Which CBD Oil Is Best for Parkinson’s Disease?

Are you looking for essential oils to help alleviate the symptoms of Parkinson’s disease? Read more about cannabidiol (CBD) and how its therapeutic potential may help manage Parkinson’s disease and improve your quality of life and well-being.

Rating
Highlights

Editor's Choice

Spruce 750mg Lab Grade CBD Oil

4.8 out of 5
  1. Peppermint flavor masks any unpleasant taste
  2. Contains 25mg of CBD per dropper full
  3. Bottle includes a graduated dropper for correct serving measurement

Best CBD Purity

NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil

5.0 out of 5
  1. Natural remedy for various illnesses
  2. Product is full-spectrum whole-plant extract
  3. Contains naturally occurring synergistic cannabinoids and terpenes

Best High Potency

Spruce 2400mg Lab Grade CBD Oil

5.0 out of 5
  1. Maximum possible potency
  2. Each dropper full contains 80mg of CBD
  3. Conveniently fits in a 30mL bottle

Best Value

Avida Full Spectrum CBD Oil Tincture 500mg

4.6 out of 5
  1. Proprietary full-spectrum
  2. Developed using advanced AVIDA CORE Spectrum Technology
  3. Highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3)

Best Value

cbdMD CBD Oil Tincture Natural 1500mg

4.7 out of 5
  1. Made using only CBD sourced from medical hemp
  2. Available in many flavours
  3. Safe for daily use

Best THC Free

CBDistillery THC Free CBD Oil Tinctures

4.4 out of 5
  1. Do not contain THC
  2. Available in different potencies and sizes
  3. Brand has special deals and offers

Best Customer Rated

cbdMD CBD Oil Tincture Natural 750mg

4.4 out of 5
  1. THC-free
  2. Has plenty of flavours to choose from
  3. Totally vegan

Best For Beginners

NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil

4.6 out of 5
  1. Lowest concentration for CBD beginners
  2. Fully organic and lab-tested
  3. Full-spectrum

Best Flavor Range

Hemp Bombs 750mg CBD Oil

3.9 out of 5
  1. Has a wide range of flavours
  2. Safe to intake
  3. Get 20% off when you avail of their subscription

Best Allergy Friendly

Royal CBD Full Spectrum CBD Oil

3.5 out of 5
  1. Has three flavors to choose from – Berry, Natural and Vanilla
  2. Vegan and Gluten-Free
  3. Superb customer service

Compare Which CBD Oil Is Best for Parkinson’s Disease for 2022

Product Potency Purity Customer Service Type Extraction Transparency Absorption
Spruce 2400mg Lab Grade CBD Oil
4.8 out of 5
4.5 out of 5
4.5 out of 5
5.0 out of 5
5.0 out of 5
4.5 out of 5
5.0 out of 5
5.0 out of 5
NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
5.0 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
4.0 out of 5
5.0 out of 5
5.0 out of 5
Spruce 2400mg Lab Grade CBD Oil
5.0 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
4.0 out of 5
5.0 out of 5
5.0 out of 5
Avida Full Spectrum CBD Oil Tincture 500mg
4.6 out of 5
5.0 out of 5
3.5 out of 5
3.0 out of 5
5.0 out of 5
4.5 out of 5
4.5 out of 5
5.0 out of 5
cbdMD CBD Oil Tincture Natural 1500mg
4.7 out of 5
5.0 out of 5
3.5 out of 5
5.0 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
4.0 out of 5
CBDistillery THC Free CBD Oil Tinctures
4.4 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
4.5 out of 5
cbdMD CBD Oil Tincture Natural 750mg
4.4 out of 5
4.5 out of 5
3.5 out of 5
5.0 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
4.0 out of 5
NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
4.6 out of 5
2.5 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
4.5 out of 5
5.0 out of 5
5.0 out of 5
Hemp Bombs 750mg CBD Oil
3.9 out of 5
4.5 out of 5
3.5 out of 5
2.5 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
4.0 out of 5
Royal CBD Full Spectrum CBD Oil
3.5 out of 5
2.5 out of 5
3.5 out of 5
5.0 out of 5
5.0 out of 5
4.0 out of 5
1.0 out of 5
5.0 out of 5

Which CBD Oil Is Best for Parkinson’s Disease?

