How to Make CBD Oil

More states are beginning to legalize marijuana as the knowledge of its medicinal value spreads, and various products based on the Cannabis plant are gaining popularity as more and more people want to take advantage of its benefits. People who want to take advantage of CBD’s benefits also have the option to make their own CBD oil. 

There are several steps in making CBD oil from large-scale production processes to do-it-yourself steps. The equipment needed for creating CBD oil can be found in most modern kitchens, and the entire process is simple enough for a do-it-yourself home project for the weekend. Furthermore, CBD oil and related products are readily available in dispensaries, specialty stores, and online shops.

But what are the specific benefits of taking CBD oil?

Why Use CBD Oil?

Cannabidiol, also known as CBD, is one of the active ingredients in Cannabis. CBD works to help restore the body’s functionalities by binding with a variety of receptor sites in the brain. Hence, products like hemp oil and CBD oil have increasing demands in the market due to its ability to aid in managing pain, depression, anxiety, and more.

CBD targets the endocannabinoid system (ECS) in the body. The ECS is responsible for regulating several functions such as pain, appetite, sleep, digestion, and even some immune system response. Additionally, it is also involved in fighting diseases. Furthermore, a growing number of studies are beginning to prove the potential of CBD in managing severe symptoms of serious illnesses. 

CBD oil is a popular option for those who want to try the therapeutic and medical benefits of Cannabis. Another popular option is hemp oil, which is derived from industrial hemp seed. However, it contains high-CBD strains compared to hemp oil, which makes the former a better product for more severe conditions.

Additionally, it is easy to incorporate CBD oil into other products such as edibles, tinctures, vaporizers, and topicals. 

Pain Reliever

Much like medical marijuana’s purpose, pain relief is a well-known benefit of CBD. However, using CBD oil does not require a doctor’s prescription, unlike medical Cannabis. 

Experts are now beginning to discover that specific components of CBD have significant pain-relieving qualities. Endocannabinoids, a type of neurotransmitter, bind to the nervous system’s cannabinoid receptors. These studies have shown the significant effects of CBD in interacting with neurotransmitters and reducing inflammation.

A research conducted by Pharmacology experts found that rats injected with CBD exhibited lesser pain response to surgical incisions. Another study showed that rats orally treated with CBD have a significant reduction of sciatic inflammation and nerve pain.

In humans, experiments have shown that a combination of CBD and tetrahydrocannabinol (THC) is beneficial in minimizing pains caused by arthritis and multiple sclerosis.

Treat Skin Conditions

CBD oil has a high potential to decrease symptoms of skin conditions like eczema. It facilitates abnormal cell death, which results in reducing the noticeable effects of the illness. Additionally, it has significant effects on regulating the oil production of the skin, which reduces acne. 

A study published in the Journal of Clinical Investigation, a biomedical journal by the American Society for Clinical Investigation, revealed CBD actively lowers the sebum production due to its anti-inflammatory characteristics. It opens the potential for the product to become a leading treatment for common types of acne.

It is also important to note the Cannabis contains nutrients, including vitamin E, that nourish the skin and protect it from infections.

Alleviate Seizures in Epilepsy

CBD also includes anti-seizure properties that have been proven to successfully cure children who suffer from drug-resistant disorders that affect their neurological functions such as epilepsy.

A team of experts conducted a study published in the New England Journal of Medicine involved the observation of patients suffering from seizures. Those who received CBD treatment showed a significant decrease in the frequency of seizures by 23 percent compared to those who took a placebo.

Consequently, the US Food and Drug Administration (FDA) approved the use of Epidiolex in June 2018. The drug contains a pure form of CBD that aims to alleviate the symptoms of epilepsy in patients who are 2 years old and up. These patients often suffer from two types of epilepsy that generally do not respond to anti-seizure medicines. It proves to be effective in minimizing seizures due to Dravet Syndrome (DS) and Lennox-Gastaut Syndrome (LGS).

