Best CBD for RLS
An uncontrollable urge to move your limbs, usually during bedtime, is a common sign of restless leg syndrome (RLS). Can CBD help with RLS? CBD Clinicals gives you all the information about CBD and its potential health benefits for RLS and its symptoms.
Best CBD for RLS 2024
- Spruce 750mg Lab Grade CBD Oil Editor's Pick
- NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil Best Organic
- Spruce 2400mg Lab Grade CBD Oil Editor's Pick
- Avida Full Spectrum CBD Oil Tincture 500mg Best Seller
- cbdMD CBD Oil Tincture Natural 1500mg Best Natural Alternative
- CBDistillery THC Free CBD Oil Tinctures Best THC-Free
- cbdMD CBD Oil Tincture Natural 750mg Best Customer Rated
- NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil Best Starter
- Hemp Bombs 750mg CBD Oil Best Flavor Range
Compare the Best CBD for RLS in 2022
Best CBD for RLS
1. Spruce 750mg Lab Grade CBD Oil
cbdc overall score
4.8
CBDC Evaluation Table/Score
| Pros | Cons |
|---|---|
|
Mid-strength |
No other flavors |
|
Natural peppermint flavor |
|
|
Made from 100% organic and natural ingredients |
Overview
Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.
2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
cbdc overall score
5.0
CBDC Evaluation Table/Score
| Pros | Cons |
|---|---|
|
Pure CBD hemp |
No other flavors |
|
All natural |
|
|
Approximately 300 drops total |
Overview
Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.
3. Spruce 2400mg Lab Grade CBD Oil
cbdc overall score
5.0
CBDC Evaluation Table/Score
| Pros | Cons |
|---|---|
|
Extra Strength |
Tastes bitter |
|
No artificial flavoring or colors |
No THC-free option |
|
Made from 100% organic and natural ingredients |
Overview
The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.
4. Avida Full Spectrum CBD Oil Tincture 500mg
cbdc overall score
4.6
CBDC Evaluation Table/Score
| Pros | Cons |
|---|---|
|
Light Spearmint flavor |
No other flavor |
|
Non-THC, Non-detected in drug test |
Overview
Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.
5. cbdMD CBD Oil Tincture Natural 1500mg
cbdc overall score
4.7
CBDC Evaluation Table/Score
| Pros | Cons |
|---|---|
|
Various delicious flavors to choose from |
cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options |
|
Has vegan, organic, and gluten-free ingredients |
|
|
Free shipping for this particular product within USA |
|
|
World-class customer service team |
Overview
cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.
6. CBDistillery THC Free CBD Oil Tinctures
cbdc overall score
4.4
CBDC Evaluation Table/Score
| Pros | Cons |
|---|---|
|
60-Day Satisfaction Guarantee |
Dropper is a bit shaky |
|
Various strengths |
|
|
Oil extracted from aerial plant parts of US grown industrial hemp |
|
|
Sourced from non-GMO industrial hemp grown in the USA through natural farming practices |
Overview
CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.
7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
cbdc overall score
4.6
CBDC Evaluation Table/Score
| Pros | Cons |
|---|---|
|
Pure CBD hemp |
No other flavors |
|
All natural |
A bit pricey compared to competitors |
|
Approximately 100 drops total |
Overview
This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.
8. cbdMD CBD Oil Tincture Natural 750mg
cbdc overall score
4.4
CBDC Evaluation Table/Score
| Pros | Cons |
|---|---|
|
Vegan and Gluten free |
Does not ship internationally |
|
Has a third-party lab test |
|
|
Wide variety of CBD strengths and sizes |
Overview
A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.
9. Hemp Bombs 750mg CBD Oil
cbdc overall score
3.9
CBDC Evaluation Table/Score
| Pros | Cons |
|---|---|
|
Wide variety of flavors |
Incomplete information about the product |
|
Lab test results are complete |
Does not ship to all international countries |
|
30-day money-back guarantee |
Overview
Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.