1. Spruce 750mg Lab Grade CBD Oil
cbdc overall score

4.8

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

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Transparency

Pros Cons

Mid-strength

No other flavors

Natural peppermint flavor

Made from 100% organic and natural ingredients

Overview

Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
cbdc overall score

5.0

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

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Pros Cons

Pure CBD hemp

No other flavors

All natural

Approximately 300 drops total

Overview

Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

3. Spruce 2400mg Lab Grade CBD Oil
cbdc overall score

5.0

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

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Pros Cons

Extra Strength

Tastes bitter

No artificial flavoring or colors

No THC-free option

Made from 100% organic and natural ingredients

Overview

The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.

4. Avida Full Spectrum CBD Oil Tincture 500mg
cbdc overall score

4.6

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

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Pros Cons

Light Spearmint flavor

No other flavor

Non-THC, Non-detected in drug test

Overview

Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.

5. cbdMD CBD Oil Tincture Natural 1500mg
cbdc overall score

4.7

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Various delicious flavors to choose from

cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options

Has vegan, organic, and gluten-free ingredients

Free shipping for this particular product within USA

World-class customer service team

Overview

cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

6. CBDistillery THC Free CBD Oil Tinctures
cbdc overall score

4.4

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

60-Day Satisfaction Guarantee

Dropper is a bit shaky

Various strengths

Oil extracted from aerial plant parts of US grown industrial hemp

Sourced from non-GMO industrial hemp grown in the USA through natural farming practices

Overview

CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.

7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
cbdc overall score

4.6

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Pure CBD hemp

No other flavors

All natural

A bit pricey compared to competitors

Approximately 100 drops total

Overview

This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.

8. cbdMD CBD Oil Tincture Natural 750mg
cbdc overall score

4.4

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Vegan and Gluten free

Does not ship internationally

Has a third-party lab test

Wide variety of CBD strengths and sizes

Overview

A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.

9. Hemp Bombs 750mg CBD Oil
cbdc overall score

3.9

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Wide variety of flavors

Incomplete information about the product

Lab test results are complete

Does not ship to all international countries

30-day money-back guarantee

Overview

Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.

10. Royal CBD Full Spectrum CBD Oil
cbdc overall score

3.7

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

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Transparency

Pros Cons

Rich in phytochemicals including CBD, CBC, CBG, and a variety of flavorful terpenes

Shipping not specified on website

More flavors to choose from

3rd party lab result is currently not available on website

Extracts contain a whole array of cannabinoids and terpenes from the hemp plant — rather than pure CBD isolate

Overview

Excellent products and superb customer service. Whenever you want to ask them about the dosage, recommended consumption methods, or which CBD oil will work best for you, just give them a call, send them a message, or get in touch with their social media channels. They won’t leave you with any unanswered questions.

How CBD May Help With Parkinson’s Disease

There is no conclusive evidence that CBD helps manage Parkinson’s disease or alleviate the symptoms of this disorder.

However, researchers have been interested in CBD’s therapeutic properties as a potential remedy to help with Parkinson’s disease or its symptoms(1).

CBD is purported to have anti-inflammatory, anticonvulsant, anxiolytic (antianxiety), antioxidant, and neuroprotective properties(2). These potential benefits suggest that CBD may help alleviate neuroinflammation, epilepsy, anxiety, oxidative injury, and nausea.

Individuals with Parkinson’s disease (PD) may experience trembling hands, arms, legs, or head. Other symptoms include limb and trunk stiffness, slowness of movement, impaired balance leading to falling, depression, and sleep disruptions(3).

CBD works by engaging the body’s endocannabinoid system (ECS) and inhibiting the fatty acid amide hydrolase (FAAH) enzyme(4). Inhibiting these enzymes may help exert CBD’s neuroprotective properties, which may be beneficial for Parkinson’s disease.

The ECS also contains the CB1 and CB2 cannabinoid receptors, which have regulatory functions within the body.

CB1 receptors are primarily prominent in the brain and spinal cord and provide an effect on pain, appetite regulation, and memory. Meanwhile, CB2 receptors are present in the peripheral nervous system and immune system cells and help regulate inflammation(5).

However, cannabinoids may have a hypokinetic profile by activating the CB1 receptors(6). This characteristic may be disadvantageous to Parkinson’s disease cases as the compound may worsen rather than reduce motor disability.

Hypokinesia, also called bradykinesia, is a state wherein the body lacks sufficient motor function leading to a limited range of motions.

Studies using experimental parkinsonism models showed that CBD may provide neuroprotective effects by acting through antioxidant mechanisms that do not involve the CB1 and CB2 receptors(7).

Researchers are focusing on how cannabinoids may provide neuroprotection through the compounds’ antioxidant properties without activating the CB1 receptors.

