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Best CBD Oil for GERD

Are you seeking an alternative treatment to help relieve chest pain, food regurgitation, and other GERD-related symptoms? CBD Clinicals lists some of the best CBD oil products for GERD to help you decide which CBD oil product is right for you.

Rating
Highlights

Editor's Choice

Spruce 750mg Lab Grade CBD Oil


4.8 out of 5
  1. Peppermint flavor masks any unpleasant taste
  2. Contains 25mg of CBD per dropper full
  3. Bottle includes a graduated dropper for correct serving measurement

Best CBD Purity

NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil


5.0 out of 5
  1. Natural remedy for various illnesses
  2. Product is full-spectrum whole-plant extract
  3. Contains naturally occurring synergistic cannabinoids and terpenes

Best High Potency

Spruce 2400mg Lab Grade CBD Oil


5.0 out of 5
  1. Maximum possible potency
  2. Each dropper full contains 80mg of CBD
  3. Conveniently fits in a 30mL bottle

Best Value

Avida Full Spectrum CBD Oil Tincture 500mg


4.6 out of 5
  1. Proprietary full-spectrum
  2. Developed using advanced AVIDA CORE Spectrum Technology
  3. Highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3)

Best Value

cbdMD CBD Oil Tincture Natural 1500mg


4.7 out of 5
  1. Made using only CBD sourced from medical hemp
  2. Available in many flavours
  3. Safe for daily use

Best THC Free

CBDistillery THC Free CBD Oil Tinctures


4.4 out of 5
  1. Do not contain THC
  2. Available in different potencies and sizes
  3. Brand has special deals and offers

Best Customer Rated

cbdMD CBD Oil Tincture Natural 750mg


4.4 out of 5
  1. THC-free
  2. Has plenty of flavours to choose from
  3. Totally vegan

Best For Beginners

NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil


4.6 out of 5
  1. Lowest concentration for CBD beginners
  2. Fully organic and lab-tested
  3. Full-spectrum

Best Flavor Range

Hemp Bombs 750mg CBD Oil


3.9 out of 5
  1. Has a wide range of flavours
  2. Safe to intake
  3. Get 20% off when you avail of their subscription

Compare the Best CBD Oil for GERD in 2022

Product Potency Purity Customer Service Type Extraction Transparency Absorption
Spruce 2400mg Lab Grade CBD Oil
4.8 out of 5

4.5 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5
NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.0 out of 5

5.0 out of 5

5.0 out of 5
Spruce 2400mg Lab Grade CBD Oil
5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.0 out of 5

5.0 out of 5

5.0 out of 5
Avida Full Spectrum CBD Oil Tincture 500mg
4.6 out of 5

5.0 out of 5

3.5 out of 5

3.0 out of 5

5.0 out of 5

4.5 out of 5

4.5 out of 5

5.0 out of 5
cbdMD CBD Oil Tincture Natural 1500mg
4.7 out of 5

5.0 out of 5

3.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5
CBDistillery THC Free CBD Oil Tinctures
4.4 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.5 out of 5
cbdMD CBD Oil Tincture Natural 750mg
4.4 out of 5

4.5 out of 5

3.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5
NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
4.6 out of 5

2.5 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5
Hemp Bombs 750mg CBD Oil
3.9 out of 5

4.5 out of 5

3.5 out of 5

2.5 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5

Best CBD Oil for GERD

1. Spruce 750mg Lab Grade CBD Oil
cbdc overall score
4.8
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Mid-strength  No other flavors
 Natural peppermint flavor
 Made from 100% organic and natural ingredients
Pros
 Mid-strength
 Natural peppermint flavor
 Made from 100% organic and natural ingredients
Cons
 No other flavors
Overview

Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
cbdc overall score
5.0
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Pure CBD hemp  No other flavors
 All natural
 Approximately 300 drops total
Pros
 Pure CBD hemp
 All natural
 Approximately 300 drops total
Cons
 No other flavors
Overview

Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

3. Spruce 2400mg Lab Grade CBD Oil
cbdc overall score
5.0
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Extra Strength  Tastes bitter
 No artificial flavoring or colors  No THC-free option
 Made from 100% organic and natural ingredients
Pros
 Extra Strength
 No artificial flavoring or colors
 Made from 100% organic and natural ingredients
Cons
 Tastes bitter
 No THC-free option
Overview

The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.

