Best CBD Gummies for Sleep - April 2024

How CBD Gummies May Help With Sleep

CBD gummies are cannabidiol-infused candy. These gummies have grown in popularity among CBD users because of the variety of flavors, colors, forms, and CBD concentrations⁽¹⁾.

The manufacturers of CBD gummies indicated that their CBD gummies may assist with anxiety, pain, inflammation, and sleep issues⁽²⁾.

CBD gummies are CBD-infused candies available in several flavors, shapes, and CBD dosages.

Cannabidiol, often known as CBD, is a cannabinoid compound present in the Cannabis sativa plant⁽³⁾.

While cannabis compounds, such as THC and CBD, may promote sleep, their mechanisms vary⁽⁴⁾. The THC content of hemp is below the legal limit of 0.3%. In addition, CBD is nonpsychoactive.

There are no direct studies about CBD gummies and sleep. However, a 2019 case series indicated that 66.7% of adult participants with anxiety and sleep problems had improved sleep scores within the first month of CBD administration⁽⁵⁾. CBD may also alleviate anxiety⁽⁶⁾ and chronic pain⁽⁷⁾.

Chronic pain may impair sleep, depending on the discomfort a person is feeling. Some sleeping postures or circumstances may also affect sleep quality.

On the other hand, fear and anxiety make falling asleep and keeping asleep harder. Stress can be exacerbated by sleep deprivation, producing a vicious cycle.

The endocannabinoid system modulates physiological responses, including pain, mood, memory, and appetite⁽⁸⁾.

Endocannabinoid System and Sleep

Cannabinoids, mainly THC and CBD, are being utilized in managing sleep disorders, such as insomnia⁽⁹⁾.

Cannabinoids, such as CBD, bind to receptors⁽¹⁰⁾.

Aside from anxiety and mood, the endocannabinoid system regulates the autonomic function and the circadian sleep-wake cycle⁽¹¹⁾.

Many plants and fruits include phytochemicals and cannabimimetic⁽¹²⁾.

Cannabimimetics are a wide range of compounds and metabolites that can interact with the active components of the endocannabinoid system in plants and fruits.

Pharmacological experiments have shown that endocannabinoid administration induces cannabimimetic effects, including sleep promotion⁽¹³⁾.

Exogenous and endogenous cannabinoids affect various physiological processes that demonstrate a circadian rhythm⁽¹⁴⁾. Circadian rhythm includes body temperature, food intake, and sleep-wakefulness⁽¹⁵⁾.

Research on CBD Gummies and Sleep

While there is a need for a conclusive study on CBD gummies as a sleep aid, there are existing research studies on the use of CBD for sleep-related symptoms.

For instance, rapid eye movement sleep behavior disorder, or RBD, is a common non-motor symptom of Parkinson’s disease (PD). CBD may be a potential therapeutic agent for RBD⁽¹⁶⁾.

Researchers conducted a phase II/III, double-blind, placebo-controlled clinical investigation on 33 patients with RBD and PD. Patients were randomly randomized to receive 75–300 milligrams of CBD or a placebo capsule⁽¹⁷⁾.

CBD was shown not to affect RBD symptoms in PD patients when administered with other medications. However, a 300mg dose of CBD was observed to provide a temporary boost in sleep satisfaction⁽¹⁸⁾.

CBD may be beneficial in the prevention of insomnia, according to research. While delta-9 THC appears to shorten sleep latency, the psychoactive compound may have a long-term effect on sleep quality⁽¹⁹⁾.

On the other hand, synthetic cannabinoids like nabilone and dronabinol may have short-term benefits for sleep apnea owing to their modulatory effects on serotonin-mediated apneas⁽²⁰⁾.

Additionally, CBD may help with REM sleep behavior disorder and excessive daytime drowsiness. In contrast, nabilone may reduce nightmares associated with PTSD (post-traumatic stress disorder) and improve the sleep quality of individuals with chronic pain⁽²¹⁾.

Research regarding the effects of cannabis and cannabinoids on sleep is still in its infancy. Thus, there is a need for a more controlled and longitudinal study.

Benefits of Using CBD Gummies for Sleep

As a result of the side effects of many pharmacological sleeping pills⁽²²⁾, CBD sleep gummies may be a natural alternative to improve sleep quality.

