Does CBD Oil interact with Tramadol & other analgesics? What are the risks of taking CBD Oil with Tramadol or other analgesics?

  • CBD oil lessens Tramadol’s high dosage analgesic effects(1).
  • A National Institutes of Health research showed that using CBD in high doses with Tramadol may considerably lessen Tramadol’s analgesic effectiveness. It does not state CBD’s effect with low doses of Tramadol(2).
  • A prospective cohort study stated that CBD could significantly lessen opioid use and improve chronic pain and sleep quality among patients who use opioids to manage pain(3).
  • However, a study made by The American Society for Pharmacology and Experimental Therapeutics concludes that using CBD may inhibit the liver enzyme CYP2DC responsible for metabolizing Tramadol in the body(4).
  • With not enough studies regarding specific drug dosage interaction between CBD oil and Tramadol, it is still best to consult a physician before use.

Looking for CBD Oil for Pain? 

Editor's Pick

Spruce 750mg Lab Grade CBD Oil

Specifically formulated to be more palatable to CBD users
Spruce 750mg Lab Grade CBD Oil Bottle
  • Overall Clinical Score
    99%
    Editor's Pick
  • Clinical Scores
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
    Perfect for...New CBD users
  • Summary

    Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

    Pro's
    Cons's
     Mid-strength  No other flavors
     Natural peppermint flavor
     Made from 100% organic and natural ingredients
  • Features
    Discount pricing available?20% Off Coupon Code: CBDCLINICALS
    Source
    Source of Hemp
    Kentucky, USA & North Carolina, USA
    FormOil Tincture
    IngredientsOrganic Hemp Seed Oil, Full Spectrum CBD Oil
    Type
    Type of CBD
    Full Spectrum
    Extraction
    Extraction Method
    Moonshine extraction method
    How to take itUnder tongue
    Potency
    Potency - CBD Per Bottle
    750 mg per bottle
    Carrier OilOrganic Hemp Seed Oil
    Concentration
    CBD Concentration Per Serving
    25mg of CBD per dropper full (1ml)
    Drug TestContains 0.3% THC but there is a chance you may test positive for marijuana
    FlavoursPeppermint
    Price Range$89 ($75.65 for subscriptions, 15% discount from regular price)
    $/mg CBD
    Price ($/mg)
    $0.12/mg ($0.10/mg with subscription)
    Shipping
    Shipping/Time to delivery
    2-4 business days (first class USPS)
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    ContaminantsOrganic, Non-GMO, no pesticides, no herbicides, no solvents or chemical fertilizers, No preservatives or sweeteners
    AllergensVegan, Gluten free
    Refund policyWithin 30 days
    Recommended forNew CBD users
    Countries servedUSA only (all 50 states)
Check Latest Prices
Best Customer Service

Sabaidee Super Good Vibes CBD Oil

4x the strength of a regular cbd oil
Sabaidee Super Good Vibes CBD Oil
  • Overall Clinical Score
    99%
    Best Customer Service
  • Clinical Scores
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
    Perfect for...Patients who are looking for serious CBD oil support
  • Summary

    Super Good Vibes CBD Oil provides the purest and highest quality Cannabidiol (CBD) on the market as well as other high quality phytocannabinoids, terpenes, vitamins, omega fatty acids, trace minerals, and other beneficial for your health elements, which all work together to provide benefits.

    Pro's
    Cons's
     Extra strong  No other flavors
     Significant benefits with just a few drops
     100% Natural ingredients
  • Features
    Discount pricing available?15% Off Coupon Code: CBDCLINICALS15
    Source
    Source of Hemp
    Colorado, USA
    FormOil Tincture
    IngredientsCannabidiol (CBD), Coconut Medium-chain triglycerides (MCT) Oil, Peppermint oil
    Type
    Type of CBD
    Broad Spectrum
    Extraction
    Extraction Method
    CO2-extraction
    How to take itUsing 1-3 servings per day as needed is a good start to determine how much you need
    Potency
    Potency - CBD Per Bottle
    1000 mg per bottle
    Carrier OilCoconut MCT Oil
    Concentration
    CBD Concentration Per Serving
    33.5 mg per dropper (1ml)
    Drug TestContains 0.3% THC but there is a chance you may test positive for marijuana
    FlavoursPeppermint
    Price RangeSingle Bottle - $119.95, 2-Pack - $109.97 each, 3-Pack - $98.31 each, 6-Pack - $79.99 each
    $/mg CBD
    Price ($/mg)
    Single bottle - $0.010, 2-Pack - $0.011, 3-Pack - $0.009, 6-Pack - $0.007
    Shipping
    Shipping/Time to delivery
    3-5 Business days
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    ContaminantsContaminant-free
    AllergensVegan and Gluten-free
    Refund policyWithin 30 days
    Recommended forPatients who are looking for serious CBD oil support
    Countries servedUSA only (all 50 states)
Check Latest Prices
Best Organic