How CBD May Help With RLS
Willis-Ekbom Disease, more popularly known as restless legs syndrome (RLS), is a neurological condition that induces painful, involuntary movement of limbs, often at night(1).
Sleep problems are prevalent among individuals suffering from RLS. These sleep disturbances are due to the periodic leg movements and sensory symptoms of RLS(2).
Studies have indicated that cannabidiol (CBD) may possess analgesic properties that may help with chronic pain(3).
The compound may also offer therapeutic benefits that may lead to improvements in sleep(4).
Other research hypothesized that CBD may have possible neuroprotective effects that may protect against nerve cell damage(5).
Cannabidiol, more known for its popular name, CBD, is a non-psychoactive compound from the cannabis plant(6). This compound may interact with the endocannabinoid system (ECS) of the body(7).
The ECS comprises many cannabinoid receptors, including CB1 and CB2 receptors located in the nervous and immune systems.
CB1 receptors are in charge of pain regulation, while CB2 stimulates the body’s anti-inflammatory response(8).
These two receptors may produce analgesic and anti-inflammatory effects when they interact with CBD(9).
Additionally, the activation of CB1 receptors is noted to impact sleep regulation(10).
The said properties of CBD may offer comfort and ease to individuals with restless leg syndrome.
Benefits of Using CBD for RLS
Restless leg syndrome is categorized as a neurological condition associated with uncontrollable movements and unpleasant sensations in the legs(11).
A 2018 review noted that CBD’s purported neuroprotective and anti-inflammatory properties may help manage neurological disorders(12).
A study suggested that cannabidiol use may improve the quality of life of individuals with Parkinson’s disease, a neurological disorder(13).
RLS may cause sleeping difficulties due to uncontrollable movement of the legs. This condition may lead to sleep disturbance at night and excessive drowsiness during the day(14).
A 2018 study indicated that CBD may benefit individuals suffering from sleep disorders(15).
In a study in 2019, participants were given a dose of CBD to manage their sleep problems(16). Results showed that CBD may have calming effects on an individual’s central nervous system, improving sleep and reducing anxiety.
Research has hypothesized that individuals with restless legs syndrome have lower iron levels in their brains(17).
CBD does not have any effects on iron deficiency. However, the carrier oil used in CBD products, hemp seed oil, contains vitamin E and minerals such as magnesium, potassium, calcium, and iron(18).
A hundred grams of hemp seed oil may contain about 14 mg of iron(19).
While there is no treatment for this condition, symptoms of RLS can be relieved with certain medications.
RLS has no known cause. Studies have hypothesized that the condition may be due to an imbalance of dopamine, a neurotransmitter that regulates muscle movement(20).
Dopaminergic or dopamine-inducing drugs are the prescribed medication for moderate to severe RLS(21).
However, if used long-term, these medications may cause RLS augmentation, in which RLS symptoms also occur during the day, as opposed to the condition only happening during night time(22).
Individuals with RLS may also be prescribed sleep medications to manage insomnia and anxiety(23). However, this medication only provides restful sleep and does not affect other RLS symptoms such as involuntary limb movement.
Meanwhile, individuals with severe cases of RLS may also be prescribed opioids. These are potent painkillers only given in low doses due to their addictive properties(24).
CBD may provide a natural alternative to managing symptoms of RLS, as the compound is well tolerated by humans, has a good safety profile, and is non-addictive(25).
How to Take CBD Oil for RLS
Edibles like CBD gummies and supplements work by passing through the gastrointestinal tract before the compound enters the bloodstream(26).
CBD tinctures may be applied sublingually (under the tongue) using a dropper. Individuals should wait for one to two minutes before swallowing the compound(27).
Inhaling or smoking CBD using vape pens is the fastest way for the compound to enter the bloodstream(28).
However, vaping is linked with lung damage, so caution is advised for this method(29).
Lastly, topical CBD like CBD creams and salves commonly used for localized pain relief(30), may also be used for RLS.
