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Best CBD Oil for Trigeminal Neuralgia

Does the pain brought by trigeminal neuralgia bother you? Perhaps you want to consider using CBD oil to manage your symptoms and improve your quality of life.

Rating
Highlights

Editor's Choice

Spruce 750mg Lab Grade CBD Oil


4.8 out of 5
  1. Peppermint flavor masks any unpleasant taste
  2. Contains 25mg of CBD per dropper full
  3. Bottle includes a graduated dropper for correct serving measurement

Best CBD Purity

NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil


5.0 out of 5
  1. Natural remedy for various illnesses
  2. Product is full-spectrum whole-plant extract
  3. Contains naturally occurring synergistic cannabinoids and terpenes

Best High Potency

Spruce 2400mg Lab Grade CBD Oil


5.0 out of 5
  1. Maximum possible potency
  2. Each dropper full contains 80mg of CBD
  3. Conveniently fits in a 30mL bottle

Best Value

Avida Full Spectrum CBD Oil Tincture 500mg


4.6 out of 5
  1. Proprietary full-spectrum
  2. Developed using advanced AVIDA CORE Spectrum Technology
  3. Highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3)

Best Value

cbdMD CBD Oil Tincture Natural 1500mg


4.7 out of 5
  1. Made using only CBD sourced from medical hemp
  2. Available in many flavours
  3. Safe for daily use

Best THC Free

CBDistillery THC Free CBD Oil Tinctures


4.4 out of 5
  1. Do not contain THC
  2. Available in different potencies and sizes
  3. Brand has special deals and offers

Best Customer Rated

cbdMD CBD Oil Tincture Natural 750mg


4.4 out of 5
  1. THC-free
  2. Has plenty of flavours to choose from
  3. Totally vegan

Best For Beginners

NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil


4.6 out of 5
  1. Lowest concentration for CBD beginners
  2. Fully organic and lab-tested
  3. Full-spectrum

Best Flavor Range

Hemp Bombs 750mg CBD Oil


3.9 out of 5
  1. Has a wide range of flavours
  2. Safe to intake
  3. Get 20% off when you avail of their subscription

Compare the Best CBD Oil for Trigeminal Neuralgia in 2022

Product Potency Purity Customer Service Type Extraction Transparency Absorption
Spruce 2400mg Lab Grade CBD Oil
4.8 out of 5

4.5 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5
NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.0 out of 5

5.0 out of 5

5.0 out of 5
Spruce 2400mg Lab Grade CBD Oil
5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.0 out of 5

5.0 out of 5

5.0 out of 5
Avida Full Spectrum CBD Oil Tincture 500mg
4.6 out of 5

5.0 out of 5

3.5 out of 5

3.0 out of 5

5.0 out of 5

4.5 out of 5

4.5 out of 5

5.0 out of 5
cbdMD CBD Oil Tincture Natural 1500mg
4.7 out of 5

5.0 out of 5

3.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5
CBDistillery THC Free CBD Oil Tinctures
4.4 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.5 out of 5
cbdMD CBD Oil Tincture Natural 750mg
4.4 out of 5

4.5 out of 5

3.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5
NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
4.6 out of 5

2.5 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5
Hemp Bombs 750mg CBD Oil
3.9 out of 5

4.5 out of 5

3.5 out of 5

2.5 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5

Best CBD Oil for Trigeminal Neuralgia

1. Spruce 750mg Lab Grade CBD Oil
cbdc overall score
4.8
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Mid-strength  No other flavors
 Natural peppermint flavor
 Made from 100% organic and natural ingredients
Pros
 Mid-strength
 Natural peppermint flavor
 Made from 100% organic and natural ingredients
Cons
 No other flavors
Overview

Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
cbdc overall score
5.0
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Pure CBD hemp  No other flavors
 All natural
 Approximately 300 drops total
Pros
 Pure CBD hemp
 All natural
 Approximately 300 drops total
Cons
 No other flavors
Overview

Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

3. Spruce 2400mg Lab Grade CBD Oil
cbdc overall score
5.0
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Extra Strength  Tastes bitter
 No artificial flavoring or colors  No THC-free option
 Made from 100% organic and natural ingredients
Pros
 Extra Strength
 No artificial flavoring or colors
 Made from 100% organic and natural ingredients
Cons
 Tastes bitter
 No THC-free option
Overview

The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.