Uses and Benefits of CBD for Parkinson’s Disease

One of the potential uses for CBD is its purported anti-inflammatory effect on the central nervous system(8). This effect may be helpful for neuroinflammatory conditions.

Researchers studied the neuroprotective benefits of cannabinoids against 6-hydroxydopamine toxicity(9).

Results showed that CBD may have neuroprotective and antioxidant properties associated with the compound’s anti-inflammatory potential. The study also suggested that these positive effects may be relevant to Parkinson’s disease.

Studies often use the 6-hydroxydopamine neurotoxin as a Parkinson’s disease model to simulate the disorder(10).

Researchers implicated oxidative stress as part of the mechanisms that cause Parkinson’s disease(11). Thus, antioxidant remedies may help overcome oxidative injury due to neurological disorders such as Parkinson’s.

One study mentioned that CBD may function as a neuroprotective antioxidant, making it a potential therapeutic agent to help manage oxidative neurological disorders(12).

Another study showed that CBD may help reduce microglial activation to slow down the progression of Alzheimer’s disease(13).

Microglia are cells that help maintain neuronal networks, regulate brain development, and manage injury repair(14).

Alzheimer’s disease is a neurological condition characterized by atrophy (brain shrinkage) and brain cell death(15).

Researchers may consider the results of this study as a reference to determine whether CBD’s therapeutic potential may slow down the progression of other neurological disorders.

Meanwhile, PD patients or individuals with the disease may also experience anxiety, depression, or fear(16).

One study on individuals with social phobia mentioned that CBD may help reduce anxiety(17). This finding suggests that CBD may potentially manage anxious behavior caused by Parkinson’s disease.

Research on CBD’s putative therapeutic benefits on Parkinson’s disease or its symptoms is limited despite clinical developments. To give the results more credibility, scientists must consider conducting further randomized, placebo-controlled clinical trials with more human subjects.

How to Administer CBD Oil for Parkinson’s Disease

Here are the various delivery routes to choose from when administering CBD oil products to help with Parkinson’s disease or its symptoms:

  • Sublingual administration: CBD products delivered through this method include tinctures and oromucosal sprays.

CBD tincture formulation usually includes a carrier oil, such as coconut oil or medium-chain triglycerides (MCT) oil, for diluting the CBD concentrate.

Sublingual administration delivers CBD oil under the tongue. This method allows the compound to enter the bloodstream through the blood vessels under your tongue and bypass the gastrointestinal (GI) tract.

CBD tincture bottles typically include a calibrated dropper for accurate dosing, preventing you from taking too much or too little CBD oil than what you need.

  • Ingestion: Products using this delivery method include capsules, pills, and edibles, such as gummies, cookies, and chews.

Oral CBD products are administered through the mouth to let the drug pass through the GI tract before getting absorbed into the bloodstream.

  • Inhalation: Products such as vape pens or smokes deliver CBD oil into the body through inhalation. This method has a relatively fast onset time lasting from seconds to minutes, which may be suitable for relieving nausea or acute pain(18).

However, the FDA advises users that vaping is unsafe, especially for young people, pregnant women, and adult non-smokers(19).

  • Topical application: CBD oil products applied directly to your skin include balms, lotions, creams, ointments, and salves.

The topical application of CBD provides localized relief(20).

Regarding dosage, the Food and Drug Administration (FDA) has not endorsed any standard CBD dosage guide applicable for Parkinson’s disease.

Factors affecting your dosage include diet, exercise, stress levels, genetics, and overall medical condition(21).

However, one dosing strategy for taking CBD is to start with a low dose and gradually increase the dosage(22).

For example, you may consider starting with a 10mg dose of CBD per day(23).

How Long Does CBD Take to Help With Parkinson’s Disease?

Researchers have not conducted conclusive clinical trials determining CBD’s onset times for Parkinson’s disease.

However, general estimates for the time that CBD takes to become effective typically may depend on the delivery routes, as shown below(24):

  • Ingestion: 30 to 90 minutes
  • Sublingual method: 15 to 30 minutes
  • Inhalation: 2 to 15 minutes
  • Topical application: 15 to 30 minutes

How Long Will CBD Help With Parkinson’s Disease?

There is no conclusive scientific data on how long CBD’s effects will last for Parkinson’s disease.

