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Best CBD Oil for Seizures

We have gathered the best cannabidiol (CBD) oils you can try to reduce seizures. Find out how you can choose the right CBD product for your condition.

Rating
Highlights

Editor's Pick

Spruce 750mg Lab Grade CBD Oil


4.8 out of 5
  1. Peppermint flavor masks any unpleasant taste
  2. Contains 25mg of CBD per dropper full
  3. Bottle includes a graduated dropper for correct serving measurement

Best Organic

NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil


5.0 out of 5
  1. Natural remedy for various illnesses
  2. Product is full-spectrum whole-plant extract
  3. Contains naturally occurring synergistic cannabinoids and terpenes

Editor's Pick

Spruce 2400mg Lab Grade CBD Oil


5.0 out of 5
  1. Maximum possible potency
  2. Each dropper full contains 80mg of CBD
  3. Conveniently fits in a 30mL bottle

Best Seller

Avida Full Spectrum CBD Oil Tincture 500mg


4.6 out of 5
  1. Proprietary full-spectrum
  2. Developed using advanced AVIDA CORE Spectrum Technology
  3. Highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3)

Best Natural Alternative

cbdMD CBD Oil Tincture Natural 1500mg


4.7 out of 5
  1. Made using only CBD sourced from medical hemp
  2. Available in many flavours
  3. Safe for daily use

Best THC-Free

CBDistillery THC Free CBD Oil Tinctures


4.4 out of 5
  1. Do not contain THC
  2. Available in different potencies and sizes
  3. Brand has special deals and offers

Best Customer Rated

cbdMD CBD Oil Tincture Natural 750mg


4.4 out of 5
  1. THC-free
  2. Has plenty of flavours to choose from
  3. Totally vegan

Best Starter

NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil


4.6 out of 5
  1. Lowest concentration for CBD beginners
  2. Fully organic and lab-tested
  3. Full-spectrum

Best Flavor Range

Hemp Bombs 750mg CBD Oil


3.9 out of 5
  1. Has a wide range of flavours
  2. Safe to intake
  3. Get 20% off when you avail of their subscription

Compare the Best CBD Oil for Seizures in 2021

Product Potency Purity Customer Service Type Extraction Transparency Absorption
Spruce 2400mg Lab Grade CBD Oil
4.8 out of 5

4.5 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5
NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.0 out of 5

5.0 out of 5

5.0 out of 5
Spruce 2400mg Lab Grade CBD Oil
5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.0 out of 5

5.0 out of 5

5.0 out of 5
Avida Full Spectrum CBD Oil Tincture 500mg
4.6 out of 5

5.0 out of 5

3.5 out of 5

3.0 out of 5

5.0 out of 5

4.5 out of 5

4.5 out of 5

5.0 out of 5
cbdMD CBD Oil Tincture Natural 1500mg
4.7 out of 5

5.0 out of 5

3.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5
CBDistillery THC Free CBD Oil Tinctures
4.4 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.5 out of 5
cbdMD CBD Oil Tincture Natural 750mg
4.4 out of 5

4.5 out of 5

3.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5
NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
4.6 out of 5

2.5 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5
Hemp Bombs 750mg CBD Oil
3.9 out of 5

4.5 out of 5

3.5 out of 5

2.5 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5

Best CBD Oil for Seizures

1. Spruce 750mg Lab Grade CBD Oil
cbdc overall score
4.8
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Mid-strength  No other flavors
 Natural peppermint flavor
 Made from 100% organic and natural ingredients
Pros
 Mid-strength
 Natural peppermint flavor
 Made from 100% organic and natural ingredients
Cons
 No other flavors
Overview

Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
cbdc overall score
5.0
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Pure CBD hemp  No other flavors
 All natural
 Approximately 300 drops total
Pros
 Pure CBD hemp
 All natural
 Approximately 300 drops total
Cons
 No other flavors
Overview

Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

3. Spruce 2400mg Lab Grade CBD Oil
cbdc overall score
5.0
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Extra Strength  Tastes bitter
 No artificial flavoring or colors  No THC-free option
 Made from 100% organic and natural ingredients
Pros
 Extra Strength
 No artificial flavoring or colors
 Made from 100% organic and natural ingredients
Cons
 Tastes bitter
 No THC-free option
Overview

The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.

4. Avida Full Spectrum CBD Oil Tincture 500mg
cbdc overall score
4.6
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Light Spearmint flavor  No other flavor
 Non-THC, Non-detected in drug test
Pros
 Light Spearmint flavor
 Non-THC, Non-detected in drug test
Cons
 No other flavor
Overview

Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.

