Can CBD help with allergies?

  • Allergies are among the most common health conditions in people around the world. A person exposed to allergic substances like pollen, mold, or dust may experience excess production of antibodies in their immune system.
  • Cannabidiol (CBD), the non-psychoactive compound derived from Cannabis sativa, is said to possess anti-inflammatory properties that could be useful in managing allergies ⁽¹⁾. One example of how CBD can help with allergies is by reducing the antibodies that trigger inflammatory responses from the body.
  • Several studies on CBD suggests that the phytocannabinoid has the potential of being an effective treatment for allergies ⁽²⁻⁵⁾.
  • Although the findings on CBD are very positive, medical experts warn that many of the therapeutic properties of CBD products are still hypothetical. People that are interested in including cannabidiol in their regimen should consult a doctor to avoid complications.

Best CBD for Managing Allergies

Editor's Pick

Spruce 750mg Lab Grade CBD Oil

Specifically formulated to be more palatable to CBD users
Spruce 750mg Lab Grade CBD Oil Bottle
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  • Summary

    Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

    Pro's
    Cons's
    •  Mid-strength
    •  Natural peppermint flavor
    •  Made from 100% organic and natural ingredients
    •  No other flavors
  • Features
    Discount pricing available? 20% Off Coupon Code: CBDCLINICALS
    Source
    Source of Hemp
    Kentucky, USA & North Carolina, USA
    Form Oil Tincture
    Ingredients Organic Hemp Seed Oil, Full Spectrum CBD Oil
    Type
    Type of CBD
    Full Spectrum
    Extraction
    Extraction Method
    Moonshine extraction method
    How to take it Under tongue
    Potency
    Potency - CBD Per Bottle
    750 mg per bottle
    Carrier Oil Organic Hemp Seed Oil
    Concentration
    CBD Concentration Per Serving
    25mg of CBD per dropper full (1ml)
    Drug Test Contains 0.3% THC but there is a chance you may test positive for marijuana
    Flavours Peppermint
    Price Range $89 ($75.65 for subscriptions, 15% discount from regular price)
    $/mg CBD
    Price ($/mg)
    $0.12/mg ($0.10/mg with subscription)
    Shipping
    Shipping/Time to delivery
    2-4 business days (first class USPS)
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants Organic, Non-GMO, no pesticides, no herbicides, no solvents or chemical fertilizers, No preservatives or sweeteners
    Allergens Vegan, Gluten free
    Refund policy Within 30 days
    Recommended for New CBD users
    Countries served USA only (all 50 states)
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Best Organic

NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil

Perfect for anyone who are looking for CBD products that promote a healthy body and mind.
NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
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    99%
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    Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

    Pro's
    Cons's
    •  Pure CBD hemp
    •  All natural
    •  Approximately 300 drops total
    •  No other flavors
  • Features
    Discount pricing available? 20% Off Coupon Code: CBDCLINICALS20
    Source
    Source of Hemp
    Colorado, USA
    Form Oil Tincture
    Ingredients Full Spectrum Hemp Extract, Organic Virgin Hemp Seed Oil
    Type
    Type of CBD
    Full Spectrum CBD
    Extraction
    Extraction Method
    CO2 Method
    How to take it Under the tongue for approximately 30 seconds before swallowing
    Potency
    Potency - CBD Per Bottle
    900mg per bottle
    Carrier Oil Organic Hemp Oil
    Concentration
    CBD Concentration Per Serving
    60mg per dropper full (1ml)
    Drug Test Contains 0.3% THC but there is a chance you may test positive for marijuana
    Flavours Natural
    Price Range $99 - $434
    $/mg CBD
    Price ($/mg)
    $0.08 - $0.13
    Shipping
    Shipping/Time to delivery
    2-3 Days via USPS
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants No additives or preservatives, Non-GMO, NO herbicides, pesticides, or chemical fertilizers
    Allergens Not specified
    Refund policy Within 30 days
    Recommended for Health-conscious persons
    Countries served USA (all 50 states) and over 40 countries including Australia, Azerbaijan, Beliza, Bosnia & Herzegovina, Brazil, Chile, China, Croatia, Czech Republic, Estonia, France, Hong Kong, Hungary, Ireland, Israel, Japan, Latvia, Lebanon, Lithuania, Macao, Malaysia, Malta, Netherlands, New Zealand, Oman, Paraguay, Poland, Portugal, Saudi Arabia, Serbia, Singapore, South Korea, Sweden, Switzerland, United Arab Emirates, United Kingdom, Uruguay, and many more.
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Best Customer Service