However, different administration methods may cause the duration of effects to vary, such as the following(25):

  • Ingestion: six to eight hours
  • Sublingual administration: two to four hours
  • Inhalation: two to four hours
  • Topical application: two to four hours

Side Effects and Risks of Using CBD for Parkinson’s Disease

Researchers have not conducted extensive studies on CBD’s adverse effects on individuals with Parkinson’s disease.

However, CBD may induce minor side effects, such as dry mouth, reduced appetite, diarrhea, drowsiness, and fatigue(26).

Other reported side effects of CBD are tiredness and changes in body weight(27).

Choosing the Best CBD Oil for Parkinson’s Disease

When looking for the best CBD oil from online stores or dispensaries to help with Parkinson’s disease or its symptoms, factors like extraction methods, product categories, lab test results, and personal preferences may influence your decisions.

Extraction Methods

Manufacturers use various extraction methods, such as carbon dioxide (CO2), ethanol, and hydrocarbon when deriving CBD and other cannabinoids from the cannabis plant. 

  • CO2 extraction: Carbon dioxide is a non-combustible and odorless gas that the FDA rated as generally recognized as safe (GRAS) for food use(28).

This method is a popular extraction process used by medium- and large-scale manufacturers because carbon dioxide is a natural chemical substance that does not leave residues(29).

  • Ethanol extraction: Ethyl alcohol or ethanol is a solvent used for CBD extraction purported to be more efficient than CO2 while being safer than hydrocarbons such as butane(30).

For centuries, many cultures have utilized ethanol extraction for deriving medicinal compounds from the cannabis plant(31).

  • Hydrocarbon extraction: Some manufacturers use hydrocarbons, such as butane, for CBD extraction due to their affordability(32).

Although hydrocarbons have a modest price, they are flammable and neurotoxic. If not fully removed from the CBD extract, these chemicals may cause a health and safety hazard.

Product Category

After extracting the cannabis extract, manufacturers process it into CBD oil products and categorize it as full-spectrum, broad-spectrum, or isolate.

  • Full-spectrum CBD oil: This CBD form contains all essential cannabis compounds and cannabinoids, such as tetrahydrocannabinol (THC), terpenes, and flavonoids.

THC is a psychoactive cannabinoid that induces a “high” associated with marijuana usage(33).

Meanwhile, terpenes are plant compounds that give cannabis plants a distinct scent and are used as essential oil constituents(34).

On the other hand, flavonoids are substances purported to have antimicrobial and antioxidant benefits(35).

  • Broad-spectrum CBD oil: This product type contains most compounds and cannabinoids found in full-spectrum CBD oil. However, broad-spectrum CBD oil does not contain THC.
  • CBD isolates: These products are made of pure CBD only. CBD isolates are THC-free and do not contain any other cannabinoids or compounds.

If you prefer to experience the full benefits of all the cannabinoids and compounds, consider full-spectrum CBD oil products. However, if you have an aversion to THC or its psychoactive effects, choose broad-spectrum CBD oil or CBD isolates.

Laboratory Testing

CBD companies usually send samples of CBD oil items to third-party laboratories to examine and verify the consistency and safety of their products.

These third-party labs document the test results on a certificate of analysis (COA). This document contains detailed information about the product, including the total amount of CBD, THC, and other compounds.

COAs also show whether the THC concentration in a CBD product is less than 0.3%. Cannabis-based products whose THC level falls within this limit are not considered controlled substances under U.S. federal law(36).

Third-party labs also check the products for contaminants and include the findings in the COA. These contaminants include pesticides, heavy metals, or solvents that can become a health hazard to consumers.

For these reasons, compare the COA results to the CBD product’s label to verify whether the information provided is accurate. Reputable CBD brands get their products analyzed regularly and post updated COAs on their websites.

Legality of CBD

United States federal law states that CBD products containing more than 0.3% THC concentration are considered illegal(37).

The 2018 Farm Bill established a framework for regulating U.S. hemp production(38). The law also removed hemp from the definition of “marijuana” under the Controlled Substances Act(39).

CBD and medical marijuana laws are implemented with varying restriction levels across all U.S. states. As of February 2022, states like Colorado, California, New York, Arizona, and Nevada have regulated medical cannabis programs(40).

Thus, you must review your state’s laws before using CBD products to determine if such products are legal in your area.

What the FDA Says About CBD

The FDA warns suppliers and consumers that marketing or labeling CBD products as food additives or dietary supplements is prohibited(41).

Additionally, the federal agency approved Epidiolex in 2018 as a pure CBD prescription medication for treating seizures due to epilepsy(42). This approval makes Epidiolex the first and only FDA-approved CBD product.

What Is Parkinson’s Disease?