The decision makes Epidiolex the first drug that includes a pure form of components from Cannabis. It has notable effects in reducing seizures. InFDA-approved  some cases, the drug stops the frequency of seizures altogether.

Several studies also indicate the effects of CBD in decreasing complications from epilepsy, including psychiatric conditions, neurodegeneration, and neuronal injuries.

Treatment for Type 1 Diabetes

CBD oil can also help people with more severe diseases such as Type 1 Diabetes. The condition causes the immune system to attack the pancreatic cells. The anti-inflammatory characteristics of CBD aids in reducing the harmful effects of the illness in the pancreas.

Clinical Hemorheology and Microcirculation, a peer-reviewed scientific journal, recently published a study that showed a decrease of pancreatic inflammation in mice that received CBD treatment. Similarly, another research was presented in Lisbon, Portugal, corroborating the anti-inflammatory effects of CBD and how it helps minimize further pancreatic damage. The experiment also showed promising potential for CBD to delay the progress of Type 1 Diabetes.

Three Methods of Making CBD Oil

In its purest form, cannabidiolic acid (CBDA) can be extracted from hemp plants as these have lower THC content than marijuana plants. The decarboxylation process converts CBDA to CBD, which goes through a few more processes to achieve CBD oil. Decarboxylation refers to the exposure of Cannabis to sunlight or heat.

CBD oil is one of the most popular Cannabis products as it is relatively easy to manufacture. Furthermore, it is easy to combine the oil with other ingredients without affecting the overall quality of the end product. The extraction process is continuously changing as new technology develops, but these are the most common extraction methods.

CO2 Extraction

CO2 extraction is conventional among manufacturers of Cannabis products as it allows control over how much CBD finds its way into their products. The extraction method starts with a type of solvent that removes the plant material and extricates the valuable compounds. Cannabis extraction uses carbon dioxide as a solvent to dissolve aromatic terpenes and active cannabinoids from the organic material.

The chemical reaction from heating CO2 separates various active compounds like cannabinoids. CO2 changes into its supercritical form, which fluctuates between the states of solid, liquid, and gas. At this stage, it becomes a useful solvent in compound and oil extraction from various organic matter. 

The supercritical fluid infused with cannabis compounds is then placed in a separate vessel. As CO2 stabilizes and returns to its gas form, it leaves the active cannabinoids, which separate further using pressure and temperature. The process results in a pure form of CBD, which is infused with oil carriers to produce CBD oil.

While the principles in extracting cannabinoids using CO2 extraction is relatively simple, it requires personnel with specialized training along with specific equipment. However, most manufacturers favor this method as it produces the cleanest cannabinoid compound.

Extracting CBD Using Ethanol

Another method of extracting cannabinoids and making CBD oil is through the use of ethanol. It is a form of alcohol that can also serve as a solvent in extraction processes. The general process involves steeping the hemp plant in ethanol. This releases the full spectrum of cannabinoids from the organic material. 

Ethanol extraction can be implemented using warm or cold methods. The Soxhlet technique involves boiling ethanol in a container. The alcohol goes through a cooled-coil that drips through a packed Cannabis material. During this process, the ethanol stripes the terpenes and cannabinoids from the plant. The warm method is ideal for processing small batches of the hemp plant. It skips the cooling coil and directly extracts CBD from the plant, which decarboxylates its active ingredients. The process may require an additional clarification process.

The final product of ethanol extraction is then used to infuse CBD with a type of carrier oil, such as coconut oil.

Extracting CBD Using Oil

Extracting CBD using oil is one of the most popular DIY processes. It allows hobbyists with essential equipment to make their own CBD oil. The process can use different types of oils, but each one results in different quality, shelf life, and taste. Olive oil is a popular carrier of CBD because of its mild qualities. It neutralizes the distinct flavor of CBD that may overpower some people.