4. Avida Full Spectrum CBD Oil Tincture 500mg
cbdc overall score
4.6
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Light Spearmint flavor  No other flavor
 Non-THC, Non-detected in drug test
Pros
 Light Spearmint flavor
 Non-THC, Non-detected in drug test
Cons
 No other flavor
Overview

Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.

5. cbdMD CBD Oil Tincture Natural 1500mg
cbdc overall score
4.7
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Various delicious flavors to choose from  cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
 Has vegan, organic, and gluten-free ingredients
 Free shipping for this particular product within USA
 World-class customer service team
Pros
 Various delicious flavors to choose from
 Has vegan, organic, and gluten-free ingredients
 Free shipping for this particular product within USA
 World-class customer service team
Cons
 cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
Overview

cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

6. CBDistillery THC Free CBD Oil Tinctures
cbdc overall score
4.4
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 60-Day Satisfaction Guarantee  Dropper is a bit shaky
 Various strengths
 Oil extracted from aerial plant parts of US grown industrial hemp
 Sourced from non-GMO industrial hemp grown in the USA through natural farming practices
Pros
 60-Day Satisfaction Guarantee
 Various strengths
 Oil extracted from aerial plant parts of US grown industrial hemp
 Sourced from non-GMO industrial hemp grown in the USA through natural farming practices
Cons
 Dropper is a bit shaky
Overview

CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.

7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
cbdc overall score
4.6
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Pure CBD hemp  No other flavors
 All natural  A bit pricey compared to competitors
 Approximately 100 drops total
Pros
 Pure CBD hemp
 All natural
 Approximately 100 drops total
Cons
 No other flavors
 A bit pricey compared to competitors
Overview

This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.

8. cbdMD CBD Oil Tincture Natural 750mg
cbdc overall score
4.4
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Vegan and Gluten free  Does not ship internationally
 Has a third-party lab test
 Wide variety of CBD strengths and sizes
Pros
 Vegan and Gluten free
 Has a third-party lab test
 Wide variety of CBD strengths and sizes
Cons
 Does not ship internationally
Overview

A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.

9. Hemp Bombs 750mg CBD Oil
cbdc overall score
3.9
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Wide variety of flavors  Incomplete information about the product
 Lab test results are complete  Does not ship to all international countries
 30-day money-back guarantee
Pros
 Wide variety of flavors
 Lab test results are complete
 30-day money-back guarantee
Cons
 Incomplete information about the product
 Does not ship to all international countries
Overview

Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.

How CBD May Help With Trigeminal Neuralgia

TN (trigeminal neuralgia) is a medical condition characterized by chronic pain from the trigeminal nerve, which carries sensation from the face to the brain(1).

CBD’s activity in the ECS (endocannabinoid system) may explain how this non-psychoactive compound may help with chronic pain and conditions like trigeminal neuralgia

The ECS is vital to the CNS (central nervous system) and plays a role in regulating pain and inflammation(2)

The ECS consists of cannabinoid receptors type 1 and 2 (CB1 and CB2), endocannabinoids, and enzymes. 

Cannabinoids, like CBD and THC, may exert their antinociceptive properties through complex mechanisms involving effects on the CNS, spinal cord, and peripheral sensory nerves(3)

Antinociceptive agents are compounds that can diminish pain without adverse effects on consciousness. 

CB1 receptors play a key role in pain sensation(4). Meanwhile, recent studies suggest that CB2 receptors may be involved in the antihyperalgesic activity of cannabinoids in acute, chronic, and neuropathic pain(5)

Antihyperalgesic activity refers to the ability of certain compounds to counteract hyperalgesia or extreme sensitivity to pain. 

Although CBD has a low binding affinity for both cannabinoid receptors, it may antagonize them in the presence of THC(6)

The non-psychoactive compound may also regulate pain perception(7). Thus, CBD may help with painful conditions such as trigeminal neuralgia.    