Nuleaf Naturals 725mg Full Spectrum CBD Oil

Perfect for anyone who are looking for CBD products that promote a healthy body and mind.
Nuleaf Naturals 725mg Full Spectrum CBD Oil
  • Overall Clinical Score
    99%
    Best Organic
  • Clinical Scores
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
    Perfect for...Health conscious
  • Summary

    Natural remedy for various illnesses. There are approximately 300 drops in this 0.5 FL OZ bottle, where 1 drop = 2.4 mg of CBD.

    Pro's
    Cons's
     Pure CBD hemp  No other flavors
     All natural
     Approximately 300 drops total
  • Features
    Discount pricing available?20% Off Coupon Code: CBDCLINICALS20
    Source
    Source of Hemp
    Colorado, USA
    FormOil Tincture
    IngredientsUSDA Certified Organic Hemp Oil, Full Spectrum Hemp Extract
    Type
    Type of CBD
    Full Spectrum CBD
    Extraction
    Extraction Method
    CO2 Method
    How to take itUnder the tongue for approximately 30 seconds before swallowing
    Potency
    Potency - CBD Per Bottle
    725mg of CBD per 0.5 FL OZ (15ml)
    Carrier OilOrganic Hemp Oil
    Concentration
    CBD Concentration Per Serving
    48.33mg to a max of 51.82mg per 1ml
    Drug TestContains 0.3% THC but there is a chance you may test positive for marijuana
    FlavoursNatural
    Price Range$99.00 - 1-pack, $434.00 - 6-pack
    $/mg CBD
    Price ($/mg)
    1-pack - $0.13, 6-pack - $0.59
    Shipping
    Shipping/Time to delivery
    2-3 Days via USPS
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    ContaminantsNo additives or preservatives, Non-GMO, NO herbicides, pesticides, or chemical fertilizers
    AllergensNot specified
    Refund policyWithin 30 days
    Recommended forHealth conscious
    Countries servedUSA (all 50 states) and over 40 countries including Australia, Azerbaijan, Beliza, Bosnia & Herzegovina, Brazil, Chile, China, Croatia, Czech Republic, Estonia, France, Hong Kong, Hungary, Ireland, Israel, Japan, Latvia, Lebanon, Lithuania, Macao, Malaysia, Malta, Netherlands, New Zealand, Oman, Parguay, Poland, Portugal, Saudi Arabia, Serbia, Singapore, South Korea, Sweden, Switzerland, United Arab Emirates, United Kingdom, Uruguay, and many more.
Check Latest Prices
Natural Alternative

cbdMD CBD Oil Tinctures

Uses USA hemp that is grown on non-GMO farms, and is both vegan and gluten-free
cbdMD CBD Oil Tinctures Products
  • Overall Clinical Score
    99%
    Natural Alternative
  • Clinical Scores
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
    Perfect for...CBD users with different needs
  • Summary

    cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

    Pro's
    Cons's
     Plenty of concentrations to choose from for all people with various kinds of needs  cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
     Has vegan, organic, and gluten-free ingredients
     Affordable pricing
     Affordable pricing
  • Features
    Discount pricing available?15% Off Coupon Code: cbdMD15
    Source
    Source of Hemp
    Kentucky, USA
    FormOil Tincture
    IngredientsCannabidiol (CBD), MCT Oil, and Flavoring
    Type
    Type of CBD
    Broad Spectrum
    Extraction
    Extraction Method
    CO2 extraction method
    How to take itUnder tongue
    Potency
    Potency - CBD Per Bottle
    300 mg - 7500 mg / 30 ml bottle, 1000 mg - 1500 mg / 60 ml bottle
    Carrier OilOrganic Coconut MCT Oil
    Concentration
    CBD Concentration Per Serving
    30 ml: 300 mg - 10 mg per dropper (1ml), 750 mg - 25 mg per dropper (1ml), 1500 mg - 50 mg per dropper (1ml), 3000 mg - 100 mg per dropper (1ml), 5000 mg - 166.6 mg per dropper (1ml), 7500 mg - 250 mg per dropper (1ml), 60 ml: 1000 mg - 16.6 mg per dropper (1ml), 1500 mg - 25 mg per dropper (1ml)
    Drug TestContaining less than 0.3% THC, there are still trace amounts
    FlavoursNatural, Berry, Orange and Mint
    Price Range30 ml Bottles: $29.99 for 300 mg, $69.99 for 750 mg, $99.99 for 1500 mg, $149.99 for 3000 mg, $239.99 for 5000 mg, $339.99 for 7500 mg 60 ml Bottles: $74.99 for 1000 mg, $99.99 for 1500 mg
    $/mg CBD
    Price ($/mg)
    30 ml - $0.05 - $0.10, 60 ml - $0.06 - $0.07
    Shipping
    Shipping/Time to delivery
    2-5 Business days (via Fedex)
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants100% organic, non-GMO, and vegan-certified
    AllergensVegan, Gluten free
    Refund policyWithin 30 days
    Recommended forCBD users with different needs
    Countries servedUSA only (all 50 states)
Check Latest Prices

Can CBD Oil Be Taken with Tramadol? 

Tramadol has been used as a pain reliever for years. However, because of its potential for abuse, it may not be for everyone. Veterinarians also use Tramadol for dogs in pain.

CBD and tramadol may be useful pain relievers. However, using them in combination brings about adverse effects and is, therefore, not recommended.

Many drug interaction reports between CBD oil and Tramadol do not state specific dosage interaction, except for the National Institutes of Health research which stated that CBD oil could lessen the analgesic efficacy of high dosage Tramadol(5).

Tramadol is an analgesic that modulates moderate to severe pain by traveling within the central nervous system through metabolite binding to specific opioid receptors(6).

The primary mu-opioid receptors (muORs) mediate the analgesic effects of opioids(7)

A prospective cohort study stated that the use of cannabidiol, which has psychoactive effects, could significantly lessen opioid use and improve chronic pain and sleep quality among patients who use opioids to manage pain(8).

However, a study made by The American Society for Pharmacology and Experimental Therapeutics concluded that the use of CBD might inhibit the liver enzyme CYP2DC responsible for metabolizing Tramadol and other opioids, such as codeine which is commonly used as an alternative to Tramadol when pain is mild to moderate, in the body(9).

Can another analgesic be a substitute for Tramadol so that CBD Oil can be taken? 

There is no established alternative to Tramadol so that CBD oil can be taken. 

Tramadol relieves acute and chronic pain with moderate to severe intensity. It is used in the pain management of osteoarthritis, acute myocardial infarction, acute myocardial infarction, and Brugada syndrome(10).

It is also used for dental, post-operative, chronic cancer, back pain, and acute renal pain relief(11).

However, Tramadol can cause common side effects like headaches, constipation, and dry mouth(12).

The more severe side effects are breathing difficulty or short, shallow breathing, hallucinations, urinary difficulty, seizures, confusion, and the low blood pressure symptoms of dizziness, exhaustion, and lack of energy(13).

Severe allergic reaction (anaphylaxis) also happens, but rarely(14).

Other analgesics can be used as a replacement for Tramadol that have fewer side effects when compared to Tramadol. 

A 2005 experimental study concluded that metoclopramide is a viable low-cost alternative to Tramadol in treating post-operative pain because it offers fewer side effects commonly linked to Tramadol, such as nausea, tremor, and vomiting(15).

Since there are no studies currently available about drug interactions between metoclopramide and CBD oil, consulting a doctor before use is highly recommended.

According to a February 2020 JAMA medical journal research, Tramadol had a higher mortality risk compared to the anti-inflammatory medications naproxen, diclofenac, and etoricoxib(16).

More clinical trials are needed to confirm the research because it did not attribute the result to specific causes. Several external factors may have led to the conclusion(17).