Sabaidee Super Good Vibes CBD Oil

4x the strength of a regular cbd oil
Sabaidee Super Good Vibes CBD Oil
  • Overall Clinical Score
    99%
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  • Score breakdown
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  • Summary

    Super Good Vibes CBD Oil provides the purest and highest quality Cannabidiol (CBD) on the market as well as other high quality phytocannabinoids, terpenes, vitamins, omega fatty acids, trace minerals, and other beneficial for your health elements, which all work together to provide benefits.

    Pro's
    Cons's
    •  Extra strong
    •  Significant benefits with just a few drops
    •  100% Natural ingredients
    •  No other flavors
  • Features
    Discount pricing available? 15% Off Coupon Code: CBDCLINICALS15
    Source
    Source of Hemp
    Colorado, USA
    Form Oil Tincture
    Ingredients Cannabidiol (CBD), Coconut Medium-chain triglycerides (MCT) Oil, Peppermint oil
    Type
    Type of CBD
    Broad Spectrum
    Extraction
    Extraction Method
    CO2-extraction
    How to take it Using 1-3 servings per day as needed is a good start to determine how much you need
    Potency
    Potency - CBD Per Bottle
    1000 mg per bottle
    Carrier Oil Coconut MCT Oil
    Concentration
    CBD Concentration Per Serving
    33.5 mg per dropper (1ml)
    Drug Test Contains 0.3% THC but there is a chance you may test positive for marijuana
    Flavours Peppermint
    Price Range Single Bottle - $119.95, 2-Pack - $109.97 each, 3-Pack - $98.31 each, 6-Pack - $79.99 each
    $/mg CBD
    Price ($/mg)
    Single bottle - $0.010, 2-Pack - $0.011, 3-Pack - $0.009, 6-Pack - $0.007
    Shipping
    Shipping/Time to delivery
    3-5 Business days
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants Contaminant-free
    Allergens Vegan and Gluten-free
    Refund policy Within 30 days
    Recommended for Patients who are looking for serious CBD oil support
    Countries served USA only (all 50 states)
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Natural Alternative

cbdMD CBD Oil Tinctures

Uses USA hemp that is grown on non-GMO farms, and is both vegan and gluten-free
cbdMD CBD Oil Tinctures Products
  • Overall Clinical Score
    99%
    Natural Alternative
  • Score breakdown
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    Lab Testing Transparency
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  • Summary

    cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

    Pro's
    Cons's
    •  Plenty of concentrations to choose from for all people with various kinds of needs
    •  Has vegan, organic, and gluten-free ingredients
    •  Affordable pricing
    •  Affordable pricing
    •  cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
  • Features
    Discount pricing available? 15% Off Coupon Code: cbdMD15
    Source
    Source of Hemp
    Kentucky, USA
    Form Oil Tincture
    Ingredients Cannabidiol (CBD), MCT Oil, and Flavoring
    Type
    Type of CBD
    Broad Spectrum
    Extraction
    Extraction Method
    CO2 extraction method
    How to take it Under tongue
    Potency
    Potency - CBD Per Bottle
    300 mg - 7500 mg / 30 ml bottle, 1000 mg - 1500 mg / 60 ml bottle
    Carrier Oil Organic Coconut MCT Oil
    Concentration
    CBD Concentration Per Serving
    30 ml: 300 mg - 10 mg per dropper (1ml), 750 mg - 25 mg per dropper (1ml), 1500 mg - 50 mg per dropper (1ml), 3000 mg - 100 mg per dropper (1ml), 5000 mg - 166.6 mg per dropper (1ml), 7500 mg - 250 mg per dropper (1ml), 60 ml: 1000 mg - 16.6 mg per dropper (1ml), 1500 mg - 25 mg per dropper (1ml)
    Drug Test Containing less than 0.3% THC, there are still trace amounts
    Flavours Natural, Berry, Orange and Mint
    Price Range 30 ml Bottles: $29.99 for 300 mg, $69.99 for 750 mg, $99.99 for 1500 mg, $149.99 for 3000 mg, $239.99 for 5000 mg, $339.99 for 7500 mg 60 ml Bottles: $74.99 for 1000 mg, $99.99 for 1500 mg
    $/mg CBD
    Price ($/mg)
    30 ml - $0.05 - $0.10, 60 ml - $0.06 - $0.07
    Shipping
    Shipping/Time to delivery
    2-5 Business days (via Fedex)
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants 100% organic, non-GMO, and vegan-certified
    Allergens Vegan, Gluten free
    Refund policy Within 30 days
    Recommended for CBD users with different needs
    Countries served USA only (all 50 states)
Check Latest Prices

