Best CBD Oil for TMJ Disorders

Finding it challenging to handle TMJ pain? Read on to determine how cannabidiol (CBD) products may help you manage and alleviate symptoms of temporomandibular joint (TMJ) disorder.

Rating
Highlights

Editor's Choice

Spruce 750mg Lab Grade CBD Oil

4.8 out of 5
  1. Peppermint flavor masks any unpleasant taste
  2. Contains 25mg of CBD per dropper full
  3. Bottle includes a graduated dropper for correct serving measurement

Best CBD Purity

NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil

5.0 out of 5
  1. Natural remedy for various illnesses
  2. Product is full-spectrum whole-plant extract
  3. Contains naturally occurring synergistic cannabinoids and terpenes

Best High Potency

Spruce 2400mg Lab Grade CBD Oil

5.0 out of 5
  1. Maximum possible potency
  2. Each dropper full contains 80mg of CBD
  3. Conveniently fits in a 30mL bottle

Best Value

Avida Full Spectrum CBD Oil Tincture 500mg

4.6 out of 5
  1. Proprietary full-spectrum
  2. Developed using advanced AVIDA CORE Spectrum Technology
  3. Highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3)

Best Value

cbdMD CBD Oil Tincture Natural 1500mg

4.7 out of 5
  1. Made using only CBD sourced from medical hemp
  2. Available in many flavours
  3. Safe for daily use

Best THC Free

CBDistillery THC Free CBD Oil Tinctures

4.4 out of 5
  1. Do not contain THC
  2. Available in different potencies and sizes
  3. Brand has special deals and offers

Best Customer Rated

cbdMD CBD Oil Tincture Natural 750mg

4.4 out of 5
  1. THC-free
  2. Has plenty of flavours to choose from
  3. Totally vegan

Best For Beginners

NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil

4.6 out of 5
  1. Lowest concentration for CBD beginners
  2. Fully organic and lab-tested
  3. Full-spectrum

Best Flavor Range

Hemp Bombs 750mg CBD Oil

3.9 out of 5
  1. Has a wide range of flavours
  2. Safe to intake
  3. Get 20% off when you avail of their subscription

Best Allergy Friendly

Royal CBD Full Spectrum CBD Oil

3.7 out of 5
  1. Has three flavors to choose from – Berry, Natural and Vanilla
  2. Vegan and Gluten-Free
  3. Superb customer service

Compare the Best CBD Oil for TMJ Disorders 2022

Product Potency Purity Customer Service Type Extraction Transparency Absorption
Spruce 2400mg Lab Grade CBD Oil
4.8 out of 5
4.5 out of 5
4.5 out of 5
5.0 out of 5
5.0 out of 5
4.5 out of 5
5.0 out of 5
5.0 out of 5
NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
5.0 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
4.0 out of 5
5.0 out of 5
5.0 out of 5
Spruce 2400mg Lab Grade CBD Oil
5.0 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
4.0 out of 5
5.0 out of 5
5.0 out of 5
Avida Full Spectrum CBD Oil Tincture 500mg
4.6 out of 5
5.0 out of 5
3.5 out of 5
3.0 out of 5
5.0 out of 5
4.5 out of 5
4.5 out of 5
5.0 out of 5
cbdMD CBD Oil Tincture Natural 1500mg
4.7 out of 5
5.0 out of 5
3.5 out of 5
5.0 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
4.0 out of 5
CBDistillery THC Free CBD Oil Tinctures
4.4 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
4.5 out of 5
cbdMD CBD Oil Tincture Natural 750mg
4.4 out of 5
4.5 out of 5
3.5 out of 5
5.0 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
4.0 out of 5
NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
4.6 out of 5
2.5 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
4.5 out of 5
5.0 out of 5
5.0 out of 5
Hemp Bombs 750mg CBD Oil
3.9 out of 5
4.5 out of 5
3.5 out of 5
2.5 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
4.0 out of 5
Royal CBD Full Spectrum CBD Oil
3.7 out of 5
2.5 out of 5
3.5 out of 5
5.0 out of 5
5.0 out of 5
4.0 out of 5
1.0 out of 5
5.0 out of 5