A study noted that topical application of a cream containing cannabinoids may reduce RLS and itchiness caused by end-stage kidney disease(31).
You must consult your doctor for recommendations on the best CBD product for restless leg syndrome or any of your medical conditions.
CBD Dosage for RLS
The FDA (Food and Drug Administration) does not consider CBD as a medical treatment for RLS. Therefore, there is no set CBD dosage for the medical condition.
According to a study on the safety and side effects of CBD, humans may tolerate up to 1,500mg of cannabidiol per day(32).
Nonetheless, it is advisable to consult your doctor for the appropriate dosage of CBD for RLS or any medical condition.
How Long Does CBD Take to Help With RLS?
The CBD form and administration method may determine how long it takes for CBD products to affect the system.
CBD edibles, gummies, and supplements may take effect within 30 to 90 minutes(33). Meanwhile, CBD tinctures may take effect within 15 to 30 minutes(34).
CBD inhalation using vape pens may be the fastest way to feel the effects of CBD. This method may only take 2 to 15 minutes before the compound takes effect(35).
However, note that smoking and vaping may lead to severe pulmonary disease(36).
Lastly, topical CBD, such as creams, lotions, and balms, may take effect within 10 to 15 minutes(37).
How Long Will CBD Help With RLS?
No current research has determined how long the effects of CBD in the body can last to help with restless leg syndrome.
The compound’s effects may linger in the system depending on factors such as CBD form, potency, and administration method. An individual’s body weight, metabolism, and diet may also affect the duration of effects(38).
How to Choose the Right CBD Oil for RLS
Various CBD brands in the market aim to offer the best CBD oil for RLS and other related medical conditions.
Below are some essential factors to consider to help you find the best CBD oil for restless leg syndrome:
CBD Extracts
CBD extracts can be categorized as full-spectrum CBD oil, broad-spectrum CBD oil, and CBD isolates(39).
Full-spectrum CBD oil has all the compounds found in cannabis plants, including CBD, cannabinoids, flavonoids, terpenes, and essential oils.
Flavonoids are compounds that may provide anti-inflammatory, antiviral, and antioxidant properties(40). Terpenes are responsible for the aroma of cannabis plants(41).
Additionally, full-spectrum CBD oil contains less than 0.3% tetrahydrocannabinol (THC), which is the psychoactive compound of the cannabis plant.
Furthermore, because of the presence of all the cannabis compounds, full-spectrum CBD oil may provide the entourage effect.
The entourage effect is the mechanism wherein the active components of cannabis will work better if administered together(42).
Broad-spectrum CBD oil has all of the natural compounds of cannabis except for THC(43).
Meanwhile, CBD isolates are pure CBD(44).
Hemp Source
Trusted CBD brands that produce high-quality CBD products usually get hemp extracts from organic, non-GMO (genetically modified organism) hemp plants.
Choosing brands that outsource the highest quality hemp plants from states with leading CBD industries, such as California, Colorado, and Texas, is highly recommended.
Extraction Method
Carbon dioxide, ethanol, or solvent extraction are preferred extraction methods to create a safe CBD product(45).
Using butane or hexane as extraction techniques may leave behind harmful residues such as pesticides and heavy metals.
Carrier Oils
Cannabidiol is usually infused into a carrier oil upon the compound’s extraction from the hemp plant. Hempseed, coconut, and MCT oils are the most commonly used carrier oils(46).
Keep in mind that ‘hempseed oil’ and ‘hemp oil’ have significant differences.
Hempseed oil is made from the pressed seeds of hemp. Hemp oil, a term often used to refer to CBD oil, is an essential oil from the flowers and leaves of hemp plants.
Furthermore, hempseed oil is rich in nutrients and fatty acids but does not contain CBD(47).
Third-Party Lab Testing
Looking at third-party lab reports and certificates of analysis (COAs) are ways to verify whether a CBD product contains what is advertised.
Ensure that the lab results or the COAs come from a trusted third-party laboratory and are up-to-date.
In addition, the information on the COA should match the claims on the CBD product label.