Why People Are Using CBD for Allergies

An allergic reaction is one of the most prevalent chronic health conditions in the world. When a person encounters substances that they are allergic to, such as with pollen, mold, or dust, the immune system may overreact by producing excess antibodies.

Cannabidiol (CBD), the non-psychoactive compound from the Cannabis sativa plant, reportedly contains anti-inflammatory properties that could be useful in treating allergies⁽⁶⁾. One way CBD can help with allergies is by reducing antibodies that trigger histamine –the leading cause of inflammatory responses in the body. 

How CBD Oil Works to Help with Allergies

A study in 2009 found that cannabinoids are capable of inhibiting the activation of a specific type of white blood cell (T-cells) in mice.  By impairing the release of these cells, CBD may be able to lessen antibody responses and reduce allergic symptoms ⁽⁷⁾.

Terpenes, which are present in full-spectrum CBD oil, have also shown to help lower antibody levels, as seen in a 2014 study. Researchers learned that alpha-pinene, a common terpene in Cannabis sativa, decreased the clinical symptoms of allergies in mice ⁽⁸⁾.

Researchers observed that the rodents rubbed their nose, eyes, and ears less frequently, indicating an improvement from allergic reactions. Lower levels of immunoglobulin E, a vital component that releases histamine, were also noticed in the mice. Histamine is responsible for the symptoms such as a runny nose, itching, and swelling in the nasal cavities.

Another study in 2005 suggests that cannabinoids may prevent heightened histamine responses. The research shows that certain cannabinoids could suppress the activation of mast cells that trigger histamine release ⁽⁹⁾.

Inflammation plays a crucial role during the onset of allergies, and one way that cannabis may help alleviate allergic symptoms is by reducing or preventing inflammation. Dr. Sue Sisley, a researcher on medical marijuana, notes that the Cannabis sativa plant may inhibit the inflammatory pathway.

“And that certainly does relate to allergies because if you can cut the inflammatory pathway, then it could certainly help the untreated allergies, all the classic symptoms, the itchy, runny nose, itchiness, hives, all those kinds of things,” Dr. Sisley states.

Besides reducing the symptoms of itchy skin, watery eyes, sneezing, and runny nose, cannabidiol can also alleviate allergy symptoms such as difficulty breathing in asthma. A study released in 2019 reveals that CBD treatment reduces inflammation in the airway, wheezing, and scarring of lung tissue in allergic asthma ⁽¹⁰⁾.

Another research study suggests that cannabinoids may affect mast cells similar to antihistamines ⁽¹¹⁾.

Despite these preliminary findings, Dr. Sisley cautions that the therapeutic properties of CBD tincture are still theoretical. Although proof of its effectiveness is not yet proven, the initial studies show CBD to have the potential of being a possible treatment for allergies.

The Pros and Cons of CBD Oil for Allergies

The Pros

  • The studies mentioned above show that the anti-inflammatory and antihistamine properties of CBD oil may help treat allergies.
  • Cannabidiol, unlike tetrahydrocannabinol (THC), does not alter the consciousness or trigger a “high” in individuals that consume its products ⁽¹²⁾.
  • Based on a report from the World Health Organization (WHO), CBD oil is generally well tolerated and comes with an excellent safety profile ⁽¹³⁾.
  • Although mostly performed on animals, the findings above show that CBD may be an effective treatment in reducing allergy symptoms.