Best CBD Oil for TMJ Disorders

1. Spruce 750mg Lab Grade CBD Oil
cbdc overall score

4.8

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Mid-strength

No other flavors

Natural peppermint flavor

Made from 100% organic and natural ingredients

Overview

Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
cbdc overall score

5.0

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Pure CBD hemp

No other flavors

All natural

Approximately 300 drops total

Overview

Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

3. Spruce 2400mg Lab Grade CBD Oil
cbdc overall score

5.0

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Extra Strength

Tastes bitter

No artificial flavoring or colors

No THC-free option

Made from 100% organic and natural ingredients

Overview

The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.

4. Avida Full Spectrum CBD Oil Tincture 500mg
cbdc overall score

4.6

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Light Spearmint flavor

No other flavor

Non-THC, Non-detected in drug test

Overview

Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.

5. cbdMD CBD Oil Tincture Natural 1500mg
cbdc overall score

4.7

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Various delicious flavors to choose from

cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options

Has vegan, organic, and gluten-free ingredients

Free shipping for this particular product within USA

World-class customer service team

Overview

cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

6. CBDistillery THC Free CBD Oil Tinctures
cbdc overall score

4.4

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

60-Day Satisfaction Guarantee

Dropper is a bit shaky

Various strengths

Oil extracted from aerial plant parts of US grown industrial hemp

Sourced from non-GMO industrial hemp grown in the USA through natural farming practices

Overview

CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.

7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
cbdc overall score

4.6

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Pure CBD hemp

No other flavors

All natural

A bit pricey compared to competitors

Approximately 100 drops total

Overview

This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.

8. cbdMD CBD Oil Tincture Natural 750mg
cbdc overall score

4.4

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Vegan and Gluten free

Does not ship internationally

Has a third-party lab test

Wide variety of CBD strengths and sizes

Overview

A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.

9. Hemp Bombs 750mg CBD Oil
cbdc overall score

3.9

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Wide variety of flavors

Incomplete information about the product

Lab test results are complete

Does not ship to all international countries

30-day money-back guarantee

Overview

Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.

10. Royal CBD Full Spectrum CBD Oil
cbdc overall score

3.7

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Rich in phytochemicals including CBD, CBC, CBG, and a variety of flavorful terpenes

Shipping not specified on website

More flavors to choose from

3rd party lab result is currently not available on website

Extracts contain a whole array of cannabinoids and terpenes from the hemp plant — rather than pure CBD isolate

Overview

Excellent products and superb customer service. Whenever you want to ask them about the dosage, recommended consumption methods, or which CBD oil will work best for you, just give them a call, send them a message, or get in touch with their social media channels. They won’t leave you with any unanswered questions.

How CBD May Help With TMJ Disorder 

A 2019 study hypothesized that CBD may help improve the myofascial pain experienced by individuals with temporomandibular joint disorders (TMD)(1).

Myofascial pain syndrome (MPS), a chronic pain disorder, affects the muscles and fascia (casing of connective tissue).

Research has shown that cannabinoids from the Cannabis sativa plant may help relieve chronic pain(2). TMJ disorders may include facial, jaw, and temporomandibular joint pain(3)

The endocannabinoid system (ECS) maintains a critical role in regulating different types of pain(4). Signaling of the ECS’ cannabinoid receptors is involved in nociceptive pain processing. Nociceptive pain is attributed to body tissue damage.

Cannabidiol is one of the naturally occurring plant-based phytocannabinoids of Cannabis sativa. Unlike the psychoactive component of cannabis plants, tetrahydrocannabinol (THC), CBD works as a non-psychoactive cannabinoid

Research suggests that CBD as an oral cannabis extract (OCE) may lower the painful spasms and spasticity of multiple sclerosis (MS) patients within one year of therapy(5)

The OCE used in the study includes CBD and THC. Spasticity is abnormal muscle tightness. 