Opioids are medications for persistent or severe pain. Despite their high potential for abuse, these prescription drugs are used mostly as an adjunct to anticonvulsants(8)

Opioids are also prevalent in patients with facial pain, including those who have TN(9)

However, opioid abuse has become a national crisis in the United States, in which 90 Americans die by overdose each day(10). For this reason, more studies are exploring the use of cannabis as a substitute for opioids(11)

Cannabis refers to a group of plants, such as Cannabis sativa, Cannabis indica, and Cannabis ruderalis. These plants have more than 100 chemical components known as cannabinoids. 

THC (tetrahydrocannabinol) and CBD (cannabidiol) are among the phytocannabinoids (plant-based cannabinoids) found in cannabis plants

THC is the principal psychoactive compound of cannabis. The compound is responsible for the euphoric high users’ experience. 

A study published in 2021 noted that, unlike opioids, cannabis has no reported deaths due to overdodse(12)

Meanwhile, CBD is non-psychoactive. Some studies also suggest that CBD may antagonize at least some of the adverse effects of THC(13)

The non-psychoactive compound has been of particular interest as a target for opioid use disorder(14)

In a survey in California, about 80% of patients who used medical cannabis either as a substitute or in conjunction with opioid-based pain medication claimed that cannabis is more effective than opioids for pain(15)

A study from the journal Neurology assessed the efficacy of medical cannabis in patients with trigeminal neuralgia(16)

Of the 42 patients with TN, 81% reported improvements in their symptoms, while 50% said they reduced their opioid consumption with medical cannabis(17)

The most efficacious dosage for the patients involved was a 1:1 ratio of THC to CBD(18).

Although CBD may not be a standalone treatment for chronic pain, it is believed that using CBD as an adjunct therapy may provide pain relief, reduce the amount of opioid medication a patient is taking, and improve the overall quality of life(19).

Benefits of Using CBD for Trigeminal Neuralgia

Cannabidiol has been shown to have anti-inflammatory and analgesic properties(20). These potential health benefits may help individuals with trigeminal neuralgia.

TN is inflammation of the trigeminal nerve, a large three-part nerve in the head that provides sensation. It is a form of neuropathic pain associated with nerve lesions or nerve injuries. 

It is believed that trigeminal nerve pain may be triggered by the contraction of blood vessels in the trigeminal nerve, damaging the trigeminal protective tissue(21)

For individuals with TN, even mild stimulation of their faces, such as putting on makeup or brushing their teeth, may trigger an excruciating pain similar to an electric shock(22).

A study from the European Journal of Pharmacology examined CBD’s efficacy in rat chronic inflammatory and neuropathic pain(23).  

The researchers administered 2.5-20 mg of CBD to neuropathic models and 20 mg of CBD to adjuvant-injected rats from days 7 to 14. 

An adjuvant is an ingredient that may help create a more robust immune response in individuals receiving vaccines. 

The findings indicated a potential for the therapeutic use of CBD in chronic painful states(24).  

It has been demonstrated that trigeminal neuralgia is common in patients with MS (multiple sclerosis), a disease that particularly affects the brain and spinal cord(25)

Pain is a common symptom in multiple sclerosis, and about 75% of MS patients experience it(26)

An elevated relative risk has also been associated with high blood pressure, particularly among women with trigeminal neuralgia(27)

Preclinical studies showed that CBD may reduce blood pressure response to stress(28)

These studies seem promising. However, they are either based on animal research or small clinical trials

Still, the findings may be useful to researchers conducting further studies on CBD’s efficacy in painful conditions, like trigeminal neuralgia

How to Take CBD for Trigeminal Neuralgia 

Below are standard delivery methods by which CBD is taken into the body(29):

  • Inhalation (vape pens)
  • Ingestion (edibles like gummies and capsules) 
  • Sublingual or under the tongue (tinctures, strips, tablets, and sprays)
  • Topical (CBD creams, salves, lotions, and balms) 

TN patients may initially experience mild attacks that can progress to more-frequent bouts of pain(30)

Inhaling CBD using vape pens is the quickest way to benefit from the compound. CBD usually takes effect within two to 15 minutes via the inhalation route(31-32). However, vaping may damage the lungs(33).  

