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Best CBD for Suicide Prevention

Suicide is a serious public health problem. The Centers for Disease Control and Prevention reported that most suicide victims may have been battling an undiagnosed mental health issue(1). Read on to know whether CBD is a good natural option to improve well-being and help with suicide prevention.

Rating
Highlights

Editor's Choice

Spruce 750mg Lab Grade CBD Oil


4.8 out of 5
  1. Peppermint flavor masks any unpleasant taste
  2. Contains 25mg of CBD per dropper full
  3. Bottle includes a graduated dropper for correct serving measurement

Best CBD Purity

NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil


5.0 out of 5
  1. Natural remedy for various illnesses
  2. Product is full-spectrum whole-plant extract
  3. Contains naturally occurring synergistic cannabinoids and terpenes

Best High Potency

Spruce 2400mg Lab Grade CBD Oil


5.0 out of 5
  1. Maximum possible potency
  2. Each dropper full contains 80mg of CBD
  3. Conveniently fits in a 30mL bottle

Best Value

Avida Full Spectrum CBD Oil Tincture 500mg


4.6 out of 5
  1. Proprietary full-spectrum
  2. Developed using advanced AVIDA CORE Spectrum Technology
  3. Highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3)

Best Value

cbdMD CBD Oil Tincture Natural 1500mg


4.7 out of 5
  1. Made using only CBD sourced from medical hemp
  2. Available in many flavours
  3. Safe for daily use

Best THC Free

CBDistillery THC Free CBD Oil Tinctures


4.4 out of 5
  1. Do not contain THC
  2. Available in different potencies and sizes
  3. Brand has special deals and offers

Best Customer Rated

cbdMD CBD Oil Tincture Natural 750mg


4.4 out of 5
  1. THC-free
  2. Has plenty of flavours to choose from
  3. Totally vegan

Best For Beginners

NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil


4.6 out of 5
  1. Lowest concentration for CBD beginners
  2. Fully organic and lab-tested
  3. Full-spectrum

Best Flavor Range

Hemp Bombs 750mg CBD Oil


3.9 out of 5
  1. Has a wide range of flavours
  2. Safe to intake
  3. Get 20% off when you avail of their subscription

Best Allergy Friendly

Royal CBD Full Spectrum CBD Oil


3.5 out of 5
  1. Has three flavors to choose from – Berry, Natural and Vanilla
  2. Vegan and Gluten-Free
  3. Superb customer service

Compare the Best CBD for Suicide Prevention in 2022

Product Potency Purity Customer Service Type Extraction Transparency Absorption
Spruce 2400mg Lab Grade CBD Oil
4.8 out of 5

4.5 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5
NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.0 out of 5

5.0 out of 5

5.0 out of 5
Spruce 2400mg Lab Grade CBD Oil
5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.0 out of 5

5.0 out of 5

5.0 out of 5
Avida Full Spectrum CBD Oil Tincture 500mg
4.6 out of 5

5.0 out of 5

3.5 out of 5

3.0 out of 5

5.0 out of 5

4.5 out of 5

4.5 out of 5

5.0 out of 5
cbdMD CBD Oil Tincture Natural 1500mg
4.7 out of 5

5.0 out of 5

3.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5
CBDistillery THC Free CBD Oil Tinctures
4.4 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.5 out of 5
cbdMD CBD Oil Tincture Natural 750mg
4.4 out of 5

4.5 out of 5

3.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5
NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
4.6 out of 5

2.5 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5
Hemp Bombs 750mg CBD Oil
3.9 out of 5

4.5 out of 5

3.5 out of 5

2.5 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5
Royal CBD Full Spectrum CBD Oil
3.5 out of 5

2.5 out of 5

3.5 out of 5

5.0 out of 5

5.0 out of 5

4.0 out of 5

1.0 out of 5

5.0 out of 5

1. Spruce 750mg Lab Grade CBD Oil
cbdc overall score
4.8
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Mid-strength  No other flavors
 Natural peppermint flavor
 Made from 100% organic and natural ingredients
Pros
 Mid-strength
 Natural peppermint flavor
 Made from 100% organic and natural ingredients
Cons
 No other flavors
Overview

Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
cbdc overall score
5.0
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Pure CBD hemp  No other flavors
 All natural
 Approximately 300 drops total
Pros
 Pure CBD hemp
 All natural
 Approximately 300 drops total
Cons
 No other flavors
Overview

Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

3. Spruce 2400mg Lab Grade CBD Oil
cbdc overall score
5.0
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Extra Strength  Tastes bitter
 No artificial flavoring or colors  No THC-free option
 Made from 100% organic and natural ingredients
Pros
 Extra Strength
 No artificial flavoring or colors
 Made from 100% organic and natural ingredients
Cons
 Tastes bitter
 No THC-free option
Overview

The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.