On the other hand, CBD may have neuropsychiatric and other beneficial effects. Still, little is known about the effects of CBD on the sleep-wake cycle⁽²³⁾.

On the first night of a double-blind study, the researchers selected 27 healthy volunteers to receive a placebo or CBD. The participants were then followed on the second night with the same treatment⁽²⁴⁾.

Before starting a polysomnography session, volunteers were given either a placebo or a high-dose CBD extract. After 8 hours, they were asked to perform various cognitive and subjective measures. The researchers observed that CBD did not affect the participants’ sleep cycles.

Although the present study supports the idea that CBD may not alter the sleep-wake cycle, future studies should also investigate the effects of various doses of cannabidiol on different sleep-wake cycles.

Meanwhile, some gummy bears are infused with melatonin and cannabidiol for better sleep.

Melatonin is the body’s natural sleep hormone. The melatonin production rises as nighttime darkness approaches, facilitating good sleep and assisting in synchronizing our circadian cycle.

While some CBD sleep products may help users sleep faster than prescription sleeping medications, users may need medical advice before using CBD products.

How to Use CBD Gummies for Sleep

No solid scientific evidence suggests that hemp gummies provide therapeutic advantages. Still, manufacturers of hemp gummies may claim that their products have numerous medicinal benefits, such as promoting sleep quality.

Taking CBD gummies is a convenient way to absorb CBD because individuals can chew them easily like conventional sweets. However, gummies infused with CBD may have high potency and concentration.

Consumers who practice veganism may try vegan full-spectrum CBD gummies.

Full-spectrum CBD products like CBD gummies contain all compounds of the cannabis plant with less than 0.3% THC concentration. A full-spectrum CBD variant is also known to provide the entourage effect.

The entourage effect refers to how the many chemicals in a plant work together to provide the most beneficial results⁽²⁵⁾.

Users get an appropriate dose of CBD in various fruit flavors, along with trace amounts of other cannabinoids such as THC, CBG, and CBN.

CBG is found in trace amounts in cannabis plants. Research indicates that this chemical may possess anti-cancer and anti-inflammatory properties⁽²⁶⁾.

CBN is produced when THC is dried, stored, and heated in cannabis products and may possess anticonvulsant and sedative characteristics⁽²⁷⁾.

Also, most high-quality CBD gummies are sold in packs of 20 to 60 and contain 5 mg of CBD or more in each gummy.

For first-time users of CBD products, consumers may start with a 5mg gummy. If they want to start with a much lower dose, they can slice CBD gummies in half.

How Long Do CBD Gummies Take to Help With Sleep?

Researchers have not been able to predict how long CBD gummies take to help with sleep.

However, CBD edibles may be effective for six to eight hours following intake⁽²⁸⁾.

However, CBD products used orally, such as capsules and edibles, often take 30 to 90 minutes to become effective before they become effective⁽²⁹⁾.

Sometimes, the onset timings are between one and two hours, depending on the CBD substance⁽³⁰⁾.

The research found that a 10 milligram (mg) dosage of orally delivered CBD had a time to maximum plasma concentration of 1.27 hours after oral administration⁽³¹⁾.

After delivery, the most significant drug concentration in the bloodstream is the maximum plasma concentration⁽³²⁾.

If you are still unsure if CBD is working after several hours, you may want to try increasing the CBD gummies dosage the next time you take it.

You may begin with a small dose and work your way up carefully to prevent any possible adverse effects.

Additionally, it is recommended that you see your doctor before including CBD into your sleep regimen for your wellness.

How Long Will CBD Gummies Help With Sleep?

There is no conclusive evidence on the onset timings of CBD gummies based on current studies.

However, according to one study, CBD’s half-life after a single dosage of 10 and 20 milligrams (mg) of CBD may be roughly 1.09 and 1.97 hours after oral administration⁽³³⁾.

The half-life of medicine is the amount of time it takes for its quantity or concentration in the body to be decreased by half.

Risks and Side Effects of Using CBD Gummies for Sleep

Generally, CBD has a favorable safety profile, and humans may tolerate it⁽³⁴⁾.

Still, CBD may induce minor side effects, including dry mouth, diarrhea, decreased appetite, and tiredness⁽³⁵⁾. CBD may also interfere with other drugs, including blood thinners.

