Does CBD Work for Dog Lymphoma?

  • CBD may be promising in the treatment of canine lymphoma, a blanket term for cancers that affect the lymphocytes or the white blood cells that fight infections in a dog’s body(1).   
  • A study has found that CBD can induce the death of cancer cells in lymphoma(2)
  • Another study outlines CBD’s anti-cancer properties, including its ability to help inhibit rapid cancer cell production. The study also reports that CBD helps clean out damaged cells so the body can regenerate healthy cells(3).
  • The use of CBD may alleviate the symptoms of various dog lymphoma types. However, further research is needed on CBD’s effect on the lymphoma types themselves.  
  • Before using CBD products in the treatment of dog lymphoma, pet owners should consult with their veterinarian or oncologist first. 

Best CBD Oils for Dog Lymphoma

Best Overall

Spruce Dog CBD Oil 750mg

Dog-Friendly CBD Oil
Spruce Dog CBD Oil 750mg Bottle
  • Overall Clinical Score
    99%
    Best Overall
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  • Summary

    Spruce’s dog-friendly CBD has been specially formulated for dogs. Instead of hemp seed oil for the carrier oil, the product contains coconut oil, which is generally easier on the digestion for dogs. The taste is also milder with no flavorings, making it more likely that dogs will eat it with their food.

    Using Spruce CBD for dogs is simple. All owners have to do is sprinkle the desired dose on the dog’s food at mealtime once or twice a day. Each dose should consist of about two to three drops per 20 pounds of dog weight.

    Pro's
    Cons's
    •  Same as human lab grade, full spectrum CBD oil
    •  Easier on Dog's digestion
    •  Made from 100% organic and natural ingredients
    •  No other flavors
  • Features
    Discount pricing available? 20% Off Coupon Code: CBDCLINICALS
    Source
    Source of Hemp
    Kentucky, USA & North Carolina, USA
    Form Oil
    Ingredients Full Spectrum Organic CBD Oil, Organic Coconut MCT Oil
    Type
    Type of CBD
    Full Spectrum
    Extraction
    Extraction Method
    Moonshine extraction method
    How to take it Squirt 2 to 3 drops per 20lbs. of dog weight on the dog food one to two times per day. Picky eaters may need it stirred in, or covered with some food Up to 25lbs./11kg – 2 drops one to two times per day on the dog food 25-50lbs./11-23kg – 4 drops one to two times per day on the dog food 50-75lbs./23-34kg – 6 drops one to two times per day on the dog food Over 75lbs./34kg – 8+ drops one to two times per day on the dog food
    Potency
    Potency - CBD Per Bottle
    750 mg per bottle
    Carrier Oil Organic Coconut MCT Oil
    Concentration
    CBD Concentration Per Serving
    25mg of CBD per dropper full (1ml)
    Drug Test Not applicable
    Flavours Natural
    Price Range $89 ($75.65 for subscriptions, 15% discount from regular price)
    $/mg CBD
    Price ($/mg)
    $0.11 ($0.10/mg with subscription)
    Shipping
    Shipping/Time to delivery
    2-4 business days (first class USPS)
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants Organic, Non-GMO, no pesticides, no herbicides, no solvents or chemical fertilizers, No preservatives or sweeteners
    Allergens Contains tree nuts (Coconut)
    Refund policy Within 30 days
    Recommended for All dog breeds
    Countries served USA only (all 50 states)
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Most Natural

HolistaPet Full Spectrum CBD Oil for Dogs & Cats

We believe that all pets also deserve only the best and the highest quality in healthy ingredients.
  • Overall Clinical Score
    99%
    Most Natural
  • Score breakdown
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    HolistaPet CBD Oil only use all-natural, non-GMO organic & vegan ingredients and never put any wheat, animal by-products, cornmeal, artificial flavors or colors in any of the products.

