L., Manzo, L., Peyraube, R., Arnaiz, J., Curi, L., & Orihuela, S. (2018). Chronic Pain Treatment With Cannabidiol in Kidney Transplant Patients in Uruguay. Transplantation Proceedings, 50(2), 461–464. https://doi.org/10.1016/j.transproceed.2017.12.042
  2. Puisys, A., Auzbikaviciute, V., Kubilius, R., Linkevicius, R., Razukevicius, D., & Linkevicius, T. (2019, March 11). Postoperative Healing Assessment Using Cannabinoids in Oral Surgery. Retrieved from https://www.ecronicon.com/ecde/pdf/ECDE-18-00953.pdf
  3. (2019, October 18). Surgeons Interested in Using Cannabidiol (CBD) as a Potential Pain Management Strategy After Surgery. Retrieved from https://news.hss.edu/surgeons-interested-in-using-cannabidiol-cbd-as-a-potential-pain-management-strategy-after-surgery/
  4. Rong, C., Carmona, N. E., Lee, Y. L., Ragguett, R. M., Pan, Z., Rosenblat, J. D., Subramaniapillai, M., Shekotikhina, M., Almatham, F., Alageel, A., Mansur, R., Ho, R. C., & McIntyre, R. S. (2018). Drug-drug interactions as a result of co-administering Δ9-THC and CBD with other psychotropic agents. Expert opinion on drug safety, 17(1), 51–54. https://doi.org/10.1080/14740338.2017.1397128
  5. Mayo Clinic Staff. (2020, February 22). Pain medications after surgery. Retrieved from https://www.mayoclinic.org/pain-medications/art-20046452
  6. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). (n.d.). Retrieved from https://my.clevelandclinic.org/health/drugs/11086-non-steroidal-anti-inflammatory-medicines-nsaids
  7. Mayo Clinic Staff. op. cit.
  8. Summary of Misuse of Prescription Drugs. (2020, June). Retrieved from https://www.drugabuse.gov/publications/research-reports/misuse-prescription-drugs/overview
  9. Surgeons Interested in Using Cannabidiol (CBD) as a Potential Pain Management Strategy After Surgery. op. cit.
  10. Ibid.
  11. Puisys, A. op. cit.
  12. Cuñetti, L. op. Cit.
  13. Capano, A., Weaver, R., & Burkman, E. (2019, November 12). Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: A prospective cohort study. Retrieved from https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1685298
  14. After Surgery: Discomforts and Complications. (n.d.). Retrieved from https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/after-surgery-discomforts-and-complications
  15. Rock, Erin & Bolognini, Daniele & Limebeer, Cheryl & Cascio, Maria & Anavi-Goffer, S & Fletcher, Paul & Mechoulam, Raphael & Pertwee, Roger & Parker, LA. (2011). Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behavior via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus. British journal of pharmacology. 165. 2620-34. 10.1111/j.1476-5381.2011.01621.x. 
  16. Parker, L. A., Rock, E. M., & Limebeer, C. L. (2011). Regulation of nausea and vomiting by cannabinoids. British journal of pharmacology, 163(7), 1411–1422. https://doi.org/10.1111/j.1476-5381.2010.01176.x
  17. Human Endocannabinoid System. (n.d.). Retrieved from https://www.uclahealth.org/cannabis/human-endocannabinoid-system
  18. Russo E. B. (2008). Cannabinoids in the management of difficult to treat pain. Therapeutics and clinical risk management, 4(1), 245–259. https://doi.org/10.2147/tcrm.s1928
  19. Wade, D. T., Robson, P., House, H., Makela, P., & Aram, J. (2003). A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms. Clinical Rehabilitation, 17(1), 21–29. https://doi.org/10.1191/0269215503cr581oa
  20. Mayo Clinic Staff. (2020, April 15). Brachial plexus injury. Retrieved from https://www.mayoclinic.org/diseases-conditions/brachial-plexus-injury/symptoms-causes/syc-20350235
  21. Neurofibromatosis. (2019, October 31). Retrieved from https://medlineplus.gov/neurofibromatosis.html
  22. Shannon, S., Lewis, N., Lee, H., & Hughes, S. (2019). Cannabidiol in Anxiety and Sleep: A Large Case Series. The Permanente Journal, 23, 18–041. https://doi.org/10.7812/TPP/18-041
  23. Babson, K. A., Sottile, J., & Morabito, D. (2017). Cannabis, Cannabinoids, and Sleep: a Review of the Literature. Current psychiatry reports, 19(4), 23. https://doi.org/10.1007/s11920-017-0775-9
  24. Mayo Clinic Staff. (2018, January 18). REM sleep behavior disorder. Retrieved from https://www.mayoclinic.org/diseases-conditions/rem-sleep-behavior-disorder/symptoms-causes/syc-20352920
  25. Rock, E. op. cit.
  26. Luo1, M., & And, J. (1970, January 01). Minmin Luo. Retrieved from http://learnmem.cshlp.org/content/22/9/452.full.html
  27. Serotonin. (n.d.). Retrieved from https://www.hormone.org/your-health-and-hormones/glands-and-hormones-a-to-z/hormones/serotonin
  28. De Gregorio, D., McLaughlin, R. J., Posa, L., Ochoa-Sanchez, R., Enns, J., Lopez-Canul, M., Aboud, M., Maione, S., Comai, S., & Gobbi, G. (2019). Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain. Pain, 160(1), 136–150. https://doi.org/10.1097/j.pain.0000000000001386
  29. Iffland, Kerstin, and Franjo Grotenhermen. “An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies.” Cannabis and cannabinoid research vol. 2,1 139-154. 1 Jun. 2017, doi:10.1089/can.2016.0034
  30. World Health Organization (2018 June). CANNABIDIOL (CBD) Critical Review Report. Retrieved from: https://www.who.int/medicines/access/controlled-substances/CannabidiolCriticalReview.pdf
  31. Iffland, K. op. cit. 
  32. Coetzee, C., Levendal, R. A., van de Venter, M., & Frost, C. L. (2007). Anticoagulant effects of a Cannabis extract in an obese rat model. Phytomedicine : international journal of phytotherapy and phytopharmacology, 14(5), 333–337. https://doi.org/10.1016/j.phymed.2006.02.004
  33. Rong, C. op. cit. 
  34. Friedericy, H., & Bovill, J. (2005, October 17). 4 The role of the cytochrome P450 system in drug interactions in anaesthesia. Retrieved from https://www.sciencedirect.com/science/article/abs/pii/S0950350198800299
  35. Zhu, Qing & Sun, Yuehua & Yun, Xiaodi & Ou, Yuntao & Zhang, Wei & Li, Jun-Xu. (2014). Antinociceptive effects of curcumin in a rat model of postoperative pain. Scientific reports. 4. 4932. 10.1038/srep04932. 
  36. States with Legal Cannabidiol (CBD) – Medical Marijuana – ProCon.org. (n.d.). Retrieved from https://medicalmarijuana.procon.org/states-with-legal-cannabidiol-cbd/
  37. “Outbreak of Lung Injury Associated with the Use of E-Cigarette, or Vaping Products.” Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, 25 Feb. 2020, www.cdc.gov/tobacco/basic_information/e-cigarettes/severe-lung-disease.html
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NuLeaf Naturals Review