Using olive oil also allows the production of high-quality CBD that can enhance various dishes without significantly affecting their flavor.

Here are the necessary steps on how to make CBD oil at home.

Step 1 – Preparing the Hemp Plant

Homemade CBD oil requires a high-quality Cannabis plant. Typically, Cannabis buds are available in specialty shops and dispensaries. Strains of Cannabis with high-CBD content such as Charlotte’s Web and ACDC are perfect for this process. 

For the body to absorb the active components of Cannabis, CBDA needs to undergo heat to convert it to CBD. Put the buds on a baking sheet and decarboxylate them at 230 degrees Fahrenheit for about 30 minutes. The buds should turn brown and slightly crispy, but they should not thoroughly cook or burn.

Step 2 – Steep the Cannabis in Oil

Olive oil, especially the extra virgin variety, burns quickly during the process. Hence, it is crucial to consider the type of stovetop to use during the steeping process. In a saucepan or double boiler, make a mixture of half water and half olive oil. Add the Cannabis buds, then set the heat at a low setting. Stirring the mixture prevents any buds from burning.

Slowly increase the heat until it is near boiling temperature. Look for tiny bubbles floating in the mixture. At this point, lower the heat and maintain a low boil. The ideal temperature at this point is around 200 degrees Fahrenheit. Keep stirring the mixtures until it gently simmers.

Cook the mixture for about 30 minutes or until most of the water evaporates. Also, the Cannabis buds float to the top of the liquid.

Step 3 – Separating and Cooling the Oil

Once the previous process extracts CBD from the buds, let the mixture cool. Ideally, it should reach room temperature for the next steps. Prepare a fine-mesh sieve or cheesecloth to strain the liquid. It ensures that only pure oil passes through by removing solid plant materials.

Strain the infusion into a container that keeps the solution free of any impurities such as a receptacle with a jar. Store the container in the refrigerator for about two hours to overnight. When the mixture cools, the olive oil coagulates and hardens on top. At this point, it is easy to separate the dense layer of CBD-rich oil from the water at the bottom.

Allow the oil to return to its liquid form at room temperature. Store the oil in a mason jar or similar storage that maintains its purity. 

On the other hand, the leftover buds are perfect as garnishes for salads and other CBD-infused dishes.

Side Effects of CBD Oil

Taking CBD in any form is not without complications. It is important to note that cannabinoids have varying effects on different types of people. Further issues may arise on people with existing conditions or taking other drugs.

A Drop in Blood Pressure

Some people with diabetes and heart diseases take CBD oil to help regulate their blood pressure. This quality of cannabinoid can cause significant changes in the blood pressure of people who do not have similar illnesses. The drop in blood pressure causes lightheadedness, especially for people who take products with relatively high CBD content. It may even cause drowsiness and dizziness in other people.

Additionally, people with low blood pressure should avoid taking high doses of CBD. It is best to consult a medical expert if one is considering CBD oil. While these effects may be temporary, it may be fatal to those who are not aware of its side effects.

Interaction with Other Drugs

People who are currently taking medications for pre-existing conditions or diseases may want to be careful of considering CBD as an alternative treatment. CBD significantly affects the activity of specific enzymes in the liver, such as the cytochrome P450 enzyme system. 

P450 enzyme system includes more than 50 enzymes that eliminate and process toxins in the liver. When taken in high dosage, it can completely neutralize the activity of P450 enzymes. The liver metabolizes cannabinoid with the exact similar enzymes. 

Additionally, certain pharmaceutical drugs inhibit the P450 enzyme system, which causes a slower breakdown of cannabidiol. It increases the physiological effects of cannabinoids. On the other hand, some medications cause a faster breakdown of CBD, resulting in shorter therapeutic effects.

While such issues are often minor and typically temporary, it is best to consult with a doctor before taking CBD products.


Cannabis has been used for ages to alleviate symptoms of stress, anxiety, depression, and other physical pain. Recent studies have shown that active chemical compounds in Cannabis have significant effects in treating critical diseases such as diabetes, skin conditions, and epilepsy.