Parkinson’s disease is a neurological disorder associated with walking and balance difficulties, shaking, and coordination problems.

Over time, this neurodegenerative disease can cause non-motor symptoms or behavioral and mental changes, such as depression, fatigue, sleep disorders, and memory issues(43).

Causes

The disease occurs when the basal ganglia’s nerve cells (neurons) die or become impaired. The basal ganglia are structures within the brain that control movement.

The death or impairment of these brain cells causes lower dopamine production, resulting in movement problems associated with Parkinson’s disease. Scientists have not discovered the cause of death of these dopamine-producing cells.

Individuals with Parkinson’s disease also lose the nerve endings producing norepinephrine. This chemical messenger is part of the sympathetic nervous system, controlling blood pressure and heart rate.

Thus, norepinephrine loss may be associated with blood pressure irregularity, fatigue, food digestion reduction, and blood pressure drop when standing up(44).

Parkinson’s disease may cause shaking or tremors in the hands, bradykinesia, rigidity in the limbs, and problems with walking(45).

Other symptoms of Parkinson’s disease include the following(46):

  • Speaking, chewing, and swallowing difficulties
  • Constipation
  • Urinary problems
  • Sleep disruptions
  • Skin problems

Diagnosis

There are no reliable testing methods to diagnose Parkinson’s disease. However, a neurologist or doctor specializing in nervous system conditions can analyze this condition based on your symptoms, medical history, or physical exam results(47).

Your doctor can recommend a dopamine transporter scan (DaTscan) to support any suspicion of the disease. However, experts still consider neurological exams and symptoms more reliable in making the correct diagnosis(48).

Additionally, your doctor can request other tests to rule out other conditions causing the symptoms. These tests include blood tests, magnetic resonance imaging (MRI), positron emission tomography (PET) scan, or brain ultrasound.

However, these imaging tests do not help detect Parkinson’s disease(49).

Treatment Options

There is no cure for Parkinson’s disease. However, medications may help manage tremors and movement disorders or serve as dopamine substitutes(50). These medications include the following:

  • Carbidopa-levodopa: Doctors can give this medication to treat the symptoms of Parkinson’s disease. This drug may also treat Parkinson’s-like symptoms caused by nervous system injury due to monoxide or manganese poisoning(51).

Levodopa is a central nervous system (CNS) agent that works in the brain and converts into dopamine.

Carbidopa is a decarboxylase inhibitor that prevents levodopa from breaking down before reaching the brain. Carbidopa helps lower levodopa dosage and minimize the risk of vomiting or nausea(52).

One side effect of levodopa, especially when taking this medication at higher doses, is dyskinesia or involuntary movements. Your doctor can lessen the dosage to manage or minimize this side effect.

You may take carbidopa-levodopa in tablet, capsule, or liquid suspension form. The regular oral capsules are typically taken three or four times daily, while the extended-release tablet is taken two to four times a day(53).

However, you still need to follow the doctor’s prescription and take carbidopa-levodopa as directed. Additionally, do not administer or take more or less of the medicine than the doctor prescribed.

For example, you should take the extended-release tablets or capsules one or two hours before meals and swallow the medicine whole instead of chewing or crushing them(54).

  • Dopamine agonists: These medications mimic the effects of dopamine. These drugs are not as effective as levodopa. However, dopamine agonists last longer and may be used with levodopa(55).

Examples of dopamine agonists are ropinirole (Requip), rotigotine (Neupro), and pramipexole (Mirapex).

Dopamine agonists have similar side effects as carbidopa-levodopa and may cause sleepiness, hallucinations, and compulsive behaviors like eating, gambling, and hypersexuality(56).

Hallucinations are symptoms of psychosis that cause false perceptions, such as seeing, hearing, or feeling something that is not present(57).

  • MAO B inhibitors: These drugs inhibit the monoamine oxidase B (MAO B) brain enzymes and help prevent dopamine breakdown.

Side effects include nausea, headaches, and insomnia. Adding MAO B inhibitors to carbidopa-levodopa may cause hallucinations.

  • Amantadine: Doctors can prescribe amantadine for the short-term relief of early-stage Parkinson’s disease.

For controlling involuntary movements, you may administer amantadine with carbidopa-levodopa for late-stage Parkinson’s disease.

Amantadine’s side effects include ankle-swelling, purple mottling or skin marbling, or psychotic symptoms such as hallucinations.

  • Anticholinergics: These medications may help control tremors caused by Parkinson’s disease(58). These drugs include benztropine or trihexyphenidyl.