Cons

  • The studies on the efficacy of CBD in human beings are minimal and do not clarify whether or not the compound can reliably treat allergies.
  • According to Dr. Peter Grinspoon, a primary care physician that advocates the use of cannabis, states that fatigue, irritability, and nausea are common side effects of CBD ⁽¹⁴⁾.
  • Most of the research on the anti-inflammatory properties of CBD were clinical trials carried out on rodents and not human beings.

The labeling accuracy of cannabidiol products sold online leaves much to be desired. Dr. Grinspoon, as well as several researchers in a 2017 study by the Journal of the American Medical Association (JAMA), share the same sentiment⁽¹⁵⁾.

Consulting a doctor that is knowledgeable in CBD use is highly recommended. At the very least, seeking such medical advice can help ensure that the extract does not have a negative interaction with other allergy medications currently being taken ⁽¹⁶⁾.

How CBD Oil Compares to Alternative Treatments for Allergies

At the time of writing, no evidence points to CBD as a proper antihistamine. Based on findings, scientists theorize that CBD can affect mast cells enough to reduce allergic symptoms ⁽¹⁷⁾.

Many people suffering from seasonal allergies find that traditional antihistamines are only effective if started early. Over time, its efficacy begins to diminish to the point where it may no longer be useful against an allergic response.

As mentioned earlier, CBD has anti-inflammatory potential that may be useful in treating allergy. Several studies suggest that there are therapeutic properties present in cannabidiol.

One frequently cited study is in 2009 published by Future Medicinal Chemistry. The researchers in the study analyzed the importance of the CB1 and CB2 receptors and how cannabinoids could play a crucial role in regulating the immune system ⁽¹⁸⁾.

The main point of the said research is that cannabinoids can potentially be active anti-inflammatory agents. The authors learned that CBD is as effective as many of the widely available anti-inflammatory medications in the market.

Nagarkatti and associates looked at cannabidiol’s interaction with the endocannabinoid system (ECS) and how it appears to inhibit inflammation ⁽¹⁹⁾. The ECS is a system in both humans and animals that regulates much of the immune system.

A more recent study in 2018 analyzed how chronic pain and inflammation can be treated through various cannabinoid delivery systems. 

The researchers mentioned that the trials support the potential anti-inflammatory properties of cannabinoids. This data makes cannabinoids suitable candidates for nano-sized drug delivery systems ⁽²⁰⁾.

The majority of findings on CBD’s effects on inflammation ultimately points towards its effects on the endocannabinoid system.

Scientists in a 2014 study had the same sentiment when they analyzed how the ECS plays a considerable part in handling inflammation. Their findings suggest that activating the ECS in a certain way can help regulate inflammation linked to various diseases ⁽²¹⁾.

In theory, the use of CBD oil to treat allergies may promote the increased production of healthy cannabinoids in the ECS. Although CBD does not directly affect the receptors present in the system, it may be sufficient enough to promote anti-inflammatory effects.

How to Choose the Right CBD for Allergies

A CBD nasal spray containing a concentration of anti-inflammatory cannabinoids and terpenes is something that the marijuana plant advocate Dr. Grinspoon envisions can treat allergies. Full-spectrum CBD oil is an example of a CBD product that contains all of the phytonutrients from industrial hemp as it comes with THC, terpenes, flavonoids, and essential oils.

There are also broad-spectrum CBD products, or CBD without the THC content, for consumers that have cannabis allergy to THC.

CBD isolates are also available, which are extracts that are made up of pure cannabidiol. Farmers typically obtain this type of CBD from hemp plants, due to its low or non-existent THC content.

Whichever type of CBD product people choose to use, it is always in their best interest to consult a doctor first before deciding to apply CBD oil for allergies.

The following factors are essential to ensure the safety and reliability of the CBD products purchased:

  1. Research on the exact legal stipulations applicable to CBD in the area where it would be purchased and used.
  2. Purchase only high-quality CBD products from legitimate and reliable brands. The majority of companies that manufacture the best CBD oil products grow their hemp from their farm, or they purchase from licensed hemp producers.
  3. Research product reviews before buying from an online store. When purchasing from a physical store or dispensary, check whether the store is authorized by the government to sell CBD.
  4. One important thing to look for in CBD products is certification codes. Several certification authorities approve certain products only after some thorough screening tests.
  5. Compare company claims about their products’ potency with that of the third-party lab reports.
  6. Consulting with a trusted medical professional who is experienced in CBD use is ideal before one purchases his or her first bottle of CBD.