4. Avida Full Spectrum CBD Oil Tincture 500mg
cbdc overall score
4.6
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Light Spearmint flavor  No other flavor
 Non-THC, Non-detected in drug test
Pros
 Light Spearmint flavor
 Non-THC, Non-detected in drug test
Cons
 No other flavor
Overview

Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.

5. cbdMD CBD Oil Tincture Natural 1500mg
cbdc overall score
4.7
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Various delicious flavors to choose from  cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
 Has vegan, organic, and gluten-free ingredients
 Free shipping for this particular product within USA
 World-class customer service team
Pros
 Various delicious flavors to choose from
 Has vegan, organic, and gluten-free ingredients
 Free shipping for this particular product within USA
 World-class customer service team
Cons
 cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
Overview

cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

6. CBDistillery THC Free CBD Oil Tinctures
cbdc overall score
4.4
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 60-Day Satisfaction Guarantee  Dropper is a bit shaky
 Various strengths
 Oil extracted from aerial plant parts of US grown industrial hemp
 Sourced from non-GMO industrial hemp grown in the USA through natural farming practices
Pros
 60-Day Satisfaction Guarantee
 Various strengths
 Oil extracted from aerial plant parts of US grown industrial hemp
 Sourced from non-GMO industrial hemp grown in the USA through natural farming practices
Cons
 Dropper is a bit shaky
Overview

CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.

7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
cbdc overall score
4.6
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Pure CBD hemp  No other flavors
 All natural  A bit pricey compared to competitors
 Approximately 100 drops total
Pros
 Pure CBD hemp
 All natural
 Approximately 100 drops total
Cons
 No other flavors
 A bit pricey compared to competitors
Overview

This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.

8. cbdMD CBD Oil Tincture Natural 750mg
cbdc overall score
4.4
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Vegan and Gluten free  Does not ship internationally
 Has a third-party lab test
 Wide variety of CBD strengths and sizes
Pros
 Vegan and Gluten free
 Has a third-party lab test
 Wide variety of CBD strengths and sizes
Cons
 Does not ship internationally
Overview

A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.

9. Hemp Bombs 750mg CBD Oil
cbdc overall score
3.9
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Wide variety of flavors  Incomplete information about the product
 Lab test results are complete  Does not ship to all international countries
 30-day money-back guarantee
Pros
 Wide variety of flavors
 Lab test results are complete
 30-day money-back guarantee
Cons
 Incomplete information about the product
 Does not ship to all international countries
Overview

Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.

How CBD May Help With GERD

GERD (gastroesophageal reflux disease) is a chronic type of acid reflux(1). It occurs when stomach acid frequently flows back into the tube connecting the mouth and stomach.

The most common symptoms of GERD include food regurgitation, heartburn, chest pain, difficulty swallowing, sore throat, hoarseness, and vomiting.

Cannabidiol, commonly referred to as CBD, is a cannabinoid found in the cannabis plant with potential analgesic and anti-inflammatory effects(2)

CBD, found mostly in hemp plants, is non-psychoactive. On the other hand, the primary psychoactive constituent of cannabis (sometimes called marijuana) is THC

THC (tetrahydrocannabinol) is responsible for the euphoric effect that users experience(3)

There is insufficient direct research on CBD’s efficacy for GERD. However, the purported therapeutic benefits of cannabidiol and its activity on the endocannabinoid system may explain how CBD may help with GERD.  

A study from the Cannabis and Cannabinoid Research journal examined the role of cannabinoids like CBD and THC on esophageal function(4).

The ECS (endocannabinoid system) consists of cannabinoid receptors (CB1 and CB2 receptors), enzymes, and endogenous ligands, which are naturally occurring small molecules(5)

The major endogenous ligands, AEA (anandamide) and 2-AG (2-arachidonoylglycerol) exert effects on the cannabinoid receptors and maintain gastrointestinal homeostasis(6)

GI homeostasis refers to the dynamic balance between the host, gastrointestinal tract, nutrition, and energy metabolism(7)

Like endogenous ligands, plant-based cannabinoids like CBD and THC may also be involved in the direct activation of cannabinoid receptors(8).  