5. cbdMD CBD Oil Tincture Natural 1500mg
cbdc overall score
4.7
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Various delicious flavors to choose from  cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
 Has vegan, organic, and gluten-free ingredients
 Free shipping for this particular product within USA
 World-class customer service team
Pros
 Various delicious flavors to choose from
 Has vegan, organic, and gluten-free ingredients
 Free shipping for this particular product within USA
 World-class customer service team
Cons
 cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
Overview

cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

6. CBDistillery THC Free CBD Oil Tinctures
cbdc overall score
4.4
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 60-Day Satisfaction Guarantee  Dropper is a bit shaky
 Various strengths
 Oil extracted from aerial plant parts of US grown industrial hemp
 Sourced from non-GMO industrial hemp grown in the USA through natural farming practices
Pros
 60-Day Satisfaction Guarantee
 Various strengths
 Oil extracted from aerial plant parts of US grown industrial hemp
 Sourced from non-GMO industrial hemp grown in the USA through natural farming practices
Cons
 Dropper is a bit shaky
Overview

CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.

7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
cbdc overall score
4.6
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Pure CBD hemp  No other flavors
 All natural  A bit pricey compared to competitors
 Approximately 100 drops total
Pros
 Pure CBD hemp
 All natural
 Approximately 100 drops total
Cons
 No other flavors
 A bit pricey compared to competitors
Overview

This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.

8. cbdMD CBD Oil Tincture Natural 750mg
cbdc overall score
4.4
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Vegan and Gluten free  Does not ship internationally
 Has a third-party lab test
 Wide variety of CBD strengths and sizes
Pros
 Vegan and Gluten free
 Has a third-party lab test
 Wide variety of CBD strengths and sizes
Cons
 Does not ship internationally
Overview

A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.

9. Hemp Bombs 750mg CBD Oil
cbdc overall score
3.9
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pros Cons
 Wide variety of flavors  Incomplete information about the product
 Lab test results are complete  Does not ship to all international countries
 30-day money-back guarantee
Pros
 Wide variety of flavors
 Lab test results are complete
 30-day money-back guarantee
Cons
 Incomplete information about the product
 Does not ship to all international countries
Overview

Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.

How CBD Helps With Seizures

CBD has been gaining interest as a potential treatment for the medical condition

In a 2014 study published in Epilepsy and Behavior, CBD reduced the frequency of seizures among patients dealing with treatment-resistant epilepsy(1)

Treatment-resistant epilepsy is associated with a low quality of life (QOL)(2). It was suggested that CBD may improve patients’ QOL through effective seizure control(3)

Seizures are bursts of uncontrolled electrical activity between neurons (brain cells) that cause temporary abnormalities in movements, behaviors, consciousness, or sensations. Meanwhile, epilepsy occurs when an individual has recurring seizures(4)

The two types of seizures are focal and generalized seizures. Focal or partial seizures start with an electrical discharge in one area of the brain, while generalized seizures can spread to both sides of the brain(5)

The therapeutic effects of CBD on seizures are realized by CBD’s interaction with the body’s endocannabinoid system (ECS) and its cannabinoid receptors

The ECS regulates various functions in the body, including immune response, pain sensation, mood, memory processing, metabolism, appetite, anxiety, and sleep. 

CB1 and CB2 are the two main types of receptors of the ECS. Each receptor has specific roles and is located in different parts of the body. 

CB1 receptors are prevalently expressed in the central nervous system, including the brain.  These receptors are also found in the liver, lungs, retina, gastrointestinal and urinary tracts, and reproductive organs(6)

CB1 receptors’ activation in the body has been linked to neuroprotective responses(7)

This mechanism suggests that cannabinoids with a high affinity for CB1 receptors, like CBD, may help prevent and treat neurodegenerative conditions(8).

Cannabinoids are naturally occurring compounds that may come from the cannabis plant. 

Meanwhile, CB2 receptors are mainly situated on the immune system’s cells and their associated structures. When activated, these receptors stimulate a response that reduces pain, fights inflammation, and minimizes tissue damage.

According to a study, CBD compounds have a weak affinity for CB1 and CB2 receptors. CBD’s anti-seizure activity at certain concentrations is brought about by other mechanisms(9)

The blocking of GPR55 receptors and the reabsorption of adenosine in the brain have been suggested to play a vital role in CBD’s anti-seizure activity(10)

Adenosine is a neurotransmitter that may stop seizures and convulsions(11). A 2017 study in the Neuropharmacology journal noted that the therapeutic increase of adenosine prevents epileptic seizures(12)

GPR55 (G protein-coupled receptor) is a type of protein found in the brain. A study found that the function of GPR55 receptors was enhanced by epilepsy that made seizures worse(13)

However, CBD remained adequately potent in epileptic brains, which suggests the anticonvulsant properties of CBD. These anticonvulsant characteristics may be related in part to CBD-mediated modulation of the ECS(14)

The modulation is done through inhibiting anandamide degradation or decline, resulting in reduced excess brain activity(15)

Anandamide is an endocannabinoid (cannabinoids produced within the body) that acts as a neurotransmitter and regulates emotional behavior.