A 2020 study from the journal Epilepsia showed that CBD was well tolerated, and no severe or significant adverse effects occurred throughout this clinical trial⁽³⁶⁾.

Before utilizing CBD products, always contact your doctor, mainly if you take any drugs or supplements.

What Is CBD?

Cannabis sativa is an annual herbaceous plant native to Central and Western Asia. The plant is known for its purported medicinal qualities with about 400 chemical components, 80 of which are biologically active⁽³⁷⁾.

The most significant cannabis components are cannabinoids generated by terpene and resorcinol.

Terpenes are chemical compounds present in plants that contribute to their distinctive aroma⁽³⁸⁾. Also, the active ingredient in resorcinol is a natural product that helps remove rough and hard skin and commonly used as a topical treatment⁽³⁹⁾.

On the other hand, the psychoactive component is tetrahydrocannabinol (THC), especially the isomer delta (9-THC)⁽⁴⁰⁾.

Since discovering the Cannabis sativa plant, CBD has gained widespread attention from various scientific communities⁽⁴¹⁾.

According to a survey, one of the primary reasons users take CBD is to manage their anxiety and other issues, such as sleep and stress⁽⁴²⁾. However, these patterns vary depending on the demographic. Further research is needed to understand how low doses might affect mental health.

Unlike THC, which is known to cause psychoactive effects, cannabidiol is nonpsychoactive.

Cross-sectional research of 2,409 cannabidiol users in the United States found that chronic pain, arthritis or joint pain, and anxiety were the most often reported medical complaints, followed by depression and sleeplessness⁽⁴³⁾.

Likewise, researchers recently conducted a study of 340 young individuals, some of whom were CBD users⁽⁴⁴⁾. Experts discovered that the top reasons for using CBD were stress alleviation, relaxation, and sleep enhancement.

CBD Types 

CBD is available in different forms, including full-spectrum CBD, broad-spectrum CBD, and CBD isolate. CBD companies manufacture CBD oils, tinctures, gummies, topicals, and other forms of CBD for various possible applications.

Also, CBD manufacturers extract the component from the cannabis plant in different ways. Diffusion rates vary, resulting in a variety of CBD forms. There are three forms of CBD, each with a unique composition and concentration:

• Full-spectrum CBD oil consists of all cannabis plant components. Full-spectrum hemp extract also contains less than 0.3% THC concentration.

• Broad-spectrum CBD oil contains most of the cannabinoids found in the cannabis plant. In contrast to full-spectrum CBD, broad-spectrum CBD variants include trace quantities of THC or none at all.

• CBD isolates are pure CBD which does not include any additional cannabinoids or THC.

How to Choose CBD Gummies

For first time CBD consumers, here are some valuable guides when choosing CBD products, such as CBD sleep gummies:

Hemp gummies and CBD gummies are usually made from hemp plants, a cannabis plant variation. Hemp gummies contain less than 0.3% THC. However, commercial hemp gummies utilize hempseed extract manufactured from hemp seeds. Hemp seed products have little to no CBD⁽⁴⁵⁾.

CBD gummies include gelatin, which is not vegan. However, some CBD businesses claim to provide vegan gummies made from veggie components. Also, some CBD gummies are THC-free and gluten-free.

The ideal high-potency CBD gummy is sourcing organic hemp grown with non-GMO ingredients, real sugar, and natural flavorings.

CBD manufacturers must submit samples of their CBD gummies to third-party laboratories for testing. These labs analyze the goods and provide a certificate of analysis (COA).

Consumers must check the COA in the CBD label to ensure that the product has been tested for contaminants like molds, heavy metals, and pesticides. The COA is printed, and batch-specific third-party lab reports are included in each CBD package.

Reputable CBD manufacturers keep their COAs up to date and make them available on their websites. This openness enables the public to get these COAs at any time.

There are also CBD products that claim that they make their CBD items from phytocannabinoid-rich hemp. Some CBD brands use a specific strain of hemp that contains much higher levels of CBD than standard hemp.

Consumers may also choose CBD gummies containing spirulina. In addition to being high in protein, vitamins, minerals, carotenoids, and antioxidants, spirulina is also high in protein. In addition to B vitamins, gamma linolenic acid (GLA) and vitamin E are found in spirulina.

Likewise, CBD gummies contain 5mg of broad-spectrum CBD plus turmeric. Turmeric also has anti-inflammatory and antioxidant properties⁽⁴⁶⁾.