Anticholinergics may cause side effects such as constipation, dry mouth, confusion, and impaired memory.

Another solution is deep brain stimulation (DBS), involving implanting electrodes surgically in the brain(59). These electrodes are connected to a generator implanted in the chest and send electrical signals to the brain to help reduce Parkinson’s disease symptoms.

Doctors usually recommend DBS for Parkinson’s disease patients or individuals with advanced Parkinson’s disease. The doctor will adjust the settings of the device based on the severity of your condition.

However, DBS may cause strokes, infections, or brain hemorrhage. Additionally, although this method may be beneficial for Parkinson’s symptoms, it cannot prevent the disease progression.

Alternative methods to help manage Parkinson’s disease or its symptoms include lifestyle changes or home remedies such as exercising, eating healthy food, avoiding situations that increase fall risk, and consulting an occupational therapist(60).

Product Frequently
Asked Questions

  • How can CBD help with Parkinson’s disease?

    There is no definite cure for Parkinson’s disease, a neurodegenerative disorder(61). However, CBD may help manage the symptoms of such a condition by alleviating neuroinflammation, anxiety, oxidative injury, nausea, and epilepsy(62).

    Researchers need to conduct more extensive studies to determine whether these benefits of CBD have the potential to reduce symptoms associated with Parkinson’s disease.

  • What evidence or research exists to say that CBD helps with Parkinson’s disease?

    One study showed that CBD may have anti-inflammatory, antioxidant, and neuroprotective properties relevant to managing Parkinson’s disease or its symptoms(63).

    Another study stated that CBD may act as a neuroprotective antioxidant to help manage oxidative neurological disorders(64). Antioxidants may help reduce oxidative injury caused by neurological diseases such as Parkinson’s(65).

  • Is there any evidence that CBD can make Parkinson’s disease worse?

    No conclusive studies are determining whether CBD worsens Parkinson’s disease.

    However, one study suggested that cannabinoids, such as CBD and THC, may have a hypokinetic effect through the activation of the CB1 receptors(66). This characteristic may cause hypokinesia or limiting motor movements.

    Slow movements and limited motion range are some of the symptoms of Parkinson’s disease(67). Thus, hypokinetic effects may worsen the condition.

  • Will CBD interact with any current medication I may be taking for Parkinson’s disease?

    Researchers have not conclusively determined whether CBD has adverse drug interactions with Parkinson’s disease medications.

    However, CBD may have an adverse effect on the cytochrome P450 enzymes responsible for metabolizing or processing various medications(68). One effect of this interaction is the increased risk of side effects or toxicity related to the medicine.

  • Are there other treatments I should consider alongside CBD to help with Parkinson’s disease?

    Home remedies or lifestyle changes such as eating healthy food, exercising, consulting an occupational therapist, and avoiding situations that increase fall risk may help manage Parkinson’s disease or its symptoms(69).

  • Can I fail a drug test if I use CBD for Parkinson’s disease?

    Taking CBD oil products containing no more than 0.3% THC concentration typically does not cause a drug test failure.

    However, frequent and extended use of CBD may cause the THC concentration in your body to rise to detectable levels(70). This result may cause you to fail a drug test.

  • What is the standard CBD dosage for Parkinson’s disease?

    The FDA has not approved any CBD dosage guides specifically for Parkinson’s disease. However, one dosing strategy is to start with 10mg of CBD daily(71).

  • Can CBD aggravate Parkinson’s disease?

    There is no definitive evidence that CBD aggravates Parkinson’s disease.

  • Which strain of cannabis is best for Parkinson’s disease?

    Despite the claims of various media sources and online reviews, there is no definitive cannabis strain that is considered the best for Parkinson’s disease.

    However, some CBD brands and review sites recommend cannabis strains high in CBD content and contain less than 0.3% THC concentration.

    The FDA states that cannabis plants and derivatives with THC levels not exceeding 0.3% are no longer controlled substances according to U.S. federal law(72).

  • Why is CBD controversial?

    CBD is controversial because some CBD companies claim that the compound has numerous therapeutic benefits that can help treat various illnesses.

    According to the FDA, there is limited scientific data about CBD’s safety, which may translate to real risks that consumers must consider before using CBD oil products for any reason(73).

    Therefore, the FDA cannot guarantee CBD’s safety or efficacy and thus warn CBD companies to cease selling CBD products marketed to prevent, diagnose, treat, or cure diseases(74).