Risks and Side Effects of Using CBD for RLS
According to a World Health Organization (WHO) report, CBD is safe and well tolerated by people(48).
However, the compound may induce some minor side effects like(49):
- Dry mouth
- Diarrhea
- Drowsiness
- Fatigue
Additionally, using CBD alongside certain drugs prescribed for restless leg syndrome, such as opioids and antidepressants(50), may cause increased sleepiness, fatigue, accidental falls, and possible accidents when driving(51).
It is pertinent to speak with your physician or healthcare provider before taking any CBD products alongside any medications.
Legality of CBD
Epidolex is currently the only CBD product verified by the FDA. This medication is prescribed to treat tubular sclerosis and seizures caused by two rare forms of epilepsy in children(52).
Due to the 2018 Farm Bill, CBD products are federally legal in the United States(53) as long the product contains less than 0.3% THC.
However, it is still essential for CBD users to verify state laws and check product labels before purchasing and travelling with CBD products.
Product Frequently
Asked Questions
-
How can CBD help with RLS?
RLS is a neurological condition that may cause painful and uncontrollable movement of the legs, which mainly occur at night(54).
These periodic and involuntary movements may cause sleep disturbances to individuals with the condition(55).
Research suggests that CBD may possess analgesic properties for pain(56) and therapeutic benefits for insomnia(57).
Additionally, CBD may contain neuroprotective effects against nerve cell damage(58).
-
What evidence or research exists to say that CBD helps with RLS?
CBD is hypothesized to have anti-inflammatory and neuroprotective benefits that may manage neurological disorders(59).
One study indicated that CBD use may improve the quality of life of people with the neurological disorder Parkinson’s disease(60).
RLS is a neurological condition that causes uncontrollable movements and unpleasant sensations of the limbs(61).
People with severe symptoms of RLS may be given potent painkillers like opioids. However, these drugs may contain addictive properties(62).
Meanwhile, CBD, which may have analgesic properties(63), is reported to be safe, well tolerated by the body, and non-addictive(64).
-
Is there any evidence that CBD can make RLS worse?
There is no evidence suggesting that CBD can make restless leg syndrome worse. However, it is still highly encouraged to make an appointment with a healthcare professional experienced in cannabis use before taking any CBD products.
Medical professionals can give you advice regarding possible drug interactions, risks, and allergic reactions.
-
Will CBD interact with any current medication I may be taking for RLS?
Taking CBD with medications prescribed for restless leg syndrome, such as opioids and antidepressants(65), may induce increased drowsiness, fatigue, accidental falls, and possible accidents when driving(66).
It is best to first talk to a medical professional before taking CBD alongside any prescription drugs.
-
Are there other treatments I should consider alongside CBD to help with RLS?
If RLS symptoms are mild, non-drug treatments, such as exercising, stretching, massaging the sore areas, and limiting caffeine intake, are recommended(67).
However, if RLS symptoms are frequent and severe, a physician can prescribe dopamine agonists to control muscle movement, antiseizure medication, and opioids(68).
-
Can I fail a drug test if I use CBD for RLS?
CBD is a non-psychoactive compound. Thus, it will not cause a euphoric high(69).
However, most CBD products have trace amounts of THC that may build up in the system when taken regularly(70).
An increased THC level in your bloodstream may result in a positive drug test.
-
What is the dosage for RLS?
There is no standard CBD dosage for restless leg syndrome.
It is highly recommended to speak with your physician to ask for guidance and advice on the appropriate dosage of CBD for RLS or any medical condition.
-
How do I use CBD creams for restless leg syndrome?
Topical CBD products, such as CBD creams, are applied to the affected area of the skin for localized pain relief(71). This product may also be used for RLS.
One study indicated that applying topical cream containing cannabinoids may reduce itchiness and RLS symptoms caused by end-stage kidney disease(72).
-
Is CBD for RLS safe?
According to the WHO (World Health Organization), CBD is generally well tolerated by the body, has a good safety profile, and is non-addictive(73).
