Best CBD Oil for Bipolar Disorder
Interested in buying cannabidiol (CBD) for bipolar disorder but uncertain about which product to select? CBD Clinicals can help you choose the best CBD product to meet your individual needs.
Best CBD Oil for Bipolar Disorder 2024
- Spruce 750mg Lab Grade CBD Oil Editor's Pick
- NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil Best Organic
- Spruce 2400mg Lab Grade CBD Oil Editor's Pick
- Avida Full Spectrum CBD Oil Tincture 500mg Best Seller
- cbdMD CBD Oil Tincture Natural 1500mg Best Natural Alternative
- CBDistillery THC Free CBD Oil Tinctures Best THC-Free
- cbdMD CBD Oil Tincture Natural 750mg Best Customer Rated
- NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil Best Starter
- Hemp Bombs 750mg CBD Oil Best Flavor Range
Compare the Best CBD Oil for Bipolar Disorder in 2022
Best CBD Oil for Bipolar Disorder
1. Spruce 750mg Lab Grade CBD Oil
cbdc overall score
4.8
CBDC Evaluation Table/Score
Pros | Cons |
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Mid-strength |
No other flavors |
Natural peppermint flavor |
|
Made from 100% organic and natural ingredients |
Overview
Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.
2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
cbdc overall score
5.0
CBDC Evaluation Table/Score
Pros | Cons |
---|---|
Pure CBD hemp |
No other flavors |
All natural |
|
Approximately 300 drops total |
Overview
Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.
3. Spruce 2400mg Lab Grade CBD Oil
cbdc overall score
5.0
CBDC Evaluation Table/Score
Pros | Cons |
---|---|
Extra Strength |
Tastes bitter |
No artificial flavoring or colors |
No THC-free option |
Made from 100% organic and natural ingredients |
Overview
The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.
4. Avida Full Spectrum CBD Oil Tincture 500mg
cbdc overall score
4.6
CBDC Evaluation Table/Score
Pros | Cons |
---|---|
Light Spearmint flavor |
No other flavor |
Non-THC, Non-detected in drug test |
Overview
Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.
5. cbdMD CBD Oil Tincture Natural 1500mg
cbdc overall score
4.7
CBDC Evaluation Table/Score
Pros | Cons |
---|---|
Various delicious flavors to choose from |
cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options |
Has vegan, organic, and gluten-free ingredients |
|
Free shipping for this particular product within USA |
|
World-class customer service team |
Overview
cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.
6. CBDistillery THC Free CBD Oil Tinctures
cbdc overall score
4.4
CBDC Evaluation Table/Score
Pros | Cons |
---|---|
60-Day Satisfaction Guarantee |
Dropper is a bit shaky |
Various strengths |
|
Oil extracted from aerial plant parts of US grown industrial hemp |
|
Sourced from non-GMO industrial hemp grown in the USA through natural farming practices |
Overview
CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.
7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
cbdc overall score
4.6
CBDC Evaluation Table/Score
Pros | Cons |
---|---|
Pure CBD hemp |
No other flavors |
All natural |
A bit pricey compared to competitors |
Approximately 100 drops total |
Overview
This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.
8. cbdMD CBD Oil Tincture Natural 750mg
cbdc overall score
4.4
CBDC Evaluation Table/Score
Pros | Cons |
---|---|
Vegan and Gluten free |
Does not ship internationally |
Has a third-party lab test |
|
Wide variety of CBD strengths and sizes |
Overview
A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.
9. Hemp Bombs 750mg CBD Oil
cbdc overall score
3.9
CBDC Evaluation Table/Score
Pros | Cons |
---|---|
Wide variety of flavors |
Incomplete information about the product |
Lab test results are complete |
Does not ship to all international countries |
30-day money-back guarantee |
Overview
Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.