MS is a potentially disabling disease involving the brain and central nervous system (CNS). The condition may cause muscle stiffness and spasm. Research suggests that MS may be a potential etiological factor in TMDs(6).   

The ECS has two primary receptors, cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2), that communicate with cannabinoids to produce potential therapeutic effects.

CB1 receptors are common in the CNS and peripheral nervous system (PNS), while CB2 receptors exist primarily in the immune cells. 

A study published in Current Neuropharmacology noted that cannabinoid receptor agonists may have therapeutic benefits against inflammatory and neuropathic pains(7). The researchers investigated chronic and acute pain management.  

Despite THC’s higher affinity with CB1 receptors due to its potential euphoric effects, it is limited to medical marijuana use(8)

However, CBD may modulate ion channels and the body’s non-cannabinoid receptors(9). Some CBD derivatives seem to sustain their antinociceptive and anti-inflammatory properties without affecting the CNS(10).  

Additionally, CBD was reported to inhibit inflammation and peripheral pain responses after binding with cannabinoid receptors(11)

The antihyperalgesic effects of cannabidiol are mediated by the transient receptor potential vanilloid 1 (TRPV-1) receptor(12).

Research suggests that low-dose CBD physiologically desensitizes or inhibits neuronal TRPV-1 signaling(13). This result may induce pain relief due to TRPV-1’s purported role in pain sensation(14).

Studies have shown that topical CBD may help decrease inflammation and pain in animal models(15). However, additional research is warranted, including clinical trials and studies involving human subjects

Potential Benefits and Uses of CBD for TMJ Disorders

TMD symptoms may include muscle stiffness, painful grating or clicking of the jaw joint when opening and closing the mouth, radiating pain in the lower jaw, neck, or face, and locking or limited movement of the jaw(16).

Meanwhile, research has shown that CBD may have anti-inflammatory(17), pain-relieving(18), and neuroprotective properties(19).    

CBD’s potential for chronic pain-relieving therapeutics has spurred interest in researchers(20)

A 2020 study suggested that cannabidiol may have therapeutic effects in some forms of epilepsy(21). Dislocation of the TMJ is a potential indicator of epilepsy(22).   

CBD may also have analgesic effects in certain conditions(23). Based on research on CBD’s potential benefits in chronic pain treatment, the researchers connected CBD’s anti-inflammatory and analgesic effects to its interaction with the HT1A serotonin receptors.

Furthermore, a clinical report noted that hemp-derived CBD may provide significant pain-relieving benefits for patients with chronic back pain(24)

Results of the medical study indicated that CBD is a promising compound in sports due to its purported anti-inflammatory, analgesic, neuroprotective, and anxiolytic properties(25)

In addition, research on patients with MS reported that a THC: CBD combination relieved spasticity-related symptoms such as spasms, muscle tension, and sleep quality(26). A 56.7% prevalence of TMDs in MS patients has been reported(27).  

A review examined CBD as a potential alternative pain-relieving therapeutic option(28). Researchers reported that intramuscular injection of CBD or cannabinol (CBN) decreased mechanical sensitization and increased the threshold of masseter muscle receptors.  

Still, additional research is needed to investigate whether CBD induces similar therapeutic effects in TMD patients. 

How to Take CBD for TMJ Disorders

No Food and Drug Administration (FDA)-approved method exists to suggest the best way to take CBD oil for TMJ disorders. However, researchers have used various CBD applications to treat TMD, including topical(29) and transdermal(30)

Transdermal 

A 2019 study published in the Journal of Clinical Medicine compared various methods of CBD application suggested that the transdermal method is practical for reducing inflammation and pain symptoms of TMD(31)

The transdermal application, such as CBD patches, utilizes the skin dermis to deliver cannabidiol into the bloodstream.