4. Avida Full Spectrum CBD Oil Tincture 500mg
cbdc overall score
4.6
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Light Spearmint flavor  No other flavor
 Non-THC, Non-detected in drug test
Pros
 Light Spearmint flavor
 Non-THC, Non-detected in drug test
Cons
 No other flavor
Overview

Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.

5. cbdMD CBD Oil Tincture Natural 1500mg
cbdc overall score
4.7
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Various delicious flavors to choose from  cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
 Has vegan, organic, and gluten-free ingredients
 Free shipping for this particular product within USA
 World-class customer service team
Pros
 Various delicious flavors to choose from
 Has vegan, organic, and gluten-free ingredients
 Free shipping for this particular product within USA
 World-class customer service team
Cons
 cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
Overview

cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

6. CBDistillery THC Free CBD Oil Tinctures
cbdc overall score
4.4
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 60-Day Satisfaction Guarantee  Dropper is a bit shaky
 Various strengths
 Oil extracted from aerial plant parts of US grown industrial hemp
 Sourced from non-GMO industrial hemp grown in the USA through natural farming practices
Pros
 60-Day Satisfaction Guarantee
 Various strengths
 Oil extracted from aerial plant parts of US grown industrial hemp
 Sourced from non-GMO industrial hemp grown in the USA through natural farming practices
Cons
 Dropper is a bit shaky
Overview

CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.

7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
cbdc overall score
4.6
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Pure CBD hemp  No other flavors
 All natural  A bit pricey compared to competitors
 Approximately 100 drops total
Pros
 Pure CBD hemp
 All natural
 Approximately 100 drops total
Cons
 No other flavors
 A bit pricey compared to competitors
Overview

This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.

8. cbdMD CBD Oil Tincture Natural 750mg
cbdc overall score
4.4
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Vegan and Gluten free  Does not ship internationally
 Has a third-party lab test
 Wide variety of CBD strengths and sizes
Pros
 Vegan and Gluten free
 Has a third-party lab test
 Wide variety of CBD strengths and sizes
Cons
 Does not ship internationally
Overview

A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.

9. Hemp Bombs 750mg CBD Oil
cbdc overall score
3.9
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Wide variety of flavors  Incomplete information about the product
 Lab test results are complete  Does not ship to all international countries
 30-day money-back guarantee
Pros
 Wide variety of flavors
 Lab test results are complete
 30-day money-back guarantee
Cons
 Incomplete information about the product
 Does not ship to all international countries
Overview

Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.

10. Royal CBD Full Spectrum CBD Oil
cbdc overall score
3.5
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Rich in phytochemicals including CBD, CBC, CBG, and a variety of flavorful terpenes  Shipping not specified on website
 More flavors to choose from  3rd party lab result is currently not available on website
 Extracts contain a whole array of cannabinoids and terpenes from the hemp plant — rather than pure CBD isolate
Pros
 Rich in phytochemicals including CBD, CBC, CBG, and a variety of flavorful terpenes
 More flavors to choose from
 Extracts contain a whole array of cannabinoids and terpenes from the hemp plant — rather than pure CBD isolate
Cons
 Shipping not specified on website
 3rd party lab result is currently not available on website
Overview

Excellent products and superb customer service. Whenever you want to ask them about the dosage, recommended consumption methods, or which CBD oil will work best for you, just give them a call, send them a message, or get in touch with their social media channels. They won’t leave you with any unanswered questions.

How CBD May Help With Suicide Prevention

CBD (cannabidiol) and THC (tetrahydrocannabinol) are phytocannabinoids found naturally in the resin of the cannabis plant

THC is known for its psychoactive effects. However, CBD may reverse the addictive- and anxiety-like behavior induced by THC(2).  

CBD has purported anti-anxiety (anxiolytic) and antipsychotic properties(3).