How CBD May Help With Bipolar Disorder
Cannabidiol (CBD) is a non-psychoactive compound in cannabis plants, which may contain antidepressant, anxiety-relieving, and neuroprotective properties(1).Â
CBD may help relieve symptoms of mental health-related conditions, including depression(2). Previously known as manic-depression, bipolar disorder may include episodes of depression(3). Thus, CBD may help relieve bipolar-associated depression.Â
A review published in CNS & Neurological Disorders – Drug Targets hypothesized that CBD may help manage bipolar disorder, schizophrenia, depression, epilepsy, post-traumatic stress disorder, Parkinson’s disease, substance abuse and dependence, and sleep disorders(4).Â
Additionally, CBD’s potential benefits for relieving bipolar disorder may be linked to its interaction with the human endocannabinoid system (ECS).Â
The ECS helps regulate biological functions such as mood, pain perception, appetite, sleep, and metabolism.Â
The ECS consists of cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2).Â
CB1 receptors primarily exist in the brain and central nervous system (CNS), liver, kidneys, and lungs(5). These receptors help maintain bodily functions like mood, pain sensation, memory processing, appetite, and sleep. Â
Meanwhile, CB2 receptors are contained in cells within the immune system. These cannabinoid receptors stimulate an anti-inflammatory response, reducing pain and managing tissue damage.Â
Research also indicated that CBD may produce anxiety-relieving anxiolytic effects by indirectly activating receptors such as 5-HT1A serotonin receptors(6).Â
Serotonin is among the chemical messengers known as neurotransmitters that regulate feelings of wellness and happiness.Â
A study published by Neurochemical Research noted that cannabidiol may inhibit reuptake in the brain, increasing serotonin’s availability to the body(7). CBD may help alleviate anxiety and stabilize mood disorders with improved regulation of serotonin.
Another study examined CBD’s potential antidepressant qualities(8). Results suggested that the compound may reduce the symptoms of depressive episodes in mice. Â
Future research on human subjects is needed to determine if cannabidiol produces similar results in mental disorders like bipolar disorder.Â
Researchers of a 2020 review hypothesized that CBD may produce anxiolytic effects(9). The compound may inhibit fatty acid amide hydrolase (FAAH) enzymes.Â
Such enzymes metabolize the cannabinoid anandamide in the body. Cannabinoids are a group of cannabis-derived compounds. One example is CBD. Â
Recent research studies highlighted CBD as a potential antipsychotic treatment(10-11). Cannabidiol may also provide neuroprotective effects, suggesting that it may help manage psychiatric conditions, such as bipolar disorder. Â
Benefits and Uses of CBD for Bipolar Disorder
Research suggests that cannabidiol may help relieve physical symptoms associated with various conditions, such as chronic pain(12).Â
The potential benefits of CBD for mental health conditions include anxiety-relieving and antidepressant effects(13). Thus, it may help manage the symptoms of mental disorders, such as bipolar disorder. Â
The chemical element lithium may be prescribed with psychotic medications. However, such medicines may cause side effects such as sedation, weight gain, and depression(14).Â
Cannabidiol is a potential alternative to bipolar patients who respond poorly to psychosis medications, like lithium.Â
A 2018 review evaluated the clinical use of medical cannabis and cannabidiol for mental wellness in animal and human studies(15).Â
Researchers reported that plant-based compounds known as phytocannabinoids, like CBD and tetrahydrocannabinol (THC), contain potential neuroprotective properties. Such findings suggest that bipolar patients may benefit from CBD oil products.
The result of an animal study on mice subjects suggested that CBD may produce antidepressant effects by activating serotonin receptors(16).Â
Additional research is warranted to determine if CBD also produces similar effects in humans with mental conditions like bipolar spectrum disorders.Â
Meanwhile, a human study assessed CBD’s effect on patients with generalized social anxiety disorder (SAD)(17). The participants received either an oral dose of CBD or a placebo.Â
Results suggested that CBD may reduce anxiety and boost one’s mood compared to subjects given a placebo.Â
A review on the use of cannabis assessed the role of cannabinoids like CBD and THC in bipolar affective disorder(18).Â
Researchers reported that these compounds have potential antidepressant, anxiolytic, and antipsychotic effects. These findings suggest that cannabidiol may help manage bipolar disorder.Â
Despite such promising results, additional human clinical trials are necessitated to investigate CBD as a potential treatment for bipolar disorder.Â
How to Safely Administer CBD Oil for Bipolar DisorderÂ
It is highly advised for people with bipolar disorder to avoid consuming cannabis products with a high THC content. Numerous studies have linked high-THC marijuana use to a higher risk of psychiatric disorders(19).Â
It would help if you also deliberated with your doctor before taking CBD for bipolar disorder. This step may help prevent the adverse effects of potential drug interactions.Â
A physician can also help guide you on the proper usage and dosage of CBD products.Â
You can take CBD oil products for bipolar disorder in various forms, including the following options:Â
CBD Tinctures
You can use a dropper to apply CBD oil tinctures underneath the tongue for faster absorption into the bloodstream.Â
Hold the CBD drops underneath the tongue for one or two minutes before swallowing. CBD tinctures are available in different flavors and can be mixed with coffee, smoothies, or food.Â
CBD Capsules
CBD capsules must pass through the digestive tract. Thus, they may take longer before producing significant results for bipolar disorder than other options, like CBD tinctures.Â
CBD Edibles
CBD edibles may help users avoid the earthy taste of CBD hemp extract. Options include CBD chocolate bars, CBD gummies, and CBD cookies. Â
CBD Topicals
CBD topicals include CBD creams, CBD lotions, CBD balms, and CBD salves. The skin’s surface absorbs CBD.Â
CBD Vapes
CBD vape pens may provide instant effects as the vapors enter the bloodstream through the lungs rather than the digestive system.Â
Additionally, state and local health departments, the Food and Drug Administration (FDA), and the Centers for Disease Control and Prevention (CDC) have assessed the national outbreak of e-cigarette or vaping product use-associated lung injury (EVALI)(20). Â
CBD Dosage for Bipolar Disorder
No official recommended CBD dose exists for bipolar disorder.