Before purchasing CBD gummies for sleep quality, you may contact a doctor or other qualified healthcare expert. Medical professionals can advise on the most effective therapy for sleeping disorders.

Safeness of CBD

According to Harvard Health Publishing, oral CBD (tablet, chewable, or tincture) is the safest method⁽⁴⁷⁾. The publisher advised avoiding synthetic CBD products marketed illegally as “spice” or “bath salts.” Their use has been linked to psychotic symptoms in specific individuals.

Also, the expert noted that adults may tolerate CBD. However, there are no conclusive studies if CBD products are generally safe for kids.

In addition, CBD products may interact with other medications⁽⁴⁸⁾. CBD may inhibit the liver’s capacity to break down some drugs.

Using CBD with other supplements may also cause drowsiness⁽⁴⁹⁾.

Thus, consult a physician before taking any CBD products. Do not use CBD if you are allergic to any CBD compounds.

Legality of CBD

According to the Food and Drug Administration (FDA), CBD products like CBD gummies are legal in states where marijuana has been legalized⁽⁵⁰⁾.

Cannabidiol is classified as a Schedule I substance in the United States⁽⁵¹⁾.

Many states and local governments, on the other hand, have proclaimed cannabis and cannabis-derived goods to be legal in their jurisdictions.

In terms of effectiveness, researchers from the University of Wisconsin-Madison School of Pharmacy reported that the labeling of some non-prescription CBD products is primarily inaccurate⁽⁵²⁾.

Hence, consumers are advised to purchase CBD items from reputable brands or licensed dispensaries.

Importance of Sleep

Getting enough sleep can help boost your immune system and prevent you from getting sick. Studies have shown that people who do not get enough sleep are more prone to illnesses after being exposed to a virus⁽⁵³⁾.

Your body’s immune system releases various chemicals known as cytokines during sleep. These chemicals help keep the body healthy and prevent infection. However, prolonged sleep deprivation can reduce the production of these chemicals⁽⁵⁴⁾.

Getting enough sleep is essential to boost your immune system. Most people’s ideal amount of sleep is seven to eight hours at night. However, teenagers should get nine to ten hours of sleep⁽⁵⁵⁾.

FAQs

1. How can CBD gummies help with sleep?

CBD interacts with the receptors of the endocannabinoid system which is known to regulate various aspects of the body, including the sleep-wake cycle⁽⁵⁶⁾. Cannabidiol in CBD products like sleep gummies may help reduce anxiety, a risk factor for sleep issues⁽⁵⁷⁾.

2. What evidence or research exists to say that CBD gummies help with sleep?

A preliminary study suggests that cannabidiol (CBD) may help with insomnia. However, THC results show mixed reviews⁽⁵⁸⁾. In pilot research, both CBD and nabilone seem to aid with post-traumatic stress disorder nightmares and chronic pain patients’ sleep⁽⁵⁹⁾.

3. Is there any evidence that CBD gummies can make sleep problems worse?

There are no conclusive studies that CBD gummies can make sleep problems worse. However, the safety profile of cannabidiol has been confirmed in humans⁽⁶⁰⁾.

For instance, Cannabis and Cannabinoid Research study indicated that CBD was mainly examined for epilepsy and psychotic disorders. Most of the side effects reported were diarrhea and fatigue⁽⁶¹⁾.

4. Will CBD gummies interact with any current medication I may be taking for sleep?

CBD may interact with other medications⁽⁶²⁾. CBD may inhibit the liver’s capacity to break down some drugs. Using CBD with herbs or supplements might also cause sleepiness. Thus, consult a doctor before taking CBD items like, CBD gummies even if they are considered quality products. Do not use CBD if users are allergic to any CBD compounds.

5. Are there other treatments I should consider alongside CBD gummies to help with sleep?

Healthcare practitioners propose a range of treatments, including counseling, oral medications, regular sleep routine, and workout. The doctor will typically suggest remedies depending on different cases of the individuals with sleeping issues⁽⁶³⁾.

6. Can I fail a drug test if I use CBD gummies for sleep?

CBD products like CBD gummies may include trace amounts of THC when eaten daily for four to six days⁽⁶⁴⁾. A higher trace of THC level may result in a positive drug test⁽⁶⁵⁾. Consumers may choose THC-free CBD gummies if there is a need to undergo drug testing.