The National Institute of Mental Health indicated that in 2019, suicide was the tenth leading cause of death in the U.S., claiming the lives of over 47,500 individuals(4).  

Suicide is related to psychiatric disease, with depression, psychosis, and substance use disorders the most relevant factors(5). However, anxiety and trauma-related disorders also contribute.

Aside from CBD’s potential health benefits, its activity in the ECS (endocannabinoid system) may explain how the compound may help with medical conditions linked to high suicide risks.  

The ECS is responsible for maintaining bodily homeostasis or balance. Both CBD and THC may interact with the ECS’ cannabinoid receptors, namely CB1 and CB2(6).  

An elevated level of CB1 receptors is associated with suicide(7)

CBD does not appear to target CB1 receptors directly(8). In addition, cannabidiol may act as an antagonist at CB1 receptors(9)

An antagonist binds to receptors without activating them. Instead, it decreases the ability of an agonist to activate receptors

A review from Annals of the New York Academy of Sciences indicated that the brain of suicide victims shows reduced serotonin levels(10)

CBD may interact with the serotonin receptors(11). Serotonin receptors are activated by serotonin(12), a neurotransmitter implicated in mental health conditions, such as depression and anxiety(13)

Although these findings seem promising, more research is warranted to further explain and demonstrate how CBD may help with suicide prevention. 

Benefits of Using CBD for Suicide Prevention

A study from Current Pharmaceutical Design suggested potential therapeutic effects of cannabidiol and rimonabant to help with emotional processing impairment in schizophrenia(14)

Rimonabant is a drug that acts as a selective antagonist at CB1 receptors. 

Schizophrenia is a mental disorder in which individuals have a distorted interpretation of reality. Contemporary research studies show that a lifetime suicide rate in people with schizophrenia is between 4% and 13%(15)

Meanwhile, CBD has shown promise as a novel agent to help with anxiety and mood disorders(16). However, CBD’s exact molecular mechanism of action remains undetermined.

A study from Depression and Anxiety journal stated that over 70% of individuals reporting a lifetime account of suicide attempts had an anxiety disorder(17)

In addition, research suggested that SAD (social anxiety disorder) is linked to high rates of suicidal ideation(18).

Suicidal ideation or suicidal thought is used to describe a wide range of contemplations, wishes, and preoccupations with suicide and death(19)

In a randomized controlled trial, researchers administered 600 mg of CBD and a placebo to patients with SAD(20). The participants who received CBD experienced significantly less social anxiety than those who had a placebo

The putative usefulness of CBD for mental health problems associated with high suicide risks is plausible considering the purported therapeutic benefits of CBD

Still, more research is recommended to determine the efficacy of using CBD to prevent suicide. 

How to Use CBD for Suicide Prevention 

Inhaling or smoking CBD using vape pens is the fastest way to benefit from the effects of the compound(21). The onset time of CBD via the inhalation route is between 2 to 15 minutes(22)

However, the Centers for Disease Control and Prevention or CDC specifies that smokers are more likely to have depression than non-smokers(23). Suicide is associated with mental disorders, particularly depression(24).  

A study from Addictive Behaviors indicated that depression is a prominent risk factor for nicotine dependence over and above exposure to cigarettes(25)

Nicotine, a primary agent in regular cigarettes and vape pens, is highly addictive(26). Therefore, individuals diagnosed with depression may want to use other delivery methods to try CBD for suicide prevention. 

The sublingual (under the tongue) delivery method also provides rapid effects without exposing the lungs to tar and heat(27).  

Oromucosal sprays, medicated lozenges, dissolvable strips, and tinctures are common sublingual products. 

With the sublingual route, the tiny blood vessels (capillaries) under the tongue and within the mouth can absorb cannabinoids, like CBD and THC, into the bloodstream before being swallowed(28).  

If you opt to take CBD sublingually, you will feel its effects within 15 to 30 minutes, and they may last for 2 to 4 hours(29)

Still, it is best to talk with a doctor experienced in cannabis use to determine the suitable CBD delivery method for suicide prevention. 

CBD Dosage for Suicide Prevention 

A research article from the British Journal of Pharmacology suggested that CBD may induce antidepressant-like effects comparable with imipramine(30)

Imipramine (Tofranil) is a tricyclic antidepressant to manage symptoms of depression

The authors of the study reported that CBD was only effective at 30mg per kilogram of body weight, with higher or smaller doses producing no effect(31).