Hence, talk with a healthcare professional experienced in cannabis use to determine which delivery route is best for trigeminal neuralgia or any health conditions.   

CBD Dosage

The FDA (Food and Drug Administration) has not approved CBD as a treatment for trigeminal neuralgia. Hence, there is no standard CBD dosage for such a condition. 

The general rule is to start with low doses. However, it is believed that mid-range doses between 10mg and 100mg of CBD daily may help with pain management(34)

Still, it is best to talk with a healthcare professional with a background in cannabis use and dosing. They can advise you regarding the proper CBD dosage for trigeminal neuralgia.  

How Long Does CBD Take to Help Trigeminal Neuralgia?

How long it takes for cannabidiol to help with TN depends on several factors like the route of administration used, individual body weight, and CBD potency.

If you choose to take CBD via the inhalation route, expect to feel CBD’s effect within two to 15 minutes(35). Meanwhile, when taken sublingually, the effects of CBD  take much longer, usually between 15 and 30 minutes(36)

How Long Will CBD Help With Trigeminal Neuralgia?

How long CBD will last after it takes effect depends on its half-life and bioavailability.

Half-life is the time needed for the concentration of a specific substance to decrease by 50% of its starting dose in the body. It is believed that 94% to 97% of a drug will have been eliminated following four to five half-lives(37)

The half-life of CBD was reported between 1.4 and 10.9 hours after oromucosal spray and 31 hours following smoking(38).  

Meanwhile, bioavailability is the extent to which a particular drug becomes entirely available to its biological destination. 

The bioavailability of CBD following smoking is 31%(39). The bioavailability of cannabidiol when taken under the tongue is between 6% and 20%(40)

Choosing the Best CBD Oil for Trigeminal Neuralgia

Most CBD companies are determined to provide high-quality CBD products like CBD oil for trigeminal neuralgia and overall wellness

With many CBD brands promising the same thing, choosing the right product for you can be challenging. 

Below are a few pertinent things to consider before buying any CBD product:  

CBD Extracts

A full-spectrum CBD oil includes all the compounds of the cannabis plant, including CBD and other cannabinoids, essential oils, terpenes, and flavonoids.

A full-spectrum CBD provides the entourage effect, the theory wherein the biologically active compounds of cannabis work better together. Its THC concentration is also less than 0.3%. 

Terpenes are aromatic compounds present in cannabis and many other plants. Flavonoids are plant chemicals with purported anti-inflammatory, antioxidant, and antiviral actions(41).  

A broad-spectrum CBD oil is almost the same as the full spectrum. However, it is nearly THC-free. Meanwhile, CBD isolates are made of pure CBD. 

Ingredients 

Check the ingredients to find out if there are any possible allergens or additives that may adversely affect you. 

Generally, CBD products are infused with carrier oils, including MCT (medium-chain triglycerides) oil, coconut oil, and hempseed oil. 

CBD Strength and Potency

The COA (certificate of analysis) is a document that indicates the amount of CBD, THC, and other ingredients in a CBD product

The CBD company you choose must enlist the services of a third-party laboratory to check all products, ensuring objectivity and transparency.

Extraction Method 

Carbon dioxide extraction, ethanol extraction, or solvent extraction with olive oil are preferred methods to create a safe CBD product(42)

On the other hand, extraction techniques using hexane or butane may leave harmful residues.

Brand Reputation 

Always purchase CBD products from a reputable store or dispensary authorized to sell CBD products

Read customer feedback to get more insight about the manufacturer and its products.  

The Potential Risks and Side Effects of Using CBD for Trigeminal Neuralgia

CBD is relatively safe and is well tolerated in humans and animals(43). Still, the compound may induce risks and minor side effects, including(44)

  • Dry mouth
  • Diarrhea
  • Reduced appetite
  • Drowsiness 
  • Fatigue 

The first-line treatment for trigeminal neuralgia is anticonvulsant medical therapy(45). However, these drugs, primarily used to treat epileptic seizures, may interact with CBD(46).