Sublingual 

CBD oils in tincture form are administered under the tongue and absorbed through membranes in the gums and cheeks.  

Edibles

Cannabidiol edibles include CBD gummies, CBD brownies, and CBD cookies. 

Topicals

CBD topicals, including CBD creams, lotions, balms, and salves, are designed for more targeted relief. CBD topicals may provide localized relief of TMD symptoms, including areas such as the ears and jaw. 

Regardless of how you opt to take CBD, it is advisable to consult your doctor to help prevent unwanted side effects and drug interactions. 

Ideal CBD Dosage for TMJ Disorders

In a CBD dosage review, researchers reported that 15 milligrams of CBD per kilogram of body weight (mg/kg) per day were well tolerated and reduced the severity and frequency of seizures(32).  

It is advisable to start taking cannabidiol at low doses and gradually increase the intake until achieving the desired therapeutic effects(33)

Before continuing your intake of CBD, observe any possible side effects. Discuss with your doctor or other health and wellness professional after detecting adverse effects.  

How Long CBD May Take to Help With TMJ Disorders

CBD’s efficacy duration may differ based on the administration method used. 

Sublingual CBD may induce biological effects within 15 to 30 minutes after administration(34).

CBD topicals such as CBD lotions, creams, balms, and salves may induce localized effects within 10 minutes(35).  

The transdermal administration of drugs avoids the gastrointestinal tract(36). Thus, the body may absorb CBD faster than other methods. 

Some individuals prefer vaping or CBD inhalation due to its rapid onset time as fast as under one minute(37)

This method’s fast absorption rate is due to CBD’s direct absorption through the lungs and bloodstream(38). However, inhaling vapor or smoke may also cause allergic reactions or chemical irritation(39).  

No FDA-approved guidelines indicate the onset time to experience CBD’s therapeutic effects on TMD. 

How Long CBD May Help With TMJ Disorders 

The efficacy duration of CBD for TMD may differ based on the delivery method used.  

A review in the Frontiers in Pharmacology journal determined that the half-life of CBD was two to five days after individuals took a daily oral dose(40)

Half-life is defined as how much time is required for a substance’s amount to reduce to half of its original value(41).

Meanwhile, past human and animal studies reported that the bioavailability of cannabidiol ranges from 13% to 19%(42).  

 

Bioavailability is known as the rate and degree to which an active drug ingredient is absorbed by the body and becomes available at the location of drug action(43).

CBD Risks and Side Effects: Is CBD Safe to Use for TMJ Disorders? 

The World Health Organization (WHO) deduced that CBD has a generally safe profile(44)

Epidiolex, which treats two rare forms of epilepsy, is the only FDA-approved prescription drug containing CBD(45). The CBD-based drug treats Dravet syndrome and Lennox-Gastaut syndrome(46).

Still, you should consider risk factors when using CBD for TMJ disorders(47)

CBD may interact with other medications processed in the liver(48). Cannabidiol may incur alterations through enzymes that may increase or decrease the particular drug’s effects. 

The drug-to-drug interaction may lead to particular medications becoming a less effective treatment or an increased risk of side effects(49).

These CBD side effects may include(50):

  • Dry mouth
  • Reduced appetite
  • Diarrhea
  • Fatigue
  • Drowsiness
  • Weight changes

Taking CBD alongside prescription medicines with similar side effects may increase the risk of unwanted symptoms or anxiety(51).

It is advisable to deliberate with your doctor before taking CBD to avoid adverse drug interactions(52)

How to Choose the Best CBD Oil for TMJ Disorders

CBD products are regulated by state. Still, you should do your research to find high-quality CBD brands and products.   

The Journal of the American Medical Association (JAMA) published a study revealing discrepancies in the ingredients listed for CBD online products and products’ actual constituents(53). Thus, consumers should be careful when choosing which CBD products to buy.