An NIH study stated that naproxen is not recommended to use with CBD products from the cannabis plant because naproxen’s CYP2C8/9 enzyme substrate interacts with CBD oil(18).

The study has advised either avoiding administering CBD oil with naproxen, decreasing the naproxen dose, or monitoring for adverse effects and toxicity to minimize side effects(19).

It is also not recommended to take CBD oil while taking diclofenac because there are indications that CBD decreases its metabolization because CBD may inhibit the hepatic enzyme CYP2C9(20).

Take caution in using CBD products like cannabis oil with etoricoxib used as antiepileptics because of possible drug interaction even if there is no published report(21).

Drug interactions between ibuprofen, over-the-counter medications, and other NSAIDS with cannabinoids have not yet been demonstrated. 

Can CBD replace Tramadol?

CBD can help relieve pain similarly addressed by prescribing Tramadol. 

Pain associated with cancer, neuropathy, and central pain such as multiple sclerosis can be suitably managed with CBD(22).

A study proves that CBD subdues inflammatory and neuropathic pain(23).

CBD’s anti-inflammatory properties are expounded in the Journal of Pharmacology and Experimental Allergic Contact Dermatitis(24).

CBD may also relieve muscle weakness, which is a significant symptom of neuropathy(25).

CBD can also be used to manage pain that does not respond well to other treatments like optimized opioid therapy in conditions such as intractable cancer pain and chronic musculoskeletal pain(26).

The University of Michigan Health Lab published an article declaring that the benefits of opioids like Tramadol and cannabinoids are equal(27).

Opioids are more useful for pain associated with peripheral damage or inflammation resulting in nerve pain. Symptoms of this condition include(28):

  • numbness, prickling, and tingling in hands and feet
  • sharp, burning, or throbbing pain 
  • touch sensitivity
  • muscle weakness
  • paralysis (rare)

The endocannabinoid system plays an important role in the central nervous system. 

Cannabinoids are preferred for neuropathic and centralized pain conditions like fibromyalgia(29).

Other conditions with neuropathic and centralized pain conditions are allodynia, where the pain is experienced with ordinary touch, chronic pain syndrome, and neurological injuries such as stroke and spinal cord injury(30).

Although their benefits are comparable, the article expressed that both opioids and cannabinoids should not be used as primary pain therapies because the benefits are minimal(31).

The article suggested that physicians must first establish the appropriate formulation and dose before recommending cannabinoids(32).

It also advised pharmaceutical companies to stop marketing opioids for a broad range of conditions until studies confirm opioids’ extensive scope of efficacy(33).

Tramadol vs. CBD

Tramadol was not yet classified as an opiate in 1995. However, the FDA identified Tramadol as a controlled substance in 2014 due to widespread abuse and addiction to it(34).

Contrary to Tramadol and some similar prescription medications, CBD is non-addictive according to a 2015 research conducted by Nora Volkow(35).

However, Wayne Hall of the Society for the Study of Addiction stated in 2018 that it is premature to expand access to medical cannabis to solve the U.S. opioid crisis of addiction (e.g., to Xanax) and overdose(36).

Looking for CBD Oil for Pain?

Editor's Pick

Spruce 750mg Lab Grade CBD Oil

Specifically formulated to be more palatable to CBD users
Spruce 750mg Lab Grade CBD Oil Bottle
  • Overall Clinical Score
    99%
    Editor's Pick
  • Clinical Scores
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
    Perfect for...New CBD users
  • Summary

    Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

    Pro's
    Cons's
     Mid-strength  No other flavors
     Natural peppermint flavor
     Made from 100% organic and natural ingredients
  • Features
    Discount pricing available?20% Off Coupon Code: CBDCLINICALS
    Source
    Source of Hemp
    Kentucky, USA & North Carolina, USA
    FormOil Tincture
    IngredientsOrganic Hemp Seed Oil, Full Spectrum CBD Oil
    Type
    Type of CBD
    Full Spectrum
    Extraction
    Extraction Method
    Moonshine extraction method
    How to take itUnder tongue
    Potency
    Potency - CBD Per Bottle
    750 mg per bottle
    Carrier OilOrganic Hemp Seed Oil
    Concentration
    CBD Concentration Per Serving
    25mg of CBD per dropper full (1ml)
    Drug TestContains 0.3% THC but there is a chance you may test positive for marijuana
    FlavoursPeppermint
    Price Range$89 ($75.65 for subscriptions, 15% discount from regular price)
    $/mg CBD
    Price ($/mg)
    $0.12/mg ($0.10/mg with subscription)
    Shipping
    Shipping/Time to delivery
    2-4 business days (first class USPS)
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    ContaminantsOrganic, Non-GMO, no pesticides, no herbicides, no solvents or chemical fertilizers, No preservatives or sweeteners
    AllergensVegan, Gluten free
    Refund policyWithin 30 days
    Recommended forNew CBD users
    Countries servedUSA only (all 50 states)
Check Latest Prices
Best Customer Service