At high doses, CBD may inhibit the activity of cytochrome P450, a family of liver enzymes that metabolize about 60% of pharmaceutical drugs people consume(47)

Antiepileptics or anticonvulsants use the cytochrome P450 enzyme system, which explains their possible interaction with CBD(48)

Legality of CBD

The 2018 Farm Bill indicates that Cannabis sativa L. and other derivatives of cannabis with less than 0.3% THC on a dry weight basis are federally legal in the United States(49)

In addition, some states like Colorado have passed laws allowing recreational and medical marijuana use. Still, these state laws do not change the fact that marijuana is listed as a Schedule I drug under federal law(50-51)

Some states may even require a medical marijuana card to purchase cannabis products from authorized dispensaries. Therefore, make sure to research state legislations concerning cannabis use to avoid legal repercussions. 

Product Frequently
Asked Questions

  • How can CBD help with trigeminal neuralgia?

    There is no direct study suggesting that CBD can help with TN (trigeminal neuralgia). 

    However, CBD may be effective in different types of pain due to its analgesic properties(52). The non-psychoactive compound may also help with several neurological disorders(53).

    TN is a rare neurological condition that causes chronic and severe facial pain(54). A person with such a condition may feel burning sensations in the face. 

    As mentioned, CBD has pain-relieving effects(55). These properties may help with painful conditions like trigeminal neuralgia.

  • What evidence or research exists to say that CBD helps with trigeminal neuralgia?

    A 2019 study suggested that medical cannabis may be a valuable part of a comprehensive pain management plan for TN patients(56). Researchers reported that the 1:1 ratio of THC to CBD is the most effective dosage among these patients.  

    Although CBD may not be a standalone treatment for chronic pain caused by various medical conditions like TN, the compound may provide pain relief to people and therefore contribute to their improved quality of life(57).

  • Is there any evidence that CBD can make trigeminal neuralgia worse?

    No evidence suggests that CBD can make trigeminal neuralgia worse. However, CBD may still induce risks and side effects like fatigue(58).

  • Will CBD interact with any current medication I may be taking for trigeminal neuralgia?

    CBD may interact with other medications like anticonvulsants, which are first-line treatments for TN(59-60).  

    At high doses, CBD may inhibit the activity of cytochrome P450, a family of liver enzymes that metabolize about 60% of pharmaceutical drugs people consume(61)

    Antiepileptics or anticonvulsants use the cytochrome P450 enzyme system, which explains their possible interaction with CBD(62).

  • Are there other treatments I should consider alongside CBD to help with trigeminal neuralgia?

    Painkillers like paracetamol are ineffective in managing pain associated with TN. One type of pain relief medication prescribed to TN patients is an anticonvulsant(63)

    Muscle-relaxing agents may also be used to help with TN. However, their side effects include drowsiness, confusion, and nausea(64)

    Thus, ensure to talk with your doctor if you consider other treatments alongside CBD to help manage TN symptoms. 

  • Can I fail a drug test if I use CBD for trigeminal neuralgia?

    CBD does not cause euphoria(65). Still, some CBD products have small amounts of THC that may build up in the body when taken regularly in a span of four to six days(66)

    An increased THC level in the bloodstream may result in a positive drug test.  

  • What is the dosage for trigeminal neuralgia?

    There is no standard CBD dosage for TN. However, doses between 10mg and 100mg may help with pain management(67). TN is characterized by chronic pain(68)

  • How should I use CBD oil for trigeminal neuralgia?

    Inhaling CBD using vape pens usually takes effect within 2 to 15 minutes via the inhalation route(69). However, extra caution is needed as vaping may damage the lungs(70)

  • What are some side effects of CBD for trigeminal neuralgia?

    Generally, common CBD side effects include diarrhea and fatigue(71).