Consider these issues to help find the best CBD oil for TMJ disorders:

Type of CBD Extract 

The three primary types of CBD oil extracts available on the market include:

  • Full-spectrum CBD oil
  • Broad-spectrum CBD oil
  • CBD isolates 

Each extract is differentiated depending on the THC content. 

Full-spectrum CBD oil or whole-plant extract contains all active compounds of the cannabis plant, including cannabinoids, terpenes, and flavonoids. 

Cannabinoids are cannabis-derived compounds. Terpenes are aromatic compounds, while flavonoids are plant metabolites.   

Full-spectrum products, including full-spectrum CBD oil, may induce a beneficial synergetic effect or the “entourage effect”(54). The entourage effect is the interaction of cannabis-derived constituents to cause greater therapeutic effects.

Meanwhile, broad-spectrum CBD oil contains numerous cannabis-derived compounds, although typically THC-free.

CBD isolates are pure CBD and typically only contain cannabidiol molecules. These CBD products are usually available in slabs or powder form.  

Source of CBD Extract

Information on the source of CBD extracts ensures that a CBD brand or company adheres to standard farming protocols.  

States like Colorado, Kentucky, and North Carolina adhere to the hemp pilot program established by the United States Department of Agriculture (USDA)(55)

The USDA’s hemp pilot program regulates the states’ hemp farming plans and protocols(56). Organic hemp is typically free of genetically modified organisms (non-GMO). 

Extraction Method

When looking for CBD products, consider the extraction method or how manufacturers obtain the extracts. 

The CO2 extraction method is a commonly used technique. CO2 extraction uses carbon dioxide to separate plant-based components, producing pure and safer products.   

Certificate of Analysis from Third-Party Labs

The certificate of analysis (COA) indicates all of the laboratory tests conducted to verify CBD products’ content, potency, and purity. CBD potency indicates the amount of cannabidiol per serving. 

The COA also shows tests on the possible contaminants, pesticides, heavy metals, and toxic chemicals in a product. 

Ingredients 

The ingredients list provides information on constituents like additives that may induce allergic reactions and adverse effects. 

Carrier oils like hempseed oil may complement cannabidiol’s health benefits

Legality of CBD

Over two-thirds of US states and the District of Columbia (DC) have legalized the use of cannabis through medical marijuana(57). Other U.S. states have legalized the use of cannabidiol, although restrictions may apply.   

The 2018 Farm Bill categorized hemp-derived CBD products as federally legal if they have 0.3% or lower THC content(58)

Some states have also passed specific laws regarding the production and marketing of CBD products.

Product Frequently
Asked Questions

  • How may CBD help with TMJ disorders?

    TMJ disorders may induce muscle and joint pain(59). Due to its purported benefits, CBD may act on the vanilloid receptor (TRPV-1 receptor), responsible for inflammation and pain perception(60)

    While CBD may thus provide pain relief for people with TMDs, more research is warranted.   

  • What evidence exists that CBD may help with TMJ disorders?

    A 2019 study reported improvements in myofascial pain of patients with TMJ disorders following CBD intake(61)

    Researchers have also hypothesized that peripheral CBD administration may provide analgesic relief for chronic pain disorders such as TMDs(62).  

  • Can CBD make TMJ disorders worse?

    Symptoms of TMD include chronic fatigue syndrome(63). Meanwhile, side effects of CBD may include drowsiness and fatigue(64).      

    Thus, CBD may worsen some TMJ symptoms. However,  more research is needed.  

  • Will CBD interact with any current medication I may be taking for TMJ disorders?

    CBD may produce adverse effects with particular medications(65). Consult your physician before commencing any CBD products for TMJ if you take over-the-counter (OTC) or prescription medications and painkillers(66).

    TMD symptoms may be treated using OTC medicines, such as nonsteroidal anti-inflammatory drugs (NSAIDs), or prescription medicines, including anti-inflammatory medications and muscle relaxants(67).

  • Are there other treatments I should consider alongside CBD to help with TMJ disorders?