CB1 receptors play a vital part in pain sensation, while CB2 receptors stimulate a response that fights inflammation(9)

The presence of cannabinoid receptors in the esophagus, specifically those affecting TLESRs (transient lower esophageal sphincter), offers a potential therapeutic target for treating GERD(10)

TLESRs are the principal mechanism seen in GERD(11). TLESRs occur after gastric stimuli relieve counteracting gastric pressure on the LES (lower esophageal sphincter).

LES is a ring-shaped muscle at the opening of the lower esophagus.   

The primary activity of the esophagus is to carry food and liquid from the mouth to the stomach(12)

If LES weakens or relaxes abnormally, gastric acid can flow back up into the esophagus. The continual backwash of acid can irritate the lining of the esophagus, causing it to become inflamed(13)

An animal study from the Gastroenterology journal suggested that the administration of CB1 agonists may reduce the rate of TLESRs without altering esophageal peristalsis(14)

Esophageal peristalsis is a sequential muscle contraction that moves food through the digestive tract. 

Cannabidiol has little binding affinity for CB1 and CB2 receptors. However, CBD may antagonize them in the presence of THC(15).

Cannabidiol behaves as a non-competitive negative allosteric modulator of CB1 receptors by decreasing the agonist affinity and efficacy(16). THC may act as a partial agonist at cannabinoid receptors

Additionally, it is believed that cannabinoid receptor agonists may inhibit gastric emptying and gastrointestinal motility in humans(17)

Gastrointestinal motility is the movement of food from the mouth through the throat (pharynx), esophagus, stomach, intestines, and out of the body(18). The gastrointestinal system is responsible for digestion. 

Evidence suggests that CBD may offset the psychiatric side effect of THC(19)

Scientists from the University of Western Ontario hypothesized that CBD may block the ability of THC to overstimulate the ERK (extracellular-signal-regulated kinase) pathway in the hippocampus to prevent THC’s adverse side effects(20).  

  ERK plays a significant role in numerous cellular processes, including cell proliferation, migration, differentiation, adhesion, and survival(21).  

Benefits of Using CBD for GERD

Heartburn is an acid reflux symptom(22). It is a painful burning sensation in the middle of the chest triggered by irritation to the lining of the esophagus.

An individual with GERD may experience persistent heartburn that occurs two or more times a week(23). About 20% of the U.S. population has GERD(24)

According to the American Academy of Allergy Asthma and Immunology, individuals with asthma are at higher risk of developing GERD(25)

Asthma flare-ups may cause the LES to relax, allowing stomach content to reflux into the esophagus(26)

A 2019 research study from the European Journal of Pharmacology indicated that CBD may decrease airway inflammation and fibrosis in experimental allergic asthma(27)

Fibrosis refers to scarring or thickening of the tissue. 

A 2021 animal study from the Journal of Dental Research examined how cannabidiol may promote oral ulcer healing(28)

The researchers hypothesized that CBD oral spray on acid or trauma-induced oral ulcers on mice tongues may inhibit inflammation, relieve pain, and accelerate lesion closure(29)

The reflux of gastric acids and stomach content into the esophagus that occurs with GERD can erode the esophagus lining and cause ulcers(30)

People with GERD may experience difficulty swallowing or dysphagia(31). Dysphagia can be very painful. If it becomes persistent, it can signify a severe medical condition that requires treatment(32)

Researchers from Tel Aviv University believe that cannabis may stimulate brain regions associated with swallowing reflexes(33). Cannabis refers to all products that come from the plant Cannabis sativa(34)

In some cases, GERD patients experience disrupted sleep(35)

A 2019 retrospective case series published in The Permanente Journal reported that 48 out of 72 adult participants had an improved sleep score after CBD treatment within the first month of the study(36).

Esophageal mucosal damage in GERD patients may lead to progressive deterioration of esophageal function and worsen esophageal acid exposure(37)

A study from the Journal of Clinical Biochemistry and Nutrition mentioned that the development of new therapy with antioxidant and anti-inflammatory properties is expected to assist in treating GERD(38)

CBD is known to have antioxidative and anti-inflammatory effects(39). These properties may be useful to individuals with GERD.