    Another controversy is that CBD may be associated with marijuana or the psychoactive effects caused by THC. However, CBD by itself does not cause a “high” and is typically derived from hemp(75).

    State and federal laws regulate growing hemp in the United States. According to the 2018 Farm Bill, industrial hemp is a cannabis plant whose THC concentration should not be more than 0.3%(76).

    Thus, hemp-derived CBD is not psychoactive like THC(77).

  • Is there insurance coverage for CBD?

    Some insurance agencies provide product liability insurance for the CBD and hemp industries. The conditions for this insurance type may vary among insurance providers.

    However, CBD product liability insurance works similarly to other liability insurance products, wherein the policyholder uses the insurance to protect the brand or manufacturer from customer complaints caused by a faulty item.

    Thus, this insurance coverage can shield CBD companies or help settle such legal claims, provided that the CBD products adhere to the FDA’s guidelines, such as not making promises that CBD can treat or prevent diseases


  1. Cannabidiol in Parkinson’s Disease
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115444/
  2. Cannabidiol for Neurodegenerative Disorders: Important New Clinical Applications for This Phytocannabinoid?
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579248/
  3. Parkinson’s Disease
    https://www.nia.nih.gov/health/parkinsons-disease
  4. Cannabidiol for Neurodegenerative Disorders: Important New Clinical Applications for This Phytocannabinoid?
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579248/
  5. Cannabidiol Primer for Healthcare Professionals
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340472/
  6. Cannabidiol for Neurodegenerative Disorders: Important New Clinical Applications for This Phytocannabinoid?
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579248/
  7. Ibid.
  8. Ibid.
  9. Cannabinoids Provide Neuroprotection Against 6-Hydroxydopamine Toxicity In Vivo and In Vitro: Relevance to Parkinson’s Disease
    https://pubmed.ncbi.nlm.nih.gov/15837565/
  10. The 6-Hydroxydopamine Model of Parkinson’s Disease
    https://pubmed.ncbi.nlm.nih.gov/17449457/
  11. Pharmacological Intervention in Oxidative Stress as a Therapeutic Target in Neurological Disorders
    https://academic.oup.com/jpp/advance-article-abstract/doi/10.1093/jpp/rgab064/6288400?redirectedFrom=fulltext
  12. Cannabidiol and (−)Δ9-Tetrahydrocannabinol Are Neuroprotective Antioxidants
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20965/
  13. Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer’s Disease
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102548/
  14. Microglia Function in the Central Nervous System During Health and Neurodegeneration
    https://www.annualreviews.org/doi/abs/10.1146/annurev-immunol-051116-052358
  15. Alzheimer’s Disease: Symptoms & Causes:
    https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/symptoms-causes/syc-20350447
  16. Ibid.
  17. Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079847/
  18. Best Way to Take CBD
    https://www.projectcbd.org/guidance/best-way-take-cbd
  19. Can Vaping Damage Your Lungs? What We Do (and Don’t) Know
    https://www.health.harvard.edu/blog/can-vaping-damage-your-lungs-what-we-do-and-dont-know-2019090417734
  20. Page 210 of Healing With CBD
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  21. CBD dosing
    https://www.projectcbd.org/guidance/cbd-dosing
  22. Ibid.
  23. Page 218 of Healing With CBD
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  24. Page 190-193 of Healing With CBD
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  25. Ibid.
  26. What Are the Benefits of CBD — And Is It Safe to Use?
    https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/is-cbd-safe-and-effective/faq-20446700
  27. Dosage, Efficacy and Safety of Cannabidiol Administration in Adults: A Systematic Review of Human Trials
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092763/
  28. CFR – Code of Federal Regulations Title 21
    https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1240
  29. Page 243 of Healing With CBD
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  30. Ibid.
  31. CBD Oil: An Introduction
    https://www.projectcbd.org/wellness/cbd-oil-introduction
  32. Page 244 of Healing With CBD
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  33. Tetrahydrocannabinol
    https://www.sciencedirect.com/topics/neuroscience/tetrahydrocannabinol
  34. The Cannabis Terpenes
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763918/