    Some non-drug treatment options that may help relieve TMD symptoms include oral splints, mouth guards, or physical therapy(68)

    However, you should consult your doctor regarding such therapies and whether you can consider them alongside CBD.

  • Can I fail a drug test if I use CBD for TMJ disorders?

    CBD alone may not induce a positive drug test. However, the buildup of trace amounts of THC may produce a positive drug test result over time(69)

  • What is the proper CBD dosage for TMJ disorders?

    Consider starting with low doses and then gradually increasing the dosage if you observe no adverse effects. In a CBD dosage review, 15mg of CBD per kilogram of weight per day was reported to be well tolerated(70)

  • How safe is CBD oil for TMJ disorders?

    The World Health Organization (WHO) reported that CBD has a generally safe profile(71). However, it may induce mild side effects, including dry mouth, fatigue, and reduced appetite(72).  

  • Can I legally purchase CBD for TMJ disorders online?

    Many CBD products sold online are sourced from hemp, not marijuana(73). The hemp source is critically related to the legality of buying CBD products online. On the federal level, these products must contain not more than 0.3% THC concentration(74)

  • Can I apply CBD for TMJ disorders to my jaw?

    While CBD topicals are generally well tolerated, skincare products may cause side effects, including irritation or rashes(75). 

    Consulting with your physician before applying CBD topicals to jaw muscles is advisable.  

    Other CBD administration methods include sublingual, edibles, topicals, and transdermals.