Still, it is worth noting that the FDA (Food and Drug Administration) does not recognize CBD as a medication that can be used for suicide prevention.

For this reason, it is best to talk with a healthcare professional versed in cannabis use to determine the right CBD dosage for suicide prevention.  

How Long Does CBD Take to Help With Suicide Prevention?

How long CBD takes to help with suicide prevention usually depends on several factors, including the delivery method and individual body weight. 

For instance, if you take CBD via the inhalation route, you will feel its effects within 2 to 15 minutes(32). However, vaping may damage your lungs(33).

On the other hand, the onset time of CBD via the sublingual route is between 15 and 30 minutes(34).    

How Long Will CBD Help With Suicide Prevention?

How long CBD’s effects will last after the compound starts to help depends on its bioavailability and half-life.

Bioavailability is the extent to which a particular substance becomes entirely available to its intended biological destinations. 

Meanwhile, half-life refers to the length of time required for a specific drug to reduce by 50% of its starting dose.

A review from Frontiers in Pharmacology reported that the half-life of CBD was between 1.4 and 10.9 hours following oromucosal spray and 31 hours after smoking(35).  

Meanwhile, the bioavailability of CBD after smoking is 31%(36). On the other hand, CBD’s bioavailability via the sublingual route is between 6% and 20%(37)

What to Look for When Choosing CBD for Suicide Prevention

Various brands promise to offer the best CBD oil for suicide prevention. Below are a few pertinent factors to consider that may help you find high-quality CBD products for your overall wellness.

Hemp Extracts

Full-spectrum CBD oil contains all compounds of the cannabis plant. This CBD variant also has less than 0.3% THC

Meanwhile, broad-spectrum CBD oil also contains all of the natural compounds of cannabis. However, this CBD variant is THC-free. Lastly, CBD isolates are made from pure CBD.

Source of Hemp 

It is vital to determine the source of hemp. Some CBD products may contain pesticides, heavy metals, or genetically modified organisms (GMOs). 

Thus, choose a CBD brand that provides sufficient information on the hemp used. If possible, go for organic hemp or non-GMO CBD products manufactured by reputable companies.

Legitimate producers grow hemp in accordance with the United States Department of Agriculture (USDA), state, and tribal plans and regulations.

Third-Party Lab Testing

A study from the journal Epilepsy and Behavior reported that labeling of commercially available CBD-infused products is often inaccurate(38)

For this reason, consumers must verify whether a CBD brand enlists the services of a third-party laboratory to test all the company’s products and provide COAs (certificates of analysis). 

The COAs should be readily accessible on the brand’s official website. When all pertinent information is posted online, customers can compare the values specified on the laboratory report with the figures on the product label

Comparing reports allows consumers to verify a brand’s claims regarding the concentration, potency, and effects of CBD.

Types of CBD Products 

Most CBD-derived products available in the market are:

  • CBD vapes 
  • CBD oils, tinctures, and oromucosal sprays 
  • Edibles like CBD gummies and capsules
  • Topicals like CBD creams, salves, and lotions

The type of CBD products you choose will depend on your lifestyle preferences, specific conditions, and expected effects.

Risks and Side Effects of Using CBD for Suicide Prevention

Generally, commonly reported side effects of using CBD are the following(39):

  • Drowsiness
  • Low blood pressure
  • Dry mouth 

Individuals with suicidal thoughts not considered a crisis situation may require outpatient treatment that includes medications, such as antidepressants, antipsychotics, and anti-anxiety drugs(40)

While generally considered safe, taking CBD with antipsychotics and antidepressants may increase fatigue, sleepiness, and accidental falls(41)

In addition, it is worth noting that CBD is a potent inhibitor of CYP2D6, an enzyme that metabolizes various antidepressants(42).

Cannabidiol may increase serum concentrations of antipsychotics and SSRIs (selective serotonin reuptake inhibitors)(43)

SSRIs are commonly prescribed antidepressants

Legality of CBD

Under federal law, cannabis (sometimes called marijuana) remains a Schedule I substance under the Controlled Substances Act(44)

The United States Drug Enforcement Administration or DEA said that substances listed in the Schedule I drugs category have a high abuse potential with no accepted medical use(45)

However, most states with medical marijuana laws have a patient registry to protect individuals against arrest for having a certain amount of cannabis-derived products for personal medicinal use(46)

Colorado permits recreational and medical marijuana use. The local government decriminalized the use of marijuana by passing Amendment 64 to the Colorado Constitution in November 2012(47).