    Pro's
    Cons's
    •  100% natural
    •  Formulated specifically for Pets
    •  Organic Superfoods +CBD
    •  A little bit pricey compared to other brands
  • Features
    Discount pricing available? 20% Off Coupon Code: CBDCLINICALS
    Source
    Source of Hemp
    Colorado, USA
    Form Oil Tincture
    Ingredients Hempseed Oil and CBD Oil (Cannabidiol)
    Type
    Type of CBD
    Full Spectrum
    Extraction
    Extraction Method
    CO2 Extraction
    How to take it Easily drop directly into mouth or in water/food
    Potency
    Potency - CBD Per Bottle
    150mg - 3000mg
    Carrier Oil Hempseed Oil
    Concentration
    CBD Concentration Per Serving
    5mg - 50mg
    Drug Test Not Applicable
    Flavours None
    Price Range $25.95 – $144.95
    $/mg CBD
    Price ($/mg)
    $0.04 - $0.17
    Shipping
    Shipping/Time to delivery
    Free Economy Shipping - 1 to 5 days; Priority Mail Shipping - 2 to 3 days
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants Pesticide-free
    Allergens Non-dairy, Non GMO and gluten free
    Refund policy Within 30 days
    Recommended for All cats/dogs sizes and breeds
    Countries served USA only (all 50 states)
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Best Organic

NuLeaf Naturals Full Spectrum Hemp CBD Pet Oil

Perfectly formulated CBD for Dogs, Cats, and other four-legged animals
NuLeaf Naturals Full Spectrum Hemp CBD Pet Oil
  • Overall Clinical Score
    99%
    Best Organic
  • Score breakdown
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  • Summary

    CBD for dogs, cats and other four-legged friends! Our product is concentrated to approximately 60mg cannabinoids per milliliter of oil. While this product is designed for pets, it’s great for humans, too.

    Pro's
    Cons's
    •  Pure CBD hemp
    •  All natural
    •  No other flavors
  • Features
    Discount pricing available? CBDCLINICALS20
    Source
    Source of Hemp
    Colorado, USA
    Form Oil Tincture
    Ingredients USDA Certified Organic Hemp Oil, Full Spectrum Hemp Extract
    Type
    Type of CBD
    Full Spectrum CBD
    Extraction
    Extraction Method
    CO2 Method
    How to take it 2-3 drops per 20lbs
    Potency
    Potency - CBD Per Bottle
    300mg - 900mg
    Carrier Oil Organic Hemp Oil
    Concentration
    CBD Concentration Per Serving
    60ml per dropper full (1ml)
    Drug Test Not applicable
    Flavours Natural
    Price Range $38.50 - $179.50
    $/mg CBD
    Price ($/mg)
    $0.12 - $0.19
    Shipping
    Shipping/Time to delivery
    2-3 Days via USPS
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants No additives or preservatives, Non-GMO, NO herbicides, pesticides, or chemical fertilizers
    Allergens Not specified
    Refund policy Within 30 days
    Recommended for All four-legged animals of any size and breed
    Countries served USA (all 50 states) and over 40 countries including Australia, Azerbaijan, Beliza, Bosnia & Herzegovina, Brazil, Chile, China, Croatia, Czech Republic, Estonia, France, Hong Kong, Hungary, Ireland, Israel, Japan, Latvia, Lebanon, Lithuania, Macao, Malaysia, Malta, Netherlands, New Zealand, Oman, Paraguay, Poland, Portugal, Saudi Arabia, Serbia, Singapore, South Korea, Sweden, Switzerland, United Arab Emirates, United Kingdom, Uruguay, and many more.
Check Latest Prices

Best Range

cbdMD Pet CBD Oil Tincture for Dogs

Powerful CBD oil for your canine friends
cbdMD Pet CBD Oil Tincture for Dogs
  • Overall Clinical Score
    99%
    Best Range
  • Score breakdown
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  • Summary

    With nothing but MCT oil combined with CBD oil sourced from U.S. hemp that is grown using organic farming methods, these CBD Oil Tinctures for Dogs can be added to their favorite foods while still providing the same effects that you enjoy. We have two flavors to choose from: Natural and Peanut Butter.