- What is Restless Legs Syndrome (RLS)?
https://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/restless-legs-syndrome/what-is-rls/# - Effects of restless legs syndrome (RLS) on sleep
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671944/ - Cannabinoids in the management of difficult to treat pain
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/ - Cannabis, Cannabinoids, and Sleep: a Review of the Literature
https://pubmed.ncbi.nlm.nih.gov/28349316/ - Effects of cannabidiol in the treatment of patients with Parkinson’s disease: an exploratory double-blind trial
https://pubmed.ncbi.nlm.nih.gov/25237116/ - The Endocannabinoid System, Our Universal Regulator
https://www.jyi.org/2018-june/2018/6/1/the-endocannabinoid-system-our-universal-regulator - The Endocannabinoid System, Our Universal Regulator
https://www.jyi.org/2018-june/2018/6/1/the-endocannabinoid-system-our-universal-regulator - Cannabinoids and Pain: New Insights From Old Molecules
https://www.frontiersin.org/articles/10.3389/fphar.2018.01259/full - CBD oil: What is it and how does it work?
https://www.eehealth.org/blog/2019/09/cbd-oil/ - The role of the CB1 receptor in the regulation of sleep
https://pubmed.ncbi.nlm.nih.gov/18514375/ - What is Restless Legs Syndrome (RLS)?
https://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/restless-legs-syndrome/what-is-rls/# - Review of the neurological benefits of phytocannabinoids
https://pubmed.ncbi.nlm.nih.gov/29770251/ - Effects of cannabidiol in the treatment of patients with Parkinson’s disease: an exploratory double-blind trial
https://pubmed.ncbi.nlm.nih.gov/25237116/ - Cannabis, Cannabinoids, and Sleep: a Review of the Literature
https://pubmed.ncbi.nlm.nih.gov/28349316/ - Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age
https://www.frontiersin.org/articles/10.3389/fimmu.2018.02009/full - Cannabidiol in Anxiety and Sleep: A Large Case Series
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326553 - Profile of altered brain iron acquisition in restless legs syndrome
https://pubmed.ncbi.nlm.nih.gov/21398376/ - The cardiac and haemostatic effects of dietary hempseed
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868018/ - ibid.
- Restless legs syndrome
https://www.mayoclinic.org/diseases-conditions/restless-legs-syndrome/symptoms-causes/syc-20377168 - Restless legs syndrome
https://www.mayoclinic.org/diseases-conditions/restless-legs-syndrome/diagnosis-treatment/drc-20377174 - Comparison of pregabalin with pramipexole for restless legs syndrome
https://pubmed.ncbi.nlm.nih.gov/24521108/ - Restless legs syndrome
https://www.mayoclinic.org/diseases-conditions/restless-legs-syndrome/diagnosis-treatment/drc-20377174 - ibid.
- Cannabidiol (CBD) Critical Review Report.
https://www.who.int/medicines/access/controlled-substances/CannabidiolCriticalReview.pdf - Healing with CBD. page. 202
https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view - ibid. page. 205
- How to Safely Use CBD: Should You Inhale, Spray, Apply, or Eat It?
https://www.consumerreports.org/cbd/how-to-use-cbd-inhale-spray-apply-eat/ - Outbreak of Lung Injury Associated with the Use of E-Cigarette, or Vaping, Products
https://www.cdc.gov/tobacco/basic_information/e-cigarettes/severe-lung-disease.html - Healing with CBD. page. 210.
https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view - Cannabis Use for Restless Legs Syndrome and Uremic Pruritus in in patients treated with maintenance dialysis: A Survey
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488602/ - Safety and side effects of cannabidiol, a Cannabis sativa constituent
https://pubmed.ncbi.nlm.nih.gov/22129319/ - Healing with CBD. page. 192.
https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view - ibid. page. 191
- ibid. page. 193
- Can vaping damage your lungs? What we do (and don’t) know
https://www.health.harvard.edu/blog/can-vaping-damage-your-lungs-what-we-do-and-dont-know-2019090417734 - Healing with CBD. page. 210
https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view - Healing with CBD. page. 195.
https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view - Cannabidiol primer for healthcare professionals
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340472/ - Flavonoids as antioxidants
https://pubmed.ncbi.nlm.nih.gov/10924197/ - The Cannabis Terpenes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763918/ - The “Entourage Effect”: Terpenes Coupled with Cannabinoids for the Treatment of Mood Disorders and Anxiety Disorders
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324885/ - Cannabidiol primer for healthcare professionals
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340472/ - ibid.