Meanwhile, in October 2021, California Governor Gavin Newsom signed Assembly Bill No. 45 into law(48)

The bill allows the inclusion of hemp and cannabinoids, extracts, or hemp derivatives in dietary supplements, food and beverages, cosmetics, and processed pet food provided that they contain less than 0.3% THC(49).

In New York, adults 21 years and older can buy up to three ounces or 85g of cannabis flower and 24g of concentrated cannabis(50).

In Indiana, Gov. Eric Holcomb signed Senate Enrolled Act No. 52 into law, allowing distribution and retail sale of “low-THC hemp extract”(51)

The Farm Bill indicates that Cannabis sativa L. and other derivatives of cannabis with less than 0.3% THC content on a dry weight basis are deemed legal under federal law(52).

Product Frequently
Asked Questions

  • How may CBD help with suicide prevention?

    CBD has purported anti-anxiety and antipsychotic effects(53). The non-psychoactive compound also has antidepressant properties(54)

    These therapeutic potentials may help with mental health conditions, such as depression and anxiety. 

    A study from the International Journal of Environmental Research and Public Health suggested that mental disorders are associated with high suicide risk(55).

  • What evidence or research exists to say that CBD helps with suicide prevention?

    Anxiety disorders, particularly PTSD (post-traumatic stress disorder) and panic disorder, are associated with suicide attempts(56)

    CBD may help with anxiety disorders(57). Meanwhile, a study from Frontiers in Neuroscience evaluated the potential of CBD to reduce the retention of negative PTSD memories(58).

  • Is there any evidence that CBD can be bad for suicide prevention?

    In a clinical trial involving 27,863 patients administered with Epidiolex and 16,029 patients given a placebo, the risk of suicidal thoughts was increased by one in every 530 patients. There were four suicides in the Epidiolex-treated group and none in the placebo group(59)

    However, the results are inconclusive. To date, no relevant scientific data compare over-the-counter CBD with placebo in relation to increased suicidality risk.

    Epidiolex, the FDA-approved form of CBD, is used to treat rare and severe forms of epilepsy and seizures linked to tuberous sclerosis complex in patients one year of age and older(60).

  • Will CBD interact with any current medication I may be taking for suicide prevention?

    CBD is not a biologically inert compound, so it has the potential to interact with other medications(61). Antidepressants may help lessen suicidal thoughts(62)

    However, CBD is a potent inhibitor of CYP2D6, an enzyme that metabolizes many antidepressants(63). Therefore, taking CBD with antidepressants may cause drug interactions.

  • Are there other treatments I should consider alongside CBD to help with suicide prevention?

    Medications, such as antidepressants, anti-anxiety, and antipsychotics, may help you feel less suicidal(64)

    Still, make sure to talk with your doctor before you take other treatments, particularly over-the-counter medications alongside CBD.

  • Can I fail a drug test if I use CBD for suicide prevention?

    Some CBD products have traces of THC that may build up in the body when taken regularly in a span of four to six days(65)

    An increased THC level in the bloodstream may result in a positive drug test.

  • What is the dosage for suicide prevention?

    Having major depression increases suicide risk(66). A study suggested that CBD may induce antidepressant-like effects. However, CBD was only effective at 30mg per kilogram of body weight, with higher or smaller doses producing no effect(67).

  • Does CBD cause any side effects?

    Generally, the minor side effects of CBD include changes in alertness, gastrointestinal distress, and mood changes(68).

  • Will CBD oil make me high?

    CBD does not induce a euphoric effect(69). Therefore, it will not make you high.

  • Is CBD oil legal?

    The legality of CBD depends on the rules and regulations of the state you are in. Therefore, make sure to familiarize yourself with various state laws regarding the use of CBD oil to avoid legal repercussions.

  • Is CBD safe?

    CBD is reported to have a good safety profile(70). Nonetheless, some knowledge gaps should be closed by further clinical trials for a completely well-tested pharmaceutical compound.