    Pro's
    Cons's
    •  Same CBD Oil benefits as for humans
    •  No THC Animal-specific products (dogs, cats, horses)
    •  Made from premium CBD from non-GMO USA hemp
    •  Low terpene and cannabinoid profile
  • Features
    Discount pricing available? 15% Off Coupon Code: cbdMD15
    Source
    Source of Hemp
    Kentucky, USA
    Form Oil Tincture
    Ingredients Cannabidiol (CBD) and MCT Oil (from palm kernel oil)
    Type
    Type of CBD
    Broad Spectrum
    Extraction
    Extraction Method
    CO2 extraction method
    How to take it Every dog is unique, so you need to experiment a bit to work out the optimum measurement. Start by giving your pet a small amount every day and watch for improvement. If need be, gradually increase.
    Potency
    Potency - CBD Per Bottle
    150 mg - 3000 mg
    Carrier Oil MCT Oil (from palm kernel oil)
    Concentration
    CBD Concentration Per Serving
    150 mg - 5 mg per dropper (1ml), 300 mg - 10 mg per dropper (1ml), 750 mg - 25 mg per dropper (1ml), 1500 mg - 50 mg per dropper (1ml), 3000 mg - 100 mg per dropper (1ml)
    Drug Test Not applicable
    Flavours Natural and Peanut Butter
    Price Range $19.99 - $149.99
    $/mg CBD
    Price ($/mg)
    $0.05 - $0.13
    Shipping
    Shipping/Time to delivery
    2-5 Business days (via Fedex)
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants 100% organic, non-GMO, and vegan-certified
    Allergens Vegan, Gluten free
    Refund policy Within 30 days
    Recommended for All dog breeds and sizes
    Countries served USA only (all 50 states)
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Best Value For Full Spectrum CBD

CBDistillery CBD Pet Tincture

Pets can enjoy the same full CBD benefits as humans.
CBDistillery CBD Pet Tincture
  • Overall Clinical Score
    99%
    Best Value For Full Spectrum CBD
  • Score breakdown
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
  • Summary

    CBDistillery’s Full Spectrum CBD Oil Pet Tinctures were made with your pets in mind. Formulated with cold-pressed hemp seed oil, your pets can now enjoy all of the same benefits of CBD that you do.

    Pro's
    Cons's
    •  60-Day Satisfaction Guarantee
    •  Hemp seed oil is safe for pets and aids in easy digestion
    •  Oil extracted from aerial plant parts of US grown industrial hemp
    •  Sourced from non-GMO industrial hemp grown in the USA through natural farming practices
    •  Dropper is a bit shaky
  • Features
    Discount pricing available? Save an extra 15% sitewide with code CBDCLINICALS15
    Source
    Source of Hemp
    Colorado, USA
    Form Oil Tincture
    Ingredients Hemp Seed Oil, CO2 Hemp Extract (Aerial Parts)
    Type
    Type of CBD
    Oil Tincture
    Extraction
    Extraction Method
    CO2 extraction
    How to take it Shake well. Give suggested dose at each meal at least twice per day. Suggested serving by weight: Under 25 lbs: 0.5 mL (10mg), 25-75 lbs: 0.5 – 1mL (10-20mg), Over 75 lbs: 1 – 2mL (20-40mg)
    Potency
    Potency - CBD Per Bottle
    150mg - 600mg
    Carrier Oil Hemp Seed Oil
    Concentration
    CBD Concentration Per Serving
    5mg - 20mg per full serving (1ml)
    Drug Test Not applicable
    Flavours None
    Price Range $20 - $38
    $/mg CBD
    Price ($/mg)
    $0.06 - $0.13
    Shipping
    Shipping/Time to delivery
    Standard UPS Shipping ships up to 5 business days
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants Contaminant-free
    Allergens Allergen-free
    Refund policy Within 60 days
    Recommended for All dogs and cats breeds and sizes
    Countries served USA only (all 50 states)
Check Latest Prices

Why Dog Owners Are Turning to CBD for Dog Lymphoma

Dog lymphoma pertains to various cancers involving the lymphocytes, which are infection-fighting white blood cells found throughout the body(4)

Currently, there is no cure available for canine lymphoma(5). Treatments can only enhance a dog’s quality of life. 