Research suggested that CBD dosage of up to 1,500 milligrams per day is well tolerated in human subjects(21).Â
However, Epidiolex is the only FDA-approved CBD product utilized to treat rare forms of epilepsy(22). Â
The best option is to begin taking cannabidiol at small doses and gradually increase the dosage until you achieve the intended results. Â
Seeking help from a healthcare provider with experience in CBD use is advisable to identify the proper CBD dosage based on your particular needs.Â
How Long CBD Takes to Help With Bipolar Disorder
Researchers have conducted no studies on the quantity of time required to experience the biological effects of CBD for bipolar disorder. Â
You may feel the localized effects of CBD topicals within 10 minutes(23).Â
After swallowing CBD tinctures, you may experience the effects within 15 to 30 minutes after application(24).Â
Meanwhile, you may feel the therapeutic effects of CBD edibles within 30 minutes to two hours after consumption(25).Â
CBD vape oil may produce biological effects within two minutes(26). However, inhaling vapor or smoke may cause allergic reactions and chemical irritation(27).Â
How Long CBD Helps With Bipolar Disorder
Researchers have conducted no studies on the efficacy duration of CBD products for bipolar disease.Â
A 2018 review determined that the half-life of CBD was two to five days after individuals took a daily oral dose(28). Â
Half-life refers to the amount of time necessitated for a substance’s amount to reduce to half of its original value(29).
Meanwhile, past human and animal studies suggest that the bioavailability of cannabidiol ranges from 13% to 19%(30).Â
Bioavailability is the rate and the degree to which an active drug ingredient is absorbed and becomes available at the location of drug action(31).Â
Risks and Side Effects of Utilizing CBD for Bipolar Disorder
Although cannabidiol may help manage bipolar disorder, it may induce particular side effects, including(32):Â
- Tiredness
- Fatigue
- Drowsiness
- Dry mouth
- Reduced appetite
- Changes in weightÂ
- Diarrhea
The compound may also interact with medicines, such as blood thinners.Â
Seeking professional medical advice is vital to prevent possible adverse effects from CBD.Â
How to Select the Right CBD for Bipolar Disorder
CBD for bipolar disorder is available in various forms, including CBD tinctures, CBD edibles, CBD capsules, CBD topicals, and CBD vapes. Follow these tips when selecting the best CBD oil:Â Â Â
- Seek professional help before using CBD for bipolar disorder, primarily if you use CBD products for severe health conditions, including bipolar disorder.
- Find CBD brands accredited by the Better Business Bureau (BBB). Such companies tend to have excellent customer service.