Sabaidee Super Good Vibes CBD Oil

4x the strength of a regular cbd oil
Sabaidee Super Good Vibes CBD Oil
  • Overall Clinical Score
    99%
    Best Customer Service
  • Clinical Scores
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
    Perfect for...Patients who are looking for serious CBD oil support
  • Summary

    Super Good Vibes CBD Oil provides the purest and highest quality Cannabidiol (CBD) on the market as well as other high quality phytocannabinoids, terpenes, vitamins, omega fatty acids, trace minerals, and other beneficial for your health elements, which all work together to provide benefits.

    Pro's
    Cons's
     Extra strong  No other flavors
     Significant benefits with just a few drops
     100% Natural ingredients
  • Features
    Discount pricing available?15% Off Coupon Code: CBDCLINICALS15
    Source
    Source of Hemp
    Colorado, USA
    FormOil Tincture
    IngredientsCannabidiol (CBD), Coconut Medium-chain triglycerides (MCT) Oil, Peppermint oil
    Type
    Type of CBD
    Broad Spectrum
    Extraction
    Extraction Method
    CO2-extraction
    How to take itUsing 1-3 servings per day as needed is a good start to determine how much you need
    Potency
    Potency - CBD Per Bottle
    1000 mg per bottle
    Carrier OilCoconut MCT Oil
    Concentration
    CBD Concentration Per Serving
    33.5 mg per dropper (1ml)
    Drug TestContains 0.3% THC but there is a chance you may test positive for marijuana
    FlavoursPeppermint
    Price RangeSingle Bottle - $119.95, 2-Pack - $109.97 each, 3-Pack - $98.31 each, 6-Pack - $79.99 each
    $/mg CBD
    Price ($/mg)
    Single bottle - $0.010, 2-Pack - $0.011, 3-Pack - $0.009, 6-Pack - $0.007
    Shipping
    Shipping/Time to delivery
    3-5 Business days
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    ContaminantsContaminant-free
    AllergensVegan and Gluten-free
    Refund policyWithin 30 days
    Recommended forPatients who are looking for serious CBD oil support
    Countries servedUSA only (all 50 states)
Check Latest Prices
Best Organic

Nuleaf Naturals 725mg Full Spectrum CBD Oil

Perfect for anyone who are looking for CBD products that promote a healthy body and mind.
Nuleaf Naturals 725mg Full Spectrum CBD Oil
  • Overall Clinical Score
    99%
    Best Organic
  • Clinical Scores
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
    Perfect for...Health conscious
  • Summary

    Natural remedy for various illnesses. There are approximately 300 drops in this 0.5 FL OZ bottle, where 1 drop = 2.4 mg of CBD.