Meanwhile, a study from the World Journal of Gastroenterology indicated that mental health issues like anxiety and depression may reduce the quality of life of GERD patients(40)

Evidence suggests that CBD may exhibit an anti-anxiety and antidepressant effect in animal models(41). These findings suggest CBD may help with GERD

While these studies may be promising, they are still inconclusive. In addition, most of the experiments were conducted on animal models.

Still, the results may be useful in future research involving human subjects. For this reason, direct research examining the benefits of CBD for GERD is warranted. 

How to Take CBD Oil for GERD

There are many ways you can try to take CBD oil for GERD. The different routes of administration by which CBD is brought into the body include:

  • Inhalation
  • Sublingual (under the tongue) absorption
  • Topical absorption
  • Transdermal (active ingredient delivered across the skin) 

CBD products are available in edibles like gummies, tinctures, vapes, and topicals. 

A 2021 study from the Journal of Cannabis Research reported that 54% of CBD users, focusing on self-perceived stress, anxiety, and sleep problems, stated that they use less than 50mg of CBD daily(42). About 72.6% of CBD users said they take CBD sublingually 

Evidence suggests that anxiety and depression may be higher in GERD patients, especially those who experience chest pain(43)

Hence, GERD patients experiencing mental health issues who want to try CBD may find the sublingual method particularly helpful. 

The sublingual route relies on the mucous membrane under the tongue to absorb CBD(44). Capillaries in the connective tissue diffuse the compound, which enters the bloodstream.   

The sublingual method is also a fast-acting solution, with a 15 to 30-minute onset and a fourto six-hour duration(45)

CBD Dosage for GERD

The FDA (Food and Drug Administration) does not recognize CBD as a medical treatment for GERD. Hence, there is no standard CBD dosage for the condition. 

However, doses between 10mg and 100mg of CBD per day may be effective for pain, inflammation, depression, and anxiety(46)

Still, it is best to talk with a healthcare professional experienced in cannabis use if you are considering CBD oil for acid reflux and GERD. These experts can help you with dosing and advise you on possible side effects

How Long Does CBD Take to Help GERD?

How long CBD takes to help with GERD depends on factors like body weight, the method of administration, and CBD potency. 

Taking CBD using vape pens is the quickest way to benefit from the effect of cannabidiol(47). However, vaping may damage your lungs(48)

In addition, if you have asthma and want to try CBD for GERD, it is recommended that you take another route of administration.

 Acid reflux can worsen asthma symptoms because it can irritate the airways and lungs(49). This irritation can also cause allergic reactions, making the airways more sensitive to cold air or smoke. 

Meanwhile, taking CBD sublingually ensures prompt compound delivery into one’s system(50). You may feel the effect of CBD within 15 to 30 minutes(51)

How Long Will CBD Help With GERD?

Bioavailability is the extent to which a particular substance becomes entirely available to its intended biological destination(52).  

The bioavailability of cannabidiol varies by route of administration. 

For instance, the bioavailability of sublingual CBD is between 13% and 19%(53). Meanwhile, inhaled routes have the highest bioavailability, from 17 to 44%(54-55)

Oral routes have the lowest bioavailability due to first-pass metabolism(56)

First-pass metabolism is a metabolic process by which active compounds enter the gastrointestinal system and are metabolized by the liver before becoming available in the bloodstream(57)

The bioavailability of CBD via the ingestion route is between 6% and 15%(58)

How to Choose the Best CBD Oil Product for GERD

Choosing the best CBD oil product for GERD depends on several factors, like the severity of the medical condition and personal preferences. 

Listed below are factors to consider when choosing the right CBD oil product for GERD

CBD Extracts 

CBD extracts can be categorized as(59).

  • Full-spectrum CBD
  • Broad-spectrum CBD
  • CBD isolates  

A full-spectrum CBD product contains all compounds of the cannabis plant, including CBD and other cannabinoids, terpenes, flavonoids, and essential oils. Full-spectrum CBD products have less than 0.3% THC

Terpenes are natural oils that give cannabis its aroma, color, and flavor(60)

Meanwhile, flavonoids are active compounds found in cannabis. Flavonoids contribute to cannabis’ pigmentation, aroma, and flavor via synergistic relationships with other active compounds like terpenes(61).  