- Pick organic CBD products free of genetically modified organisms (non-GMO). These options include CBD brands producing cannabidiol products from local hemp, such as plants from Oregon, Colorado, and Kentucky. Such companies promote sustainable farming.Â
- Research the type of extraction process used, such as CO2 extraction.Â
- Review a company’s disclaimers and avoid unsubstantiated health claims.Â
- Select CBD products that post third-party lab results from a certificate of analysis (COA). COAs are often available on a CBD brand’s website. The CBD products should be free of pesticides, residual solvents, and other harmful contaminants.Â
- Look for high-quality products that compare the product label claims with the COA.Â
- Learn about the three types of CBD products. Full-spectrum CBD oil products contain all cannabinoids in cannabis plants. They include flavonoids, terpenes, and fatty acids.Â
- Broad-spectrum CBD also contains a wide range of cannabis-derived compounds. However, it is usually THC-free.Â
- CBD isolates contain pure CBD and usually no other cannabinoids.Â
Legality of CBD
On the U.S. federal level, hemp-derived CBD products with 0.3% or less THC are not considered controlled substances(33).Â
The psychoactive compound THC produces a euphoric feeling. High-THC marijuana remains a Schedule I controlled drug due to its high risk for abuse because of THC’s psychoactive effects(34).Â
The FDA prohibits the legal sale of products containing CBD or THC as dietary supplements(35).Â
Epidiolex is the only FDA-approved cannabis-derived drug product(36). The prescription medications may help control seizures associated with Dravet syndrome and Lennox-Gastaut syndrome, two rare forms of epilepsy in children.
Learning state laws and purchasing CBD oil products in areas that offer medical marijuana legally is advisable.Â
What Is Bipolar Disorder?
Bipolar disorder refers to a mental illness that causes manic episodes known as mania or hypomania, extreme mood swings, and depression(37). Â
Research shows that 4.4% of adults in the United States experience bipolar disorder(38).Â
Children diagnosed with the condition known as attention deficit hyperactivity disorder (ADHD) may later develop other mental health conditions, including bipolar disorder(39).Â
Symptoms of bipolar disorder include severe mood fluctuations that may result in significant distress and life difficulties(40). People may also experience shifts in activity and energy levels(41).Â
Bipolar I disorder, bipolar II disorder, and cyclothymic disorder are the three types of bipolar disorders(42).Â
Bipolar I disorder is one manic episode followed by major depressive episodes, while bipolar II disorder is one or more major depressive episodes and one hypomanic episode(43).
Cyclothymic disorder is several periods of hypomanic symptoms and depressive symptoms(44).
Product Frequently
Asked Questions
-
How can CBD oil help with bipolar disorder?
CBD has therapeutic potential with antidepressant, anxiety-reducing, and neuroprotective properties(45). Thus, it may help reduce the symptoms of mental disorders like bipolar disorder.
-
What evidence exists saying that CBD helps with bipolar disorder?
Research showed that CBD may contain anxiety-relieving, antidepressant, and neuroprotective properties(46). Such findings indicate that CBD may help manage mental illnesses like bipolar disorder.
-
Does any evidence exist saying that CBD can make bipolar disorder worse?
Limited research has been conducted on CBD use and bipolar disorder. However, no studies have suggested that CBD may worsen bipolar disorders.Â
Recent findings suggest that CBD may produce anxiety-relieving and antidepressant effects(47).
-
Will CBD interact with any current medication I may be taking for bipolar disorder?
CBD may interact with other medications for bipolar disorders and alter how the body breaks down such drugs(48). Seek advice from medical professionals for the proper use of CBD.
-
Are there other treatments I should consider alongside CBD to help with bipolar disorder?
Treatment options for bipolar disorders include mood stabilizers and prescription medications known as antidepressant–antipsychotics.Â
However, such treatments have negative side effects like tremors, renal disease, and sexual dysfunction(49-50). Meanwhile, CBD may produce mild side effects like drowsiness and fatigue(51).Â
-
Can I fail a drug test if I use CBD oil for bipolar disorder?
CBD is a non-psychoactive compound that produces no euphoric feelings(52). However, certain CBD products contain trace amounts of the psychoactive compound THC. Using such products frequently may produce a false-positive drug test.
-
What is the proper CBD dosage for bipolar disorder?
No official dosage guidelines exist for cannabidiol. However, beginning with small doses and increasing the CBD dosage until you achieve the desired results is recommended.
-
Is CBD oil legal for bipolar disorder?
Hemp-derived CBD oil products containing 0.3% or less THC are legal at the U.S. federal level(53). However, researching state laws is necessitated to ensure the legal usage of CBD for bipolar disorder.Â
-
Is CBD safe for bipolar disorder?
Cannabidiol has a favorable safety profile and is generally well tolerated(54). However, it may cause minor side effects like dry mouth and drowsiness(55). Thus, consulting with a medical professional before using CBD is advisable to avoid such side effects.
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