    Pro's
    Cons's
     Pure CBD hemp  No other flavors
     All natural
     Approximately 300 drops total
  • Features
    Discount pricing available?20% Off Coupon Code: CBDCLINICALS20
    Source
    Source of Hemp
    Colorado, USA
    FormOil Tincture
    IngredientsUSDA Certified Organic Hemp Oil, Full Spectrum Hemp Extract
    Type
    Type of CBD
    Full Spectrum CBD
    Extraction
    Extraction Method
    CO2 Method
    How to take itUnder the tongue for approximately 30 seconds before swallowing
    Potency
    Potency - CBD Per Bottle
    725mg of CBD per 0.5 FL OZ (15ml)
    Carrier OilOrganic Hemp Oil
    Concentration
    CBD Concentration Per Serving
    48.33mg to a max of 51.82mg per 1ml
    Drug TestContains 0.3% THC but there is a chance you may test positive for marijuana
    FlavoursNatural
    Price Range$99.00 - 1-pack, $434.00 - 6-pack
    $/mg CBD
    Price ($/mg)
    1-pack - $0.13, 6-pack - $0.59
    Shipping
    Shipping/Time to delivery
    2-3 Days via USPS
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    ContaminantsNo additives or preservatives, Non-GMO, NO herbicides, pesticides, or chemical fertilizers
    AllergensNot specified
    Refund policyWithin 30 days
    Recommended forHealth conscious
    Countries servedUSA (all 50 states) and over 40 countries including Australia, Azerbaijan, Beliza, Bosnia & Herzegovina, Brazil, Chile, China, Croatia, Czech Republic, Estonia, France, Hong Kong, Hungary, Ireland, Israel, Japan, Latvia, Lebanon, Lithuania, Macao, Malaysia, Malta, Netherlands, New Zealand, Oman, Parguay, Poland, Portugal, Saudi Arabia, Serbia, Singapore, South Korea, Sweden, Switzerland, United Arab Emirates, United Kingdom, Uruguay, and many more.
Check Latest Prices
Natural Alternative

cbdMD CBD Oil Tinctures

Uses USA hemp that is grown on non-GMO farms, and is both vegan and gluten-free
cbdMD CBD Oil Tinctures Products
  • Overall Clinical Score
    99%
    Natural Alternative
  • Clinical Scores
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
    Perfect for...CBD users with different needs
  • Summary

    cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

    Pro's
    Cons's
     Plenty of concentrations to choose from for all people with various kinds of needs  cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
     Has vegan, organic, and gluten-free ingredients
     Affordable pricing
     Affordable pricing
  • Features
    Discount pricing available?15% Off Coupon Code: cbdMD15
    Source
    Source of Hemp
    Kentucky, USA
    FormOil Tincture
    IngredientsCannabidiol (CBD), MCT Oil, and Flavoring
    Type
    Type of CBD
    Broad Spectrum
    Extraction
    Extraction Method
    CO2 extraction method
    How to take itUnder tongue
    Potency
    Potency - CBD Per Bottle
    300 mg - 7500 mg / 30 ml bottle, 1000 mg - 1500 mg / 60 ml bottle
    Carrier OilOrganic Coconut MCT Oil
    Concentration
    CBD Concentration Per Serving
    30 ml: 300 mg - 10 mg per dropper (1ml), 750 mg - 25 mg per dropper (1ml), 1500 mg - 50 mg per dropper (1ml), 3000 mg - 100 mg per dropper (1ml), 5000 mg - 166.6 mg per dropper (1ml), 7500 mg - 250 mg per dropper (1ml), 60 ml: 1000 mg - 16.6 mg per dropper (1ml), 1500 mg - 25 mg per dropper (1ml)
    Drug TestContaining less than 0.3% THC, there are still trace amounts
    FlavoursNatural, Berry, Orange and Mint
    Price Range30 ml Bottles: $29.99 for 300 mg, $69.99 for 750 mg, $99.99 for 1500 mg, $149.99 for 3000 mg, $239.99 for 5000 mg, $339.99 for 7500 mg 60 ml Bottles: $74.99 for 1000 mg, $99.99 for 1500 mg
    $/mg CBD
    Price ($/mg)
    30 ml - $0.05 - $0.10, 60 ml - $0.06 - $0.07
    Shipping
    Shipping/Time to delivery
    2-5 Business days (via Fedex)
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants100% organic, non-GMO, and vegan-certified
    AllergensVegan, Gluten free
    Refund policyWithin 30 days
    Recommended forCBD users with different needs
    Countries servedUSA only (all 50 states)
Check Latest Prices

What To Look for in a CBD Oil When You Are Taking Tramadol

Obtain medical advice before taking CBD products in the form of oils or tinctures. 

It is best to follow these steps before purchasing:

  1. Although CBD products with hemp oil are legal in the U.S. federal system, verify the laws regarding the sale, possession, and use of CBD products in the state of purchase.
  2. Read online reviews before buying in the website store. Confirm whether the clinics and brick-and-mortar and stores you buy from are authorized to sell CBD products. Buy only from reliable and legitimate brands.
  3. Select pure CBD oils falling under the crystalline isolate category over full-spectrum oils that retain tetrahydrocannabinol (THC) and other cannabinoids that cause a high sensation.
  4. Check for additional ingredients. MCT oils and melatonin are safe and beneficial. Beware of high-risk ingredients like vegetable glycerin and propylene.
  5. Determine appropriate dosing by corresponding the dose for the condition it is used for.