  35. Flavonoids as antioxidants
    https://pubmed.ncbi.nlm.nih.gov/10924197/
  36. FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD)
    https://www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbd
  37. The Farm Bill, hemp legalization and the status of CBD: An explainer
    https://www.brookings.edu/blog/fixgov/2018/12/14/the-farm-bill-hemp-and-cbd-explainer/
  38. Hemp Production
    https://www.ams.usda.gov/rules-regulations/hemp
  39. Hemp Production and the 2018 Farm Bill
    https://www.fda.gov/news-events/congressional-testimony/hemp-production-and-2018-farm-bill-07252019
  40. State Medical Cannabis Laws
    https://www.ncsl.org/research/health/state-medical-marijuana-laws.aspx
  41. What You Need to Know (And What We’re Working to Find Out) About Products Containing Cannabis or Cannabis-Derived Compounds, Including CBD
    https://www.fda.gov/consumers/consumer-updates/what-you-need-know-and-what-were-working-find-out-about-products-containing-cannabis-or-cannabis
  42. FDA Approves First Drug Comprised of an Active Ingredient Derived from Marijuana to Treat Rare, Severe Forms of Epilepsy
    https://www.fda.gov/news-events/press-announcements/fda-approves-first-drug-comprised-active-ingredient-derived-marijuana-treat-rare-severe-forms
  43. Parkinson’s Disease
    https://www.nia.nih.gov/health/parkinsons-disease
  44. Ibid.
  45. What Is Parkinson’s?
    https://www.parkinson.org/understanding-parkinsons/what-is-parkinsons
  46. Parkinson’s Disease
    https://www.nia.nih.gov/health/parkinsons-disease
  47. Parkinson’s Disease: Diagnosis & Treatment
    https://www.mayoclinic.org/diseases-conditions/parkinsons-disease/diagnosis-treatment/drc-20376062
  48. Ibid.
  49. Ibid.
  50. Ibid.
  51. Levodopa and Carbidopa
    https://medlineplus.gov/druginfo/meds/a601068.html
  52. Ibid.
  53. Ibid.
  54. Ibid.
  55. Parkinson’s Disease: Diagnosis & Treatment
    https://www.mayoclinic.org/diseases-conditions/parkinsons-disease/diagnosis-treatment/drc-20376062
  56. Ibid.
  57. Psychotic Disorders
    https://medlineplus.gov/psychoticdisorders.html
  58. Parkinson’s Disease: Diagnosis & Treatment
    https://www.mayoclinic.org/diseases-conditions/parkinsons-disease/diagnosis-treatment/drc-20376062
  59. Ibid.
  60. Ibid.
  61. What Is Parkinson’s?
    https://www.parkinson.org/understanding-parkinsons/what-is-parkinsons
  62. Cannabidiol for Neurodegenerative Disorders: Important New Clinical Applications for This Phytocannabinoid?
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579248/
  63. Cannabinoids Provide Neuroprotection Against 6-Hydroxydopamine Toxicity In Vivo and In Vitro: Relevance to Parkinson’s Disease
    https://pubmed.ncbi.nlm.nih.gov/15837565/
  64. Cannabidiol and (−)Δ9-Tetrahydrocannabinol Are Neuroprotective Antioxidants
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20965/
  65. Pharmacological Intervention in Oxidative Stress as a Therapeutic Target in Neurological Disorders
    https://academic.oup.com/jpp/advance-article-abstract/doi/10.1093/jpp/rgab064/6288400?redirectedFrom=fulltext
  66. Cannabidiol for Neurodegenerative Disorders: Important New Clinical Applications for This Phytocannabinoid?
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579248/
  67. Parkinson’s Disease: Symptoms & Causes
    https://www.mayoclinic.org/diseases-conditions/parkinsons-disease/symptoms-causes/syc-20376055
  68. Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/
  69. Parkinson’s Disease: Diagnosis & Treatment
    https://www.mayoclinic.org/diseases-conditions/parkinsons-disease/diagnosis-treatment/drc-20376062
  70. Can You Take CBD and Pass a Drug Test?
    https://www.consumerreports.org/cbd/can-you-take-cbd-and-pass-a-drug-test/
  71. Page 218 of Healing With CBD
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  72. FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD)
    https://www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbd
  73. What You Need to Know (And What We’re Working to Find Out) About Products Containing Cannabis or Cannabis-derived Compounds, Including CBD
    https://www.fda.gov/consumers/consumer-updates/what-you-need-know-and-what-were-working-find-out-about-products-containing-cannabis-or-cannabis
  74. Ibid.
  75. CBD & THC: Myths and Misconceptions
    https://www.projectcbd.org/guidance/cbd-thc-myths-and-misconceptions
  76. What Is Industrial Hemp?
    https://catalog.extension.oregonstate.edu/em9240/html
  77. CBD & THC: Myths and Misconceptions
    https://www.projectcbd.org/guidance/cbd-thc-myths-and-misconceptions

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