Chemotherapy, the most usual treatment, can be highly toxic to the body and can cause several complications in dogs(6)

According to Dr. Meghan Burns, DVM, treatment for cancer in dogs should not take a “one-size-fits-all approach.” If oncologists avoid this type of approach, they can recommend therapy or a combination of therapies more customized to the condition(7).

“The veterinary profession needs to do a better job of defining cancer from a genetic perspective. Transitioning from a blanket treatment approach based on tumor-type to a more precise method based on the exact disease a patient has on a genetic level is paramount,” Burns said.  

Compared to humans, dogs tolerate chemotherapy better. Canines rarely suffer from hair loss and feel ill during the said treatment(8).

Though these are not observed in all dogs undergoing treatment, diarrhea, vomiting, and decreased appetite are the most common side effects of chemotherapy(9).

The problem with this treatment is that a dog’s cancer has a high chance of relapsing because lymphoma cells eventually develop more resistance to repeated chemo(10).

Because of some of these reasons, dog owners are turning to alternative treatments, such as cannabidiol (CBD).

CBD is the non-psychoactive component of the Cannabis Sativa plant.

A 2018 study says that CBD is effective in inducing cell death in diffuse large b-cell lymphoma (DLBCL)(11). The study also indicates that CBD reduces the chances of a DLBCL relapse. 

DLBCL is the most common lymphoma type in dogs(12)

How CBD Oil Works to Alleviate Symptoms of Lymphoma in Dogs

According to a 2016 study published in the journal OncoTargets and Therapy, CBD has an extensive range of anti-cancer properties(13). These include CBD’s contribution to the death of cancer cells (apoptosis) and induction of the body to regenerate healthy cells by cleaning out damaged cells (autophagy).

The study also discussed CBD’s ability to help inhibit the proliferation of cancer cells and the reduction of the spread of these cells (metastasis). Researchers have also found that CBD can stimulate an immune response against cancer. They have also discovered that CBD can inhibit tumor growth(14)

Though the research was conducted in mice, a study suggests that CBD may have the same efficacy in humans and all types of animals except insects. The study discusses how the endocannabinoid system (ECS) works the same way, regardless of species(15)

The ECS helps in the regulation of mood, appetite, memory, and immune system responses. Cannabinoids like CBD interact with the ECS to help enhance its functions in the body. 

Veterinarians have identified over 30 types of canine lymphoma with varying symptoms, aggressiveness, and survival rates. The primary types of lymphoma include multicentric lymphoma, alimentary lymphoma, mediastinal lymphoma, and extranodal lymphoma(16).

CBD for Multicentric Lymphoma

80 to 85% of dog lymphoma cases are identified as multicentric lymphoma. This type of lymphoma affects lymph nodes throughout the body(17).  

Lymph nodes filter body lymph so that they can identify and fight diseases and infections(18).

Lymph is defined as clear fluid traveling through the lymphatic system. 

The symptoms of this kind of lymphoma include swelling, fever, lethargy, weakness, anorexia, and dehydration(19).

CBD may help with this type of lymphoma because it has anti-inflammatory properties(20).

CBD for Alimentary Lymphoma

This type of cancer affects the gastrointestinal tract(21). Common symptoms are intestine-related, including vomiting, anorexia, diarrhea, abdominal pain, and weight loss(22)

Research shows that CBD can help manage nausea and vomiting because of its anti-emetic properties(23).

Studies have also shown that CBD offers pain relief, such as the alleviation of abdominal pain(24)

CBD for Mediastinal Lymphoma

This type of canine lymphoma is rare. It affects lymphoid organs found in the chest like the thymus and lymph nodes(25).

Symptoms include difficulty breathing because of the accumulation of fluid in the chest or the presence of a large mass within the chest, increased urination and thirst, as well as swelling of a dog’s face or front legs(26).