- Cannabidiol primer for healthcare professionals
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340472/ - Healing With CBD, page 205.
https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view - Hemp Seed Oil Properties
https://extension.okstate.edu/fact-sheets/hemp-seed-oil-properties.html - Cannabidiol (CBD), page 5.
https://www.who.int/medicines/access/controlled-substances/CannabidiolCriticalReview.pdf - What are the benefits of CBD — and is it safe to use?
https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/is-cbd-safe-and-effective/faq-20446700 - Strategies for the Treatment of Restless Legs Syndrome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480566/ - CBD and other medications: Proceed with caution
https://www.health.harvard.edu/blog/cbd-and-other-medications-proceed-with-caution-2021011121743 - FDA Approves New Indication for Drug Containing an Active Ingredient Derived from Cannabis to Treat Seizures in Rare Genetic Disease
https://www.fda.gov/news-events/press-announcements/fda-approves-new-indication-drug-containing-active-ingredient-derived-cannabis-treat-seizures-rare - Hemp Production and the 2018 Farm Bill
https://www.fda.gov/news-events/congressional-testimony/hemp-production-and-2018-farm-bill-07252019 - What is Restless Legs Syndrome (RLS)?
https://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/restless-legs-syndrome/what-is-rls/# - Effects of restless legs syndrome (RLS) on sleep
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671944/ - Cannabinoids in the management of difficult to treat pain
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/ - Cannabis, Cannabinoids, and Sleep: a Review of the Literature
https://pubmed.ncbi.nlm.nih.gov/28349316/ - Effects of cannabidiol in the treatment of patients with Parkinson’s disease: an exploratory double-blind trial
https://pubmed.ncbi.nlm.nih.gov/25237116/ - Review of the neurological benefits of phytocannabinoids
https://pubmed.ncbi.nlm.nih.gov/29770251/ - Effects of cannabidiol in the treatment of patients with Parkinson’s disease: an exploratory double-blind trial
https://pubmed.ncbi.nlm.nih.gov/25237116/ - What is Restless Legs Syndrome (RLS)?
https://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/restless-legs-syndrome/what-is-rls/# - Restless legs syndrome
https://www.mayoclinic.org/diseases-conditions/restless-legs-syndrome/diagnosis-treatment/drc-20377174 - Cannabinoids in the management of difficult to treat pain
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/ - Cannabidiol (CBD) Critical Review Report.
https://www.who.int/medicines/access/controlled-substances/CannabidiolCriticalReview.pdf - Strategies for the Treatment of Restless Legs Syndrome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480566/ - CBD and other medications: Proceed with caution
https://www.health.harvard.edu/blog/cbd-and-other-medications-proceed-with-caution-2021011121743 - Restless legs syndrome (RLS)
https://my.clevelandclinic.org/health/diseases/9497-restless-legs-syndrome - ibid.
- Cannabidiol (CBD)-what we know and what we don’t
https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476 - Can You Take CBD and Pass a Drug Test?
https://www.consumerreports.org/cbd/can-you-take-cbd-and-pass-a-drug-test/ - Healing with CBD. page. 210.
https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view - Cannabis Use for Restless Legs Syndrome and Uremic Pruritus in in patients treated with maintenance dialysis: A Survey
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488602/ - Cannabidiol (CBD)
https://www.who.int/medicines/access/controlled-substances/CannabidiolCriticalReview.pdf
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