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2. Malcom K. (2019, Oct 30). Should You Take CBD for Pain? Retrieved from https://healthblog.uofmhealth.org/health-management/should-you-take-cbd-for-pain.
3. Xiong W, Cui T, Cheng K, et al. Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. J Exp Med. 2012;209(6):1121–1134. DOI:10.1084/jem.20120242.
4. EMJ. (2017, Aug). Review of the 3rd European Academy of Neurology Congress 2017. EMJ Neurol. 2017;5[1]:12-29. Congress Review. Retrieved from https://www.emjreviews.com/neurology/congress-review/review-of-the-3rd-european-academy-of-neurology-congress-2017/.
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6. Malcom K. op. cit.
7. Russo EB. op. cit.
8. Grinspoon, P. (2019, Aug 27). Cannabidiol (CBD) — what we know and what we don’t. Retrieved from https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476.
9. The Pain Center. (April 2017). Why Do We Feel Pain?. Retrieved from: https://www.thepaincenter.com/news/why-do-we-feel-pain
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17. ibid.
18. Philpott HT, OʼBrien M, McDougall JJ. Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. Pain. 2017;158(12):2442–2451. DOI:10.1097/j.pain.0000000000001052.
19. Cleveland Clinic. (2019, Dec 16). Retrieved from https://my.clevelandclinic.org/health/diseases/14737-neuropathy.
20. Arthritis Foundation. Osteoarthritis. Retrieved from https://www.arthritis.org/diseases/osteoarthritis.
21. Xiong W, Cui T, Cheng K, et al. op cit.
22. NINDS. (2018, Aug). Peripheral Neuropathy Fact Sheet. Retrieved from https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Peripheral-Neuropathy-Fact-Sheet.
23. Perez J. Combined cannabinoid therapy via an oromucosal spray. Drugs Today (Barc) 2006;42:495–503.
24. Mücke M, Phillips T, Radbruch L, Petzke F, Häuser W. Cannabis-based medicines for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2018;3(3):CD012182. Published 2018 Mar 7. DOI:10.1002/14651858.CD012182.pub2.
25. Baron EP. Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science. Headache. 2018;58(7):1139–1186. DOI:10.1111/head.13345.
26. EMJ. op. cit.
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29. Johnson JR, Burnell-Nugent M, Lossignol D, Ganae-Motan ED, Potts R, Fallon MT. Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain. J Pain Symptom Manage. 2010;39(2):167–179. DOI:10.1016/j.jpainsymman.2009.06.008.
30. CDC.gov. Opioid Overdose. Retrieved from: https://www.cdc.gov/drugoverdose/data/index.html
31. Corroon, J., & Phillips, J. A. (2018). A cross-sectional study of cannabidiol users. Cannabis and cannabinoid research, 3(1), 152-161.
32. Reggio PH. Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown. Curr Med Chem. 2010;17(14):1468–1486. DOI:10.2174/092986710790980005.
33. Ledent C, Valverde O, Cossu G, Petitet F, Aubert JF, Beslot F, et al. Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science. 1999;283:401–4. https://doi.org/10.1126/science.283.5400.401.
34. Gallily, R., Yekhtin, Z., & Hanuš, L. O. (2015). Overcoming the bell-shaped dose-response of cannabidiol by using cannabis extract enriched in cannabidiol. Pharmacology & Pharmacy, 6(02), 75.
35. Taskar, P., Adelli, G., Patil, A., Lakhani, P., Ashour, E., Gul, W., … & Majumdar, S. (2019). Analog derivatization of cannabidiol for improved ocular permeation. Journal of Ocular Pharmacology and Therapeutics, 35(5), 301-310.
36. Broderick, S. (2020). What Does Vaping Do to Your Lungs? Johns Hopkins Medicine. https://www.hopkinsmedicine.org/health/wellness-and-prevention/what-does-vaping-do-to-your-lungs
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38. Iffland K, Grotenhermen F. An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis Cannabinoid Res. 2017;2(1):139–154. Published 2017 Jun 1. DOI:10.1089/can.2016.0034.
39. Pharmotech SA. CBD Drug Interactions. Retrieved from https://pharmotech.ch/cbd-drug-interactions/.
40. Epidiolex Full Prescribing Information. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210365lbl.pdf.
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42. FDA.gov. (October 2020). FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD). Retrieved from: https://www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbd
43. US Drug Enforcement Administration. (December 2015). DEA Eases Requirements For FDA-Approved Clinical Trials On Cannabidiol. Retrieved from: https://www.dea.gov/press-releases/2015/12/23/dea-eases-requirements-fda-approved-clinical-trials-cannabidiol
44. Hudak, J. Brookings.edu. (December 2018). The Farm Bill, hemp legalization and the status of CBD: An explainer. Retrieved from: https://www.brookings.edu/blog/fixgov/2018/12/14/the-farm-bill-hemp-and-cbd-explainer/
45. National Conference of State Legislatures. (October 2020). State Medical Marijuana Laws. Retrieved from: https://www.ncsl.org/research/health/state-medical-marijuana-laws.aspx
46. Grinspoon, P. op. cit.
47. ProCon.org. (2019, July 24). Legal Medical Marijuana States and DC Laws, Fees, and Possession Limits. Retrieved from https://medicalmarijuana.procon.org/legal-medical-marijuana-states-and-dc/.

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