Though research has yet to be made on the efficacy of CBD for mediastinal lymphoma, reports suggest that CBD improves lung function and inflammation(27).

CBD for Extranodal Lymphoma

Extranodal lymphoma is a rare type of dog lymphoma that affects organs that are not part of the lymphatic system, like the eyes, kidneys, lungs, skin, and even the nervous system(28).

The symptoms vary and depend on which organ is affected. Cutaneous lymphoma, for instance, is characterized by raised nodules or scaly lesions(29).

Lymphoma in the nervous system could result in seizures, while bone lymphoma can cause pain or fractures.

Depending on which organ is targeted by extranodal lymphoma, CBD may have a cure for it.

CBD has been found to alleviate seizures(30). It also has analgesic properties that might help in the treatment of pain(31)

The Pros and Cons of CBD Oil for Lymphoma in Dogs

Pros

  • Several studies in humans and animals outline CBD’s potential benefits in the treatment of dog lymphoma symptoms. The ECS is universal to all species except insects, so the cannabinoids that may work for one species are highly likely to be effective in another. 
  • Chemotherapy, the usual treatment for lymphoma in dogs, may have eventual adverse effects on these pets. CBD, meanwhile, generally has an excellent safety profile in canines. The most common side effects are lowered blood pressure, dry mouth, and drowsiness(32)
  • CBD is non-addictive, so dog owners should not worry about their pets developing a dependence on CBD. Research has shown that CBD even helps attenuate addictive behaviors(33).
  • Research suggests that CBD can be used as a complementary therapy for dogs with cancer(34).

Cons

  • Further research is needed on CBD’s effect on lymphoma types themselves, not just its therapeutic effects on lymphoma symptoms. 
  • The United States (US) Food and Drug Administration has not approved the use of CBD products in pets and other animals(35). The US FDA also recommends that pet parents should discuss more appropriate treatment options for their pets. 
  • Federal and state laws prohibit veterinarians from advising pet owners to give their pets CBD. According to the American Veterinary Medical Association, veterinarians cannot “administer, dispense, prescribe, or recommend cannabis or its products for animals(36).”
  • Despite some studies suggesting that CBD may complement cancer therapies, some studies report the opposite. A study in 2018 reveals that the use of CBD combined with chemotherapeutic drugs significantly reduced their efficacy compared to their viability when they were individually administered to the test subjects(37).

How CBD Oil Compares to Alternative Treatments for Lymphoma in Dogs

Aside from chemotherapy, veterinarians prescribe alternative treatments like antibody therapy and transplantation to treat canine lymphoma. 

In treating lymphoma, monoclonal antibodies help the immune system identify which cells are cancerous so that the immune system eliminates these cells quickly(38).

According to Mayo Clinic, monoclonal antibodies are molecules produced in laboratories. They serve as antibody substitutes to enhance, restore, or mimic the immune system’s attack on cancer cells(39).  

Antibody therapy can be used as a complementary therapy in lymphoma, but it cannot replace traditional chemotherapy(40).

Veterinarians also prescribe bone marrow and stem cell transplants in dogs who have lymphoma. However, bone marrow transplants have been found to be successful only in a small number of cases(41)

Transplantation is an expensive option for pet owners. Compared to bone marrow procedures in humans, bone marrow matching in dogs is not as advanced. 

Like antibody therapy, CBD also has immunosuppressive properties that may help treat dog lymphoma(42)

Compared to treatments like bone marrow and stem cell transplants, CBD is more cost-efficient. 

How to Choose the Right CBD Oil for Lymphoma in Dogs

Before purchasing CBD oil, dog owners should be aware of the different types of CBD oil. They are full-spectrum CBD oil, broad-spectrum, and isolates.

Full-spectrum CBD oil makes use of all the components of a cannabis plant. It is composed of trace amounts of tetrahydrocannabinol (THC), flavonoids, fatty acids, terpenes, and essential oils. 

Some dog owners prefer full-spectrum because it can produce an entourage effect, an occurrence when all the active ingredients synergize to give maximum therapeutic effect to the dog. 