Research noted that endocannabinoids are released by bursts of action potentials, such as seizures or events resembling spikes(16)

Benefits of Using CBD for Seizures

Studies indicated CBD’s antiepileptic efficacy in acute and chronic seizure rodent models. However, the exact mechanisms of action remain unclear(17)

In various animal studies, pure CBD used on partial and generalized epilepsy models showed anticonvulsant effects(18). These studies were conducted on mice, rats, and gerbils. 

Meanwhile, open-label studies and small randomized controlled trials of purified CBD in humans with treatment-resistant epilepsy demonstrated mixed results(19)

A study in the New England Journal of Medicine indicated that CBD use resulted in a significant reduction in convulsive-seizure frequency than placebo among people with Dravet syndrome(20)

Dravet syndrome is one of the types of epilepsy syndromes that begins in infancy or early childhood. This condition is characterized by frequent or prolonged seizures(21)

Many of these clinical trials used a product that combines a one-to-one ratio of CBD and tetrahydrocannabinol (THC), a compound with known psychoactive effects

The results of the 2017 study were promising. On average, CBD decreased convulsive seizures from nearly 13 seizures to about six seizures per month(22).  

Meanwhile, the average change with the placebo was from 15 to about 14 seizures per month. A minority of about 5% of patients became seizure-free.

In another randomized, double-blind, placebo-controlled trial in 2018, researchers investigated CBD’s efficacy on the treatment-resistant Lennox-Gastaut syndrome (LGS). 

Findings stated that CBD proved efficacious in treating patients (aged 2 to 55 years old) with drop seizures associated with LGS(23)

Drop seizures, also known as atonic seizures or drop attacks, are characterized by a sudden loss of muscle strength. This type of seizure causes an individual to fall to the ground(24)

In a 2018 study, the high-dose CBD group experienced an average reduction in the drop-seizure frequency of nearly 42% during the treatment period. 

Meanwhile, the low-dose CBD group experienced about 37% reduction while only 17% in the placebo group reported drop seizure reduction.

The researchers also suggested that CBD is generally well-tolerated. However, 74 out of 86 patients reported adverse effects, such as drowsiness, fever, decreased appetite, diarrhea, and vomiting. 

The studies on CBD as an additional anticonvulsant in patients with LGS and Dravet syndrome contributed to the decision regarding Epidiolex’s approval. 

Epidiolex is a pharmaceutical-grade purified CBD approved by the US Food and Drug Administration (FDA) as an evidence-based remedy for treatment-resistant epileptic syndromes(25)

Medical professionals’ attitudes regarding the use of CBD for epilepsy treatment appear to be divided(26). However, data about CBD’s benefits in the daily is not available. 

CBD Dosage and Delivery Methods for Seizures

Dosage

CBD dosage for seizures may depend on several factors, such as the patient’s age, seizure type, cause of seizure or epilepsy, and other medications currently taken(27)

You may start with small amounts of CBD at first, then gradually increase the dosing if there are no adverse effects. Get medical advice from your physician to determine the right CBD dosage for seizures. 

A study stated that doses of up to 50 mg CBD are safe. However, a higher permissible amount for CBD treatment cannot be defined due to a lack of data(28)

Meanwhile, the recommended Epidiolex dosages for seizures associated with Dravet or Lennox-Gastaut syndrome are the following(29):

  • Starting dosage: 2.5mg CBD per kilogram of the body weight by mouth twice daily
  • Maintenance dosage: 5mg CBD per kilogram of the body weight by mouth twice daily
  • Maximum maintenance dosage: 10mg CBD per kilogram of the body weight by mouth twice daily

Methods of Delivery

Oral administration is recommended for people with seizures, especially those with Dravet and Lennox-Gastaut syndrome. Epidiolex is an oral solution that involves placing the liquid in the mouth(30)

Tinctures may be applied through sublingual administration by placing a few drops of CBD oil under your tongue with a dropper. This method allows CBD to be absorbed into the bloodstream. 

According to a review published in the International Journal of Pharmacy and Pharmaceutical Sciences, most substances administered sublingually achieve peak blood levels (the drug’s highest level of concentration in the bloodstream) within 10 to 15 minutes, which is faster than oral ingestion(31).  