  1. Trigeminal Neuralgia
    https://www.mayoclinic.org/diseases-conditions/trigeminal-neuralgia/symptoms-causes/syc-20353344
  2. Understanding the Endocannabinoid System as a Modulator of the Trigeminal Pain Response to Concussion
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122691/
  3. The Endocannabinoid System as an Emerging Target of Pharmacotherapy
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241751/
  4. Cannabinoids and Pain: New Insights From Old Molecules
    https://www.frontiersin.org/articles/10.3389/fphar.2018.01259/full
  5. The Endocannabinoid System as an Emerging Target of Pharmacotherapy
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241751/
  6. Cannabinoids and Pain: New Insights From Old Molecules
    https://www.frontiersin.org/articles/10.3389/fphar.2018.01259/full
  7. Ibid.
  8. Patterns of Opioid Use in Patients With Trigeminal Neuralgia Undergoing Neurosurgery
    https://pubmed.ncbi.nlm.nih.gov/30641832/
  9. Ibid.
  10. Opioid Abuse
    https://www.asahq.org/madeforthismoment/pain-management/opioid-treatment/opioid-abuse/
  11. Exploring the Use of Cannabis as a Substitute for Prescription Drugs in a Convenience Sample
    https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-021-00520-5#:~:text=CaM%20is%20frequently%20used%20as,somatic%20and%20mental%20health%20conditions.
  12. Ibid.
  13. Does Cannabidiol Protect Against Adverse Psychological Effects of THC?
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797438/
  14. Exploring the Use of Cannabis as a Substitute for Prescription Drugs in a Convenience Sample
    https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-021-00520-5#:~:text=CaM%20is%20frequently%20used%20as,somatic%20and%20mental%20health%20conditions.
  15. Cannabis as a Substitute for Opioid-Based Pain Medication: Patient Self-Report
    https://www.liebertpub.com/doi/10.1089/can.2017.0012
  16. Medical Cannabis Treatment in Patients with Trigeminal Neuralgia
    https://n.neurology.org/content/92/15_Supplement/P5.10-020.abstract
  17. Ibid.
  18. Ibid.
  19. The Treatment and Management of Chronic Pain using CBD
    https://digitalcommons.murraystate.edu/cgi/viewcontent.cgi?article=1055&context=honorstheses
  20. Cannabinoids in the Management of Difficult to Treat Pain
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/
  21. Trigeminal Neuralgia Fact Sheet
    https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Trigeminal-Neuralgia-Fact-Sheet
  22. Trigeminal Neuralgia
    https://www.mayoclinic.org/diseases-conditions/trigeminal-neuralgia/symptoms-causes/syc-20353344
  23. The Non-psychoactive Cannabis Constituent Cannabidiol Is an Orally Effective Therapeutic Agent in Rat Chronic Inflammatory and Neuropathic Pain
    https://pubmed.ncbi.nlm.nih.gov/17157290/
  24. Ibid.
  25. Prevalence of Hypertension in Patients With Trigeminal Neuralgia
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3451988/pdf/10194_2009_Article_107.pdf
  26. Pain and Multiple Sclerosis: Pathophysiology and Treatment
    https://pubmed.ncbi.nlm.nih.gov/23250765/#:~:text=Pain%20is%20a%20common%20symptom,pain%20from%20various%20causes%20simultaneously.
  27. Prevalence of Hypertension in Patients With Trigeminal Neuralgia
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3451988/pdf/10194_2009_Article_107.pdf
  28. A Single Dose of Cannabidiol Reduces Blood Pressure in Healthy Volunteers in a Randomized Crossover Study
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470879/
  29. Healing With CBD, page 189.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/vie
  30. Trigeminal Neuralgia
    https://www.mayoclinic.org/diseases-conditions/trigeminal-neuralgia/symptoms-causes/syc-20353344
  31. How to Safely Use CBD: Should You Inhale, Spray, Apply, or Eat It?
    https://www.consumerreports.org/cbd/how-to-use-cbd-inhale-spray-apply-eat/
  32. Healing With CBD, page 190.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  33. Is It Safe to Vape CBD?
    https://www.consumerreports.org/cbd/is-it-safe-to-vape-cbd/