As different states and countries begin loosening their laws about CBD and its use, more and more products become available with varying amounts of cannabidiol. It has become relatively safe to use due to its reduced THC contain. Some CBD oil products do not contain any traces of THC at all.

However, it is essential to consult a medical expert before considering CBD oil as an alternative medical treatment. While it has several medical benefits, it may interact with other pharmaceutical drugs. It may result in unexpected effects in the body.

Additionally, it is best to consult with the current city regulations and laws concerning the consumption of CBD oil and other similar products. Purchasing CBD oil, whether outside the city or through online stores, may even be unlawful, which may result in significant punishment or, in some cases, imprisonment.

Daniel Bischoff

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n-Decane is one of the chemical forms (isomers) of decane (C10-H22). It has many similarities (properties and hazards) to other decanes. Some information in this record is given specifically for n-decane. Much information applies to decanes in general.

Component of gasoline, jet fuel, kerosene and petroleum solvents such as white spirit; solvent; organic synthesis; standardized hydrocarbon; rubber industry; paper industry; and a constituent of polyolefin manufacturing wastes.

Colourless liquid, gasoline-like odour. COMBUSTIBLE LIQUID AND VAPOUR. Vapour is heavier than air and may spread long distances and accumulate in low-lying areas. Liquid can float on water and may travel long distances and/or spread fire. Liquid can accumulate static charge. SKIN IRRITANT. Causes severe skin irritation. May be irritating to the eyes and respiratory tract. Mild central nervous system depressant. Extremely high vapour concentrations may cause headache, nausea, dizziness, drowsiness and confusion. Aspiration hazard. Swallowing or vomiting of the liquid may result in aspiration into the lungs.

Effects of Short-Term (Acute) Exposure


Because of the relatively low vapour pressure and relatively low saturated vapour concentration of decanes, n-decane is unlikely to produce a sufficiently high vapour concentration to cause effects unless material is heated or mists are formed. In this case depression of the central nervous system may result in drowsiness, dizziness, confusion and incoordination. Based on skin irritation resulting from dermal exposure, concentrated vapour may cause nose and throat irritation.

Skin Contact:

Based on effects in animal studies, direct skin contact with decanes may cause moderate to severe irritation.

Eye Contact:

Eye contact will probably cause moderate to severe irritation with redness and pain. Concentrated vapour is probably irritating to the eyes. This evaluation is based on an animal skin irritancy study which produced moderate to severe skin irritation.


There is no specific information for n-decane. Decanes in general have very low oral toxicity and large amounts would have to be ingested to cause depression of the central nervous system as described for inhalation above.

Based on physical properties, decanes can be easily aspirated into the lungs. Apiration is the “breathing” of a material into the lungs when it is swallowed or vomited. This could result in potentially fatal lung damage (pulmonary edema).

Ingestion is not a typical route of occupational exposure.

Effects of Long-Term (Chronic) Exposure

No chronic effects in humans have been reported.

SKIN: Based on results from animal studies, irritation and dermatitis (inflammation, reddening and swelling) may result from prolonged or repeated contact.


There is no human or animal information available.

The International Agency for Research on Cancer (IARC) has not evaluated the carcinogenicity of this chemical.

The American Conference of Governmental Industrial Hygienists (ACGIH) has no listing for this chemical.

The US National Toxicology Program (NTP) has not listed this chemical in its report on carcinogens.

Teratogenicity and Embryotoxicity:

There is no human or animal information available.

Reproductive Toxicity:

There is no human or animal information available.


There is no human information available. n-Decane was negative in a bacterial (Ames) test and in tests with cultured mammalian cells.(2)

Toxicologically Synergistic Materials:

There is no information available.

Potential for Accumulation:

Unlikely to accumulate. Decanes are readily metabolized and excreted from the body.

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