Additionally, the sublingual method is an efficient way to take CBD oil. Studies report that the sublingual form has a bioavailability of 13% to 19% and 35%(32)

Bioavailability is known as the rate and degree at which the body absorbs a drug.

CBD oil may be ingested through edibles, gummies, or added to other food and beverages. This method allows CBD to be absorbed through the digestive tract. 

CBD-infused topicals may also be used in massage therapies. However, this method provides limited absorption through the skin(33)

The Epilepsy Society in the United Kingdom stated that complementary therapies, like massages and herbal remedies, may reduce stress, promote wellbeing, and be used with any antiepileptic drugs taken by an individual(34)

Vaping provides a quick way of getting CBD into the body(35). After inhaling CBD, it enters the bloodstream by passing through the lungs. 

The effects of CBD may be felt within minutes and may last up to four hours(36). However, it may be challenging to determine the exact amount of CBD in each draw of vape.

The use of vape should be done with caution, especially for patients with seizures. Experts believe that vaping may cause lung problems due to allergic or immune reactions and chemical irritation to various substances in the inhaled vapors(37)

CBD vs. Other Treatment Options for Seizures

Prescribed medications and surgical techniques may control seizures in 70% of individuals with epilepsyseizure disorders. However, there is no available treatment of seizures in some forms of epilepsy(38)

These self-management strategies may help epilepsy patients control their seizures better and improve their overall health(39):  

  • Getting seven to eight hours of sleep.
  • Keeping a well-balanced diet and maintaining a healthy weight.
  • Finding outlets to relieve stress and seeking professional help for mental health issues. 

Multiple studies highlighted CBD’s potential therapeutic properties that may help with these self-management techniques for seizures.

A 2017 study noted that CBD may induce restful sleep and hold promise in the treatment of insomnia(40)

Full-spectrum CBD derived from hemp contains omega-3 fatty acids. A study observed that administering supplements with omega-3 and omega-6 fatty acids resulted in reduced seizures in patients with refractory epilepsy(41).

Another study indicated that CBD had anti-anxiety and antiepileptic effects on the brain that may help with anxiety and depression(42)

Risks and Side Effects of CBD for Seizures

The World Health Organization (WHO) indicated that CBD is generally safe to use(43). However, the possible side effects of CBD may include nausea, dry mouth, fatigue, diarrhea, changes in weight or appetite, and gastrointestinal problems(44)

The FDA-approved CBD drug for epilepsy, Epidiolex, may also come with mild or severe side effects. Some of the adverse reactions to Epidiolex include malaise (feeling of weakness), skin rash, insomnia, and viral or fungal infections(45)

In clinical studies, liver damage occurred in people who took Epidiolex. It was noted that between 8% and 25% of people had high levels of liver enzymes(46)

Studies also showed that CBD may interact with certain seizure medications, including clobazam (Sympazan and Onfi), diazepam (Diastat and Valium), valproate or valproic acid, and phenytoin (Dilantin and Phenytek)(47)

Data suggested that CBD may reduce the effects of the said medications and increase some side effects(48)

If you are considering CBD oil for seizures, talk to your doctor to know if CBD can be taken with your prescribed medications.

How to Choose the Best CBD Oil for Seizures

Before purchasing CBD oil for seizures, you should know the three types: full-spectrum, broad-spectrum, and CBD isolates

Full-spectrum CBD contains all nutrients from the Cannabis sativa plant, including trace amounts of THC, terpenes, fatty acids, flavonoids, and essential oils. The combination of these compounds synergizes to create an entourage effect.

This phenomenon occurs when all components work together to achieve more than the sum of what the same components could achieve individually(49). The entourage effect is believed to enhance CBD’s health benefits(50)

For individuals with seizures who do not prefer trace amounts of THC in their system, broad-spectrum CBD may be used. This type of CBD oil is similar to full-spectrum CBD without the THC compound. 

If you are allergic to certain compounds of the cannabis plant, you may opt for CBD isolates. This type of CBD oil carries pure, isolated cannabidiol only.

You should also know the differences between hempseed oil and hemp oil. Hempseed oil is obtained from hemp seeds and may have little to no THC content, while hemp oil is extracted from the oil of the hemp plant.

