Are you looking for an alternative to relieve aches and pains? Read and find out more about the various benefits of CBD oil with olive oil for pain. 

How CBD Oil With Olive Oil May Help With Pain

CBD oil is made by infusing CBD (cannabidiol) concentrate from cannabis or hemp plants with carrier oils, like olive oil, coconut oil, or hemp oil(1).

Cannabidiol, more commonly known as CBD, is a non-psychoactive compound primarily found in cannabis plants(2). This compound interacts with the body’s ECS, also called the endocannabinoid system(3).

The ECS consists of cannabinoid receptors 1 and 2 (CB1 and CB2). 

CB1 receptors influence pain sensation, whereas CB2 stimulates the body’s anti-inflammatory response(4).

When CBD interacts with these receptors, this activity produces anti-pain (analgesic) and anti-inflammatory effects(5).

Benefits of Using CBD for Pain

A study investigated the effects of transdermal CBD on rats experiencing arthritis-related pain. Results indicated that CBD may potentially decrease pain and inflammation without significant side effects(6)

The mentioned animal study on the benefits of cannabidiol may sound promising. However, further research on the effects of CBD on humans is needed. 

Moreover, a 2018 case report discussed that individuals with epidermolysis bullosa who used topically applied CBD reported reduced pain, blistering, and faster healing of wounds(7)

Epidermolysis bullosa is a rare skin condition known to induce painful blistering skin. 

CBD Oil Dosage for Pain

The FDA, or Food and Drug Administration, has not approved the use of CBD to treat any medical condition. Thus, there is no set CBD dosage.

Meanwhile, it is hypothesized that standard doses of 10mg to 100mg of CBD may be effective for pain and inflammation(8)

Nonetheless, it is best to consult a medical professional experienced in cannabis use for more accurate dosing. 

How Long Does CBD Oil With Olive Oil Take to Help Pain?

How long CBD takes to help with pain may differ depending on the administration method, the user’s body weight, and metabolism.

CBD topicals like creams, lotions, and balms have an onset time of 10 to 15 minutes(9)

CBD tinctures have a quicker onset time of 15 to 30 minutes due to the compound’s direct entrance into the bloodstream(10)

Meanwhile, CBD edibles like gummies may take effect within 30 to 90 minutes after ingestion(11).

Vaping or smoking CBD offers the fastest onset time of 2 to 15 minutes(12).

However, vaping is associated with possible health risks like lung irritation and severe pulmonary disease(13)

It is highly suggested to consult an experienced healthcare professional before taking CBD oil products for pain.

How Long Will CBD Oil With Olive Oil Help With Pain?

There are no studies that determine how long the effects of CBD can last to help with pain. 

CBD may linger in the body depending on dosage, the administration method, and frequency of use(14).

Risks and Side Effects of Using CBD Oil With Olive Oil for Pain

The WHO (World Health Organization) reported that CBD has a good safety profile, is well tolerated by the body, and is non-addictive(15). 

However, using CBD may produce minor side effects like(16)

Moreover, CBD is an inhibitor of the cytochrome P450 enzymes, which metabolizes various pharmaceutical drugs like NSAIDs (nonsteroidal anti-inflammatory drugs)(17)

This inhibition may cause the drugs’ effects and duration to increase(18).

Legality of CBD

CBD products with a THC concentration of less than 0.3% are federally legal in the United States(19).

Still, it is best to verify state laws before purchasing and using CBD products to avoid any potential legal repercussions. 


1. How can CBD oil with olive oil help with pain?

CBD interacts with the ECS and cannabinoid CB1 and CB2 receptors(20)

The activity between CBD and the two receptors may deliver analgesic and anti-inflammatory properties(21).

2. What evidence or research exists to say that CBD oil with olive oil helps with pain?

Research indicates that transdermal CBD may have reduced pain and inflammation caused by arthritis without causing detrimental side effects(22)

3. Is there any evidence that CBD oil with olive oil can make pain worse?

There are no studies that suggest CBD oil can make pain worse. 

However, CBD may cause side effects like nausea, diarrhea, sleepiness, and lightheadedness(23)

Consult with a healthcare professional before taking any CBD products. 

4. Will CBD oil with olive oil interact with any current medication I may be taking for pain?

CBD may interact with NSAIDs and corticosteroids(24), which are taken to manage pain(25)

Thus, you should consult an expert before taking medications alongside CBD. 

5.Are there other treatments I should consider alongside CBD oil with olive oil to help with pain?

Depending on the severity and cause of pain, doctors may prescribe medications like(26):

  • Over-the-counter (OTC) medications such as Tylenol and ibuprofen are easily bought in stores and may treat mild to moderate pain(27).

Prescription drugs like corticosteroids and opioids need a doctor’s prescription and offer more potent pain relief for severe and chronic pain(28).

6. Can I fail a drug test if I use CBD oil with olive oil for pain?

CBD is a non-psychoactive compound. Thus, it will not cause a euphoric high(29)

However, CBD products may have small amounts of THC, which may build up in the system and cause a positive drug test. 

7. What is the CBD dosage for pain?

The optimal CBD dosage may depend on the user’s genetics, health conditions, stress levels, diet, and exercise(30).

However, it is suggested that first-time CBD users should take lower CBD dosages(31).

8. What are the side effects of CBD oil for pain?

CBD may cause minor effects like sleepiness, lightheadedness, nausea, dry mouth, and diarrhea(32).

Therefore, CBD products should be taken after the advice of a medical professional. 

9. Is CBD oil safe?

CBD is generally safe, well-tolerated by the body, and non-addictive(33).

CBD is federally legal in the United States(34).

However, CBD products that contain more than 0.3% THC are considered illegal(35). Thus, it is best to verify state laws before purchasing and using CBD. 

  1. Healing with CBD page 205
  2. The Endocannabinoid System, Our Universal Regulator
  3. Ibid.
  4. Cannabinoids and Pain: New Insights From Old Molecules
  5. CBD oil: What is it and how does it work?
  6. Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis
  7. Self-initiated use of topical cannabidiol oil for epidermolysis bullosa
  8. CBD: A Patient’s Guide to Medicinal Cannabis, page 129.
  9. Healing With CBD. page. 210
  10. Healing with CBD. page. 192.
  11. Ibid. page. 191
  12. Healing with CBD. page. 197.
  13. Can vaping damage your lungs? What we do (and don’t) know
  14. Healing with CBD. page. 195.
  15. Cannabidiol (CBD)
  16. What are the benefits of CBD — and is it safe to use?
  17. page 114 to 115 of Healing With CBD
  18. Ibid.
  19. Hemp Production and the 2018 Farm Bill
  20. An introduction to the endogenous cannabinoid system
  21. CBD oil: What is it and how does it work?
  22. Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis
  23. What are the benefits of CBD — and is it safe to use?
  24. Healing With CBD, pages 115-116
  25. Pain Relievers
  26. Ibid.
  27. Pharmacologic Therapy for Acute Pain
  28. Pain Relievers
  29. Cannabidiol (CBD)-what we know and what we don’t
  30. CBD dosing
  31. Ibid.
  32. What are the benefits of CBD — and is it safe to use?
  33. Cannabidiol (CBD), page 5.
  34. Hemp Production and the 2018 Farm Bill
  35. CBD & THC: Myths and misconceptions
CBD Clinicals is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more