Trust the advice of an experienced medical professional specializing in CBD from hemp plants instead of searching online in Google to avoid risks and side effects like withdrawal symptoms. Proper medical guidance is needed in corresponding use, dosage, and administration concerning a patient’s health condition and maintenance medications. 

CBD can interact with other compounds that are metabolized in the body by cytochrome P450 or CYP3A4 enzymes(37).

These CYP450 and CYP3A4 enzymes break down substances such as drug medications and toxins that are formed within the cells. 

Since CBD competes for these enzymes, CBD products limit the metabolism of drugs, heightening the concentration levels of drugs in the bloodstream.

CBD can increase the blood levels when taken with the blood thinner Coumadin, and it can raise levels of certain other medications in your blood by the same mechanism that grapefruit juice does.

Important Facts About Tramadol

The pain medication Tramadol was discovered and synthesized in 1962 by the German company Grunenthal GmbH. It was introduced in the market under the name Tramadol in 1977. It became available in the U.S. after 1995(38).

Tramadol has severe drug interactions with alvimopan, procarbazine, rasagiline, and selegiline. It has severe interactions with approximately 49 drugs and moderate interactions with around 269 drugs(39).

Mild drug interactions with Tramadol include the following(40):

  • marijuana 
  • sage 
  • asenapine 
  • brimonidine
  • darifenacin
  • eucalyptus 
  • naloxone
  • nilotinib
  • dextroamphetamine
  • maraviroc
  • ziconotide 
  • paroxetine
  • lidocaine 

As a prescription drug, oral doses of Tramadol come in tablets, reconstituted suspension, and extended-release capsules(41).

Veterinarians are in consensus that Tramadol is the most common painkiller for dogs because of the minimal risk of side effects and addiction(42).

Conclusion

CBD could significantly lessen opioid use and improve chronic pain and sleep quality among patients who use opioids such as oxycodone to manage pain.

CBD has been shown as a safer alternative for pain relief. Still, more research is needed to substantiate the results regarding its efficacy and effects with long-term use.

CBD and tramadol are useful in alleviating pain. However, using both in combination may lead to severe side effects.

It is, therefore, best to seek medical advice before using CBD oil when taking Tramadol.