  1. Myorelaxant Effect of Transdermal Cannabidiol Application in Patients with TMD: A Randomized, Double-Blind Trial
    https://pubmed.ncbi.nlm.nih.gov/31698733/
  2. The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research
    https://www.ncbi.nlm.nih.gov/books/NBK425767/
  3. TMJ disorders
    https://www.mayoclinic.org/diseases-conditions/tmj/symptoms-causes/syc-20350941
  4. The Role of the Endocannabinoid System in Pain
    https://doi.org/10.1007/978-3-662-46450-2_7
  5. Systematic review: efficacy and safety of medical marijuana in selected neurologic disorders: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology
    https://n.neurology.org/content/82/17/1556.long
  6. Oral health status and temporomandibular disorders in multiple sclerosis patient
    https://pubmed.ncbi.nlm.nih.gov/16417141/
  7. Role of the cannabinoid system in pain control and therapeutic implications for the management of acute and chronic pain episodes
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430692/
  8. Cannabis and Cannabinoid Biology in Stroke
    https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.118.023587
  9. How CBD works
    https://www.projectcbd.org/science/how-cbd-works
  10. Cannabidiol analogues which bind cannabinoid receptors but exert peripheral activity only
    https://pubmed.ncbi.nlm.nih.gov/15588739/
  11. Role of the cannabinoid system in pain control and therapeutic implications for the management of acute and chronic pain episodes
    https://doi.org/10.2174/157015906778019527
  12. Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the non-psychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1575333/
  13. CBD Effects on TRPV1 Signaling Pathways in Cultured DRG Neurons
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494392/
  14. Desensitization of transient receptor potential vanilloid type-1 (TRPV1) channel as promising therapy of irritable bowel syndrome: characterization of the action of palvanil in the mouse gastrointestinal tract
    https://pubmed.ncbi.nlm.nih.gov/32002574/
  15. Efficacy of topical interventions for temporomandibular disorders compared to placebo or control therapy: a systematic review with meta-analysis
    https://doi.org/10.17245/jdapm.2020.20.6.337
  16. TMJ (Temporomandibular Joint & Muscle Disorders)
    https://www.nidcr.nih.gov/health-info/tmj/more-info#treatment
  17. Antioxidative and Anti-Inflammatory Properties of Cannabidiol
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023045/
  18. A Balanced Approach for Cannabidiol Use in Chronic Pain
    https://www.frontiersin.org/articles/10.3389/fphar.2020.00561/full
  19. Cannabidiol in sport: Ergogenic or else?
    https://www.sciencedirect.com/science/article/pii/S1043661819326143?casa_token=nYGIZH_muzsAAAAA:N7FSG-B-xp2FqzrctyssCx_9cJBLlceMOoWELsBNPCIa6mvJDabVgNun4EhT3F0kJJQT6xbXuN1m
  20. Cannabinoids in the management of difficult to treat pain
    https://doi.org/10.2147/tcrm.s1928
  21. A Balanced Approach for Cannabidiol Use in Chronic Pain
    https://www.frontiersin.org/articles/10.3389/fphar.2020.00561/full
  22. Dislocation of the Unilateral Temporomandibular Joint a Very Rare Presentation of Epilepsy
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137815/
  23. A Balanced Approach for Cannabidiol Use in Chronic Pain
    https://www.frontiersin.org/articles/10.3389/fphar.2020.00561/full
  24. Cannabidiol (CBD) as a treatment of acute and chronic back pain: A case series and literature review
    https://www.researchgate.net/profile/Jonathan-Eskander/publication/341491070_Cannabidiol_CBD_as_a_treatment_of_acute_and_chronic_back_pain_A_case_series_and_literature_review/links/5f6c0a28299bf1b53eedc4e3/Cannabidiol-CBD-as-a-treatment-of-acute-and-chronic-back-pain-A-case-series-and-literature-review.pdf
  25. Ibid.
  26. Tetrahydrocannabinol:Cannabidiol Oromucosal Spray for Multiple Sclerosis-Related Resistant Spasticity in Daily Practice
    https://www.karger.com/Article/Abstract/449413
  27. Prevalence of temporomandibular disorders symptoms in patients with multiple sclerosis
    https://pubmed.ncbi.nlm.nih.gov/24964107/
  28. Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700528/
  29. Efficacy of topical interventions for temporomandibular disorders compared to placebo or control therapy: a systematic review with meta-analysis
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783375/
  30. Myorelaxant Effect of Transdermal Cannabidiol Application in Patients with TMD: A Randomized, Double-Blind Trial
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912397/
  31. Ibid.
  32. A systematic review of cannabidiol dosing in clinical populations
    https://doi.org/10.1111/bcp.14038
  33. Should You Take CBD for Pain?
    https://healthblog.uofmhealth.org/health-management/should-you-take-cbd-for-pain
  34. Using CBD for Arthritis: Tips for How to Get Started
    https://creakyjoints.org/alternative-medicine/how-to-take-cbd-for-arthritis/
  35. Ibid.
  36. Transcutaneous Drug Delivery: A Practical Review
    https://www.mayoclinicproceedings.org/article/S0025-6196(11)64318-8/fulltext