  1. Suicide Prevention
    https://www.psychiatry.org/patients-families/suicide-prevention
  2. Cannabis Study Reveals How CBD Offsets the Psychiatric Side-Effects of THC
    https://www.sciencedaily.com/releases/2019/09/190930131115.htm
  3. Cannabidiol
    https://pubchem.ncbi.nlm.nih.gov/compound/Cannabidiol
  4. Suicide Prevention
    https://www.nimh.nih.gov/health/topics/suicide-prevention#part_2474
  5. Suicide Risk and Mental Disorders
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165520/
  6. Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877694/
  7. Chapter 5 Role of the Endocannabinoid System in the Neurobiology of Suicide
    https://www.ncbi.nlm.nih.gov/books/NBK107200/
  8. Cannabidiol (CBD), page 12.
    https://www.who.int/medicines/access/controlled-substances/CannabidiolCriticalReview.pdf
  9. Cannabidiol Is a Negative Allosteric Modulator of the Cannabinoid CB1 Receptor
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621983/
  10. Serotonin and Suicidal Behavior
    https://pubmed.ncbi.nlm.nih.gov/2252327/
  11. Cannabidiol Modulates Serotonergic Transmission and Reverses Both Allodynia and Anxiety-Like Behavior in a Model of Neuropathic Pain
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319597/
  12. Serotonin Receptors
    https://www.ncbi.nlm.nih.gov/books/NBK28234/
  13. Cannabidiol Modulates Serotonergic Transmission and Reverses Both Allodynia and Anxiety-Like Behavior in a Model of Neuropathic Pain
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319597
  14. Antipsychotic Profile of Cannabidiol and Rimonabant in an Animal Model of Emotional Context Processing in Schizophrenia
    https://pubmed.ncbi.nlm.nih.gov/22716146/
  15. Suicide in Schizophrenia: An Educational Overview
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681260/
  16. Cannabidiol as a Potential Treatment for Anxiety and Mood Disorders: Molecular Targets and Epigenetic Insights from Preclinical Research
    https://pubmed.ncbi.nlm.nih.gov/33668469/
  17. The Relationship Between Anxiety Disorders and Suicide Attempts: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940247/
  18. Social Anxiety and Suicidal Ideation: Test of the Utility of the Interpersonal-Psychological Theory of Suicide
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234685/
  19. Suicidal Ideation
    https://pubmed.ncbi.nlm.nih.gov/33351435/
  20. Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients
    https://pubmed.ncbi.nlm.nih.gov/21307846/
  21. How to Safely Use CBD: Should You Inhale, Spray, Apply, or Eat It?
    https://www.consumerreports.org/cbd/how-to-use-cbd-inhale-spray-apply-eat/
  22. Healing With CBD, page 190.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  23. Recognize Signs of Depression
    https://www.cdc.gov/tobacco/campaign/tips/quit-smoking/guide/depression-and-smoking.html
  24. Suicide Prevention
    https://www.psychiatry.org/patients-families/suicide-prevention
  25. Depression and Nicotine Dependence from Adolescence to Young Adulthood
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314348/
  26. 5 Vaping Facts You Need to Know
    https://www.hopkinsmedicine.org/health/wellness-and-prevention/5-truths-you-need-to-know-about-vaping
  27. CBD: A Patient’s Guide to Medicinal Cannabis, page 105.
    https://drive.google.com/file/d/1MILU_6ZjYkII-XMUPHLFPiPQbrz__5Sh/view
  28. CBD: A Patient’s Guide to Medicinal Cannabis, page 104.
    https://drive.google.com/file/d/1MILU_6ZjYkII-XMUPHLFPiPQbrz__5Sh/view
  29. Healing With CBD, page 192.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  30. Antidepressant-Like Effects of Cannabidiol in Mice: Possible Involvement of 5-HT1A Receptors
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823358/
  31. Ibid.
  32. Healing With CBD, page 190.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  33. Is It Safe to Vape CBD?
    https://www.consumerreports.org/cbd/is-it-safe-to-vape-cbd/
  34. Healing With CBD, page 192.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  35. A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275223/
  36. Ibid.
  37. Healing With CBD, page 192.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  38. Analysis of cannabidiol (CBD) and THC in nonprescription consumer products: Implications for patients and practitioners