Conclusion

Allergies are one of the most common medical conditions that people around the world experience, especially in the United States. Common allergens such as mold, pollen, dander, or dust, which are seemingly harmless for most individuals, may cause an overreaction (as with anaphylaxis) in the immune system of people who are allergic to them.

CBD is said to possess anti-inflammatory properties that may help allergy sufferers, especially those with rhinitis or hay fever. One example of how CBD can address allergic symptoms is by inhibiting antibodies that trigger histamine, or the main compound responsible for inflammatory responses.

Many other studies are suggesting that cannabinoids can potentially deal with allergies.  Much of the research ultimately points towards how CBD can affect the endocannabinoid system.

Despite preliminary findings, medical experts caution that the therapeutic properties of CBD oil are still theoretical. It is always best for people to consult a doctor first before deciding to include any CBD product in their regimen.


  1. Nagarkatti P, Pandey R, Rieder SA, Hegde VL, Nagarkatti M. Cannabinoids as novel anti-inflammatory drugs. Future Med Chem. 2009;1(7):1333‐1349. doi:10.4155/fmc.09.93
  2. Haitian Lu, Barbara L. F. Kaplan, Thitirat Ngaotepprutaram, and Norbert E. Kaminski. Suppression of T cell costimulator ICOS by 9-tetrahydrocannabinol. Department of Pharmacology and Toxicology and Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan, USA.
  3. Vuolo F, Abreu SC, Michels M, et al. Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma. Eur J Pharmacol. 2019;843:251‐259. doi:10.1016/j.ejphar.2018.11.029
  4. Small-Howard AL, Shimoda LM, Adra CN, Turner H. Anti-inflammatory potential of CB1-mediated cAMP elevation in mast cells. Biochem J. 2005;388(Pt 2):465‐473. doi:10.1042/BJ20041682
  5. Nagarkatti P. et al. op. cit.
  6. Ibid.
  7. Haitian Lu. et al. op. cit.
  8. Sun-Young Nam, Cha-kwon Chung, Jun-HoSeo, So-YoungRah, Hyung-Min Kim, Hyun-JaJeonge. The therapeutic efficacy of α-pinene in an experimental mouse model of allergic rhinitis. https://doi.org/10.1016/j.intimp.2014.09.010.
  9. Small-Howard AL. et al. op. cit.
  10. Vuolo F. et al. op. cit.
  11. Small-Howard AL. et al. op. cit.
  12. Shannon S, Lewis N, Lee H, Hughes S. Cannabidiol in Anxiety and Sleep: A Large Case Series. Perm J. 2019;23:18‐041. doi:10.7812/TPP/18-041
  13. World Health Organization (2018, June). Cannabidiol (CBD) Critical Review Report. Retrieved from: https://www.who.int/medicines/access/controlled-substances/WHOCBDReportMay2018-2.pdf
  14. Peter Grinspoon (2018, August 24). Cannabidiol (CBD) — what we know and what we don’t. Retrieved from: https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476
  15. Bonn-Miller MO, Loflin MJE, Thomas BF, Marcu JP, Hyke T, Vandrey R. Labeling Accuracy of Cannabidiol Extracts Sold Online. JAMA. 2017;318(17):1708‐1709. doi:10.1001/jama.2017.11909
  16. Grinspoon, P. op. cit.
  17. Giudice ED, Rinaldi L, Passarotto M, et al. Cannabidiol, unlike synthetic cannabinoids, triggers activation of RBL-2H3 mast cells. J Leukoc Biol. 2007;81(6):1512‐1522. doi:10.1189/jlb.1206738
  18. Nagarkatti P. et al. op. cit.
  19. Ibid.
  20. Bruni N, Della Pepa C, Oliaro-Bosso S, Pessione E, Gastaldi D, Dosio F. Cannabinoid Delivery Systems for Pain and Inflammation Treatment. Molecules. 2018;23(10):2478. Published 2018 Sep 27. doi:10.3390/molecules23102478
  21. Witkamp R, Meijerink J. The endocannabinoid system: an emerging key player in inflammation. Curr Opin Clin Nutr Metab Care. 2014;17(2):130‐138. doi:10.1097/MCO.0000000000000027
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