  1. Monte, Andrew A., et al. (2014 August). The effect of CYP2D6 drug-drug interactions on hydrocodone effectiveness. Acad Emerg Med, 21(8): 879–885. doi:10.1111/acem.12431. http://accurateclinic.com/wp-content/uploads/2018/07/The-Effect-of-CYP2D6-Drug-Drug-Interactions-on-Hydrocodone-Effectiveness-2014.pdf
  2. ibid.
  3. Capano, A., Weaver, R., and Burkman, E. (2020 Jan). Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study. Postgrad Med, 132(1):56-61. doi: 10.1080/00325481.2019.1685298. https://www.ncbi.nlm.nih.gov/pubmed/31711352
  4. Yamaori, Satoshi, et al. (2011 August 5). Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6”. The American Society for Pharmacology and Experimental Therapeutics. DMD, 39:2049–2056, 2011. http://accurateclinic.com/wp-content/uploads/2018/07/Cannabidiol-a-Major-Phytocannabinoid-As-a-Potent-Atypical-Inhibitor-for-CYP2D6-2011.pdf
  5. Monte, Andrew A., 2016, op. cit.
  6. National Library of Medicine, National Center for Biotechnology Information. https://pubchem.ncbi.nlm.nih.gov/compound/Tramadol#section=Pharmacology-and-Biochemistry
  7. Ibid.
  8. Capano, et al., 2020
  9. Yamaori, et al., 2011
  10. National Health Service UK. (2018 November 26). https://www.nhs.uk/medicines/tramadol/
  11. ibid.
  12. ibid.
  13. ibid.
  14. ibid.
  15. Ceyhan, A., et al. (2005 June). US National Library of Medicine, National Institutes of Health. Is metoclopramide an alternative to tramadol in management of post-operative pain? An experimental study. J Vet Med A Physiol Pathol Clin Med, 52(5): 249-53. https://www.ncbi.nlm.nih.gov/pubmed/15943610
  16. Zeng, C., et al. (2019 March 12). Association of tramadol with all-cause mortality among patients with osteoarthritis. JAMA, 321(10): 969-982. doi: 10.1001/jama.2019.1347. https://www.ncbi.nlm.nih.gov/pubmed/30860559 
  17. ibid. 
  18. Brown, Joshua D. and Winterstein, Almut G. (2019 July). Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use. J Clin Med, 8(7): 989. doi: 10.3390/jcm8070989 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/
  19. ibid.
  20. Iffland, Kirstin and Grotenhermen, Franjo. (2017 June 1). An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis Cannabinoid Res, 2(1); 139-154. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569602/
  21. Wilson-Morkeh, H., Al-Abdulla, A., Sien, L., Mohamed, H., and Youngstein, T. (2020 January). Important drug interactions exist between cannabidiol oil and commonly prescribed drugs in rheumatology practice. Rheumatology (Oxford), 59(1):249-251. https://www.ncbi.nlm.nih.gov/pubmed/31359066
  22. Russo, E. (2008 February). Cannabinoids in the Management of Difficult to Treat Pain. Therapeutics and Clinical Risk Management, 4(1): 245-259. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/
  23. Xiong W., et al. (2012). Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. J Exp Med, 209(6): 1121–1134. DOI:10.1084/jem.20120242.
  24. Petrosino S., et al. (2018 June). Anti-inflammatory Properties of Cannabidiol, a Nonpsychotropic Cannabinoid, in Experimental Allergic Contact Dermatitis. Journal of Pharmacology and Experimental Therapeutics, 365 (3) 652-663; DOI: https://doi.org/10.1124/jpet.117.244368.
  25. National Institute of Neurological Disorders and Stroke. (2018 August). Peripheral Neuropathy Fact Sheet. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Peripheral-Neuropathy-Fact-Sheet.
  26. Russo, E. (2008 February). op. cit.
  27. Clauw, Daniel. (2016  June 23). Why U.S. doctors love opioids and hate marijuana for chronic pain. M Health Lab. https://labblog.uofmhealth.org/rounds/why-us-doctors-love-opioids-and-hate-marijuana-for-chronic-pain
  28. ibid.
  29. Ibid.
  30. Dydyk, Alexander M. and Givler, Amy. (2020 April 12). Central Pain Syndrome. https://www.ncbi.nlm.nih.gov/books/NBK553027/
  31. Clauw, Daniel, 2016. op. cit.
  32. ibid.
  33. ibid.
  34. Shmerling, Robert H. (2019 June 14).  Is tramadol a risky pain medication? Harvard Health Publishing. https://www.health.harvard.edu/blog/is-tramadol-a-risky-pain-medication-2019061416844
  35. Volkow, Nora. (2015 July 20). Researching marijuana for therapeutic purposes: The potential promise of cannabidiol (CBD). National Institute of Drug Abuse. https://www.drugabuse.gov/about-nida/noras-blog/2015/07/researching-marijuana-therapeutic-purposes-potential-promise-cannabidiolcbd.
  36. Hall, Wayne, et al. (2018). It is premature to expand access to medicinal cannabis in hopes of solving the US opioid crisis. Addiction, 113, 987–988. doi:10.1111/add.14139. http://accurateclinic.com/wp-content/uploads/2018/06/It-is-premature-to-expand-access-to-medicinal-cannabis-in-hopes-of-solving-the-US-opioid-crisis-2018.pdf
  37. “Cytochrome p450”. (2020, March 17). NIH Genetics Home Reference. Retrieved from https://ghr.nlm.nih.gov/primer/genefamily/cytochromep450.
  38. Subedi, Muna, et al. (2019 March). An overview of tramadol and its usage in pain management and future perspective. Biomedicine & Pharmacotherapy, 111, 443-451. https://www.sciencedirect.com/science/article/pii/S0753332218373694
  39. RxList. Cunha, John P., ed. (n.d).) Tramadol [Fact sheet]. https://www.rxlist.com/consumer_tramadol/drugs-condition.htm
  40. Ibid.
  41. Ibid.
  42. All about Tramadol for dogs including alternatives. Innovet. https://www.innovetpet.com/blogs/recent-articles/tramadol-for-dogs
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