  34. CBD: A Patient’s Guide to Medicinal Cannabis, page 129.
    https://drive.google.com/file/d/1MILU_6ZjYkII-XMUPHLFPiPQbrz__5Sh/view
  35. Healing With CBD, page 190.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  36. Healing With CBD, page 192.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  37. Half-Life
    https://www.ncbi.nlm.nih.gov/books/NBK554498/
  38. A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans
    https://www.frontiersin.org/articles/10.3389/fphar.2018.01365/full
  39. Ibid.
  40. Healing With CBD, page 192.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  41. Flavonoids As Antioxidants
    https://pubmed.ncbi.nlm.nih.gov/10924197/
  42. Cannabidiol Primer for Healthcare Professionals
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340472/
  43. Cannabidiol (CBD)
    https://www.who.int/medicines/access/controlled-substances/CannabidiolCriticalReview.pdf
  44. What Are the Benefits of CBD — And Is It Safe to Use?
    https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/is-cbd-safe-and-effective/faq-20446700
  45. Trigeminal Neuralgia: Current Approaches and Emerging Interventions
    https://pubmed.ncbi.nlm.nih.gov/34764686/
  46. Healing With CBD, page 116.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  47. Healing With CBD, pages 114-116
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  48. Ibid.
  49. FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD)
    https://www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbd
  50. House Bill 21–1317
    https://leg.colorado.gov/sites/default/files/2021a_1317_signed.pdf
  51. The Federal Controlled Substances Act: Schedules and Pharmacy Registration
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839489/
  52. Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700528/#:~:text=In%20the%20majority%20of%20animal,THC%20%5B68%2C74%5D.
  53. Neurological Aspects of Medical Use of Cannabidiol
    https://pubmed.ncbi.nlm.nih.gov/28412918/
  54. Trigeminal Neuralgia
    https://www.yalemedicine.org/conditions/trigeminal-neuralgia
  55. Research Shows Pain-Relieving Effects of CBD
    https://www.sciencedaily.com/releases/2021/04/210423130221.htm
  56. Medical Cannabis Treatment in Patients with Trigeminal Neuralgia (P5.10-020)
    https://n.neurology.org/content/92/15_Supplement/P5.10-020.abstract
  57. The Treatment and Management of Chronic Pain using CBD
    https://digitalcommons.murraystate.edu/cgi/viewcontent.cgi?article=1055&context=honorstheses
  58. What Are the Benefits of CBD — And Is It Safe to Use?
    https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/is-cbd-safe-and-effective/faq-20446700
  59. Trigeminal Neuralgia: Current Approaches and Emerging Interventions
    https://pubmed.ncbi.nlm.nih.gov/34764686/
  60. Healing With CBD, page 116.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  61. Healing With CBD, pages 114-116
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  62. Ibid.
  63. Trigeminal Neuralgia
    https://www.nhs.uk/conditions/trigeminal-neuralgia/treatment/
  64. Trigeminal Neuralgia
    https://www.mayoclinic.org/diseases-conditions/trigeminal-neuralgia/diagnosis-treatment/drc-20353347
  65. Cannabidiol (CBD)-What We Know and What We Don’t
    https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476
  66. Can You Take CBD and Pass a Drug Test?
    https://www.consumerreports.org/cbd/can-you-take-cbd-and-pass-a-drug-test/
  67. CBD: A Patient’s Guide to Medicinal Cannabis, page 129.
    https://drive.google.com/file/d/1MILU_6ZjYkII-XMUPHLFPiPQbrz__5Sh/view
  68. Trigeminal Neuralgia
    https://www.mayoclinic.org/diseases-conditions/trigeminal-neuralgia/symptoms-causes/syc-20353344
  69. Healing With CBD, page 190.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  70. Is It Safe to Vape CBD?
    https://www.consumerreports.org/cbd/is-it-safe-to-vape-cbd/
  71. What Are the Benefits of CBD — And Is It Safe to Use?
    https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/is-cbd-safe-and-effective/faq-20446700
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