It is important to note that this type of CBD oil has THC, which may cause mild psychoactive effects in some pets. 

For pet owners who want to play it safe, broad-spectrum CBD oils contain all of the ingredients of a full-spectrum oil except for THC. However, some pets may be allergic to other ingredients of the hemp plant. 

Those who are seeking to use CBD in its purest form may purchase CBD isolates, as they only have isolated cannabidiol.

When buying CBD oils for pets, pet owners should only use high-quality products. Here are some guidelines before making a purchase:

  • Choose only high-quality CBD oils for dogs. These are free from genetically modified organisms and are usually organic and derived from hemp. 
  • Ascertain that the manufacturer of the CBD oil is credible. For more information on a CBD brand, pet owners can check the internet for a variety of reviews from trusted sources. 
  • Research on a product’s extraction method. Products that employ CO2 extraction are considered high-caliber and safer. 
  • Look for a product’s certificate of analysis. These are certifications from third-party laboratories that verify the potency and claims of a product. 
  • Dog owners should stick to the dosing instructions from the manufacturer. Before administering to their pets, the owners should also consult with their veterinarian.

CBD Dosage for Dog Lymphoma

There is no standard CBD dosage chart for lymphoma in dogs. It is advised to administer small doses of CBD to a pet initially. If no adverse effects are observed, the dose may be increased gradually. 

The use of CBD tinctures (droppers) is recommended to ascertain consistent and accurate dosage. 

More massive dogs require more amounts of CBD.

It is also advisable to use a journal for logging the dog’s CBD dosing, reactions, and behaviors while on CBD. These details can then be shared with the dog’s veterinarian.

How to Administer CBD for Dog Lymphoma

There are various CBD product formats available to pets. The most common are CBD oil, CBD dog treats, capsules, and topical preparations like sprays. 

Usually, CBD oils have different flavors to appeal to a dog. If the dog dislikes the taste, pet owners can opt to mix the oil with food or dog treats. 

CBD oils can also be used during pet massages. This is especially helpful to more senior dogs who are experiencing chronic pain due to age.

CBD tinctures are highly recommended because the dropper allows pet owners to have more control over the amount of CBD they administer to their pets. For more efficacy, CBD dog tinctures may be applied under the tongue (sublingually). 

If the pet is uncooperative, CBD dog capsules may be used. Like CBD oil, its contents may be sprinkled into a dog’s food.

CBD dog treats are also highly popular among pet owners. Aside from being appealing, treats are also convenient and are more likely to be consumed by dogs.

CBD topical formulations like creams, balms, or salves can be applied to dogs, especially if there is a specific body part of the dog that needs to be targeted.

Understanding Dog Lymphoma 

Dog lymphoma affects the lymphatic system. It is composed of the lymph, the lymph vessels, and the lymph organs.

As mentioned, the lymph is the fluid that travels through the lymphatic system. The lymph vessels carry this fluid through the body. The lymph organs, meanwhile, include the spleen, appendix, thymus, and the tonsils.

According to Dr. Catherine Barnette, DVM, lymphoma is common in dogs. It is usually diagnosed in middle-aged and more senior dogs(43)

Some dog breeds are more likely to develop lymphoma. These include golden retrievers, bullmastiffs, boxer dogs, Saint Bernards, basset hounds, Scottish terriers, bulldogs, and Airedale terriers.   

Canine lymphoma has unknown causes. However, some factors may influence its development in dogs, like bacteria, exposure to chemicals, viruses, and strong magnetic fields(44)

Lymphoma can be diagnosed through biopsy. It is a procedure that entails removing a piece from a lymph node or an organ affected by cancer. Larger biopsy samples guarantee a more accurate diagnosis. 

Another way for veterinarians to diagnose lymphoma is through a fine needle aspirate. Veterinarians perform this procedure by inserting a needle into a dog’s enlarged lymph node or another organ(45).

The insertion of the needle allows veterinarians to take a small number of cells and examine this sample to see if they are cancerous cells that could indicate lymphoma. 