Based in Colorado, USA, and founded in 2014, NuLeaf Naturals is one of America’s top pioneering hemp companies. NuLeaf Naturals wellness products are derived from specially bred therapeutic hemp (Cannabis Sativa) plants grown on licensed farms in Colorado. Their hemp CBD plants are 100% organic whole-plant extracts and grown with...

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Best CBD Oil for High Blood Pressure (Hypertension)

Why People Are Taking CBD for High Blood Pressure? According to the Centers for Disease Control and Prevention (CDC), high blood pressure can harden the arteries, which decreases the flow of blood and oxygen to the heart, leading to heart disease(5). In a 2015 study conducted by researchers from the...

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SabaiDee Review + Discount Coupon Code for 2020

SabaiDee CBD products are tested both in-house and by independent laboratories to verify the quality of every batch. Their products all come with SabaiDee’s Happiness Guarantee. 

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Best CBD for Neuropathy (Nerve Pain)

As medical cannabis products have become more popular, people are turning to them to treat everything from anxiety to depression to chronic pain. Individuals who are suffering from neuropathy may show interest in trying CBD oil. What Is CBD? CBD comes from a plant that is part of the Cannabaceae...

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CBD for Acid Reflux

CBD may show a promising position to help address acid reflux. Known for its anti-inflammatory properties, CBD modulates the movement and volatility of intestinal propulsions. CBD interacts with the surrounding soft muscles of the gastrointestinal system that results in the relaxation and contraction of the muscles.

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