7. What is the CBD dosage for sleep?

Most CBD brands list the CBD content per serving size of their edible products, such as CBD gummies, chews, pills, and capsules. The information allows users to estimate CBD dose⁽⁶⁶⁾. Some CBD gummies contain 10 to 15 milligrams of CBD. Still, the content and serving size vary per CBD brand.

According to a 2018 European Journal of Internal Medicine research, new CBD users may start with modest dosages and gradually increase their intake if no adverse effects occur⁽⁶⁷⁾.

8. Are CBD gummies legal?

The 2018 Farm Bill enables CBD products, including CBD gummies, with a THC content of less than 0.3% to be sold in the United States. On the other hand, different state laws have various CBD regulations⁽⁶⁸⁾.

---

1. What are CBD gummies? Are there any health benefits?
   https://www.drugs.com/medical-answers/cbd-gummies-health-benefits-3515165/
2. Ibid.
3. Cannabis, a complex plant: Different compounds and different effects on individuals
   https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3736954/
4. Cannabis, Cannabinoids, and Sleep: a Review of the Literature
   https://www.med.upenn.edu/cbti/assets/user-content/documents/s11920-017-0775-9.pdf
5. Cannabidiol in Anxiety and Sleep: A Large Case Series
   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326553/
6. Cannabidiol as a Potential Treatment for Anxiety Disorders
   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604171/
7. CBD for chronic pain: The science doesn’t match the marketing
   https://www.health.harvard.edu/blog/cbd-for-chronic-pain-the-science-doesnt-match-the-marketing-2020092321003
8. Cannabidiol
   https://pubchem.ncbi.nlm.nih.gov/compound/Cannabidiol
9. Cannabinoid therapies in the management of sleep disorders: A systematic review of preclinical and clinical studies
   https://www.sciencedirect.com/science/article/abs/pii/S1087079220300824
10. The Endocannabinoid System and Cannabidiol’s Promise for the Treatment of Substance Use Disorder
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390812
11. Endocannabinoid signalling: has it got rhythm?
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931554/
12. Cannabimimetic plants: are they new cannabinoidergic modulators?
    https://link.springer.com/article/10.1007/s00425-019-03138-x
13. The emerging role of the endocannabinoid system in the sleep-wake cycle modulation
    https://pubmed.ncbi.nlm.nih.gov/21919868/
14. Endocannabinoid signalling: has it got rhythm?
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931554/
15. Ibid.
16. Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson’s disease patients: a case series
    https://pubmed.ncbi.nlm.nih.gov/24845114/
17. Cannabidiol for Rapid Eye Movement Sleep Behavior Disorder
    https://pubmed.ncbi.nlm.nih.gov/33754375/
18. Cannabidiol for Rapid Eye Movement Sleep Behavior Disorder
    https://pubmed.ncbi.nlm.nih.gov/33754375/
19. Cannabis, Cannabinoids, and Sleep: a Review of the Literature
    https://pubmed.ncbi.nlm.nih.gov/28349316/
20. Ibid.
21. Cannabis, Cannabinoids, and Sleep: a Review of the Literature
    https://pubmed.ncbi.nlm.nih.gov/28349316/
22. Sleeping Pills
    https://my.clevelandclinic.org/health/drugs/15308-sleeping-pills
23. No Acute Effects of Cannabidiol on the Sleep-Wake Cycle of Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895650/
24. Ibid.
25. The “Entourage Effect”: Terpenes Coupled with Cannabinoids for the Treatment of Mood Disorders and Anxiety Disorders
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324885/
26. Chapter 99 – Potential Medical Uses of Cannabigerol: A Brief Overview
    https://www.sciencedirect.com/science/article/pii/B9780128007563001150
27. Cannabinol
    https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/cannabinol
28. Page 191 of Healing With CBD
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
29. Ibid.
30. Best Way to Take CBD
    https://www.projectcbd.org/guidance/best-way-take-cbd
31. A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans
    https://www.frontiersin.org/articles/10.3389/fphar.2018.01365/full
32. Plasma Concentration-Time Profile” as an Indefinite Claim Term: A Lesson from Forest Labs., Inc. v. Teva Pharm. USA, Inc.
    https://www.liebertpub.com/doi/10.1089/blr.2019.29116.phc