Aside from these, veterinarians also conduct bloodwork screening to check a dog’s health. Usually, red blood cells, white blood cells, and platelets are included in the examination. 

To check a dog’s internal organs, veterinarians also perform serum biochemistry on some dogs. 

Serum biochemistry tests involve the chemical analysis of blood serums. 

Conclusion

Lymphoma can have detrimental effects on a dog’s life. Veterinary medicine has yet to find a cure for dog lymphoma. Chemotherapy, the usual treatment, can only do so much in curing cancer in dogs. Usually, relapses occur because the dog’s body grows immune to the therapy.

Chemotherapy, though more well-tolerated by dogs than humans, may also cause adverse reactions long-term. Thus, pet owners have turned to CBD in the treatment of canine lymphoma. 

Enough research has been done on CBD’s ability to alleviate lymphoma’s different symptoms. However, further studies need to be conducted on CBD’s therapeutic effects on the different types of dog lymphoma. 

The US FDA has not approved CBD use in pets. Before adding CBD to a pet’s lymphoma treatment, it is best to first consult with a veterinarian. 


  1. Burke, Anna. “Lymphoma in Dogs: Symptoms, Diagnosis, and Treatment.” American Kennel Club, American Kennel Club, 6 Nov. 2016, www.akc.org/expert-advice/health/lymphoma-in-dogs-symptoms-diagnosis-and-treatment/.
  2. Xu, Sophia. “Does CBD Induce Apoptosis in Diffuse Large B Cell Lymphoma?” The Young Researcher, 2018.
  3. Pyszniak, Maria et al. “Endocannabinoid system as a regulator of tumor cell malignancy – biological pathways and clinical significance.” OncoTargets and therapy vol. 9 4323-36. 18 Jul. 2016, doi:10.2147/OTT.S106944
  4. Burke, A. 2016 Nov. 6. op. cit. 
  5. German, Alex. “Lymphoma in Dogs.” PetMD, 14 Feb. 2010, www.petmd.com/dog/conditions/cancer/c_dg_lymphoma?page=2.
  6. Ibid. 
  7. Burns, Meghan E. “The Latest in Treating Canine Lymphoma.” Veterinary Practice News, 26 June 2017, www.veterinarypracticenews.com/the-latest-in-treating-canine-lymphoma/.
  8. Barnette, Catherine. “Lymphoma in Dogs.” vca_corporate, vcahospitals.com/know-your-pet/lymphoma-in-dogs.
  9. Ibid.
  10. Purdue Veterinary Medicine. “Canine Lymphoma.” Purdue University College of Veterinary Medicine, www.purdue.edu/vet/pcop/canine-lymphoma-research.php.
  11. Xu, S. 2018. op. cit. 
  12. Parry, Nicola M. “An Update on Canine Lymphoma.” American Veterinarian, 4 Oct. 2016, www.americanveterinarian.com/news/an-update-on-canine-lymphoma.
  13. Pyszniak, M. 2016 Jul. 18. op. cit. 
  14. Ibid. 
  15. Silver, Robert J. “The Endocannabinoid System of Animals.” Animals: an open-access journal from MDPI vol. 9,9 686. 16 Sep. 2019, doi:10.3390/ani9090686
  16. Burke, A. 2016 Nov. 6. op. cit. 
  17. Barnette, C. op. cit. 
  18. National Cancer Institute. “NCI Dictionary of Cancer Terms.” National Cancer Institute, www.cancer.gov/publications/dictionaries/cancer-terms/def/lymph-node.
  19. Burke, A. 2016 Nov. 6. op. cit. 
  20. Nagarkatti, Prakash et al. “Cannabinoids as novel anti-inflammatory drugs.” Future medicinal chemistry vol. 1,7 (2009): 1333-49. doi:10.4155/fmc.09.93 
  21. Barnette, C. op. cit
  22. Burke, A. 2016 Nov. 6. op. cit
  23. Parker, Linda A et al. “Regulation of nausea and vomiting by cannabinoids.” British journal of pharmacology vol. 163,7 (2011): 1411-22. doi:10.1111/j.1476-5381.2010.01176.x