Broad-spectrum CBD contains all compounds of the cannabis plant. However, it is nearly THC-free(62). Lastly, CBD isolates are made of pure CBD. 

CBD Extraction Methods 

Cannabis plant extraction methods such as carbon dioxide extraction, ethanol extraction, or solvent extraction with olive oil are preferred when creating a safe CBD product(63)

Meanwhile, extraction techniques using hexane or butane may leave harmful residues(64)

Lab Test Results 

The CBD company you choose must enlist the services of a third-party laboratory to test all its products for consistency and potency. 

COAs (certificates of analysis), which determine whether a particular product contains contaminants, are also necessary. 

The Potential Side Effects and Risks of Using CBD for GERD

CBD is generally well tolerated in both humans and animals. It also has a good safety profile(65)

However, CBD carries some risks and minor side effects, including(66)

  • Dry mouth
  • Diarrhea
  • Reduced appetite
  • Drowsiness
  • Fatigue 

CBD may also interact with medications, such as proton pump inhibitors that can block acid production and heal the esophagus(67)

Proton pump inhibitors are drugs that use the cytochrome P450(68). Cytochrome P450 is a family of liver enzymes that metabolize approximately 60% of the pharmaceutical drugs people consume. 

At high doses, CBD may inhibit the activity of these enzymes, increasing the duration and effect of prescription medications metabolized(69).

 However, note that every individual has a unique endocannabinoid system. Since each substance seems to have a distinctive threshold for CBD sensitivity, there is no standard cut-off dose to avoid such interaction.

Individuals need to work with a healthcare professional to monitor the blood levels of their medications while taking CBD oil or other CBD products for GERD

Common over-the-counter medications for GERD include lansoprazole and omeprazole(70). These drugs are an example of proton pump inhibitors that may interact with CBD. 

Legality of CBD

The 2018 Farm Bill states that Cannabis sativa L. and other derivatives of cannabis with less than 0.3% THC content on a dry weight basis are considered legal under federal law(71)

High-quality CBD products are available in most parts of the U.S.A. Still, the legality of CBD depends on the level of restrictions implemented by each state.

Colorado is one of the states allowing recreational and medical marijuana use. The Centennial State decriminalized the use of marijuana by passing Amendment 64 to the Colorado Constitution in November 2012(72)

Although Colorado and some other states have passed laws regarding recreational and medical marijuana, these state laws do not change the fact that marijuana is still listed as a Schedule 1 drug(73)

Substances listed in the Schedule 1 drug category have high abuse potential(74). Under federal law, Schedule 1 drugs like marijuana may not be prescribed, administered, or dispensed. 

Rules and regulations regarding medical cannabis may be confusing. Hence, consumers must research and familiarize themselves with various state laws to avoid legal repercussions. 

Product Frequently
Asked Questions

  • How can CBD help with GERD?

    No direct study shows that CBD can help with GERD. However, CBD has purported health benefits, such as pain-relieving properties(75). These properties may help people with GERD who suffer from heartburn.   

    Heartburn, a painful sensation in the middle of the chest usually intensified by spicy foods, may worsen at night(76-77). It is believed that CBD may also help with sleep(78)

  • What evidence or research exists to say that CBD helps with GERD?

    No specific research exists to say that CBD helps with GERD

    However, individuals with asthma are at a higher risk of developing GERD(79). Asthma flare-ups can cause the LES (lower esophageal sphincter) to relax, allowing gastric acid to flow back into the esophagus.

    Researchers suggest that CBD may help reduce airway inflammation in experimental allergic asthma(80). Hence, CBD may help asthma sufferers with GERD

    Still, longitudinal human studies are warranted to determine whether CBD can be an effective treatment for GERD.

  • Is there any evidence that CBD can make GERD worse?

    There is no evidence suggesting that CBD can make GERD worse. However, inhaling CBD via vape pens may damage the lungs(81). Asthmatic individuals suffering from GERD should avoid this route of administration.  

    Acid reflux can worsen asthma symptoms because it can irritate the airways and lungs(82). This irritation can also trigger allergic reactions, making the airways more sensitive to smoke.

  • Will CBD interact with any current medication I may be taking for GERD?

    CBD may interact with proton pump inhibitors. Proton pump inhibitors can heal the esophagus and block gastric acid production(83).