    https://www.epilepsybehavior.com/article/S1525-5050(21)00775-7/fulltext
  39. CBD: What You Need to Know Before You Try
    https://www.cedars-sinai.org/blog/cbd-safe.html
  40. Suicide and Suicidal Thoughts
    https://www.mayoclinic.org/diseases-conditions/suicide/diagnosis-treatment/drc-20378054
  41. CBD and Other Medications: Proceed With Caution.
    https://www.health.harvard.edu/blog/cbd-and-other-medications-proceed-with-caution-2021011121743
  42. Medical Cannabis: Adverse Effects and Drug Interactions, page 11.
    https://doh.dc.gov/sites/default/files/dc/sites/doh/publication/attachments/Medical%20Cannabis%20Adverse%20Effects%20and%20Drug%20Interactions_0.pdf
  43. Ibid.
  44. State Medical Cannabis Laws
    https://www.ncsl.org/research/health/state-medical-marijuana-laws.aspx
  45. Drug Scheduling
    https://www.dea.gov/drug-information/drug-scheduling
  46. State Medical Cannabis Laws
    https://www.ncsl.org/research/health/state-medical-marijuana-laws.aspx
  47. Legal Marijuana Use in Colorado
    https://cannabis.colorado.gov/legal-marijuana-use-in-colorado
  48. Assembly Bill No. 45
    https://leginfo.legislature.ca.gov/faces/billTextClient.xhtml?bill_id=202120220AB45
  49. Ibid.
  50. Social Equity and Responsible Access to Adult-Use Cannabis for New Yorkers Ages 21 and Over
    https://cannabis.ny.gov/adult-use
  51. Senate Enrolled Act No. 52
    https://medicalmarijuana.procon.org/wp-content/uploads/sites/37/indiana-sb52.pdf
  52. FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD)
    https://www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbd
  53. Cannabidiol
    https://pubchem.ncbi.nlm.nih.gov/compound/Cannabidiol
  54. Emerging Evidence for the Antidepressant Effect of Cannabidiol and the Underlying Molecular Mechanisms
    https://pubmed.ncbi.nlm.nih.gov/31039391/
  55. Suicide Risk and Mental Disorders
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165520/
  56. The Relationship Between Anxiety Disorders and Suicide Attempts: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940247/
  57. Cannabidiol as a Potential Treatment for Anxiety Disorders
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604171/
  58. Cannabidiol as a Therapeutic Alternative for Post-traumatic Stress Disorder: From Bench Research to Confirmation in Human Trials
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066583/
  59. The Impact of Cannabidiol on Psychiatric and Medical Conditions
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331870/
  60. FDA Approves New Indication for Drug Containing an Active Ingredient Derived from Cannabis to Treat Seizures in Rare Genetic Disease
    https://www.fda.gov/news-events/press-announcements/fda-approves-new-indication-drug-containing-active-ingredient-derived-cannabis-treat-seizures-rare
  61. Potential Adverse Drug Events and Drug-Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/
  62. Suicide and Suicidal Thoughts
    https://www.mayoclinic.org/diseases-conditions/suicide/diagnosis-treatment/drc-20378054
  63. Medical Cannabis: Adverse Effects and Drug Interactions, page 11.
    https://doh.dc.gov/sites/default/files/dc/sites/doh/publication/attachments/Medical%20Cannabis%20Adverse%20Effects%20and%20Drug%20Interactions_0.pdf
  64. Suicide and Suicidal Thoughts
    https://www.mayoclinic.org/diseases-conditions/suicide/diagnosis-treatment/drc-20378054
  65. Can You Take CBD and Pass a Drug Test?
    https://www.consumerreports.org/cbd/can-you-take-cbd-and-pass-a-drug-test/
  66. Does Depression Increase the Risk for Suicide?
    https://www.hhs.gov/answers/mental-health-and-substance-abuse/does-depression-increase-risk-of-suicide/index.html
  67. Antidepressant-Like Effects of Cannabidiol in Mice: Possible Involvement of 5-HT1A Receptors
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823358/
  68. What You Need to Know (And What We’re Working to Find Out) About Products Containing Cannabis or Cannabis-derived Compounds, Including CBD
    https://www.fda.gov/consumers/consumer-updates/what-you-need-know-and-what-were-working-find-out-about-products-containing-cannabis-or-cannabis
  69. Cannabidiol (CBD)-What We Know and What We Don’t
    https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476
  70. An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569602/
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