  24. Vučković, Sonja et al. “Cannabinoids and Pain: New Insights From Old Molecules.” Frontiers in pharmacology vol. 9 1259. 13 Nov. 2018, doi:10.3389/fphar.2018.01259
  25. Barnette, C. op. cit
  26. Burke, A. 2016 Nov. 6. op. cit
  27. Ribeiro, Alison, et al. “(PDF) Cannabidiol Improves Lung Function and Inflammation in Mice Submitted to LPS-Induced Acute Lung Injury.” ResearchGate, Immunopharmacology and Immunotoxicology, Oct. 2014, www.researchgate.net/publication/267735571_Cannabidiol_improves_lung_function_and_inflammation_in_mice_submitted_to_LPS-induced_acute_lung_injury.
  28. Barnette, C. op. cit
  29. Burke, A. 2016 Nov. 6. op. cit
  30. Silvestro, Serena et al. “Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials.” Molecules (Basel, Switzerland) vol. 24,8 1459. 12 Apr. 2019, doi:10.3390/molecules24081459
  31. McGill University Health Centre. “Cannabis pain relief without the ‘high’: Mechanism of cannabidiol for safe pain relief without side effects.” ScienceDaily. ScienceDaily, 24 October 2018. <www.sciencedaily.com/releases/2018/10/181024163625.htm>.
  32. Kriss, Randa. “CBD Oil For Dogs: What You Need To Know.” American Kennel Club, American Kennel Club, 27 Oct. 2019, www.akc.org/expert-advice/health/cbd-oil-dogs/.
  33. Prud’homme, Mélissa et al. “Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Review of the Evidence.” Substance abuse: research and treatment vol. 9 33-8. 21 May. 2015, doi:10.4137/SART.S25081
  34. Johnson, Jon. “CBD for Cancer: Possible Benefits, Side Effects, and More.” Medical News Today, MediLexicon International, 19 Mar. 2019, www.medicalnewstoday.com/articles/324745.
  35. “What to Know About Products Containing Cannabis and CBD.” U.S. Food and Drug Administration, FDA, 5 Mar. 2020, www.fda.gov/consumers/consumer-updates/what-you-need-know-and-what-were-working-find-out-about-products-containing-cannabis-or-cannabis#:~:text=The%20FDA%20has%20not%20approved,treatment%20options%20for%20their%20pets.
  36. Burke, Anna. “How to Talk to Your Veterinarian About CBD Oil.” American Kennel Club, American Kennel Club, 17 Oct. 2018, www.akc.org/expert-advice/health/talk-veterinarian-cbd-oil/.
  37. Strong, Tori, et al. “Synergistic Effect of Cannabidiol with Conventional Chemotherapy Treatment.” Blood, American Society of Hematology, 29 Nov. 2018, ashpublications.org/blood/article/132/Supplement%201/5382/265911/Synergistic-Effect-of-Cannabidiol-with.
  38. Burns, M. 2017 June 26. op. cit. 
  39. Mayo Clinic Staff. “Monoclonal Antibody Drugs for Cancer: How They Work.” Mayo Clinic, Mayo Foundation for Medical Education and Research, www.mayoclinic.org/diseases-conditions/cancer/in-depth/monoclonal-antibody/art-20047808.
  40. Burns, M. 2017 June 26. op. cit. 
  41. Ibid.
  42. James M. Nichols and Barbara L.F. Kaplan.Cannabis and Cannabinoid Research.Mar 2020.12-31.http://doi.org/10.1089/can.2018.0073
  43. Barnette, C. op. cit
  44. Purdue Veterinary Medicine. “Canine Lymphoma.” Purdue University College of Veterinary Medicine, www.purdue.edu/vet/pcop/canine-lymphoma-research.php#:~:text=What%20causes%20lymphoma%20in%20dogs,of%20this%20cancer%20remains%20obscure.
  45. Barnette, C. op. cit
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