  • Are there other treatments I should consider alongside CBD to help with GERD?

    Dietary supplementation with melatonin may inhibit gastric acid secretion and nitric oxide biosynthesis(84). Nitric oxide may play a crucial role in the transient lower esophageal sphincter relaxation, a major cause of reflux in GERD patients

    However, ensure to ask your healthcare provider if you are considering other treatments alongside CBD to help with GERD. They can advise you regarding possible drug interactions.

  • Can I fail a drug test if I use CBD for GERD?

    Some CBD products have traces of THC that may build up in your body when you take them frequently(85). An increased THC level in the bloodstream may result in a positive drug test. 

  • What is the dosage for GERD?

    There is no standard CBD dosage for GERD because the FDA has not approved CBD as a medical treatment for such a condition. 

    Doses between 10mg and 100mg may help with pain and inflammation(86). These doses may help with symptoms of GERD like chest pain.

  • Is CBD Safe For GERD?

    Generally, CBD is safe and well tolerated(87).

  • What are the potential side effects of CBD oil for GERD?

    CBD may carry minor side effects like diarrhea and fatigue(88).


  1. GERD (Chronic Acid Reflux)
    https://my.clevelandclinic.org/health/diseases/17019-gerd-or-acid-reflux-or-heartburn-overview
  2. Cannabidiol and Other Non-Psychoactive Cannabinoids for Prevention and Treatment of Gastrointestinal Disorders: Useful Nutraceuticals?
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246936/
  3. Immune Responses Regulated by Cannabidiol
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173676/
  4. Review: The Role of Cannabinoids on Esophageal Function—What We Know Thus Far
    https://www.liebertpub.com/doi/10.1089/can.2017.0031
  5. Ibid.
  6. Ibid.
  7. Maintenance of Gastrointestinal Glucose Homeostasis by the Gut-Brain Axis
    https://pubmed.ncbi.nlm.nih.gov/27356933/
  8. Review: The Role of Cannabinoids on Esophageal Function—What We Know Thus Far
    https://www.liebertpub.com/doi/10.1089/can.2017.0031
  9. Cannabinoids and Pain: New Insights From Old Molecules
    https://www.frontiersin.org/articles/10.3389/fphar.2018.01259/full
  10. Review: The Role of Cannabinoids on Esophageal Function—What We Know Thus Far
    https://www.liebertpub.com/doi/10.1089/can.2017.0031
  11. Ibid.
  12. Esophagus
    https://my.clevelandclinic.org/health/body/21728-esophagus#:~:text=What%20does%20the%20esophagus%20do,to%20your%20throat%20(pharynx).
  13. Gastroesophageal Reflux Disease (Gerd)
    https://www.mayoclinic.org/diseases-conditions/gerd/symptoms-causes/syc-20361940#:~:text=Acid%20reflux%20occurs%20when%20the,gastroesophageal%20reflux%20disease%20(GERD).
  14. Cannabinoid Receptor Agonism Inhibits Transient Lower Esophageal Sphincter Relaxations and Reflux in Dogs
    https://www.gastrojournal.org/article/S0016-5085(02)00218-4/fulltext?referrer=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F
  15. Cannabinoids and Pain: New Insights From Old Molecules
    https://www.frontiersin.org/articles/10.3389/fphar.2018.01259/full#:~:text=CBD%20has%20little%20binding%20affinity,et%20al.%2C%202015).
  16. Ibid.
  17. Role of Cannabinoid Receptors in the Control of Gastrointestinal Motility and Perception
    https://pubmed.ncbi.nlm.nih.gov/19072387/
  18. Motility and Physiology
    https://health.ucsd.edu/specialties/gastro/areas-expertise/motility-physiology/pages/default.aspx#:~:text=Gastrointestinal%20(GI)%20motility%20refers%20to,body%20starts%20this%20complicated%20process.
  19. Cannabis Study Reveals How CBD Offsets the Psychiatric Side-Effects of THC
    https://www.sciencedaily.com/releases/2019/09/190930131115.htm
  20. Ibid.
  21. ERK1 and ERK2 Map Kinases: Specific Roles or Functional Redundancy?
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897767/
  22. GERD (Chronic Acid Reflux)
    https://my.clevelandclinic.org/health/diseases/17019-gerd-or-acid-reflux-or-heartburn-overview