  37. How to Safely Use CBD: Should You Inhale, Spray, Apply, or Eat It?
    https://www.consumerreports.org/cbd/how-to-use-cbd-inhale-spray-apply-eat/
  38. Is it safe to vape CBD?
    https://www.consumerreports.org/cbd/is-it-safe-to-vape-cbd/
  39. Can vaping damage your lungs? What we do (and don’t) know
    https://www.health.harvard.edu/blog/can-vaping-damage-your-lungs-what-we-do-and-dont-know-2019090417734
  40. A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275223/
  41. What is meant by half-life?
    https://atomic.lindahall.org/what-is-meant-by-half-life.html
  42. A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275223/
  43. Bioavailability and Bioequivalence in Drug Development
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157693/
  44. Cannabidiol (CBD) critical review report
    https://www.who.int/medicines/access/controlled-substances/CannabidiolCriticalReview.pdf
  45. FDA Approves First Drug Comprised of an Active Ingredient Derived from Marijuana to Treat Rare, Severe Forms of Epilepsy
    https://www.fda.gov/news-events/press-announcements/fda-approves-first-drug-comprised-active-ingredient-derived-marijuana-treat-rare-severe-forms
  46. FDA Approves New Indication for Drug Containing an Active Ingredient Derived from Cannabis to Treat Seizures in Rare Genetic Disease
    https://www.fda.gov/news-events/press-announcements/fda-approves-new-indication-drug-containing-active-ingredient-derived-cannabis-treat-seizures-rare
  47. What are the benefits of CBD — and is it safe to use?
    https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/is-cbd-safe-and-effective/faq-20446700
  48. CBD and other medications: Proceed with caution
    https://www.health.harvard.edu/blog/cbd-and-other-medications-proceed-with-caution-2021011121743
  49. Ibid.
  50. What are the benefits of CBD — and is it safe to use?
    https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/is-cbd-safe-and-effective/faq-20446700
  51. CBD and other medications: Proceed with caution
    https://www.health.harvard.edu/blog/cbd-and-other-medications-proceed-with-caution-2021011121743
  52. Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/
  53. Labeling Accuracy of Cannabidiol Extracts Sold Online
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818782/
  54. The “Entourage Effect”: Terpenes Coupled with Cannabinoids for the Treatment of Mood Disorders and Anxiety Disorders
    https://doi.org/10.2174/1570159X17666190903103923
  55. State Industrial Hemp Statutes https://www.ncsl.org/research/agriculture-and-rural-development/state-industrial-hemp-statutes.aspx
  56. Hemp
    https://www.usda.gov/topics/hemp
  57. States with Legal Cannabidiol (CBD).
    https://medicalmarijuana.procon.org/states-with-legal-cannabidiol-cbd/
  58. FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD)
    https://www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbd
  59. TMJ disorders
    https://www.mayoclinic.org/diseases-conditions/tmj/symptoms-causes/syc-20350941
  60. Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1575333/
  61. Myorelaxant Effect of Transdermal Cannabidiol Application in Patients with TMD: A Randomized, Double-Blind Trial
    https://doi.org/10.3390/jcm8111886
  62. Cannabidiol, cannabinol and their combinations act as peripheral analgesics in a rat model of myofascial pain
    https://www.sciencedirect.com/science/article/pii/S0003996919302249?casa_token=s9I19qiUxboAAAAA:-v3mXb1XmG-O9Y5y0ZksLlZZ3JCPk1vGQnf_1BAjfdbE8bpIF0PCohVrqB4nSeuQFUKcwWcvrw4l
  63. TMJ Disorders
    https://www.nidcr.nih.gov/sites/default/files/2017-12/tmj-disorders.pdf
  64. What are the benefits of CBD — and is it safe to use?
    https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/is-cbd-safe-and-effective/faq-20446700
  65. Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use
    https://pubmed.ncbi.nlm.nih.gov/31288397/
  66. CBD and other medications: Proceed with caution
    https://www.health.harvard.edu/blog/cbd-and-other-medications-proceed-with-caution-2021011121743
  67. Treatments-Medications
    https://tmj.org/living-with-tmj/treatments/medications/
  68. TMJ Disorders
    https://www.mayoclinic.org/diseases-conditions/tmj/diagnosis-treatment/drc-20350945
  69. Can You Take CBD and Pass a Drug Test?
    https://www.consumerreports.org/cbd/can-you-take-cbd-and-pass-a-drug-test/
  70. A systematic review of cannabidiol dosing in clinical populations.
    https://doi.org/10.1111/bcp.14038
  71. Cannabidiol (CBD) critical review report
    https://www.who.int/medicines/access/controlled-substances/CannabidiolCriticalReview.pdf
  72. What are the benefits of CBD — and is it safe to use?
    https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/is-cbd-safe-and-effective/faq-20446700
  73. How to shop for CBD
    https://www.consumerreports.org/cbd/how-to-shop-for-cbd/
  74. FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD)
    https://www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbd
  75. Should I Use CBD Products on My Skin?
    https://www.cedars-sinai.org/blog/cbd-beauty-products.html

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