33. A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans
    https://www.frontiersin.org/articles/10.3389/fphar.2018.01365/full
34. An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies
    https://www.liebertpub.com/doi/10.1089/can.2016.0034
35. What are the benefits of CBD — and is it safe to use?
    https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/is-cbd-safe-and-effective/faq-20446700
36. A phase 1, randomized, pharmacokinetic trial of the effect of different meal compositions, whole milk, and alcohol on cannabidiol exposure and safety in healthy subjects
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065230/
37. Cannabidiol (CBD)
    https://www.ncbi.nlm.nih.gov/books/NBK556048/
38. Therapeutic and Medicinal Uses of Terpenes
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120914/
39. Resorcinol
    https://pubchem.ncbi.nlm.nih.gov/compound/Resorcinol
40. Cannabidiol (CBD)
    https://www.ncbi.nlm.nih.gov/books/NBK556048/
41. Reasons for cannabidiol use: a cross-sectional study of CBD users, focusing on self-perceived stress, anxiety, and sleep problems
    https://jcannabisresearch.biomedcentral.com/articles/10.1186/s42238-021-00061-5
42. Reasons for cannabidiol use: a cross-sectional study of CBD users, focusing on self-perceived stress, anxiety, and sleep problems
    https://jcannabisresearch.biomedcentral.com/articles/10.1186/s42238-021-00061-5
43. Cannabidiol (CBD)
    https://www.ncbi.nlm.nih.gov/books/NBK556048/
44. Reasons for cannabidiol use: a cross-sectional study of CBD users, focusing on self-perceived stress, anxiety, and sleep problems
    https://jcannabisresearch.biomedcentral.com/articles/10.1186/s42238-021-00061-5
45. FDA Responds to Three GRAS Notices for Hemp Seed-Derived Ingredients for Use in Human Food
    https://www.fda.gov/food/cfsan-constituent-updates/fda-responds-three-gras-notices-hemp-seed-derived-ingredients-use-human-food
46. Benefits Of Turmeric
    https://healthcare.utah.edu/healthfeed/postings/2020/02/turmeric.php
47. CBD products are everywhere. But do they work?
    https://www.health.harvard.edu/newsletter_article/cbd-products-are-everywhere-but-do-they-work
48. Potential Adverse Drug Events and Drug-Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/
49. CBD and other medications: Proceed with caution
    https://www.health.harvard.edu/blog/cbd-and-other-medications-proceed-with-caution-2021011121743
50. FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD)
    https://www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbd
51. Ibid.
52. Non-Prescription CBD Product Labeling Largely Inaccurate, Study Finds
    https://pharmacy.wisc.edu/non-prescription-cbd-product-labeling-largely-inaccurate-study-finds/
53. Lack of sleep: Can it make you sick?
    https://www.mayoclinic.org/diseases-conditions/insomnia/expert-answers/lack-of-sleep/faq-20057757
54. Ibid.
55. Ibid.
56. Endocannabinoid signalling: has it got rhythm?
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931554/
57. No Acute Effects of Cannabidiol on the Sleep-Wake Cycle of Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895650/
58. Cannabis, Cannabinoids, and Sleep: a Review of the Literature
    https://pubmed.ncbi.nlm.nih.gov/28349316/
59. Cannabis, Cannabinoids, and Sleep: a Review of the Literature
    https://pubmed.ncbi.nlm.nih.gov/28349316/
60. An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies
    https://pubmed.ncbi.nlm.nih.gov/28861514/
61. Ibid.
62. Potential Adverse Drug Events and Drug-Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/
63. Common Sleep Disorders
    https://my.clevelandclinic.org/health/articles/11429-common-sleep-disorders
64. Can You Take CBD and Pass a Drug Test?
    https://www.consumerreports.org/cbd/can-you-take-cbd-and-pass-a-drug-test/
65. Cannabinoid Screen and Confirmation (Urine)
    https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=cannabinoid_screen_urine
66. page 219-220 of Healing With CBD
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
67. CBD Dosing
    https://www.projectcbd.org/guidance/cbd-dosing
68. The Farm Bill, hemp legalization and the status of CBD: An explainer
    https://www.brookings.edu/blog/fixgov/2018/12/14/the-farm-bill-hemp-and-CBD-explainer/

CBD Clinicals is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more