  23. Acid reflux and GERD: The same thing?
    https://www.mayoclinic.org/diseases-conditions/heartburn/expert-answers/heartburn-gerd/faq-20057894
  24. GERD (Chronic Acid Reflux)
    https://my.clevelandclinic.org/health/diseases/17019-gerd-or-acid-reflux-or-heartburn-overview
  25. Gastroesophageal Reflux Disease
    https://www.aaaai.org/Conditions-Treatments/related-conditions/gastroesophageal-reflux-disease
  26. Ibid.
  27. Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma
    https://pubmed.ncbi.nlm.nih.gov/30481497/
  28. CBD Promotes Oral Ulcer Healing via Inhibiting CMPK2-Mediated Inflammasome
    https://pubmed.ncbi.nlm.nih.gov/34269108/
  29. Ibid.
  30. GERD: Esophageal Erosion and Ulcers
    https://www.uofmhealth.org/health-library/rt1441#:~:text=The%20backup%2C%20or%20reflux%2C%20of,juices%20reflux%20into%20the%20esophagus.
  31. GERD (Chronic Acid Reflux)
    https://my.clevelandclinic.org/health/diseases/17019-gerd-or-acid-reflux-or-heartburn-overview
  32. Dysphagia
    https://www.mayoclinic.org/diseases-conditions/dysphagia/symptoms-causes/syc-20372028
  33. Medical Cannabis Provides Dramatic Relief for Sufferers of Chronic Ailments, Israeli Study Finds
    https://www.sciencedaily.com/releases/2013/01/130124123453.htm
  34. Cannabis (Marijuana) and Cannabinoids: What You Need To Know
    https://www.nccih.nih.gov/health/cannabis-marijuana-and-cannabinoids-what-you-need-to-know
  35. Sleep & GERD
    https://aboutgerd.org/signs-and-symptoms/sleep-gerd/#:~:text=GERD%20has%20been%20shown%20to,which%20results%20in%20sleep%20fragmentation.
  36. Cannabidiol in Anxiety and Sleep: A Large Case Series
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326553/
  37. Esophageal Mucosal Damage May Promote Dysmotility and Worsen Esophageal Acid Exposure
    https://pubmed.ncbi.nlm.nih.gov/16332488/
  38. Inflammation and Oxidative Stress in Gastroesophageal Reflux Disease
    https://www.jstage.jst.go.jp/article/jcbn/40/1/40_1_13/_article
  39. Antioxidative and Anti-Inflammatory Properties of Cannabidiol
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023045/
  40. Anxiety and Depression in Patients With Gastroesophageal Reflux Disease and Their Effect on Quality of Life
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394093/
  41. Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis sativa
    https://pubmed.ncbi.nlm.nih.gov/24923339/
  42. Reasons for Cannabidiol Use: A Cross-Sectional Study of CBD Users, Focusing on Self-Perceived Stress, Anxiety, and Sleep Problems
    https://jcannabisresearch.biomedcentral.com/articles/10.1186/s42238-021-00061-5
  43. Depression and Anxiety in Patients with Gastroesophageal Reflux Disorder With and Without Chest Pain
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858267/
  44. Healing With CBD, page 207.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  45. Ibid.
  46. CBD: A Patient’s Guide to Medicinal Cannabis, page 129.
    https://drive.google.com/file/d/1MILU_6ZjYkII-XMUPHLFPiPQbrz__5Sh/view
  47. How to Safely Use CBD: Should You Inhale, Spray, Apply, or Eat It?
    https://www.consumerreports.org/cbd/how-to-use-cbd-inhale-spray-apply-eat/
  48. Is It Safe to Vape CBD?
    https://www.consumerreports.org/cbd/is-it-safe-to-vape-cbd/
  49. Gastroesophageal Reflux Disease
    https://www.aaaai.org/Conditions-Treatments/related-conditions/gastroesophageal-reflux-disease
  50. Healing With CBD, page 207.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  51. Ibid.
  52. Drug Bioavailability
    https://www.ncbi.nlm.nih.gov/books/NBK557852/
  53. Reasons for Cannabidiol Use: A Cross-Sectional Study of CBD Users, Focusing on Self-Perceived Stress, Anxiety, and Sleep Problems
    https://jcannabisresearch.biomedcentral.com/articles/10.1186/s42238-021-00061-5
  54. Ibid.
  55. Healing With CBD, page 190.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  56. Reasons for Cannabidiol Use: A Cross-Sectional Study of CBD Users, Focusing on Self-Perceived Stress, Anxiety, and Sleep Problems
    https://jcannabisresearch.biomedcentral.com/articles/10.1186/s42238-021-00061-5
  57. Healing With CBD, pages 281-282.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  58. Healing With CBD, page 191.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  59. Cannabidiol Primer for Healthcare Professionals
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340472/
  60. Healing With CBD, page. 94.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  61. Healing With CBD, page 282.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  62. Cannabidiol Primer for Healthcare Professionals
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340472/
  63. Ibid.
  64. Ibid.
  65. Cannabidiol (CBD)
    https://www.who.int/medicines/access/controlled-substances/CannabidiolCriticalReview.pdf
  66. What Are the Benefits of CBD — And Is It Safe to Use?
    https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/is-cbd-safe-and-effective/faq-20446700#:~:text=CBD%20use%20also%20carries%20some,taking%2C%20such%20as%20blood%20thinners.
  67. Healing With CBD, pages 115-116.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  68. Ibid.
  69. Healing With CBD, page 114.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  70. Gastroesophageal Reflux Disease (Gerd)
    https://www.mayoclinic.org/diseases-conditions/gerd/diagnosis-treatment/drc-20361959
  71. FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD)
    https://www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbd
  72. Legal Marijuana Use in Colorado
    https://cannabis.colorado.gov/legal-marijuana-use-in-colorado
  73. The Federal Controlled Substances Act: Schedules and Pharmacy Registration
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839489/#:~:text=The%20Federal%20Comprehensive%20Drug%20Abuse,effective%20on%20May%201%2C%201971.&text=The%20goal%20of%20the%20Controlled,and%20dispensing%20of%20controlled%20substances.
  74. Ibid.
  75. Research Shows Pain-Relieving Effects of CBD
    https://www.sciencedaily.com/releases/2021/04/210423130221.htm
  76. Gastroesophageal Reflux Disease (GERD)
    https://www.mayoclinic.org/diseases-conditions/gerd/symptoms-causes/syc-20361940
  77. What to Eat When You Have Chronic Heartburn
    https://www.health.harvard.edu/diseases-and-conditions/what-to-eat-when-you-have-chronic-heartburn
  78. Cannabidiol (CBD)-What We Know and What We Don’t
    https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476
  79. Gastroesophageal Reflux Disease
    https://www.aaaai.org/Conditions-Treatments/related-conditions/gastroesophageal-reflux-disease
  80. Cannabidiol Reduces Airway Inflammation and Fibrosis in Experimental Allergic Asthma
    https://pubmed.ncbi.nlm.nih.gov/30481497/
  81. Is It Safe to Vape CBD?
    https://www.consumerreports.org/cbd/is-it-safe-to-vape-cbd/
  82. Gastroesophageal Reflux Disease
    https://www.aaaai.org/Conditions-Treatments/related-conditions/gastroesophageal-reflux-disease
  83. Healing With CBD, pages 115-116.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  84. Regression of Gastroesophageal Reflux Disease Symptoms Using Dietary Supplementation With Melatonin, Vitamins and Aminoacids: Comparison With Omeprazole
    https://pubmed.ncbi.nlm.nih.gov/16948779/
  85. Can You Take CBD and Pass a Drug Test?
    https://www.consumerreports.org/cbd/can-you-take-cbd-and-pass-a-drug-test/
  86. CBD: A Patient’s Guide to Medicinal Cannabis, page 129.
    https://drive.google.com/file/d/1MILU_6ZjYkII-XMUPHLFPiPQbrz__5Sh/view
  87. Cannabidiol (CBD)
    https://www.who.int/medicines/access/controlled-substances/CannabidiolCriticalReview.pdf
  88. What Are the Benefits of CBD — And Is It Safe to Use?
    https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/is-cbd-safe-and-effective/faq-20446700#:~:text=CBD%20use%20also%20carries%20some,taking%2C%20such%20as%20blood%20thinners.
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