The following factors may help you find high-quality, reliable, and safe CBD products

  • Choose quality products made from non-GMO, organic hemp, and manufactured by legitimate CBD brands.
  • Some CBD companies grow their hemp or source it from licensed hemp producers. The most common sources of hemp are Colorado and Oregon. 
  • Know the method of extraction used in the CBD product. According to a study, the FDA recognizes supercritical CO2 extraction as a safe process in pharmaceutical manufacturing(51)
  • The standard carrier oils used in CBD oil include hemp seed oil, MCT (medium-chain triglycerides), and extra-virgin olive oil.
  • CBD oil products should be tested by an accredited third-party laboratory. Companies should provide the results on their website to ensure the absence of pesticides, heavy metals, bacteria, and residual solvents.
  • See if the third-party lab results match the CBD company’s claims about the potency of its products. 
  • You may also look for certification codes in CBD products. These codes determine if the product is screened and approved by the authorities. 
  • Get advice from a healthcare professional regarding the proper dosage and recommended form of CBD to use for your condition. 
  • Research on the brand and read customer reviews when buying from an online store. 
  • If you are buying from a dispensary or local retailer, make sure that the store is authorized by the government to sell CBD products
  • Know the laws regarding CBD in the state where you will purchase and use it.

Legality of CBD

Hemp and hemp-derived CBD products with less than 0.3% THC are federally legal under the United States 2018 Farm Bill(52)

Industrial hemp is removed as a Schedule I drug from the Controlled Substances Act. Drugs under this category have no acceptable medical use and have a high potential for abuse(53)

The Farm Bill of 2018 also lifted federal restrictions surrounding CBD to allow the cultivation, manufacture, and sale of CBD products. However, state laws may vary regarding CBD with high THC content(54)

Individuals are required to follow the requirements outlined in a state’s medical marijuana program. 

Qualifying patients may purchase and use medical cannabis if they have an official diagnosis and recommendation from their physician(55)

Product Frequently
Asked Questions

  • How can CBD help with seizures?

    Research suggested that CBD has anticonvulsant properties that work with the body’s endocannabinoid system. This mechanism helps with CBD’s anti-seizure activity(56).

  • What are the benefits of CBD for seizures?

    According to studies, CBD showed efficacy in the treatment of epilepsy with its anti-seizure, antipsychotic, and neuroprotective properties. The study’s researchers also noted that CBD possessed anxiolytic and antidepressant characteristics(57).

  • Is there any evidence that CBD can make seizures worse?

    In a study published in Neurology, refractory pediatric epilepsy patients who took artisanal or store-bought CBD reported a 70% increase in seizures and side effects(58)

    Unlike pharmaceutical-grade CBD (Epidiolex), artisanal CBD may have varying THC levels and may not have undergone testing. These factors could contribute to the increase in seizure activity(59).

  • Will CBD interact with any current medication I may be taking for seizures?

    CBD has the potential to interact with seizure medications, such as clobazam (Sympazan and Onfi), diazepam (Diastat and Valium), phenytoin (Dilantin and Phenytek), and valproate or valproic acid(60).

  • Are there other treatments I should consider alongside CBD to help with seizures?

    Aside from taking CBD, you may consider different self-management techniques to help with seizures. These techniques include getting enough hours of sleep, following a well-balanced diet, and reducing your stress levels.

  • Can I fail a drug test if I use CBD for seizures?

    CBD products with high amounts of THC may show up in a drug test. It is also important to note that even if your CBD oil contains trace amounts of THC only, the compound may accumulate in your body over time with frequent use(61).

  • What is the CBD dosage for seizures?

    The general rule for CBD dosage is to begin with a low dose of CBD and slowly increase the amount. It is advisable to consult a physician to determine a suitable dosage for your needs.

  • Where do I find CBD oil for seizures and epilepsy?

    Epidiolex, an FDA-approved CBD drug for rare forms of epilepsy, may be purchased from pharmacies with a doctor’s prescription(62). You may also find CBD oil products for seizures in local dispensaries, retailers, and official online stores.

  • How do I get a prescription for medical cannabis and CBD for my seizures?

    There are different requirements regarding the purchase of medical cannabis, depending on the state’s law. 

    In most states, you need a diagnosis from a licensed physician indicating that you have a qualifying medical condition and a recommendation to use CBD-rich oils(63).


  1. Porter BE, Jacobson C. Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy. Epilepsy Behav. 2013;29(3):574‐577. DOI:10.1016/j.yebeh.2013.08.037.
  2. Gaston, T. E., Szaflarski, M., Hansen, B., Bebin, E. M., Szaflarski, J. P., & UAB CBD Program (2019). Quality of life in adults enrolled in an open-label study of cannabidiol (CBD) for treatment-resistant epilepsy. Epilepsy & behavior : E&B, 95, 10–17. https://doi.org/10.1016/j.yebeh.2019.03.035
  3. Silvestro, S., Mammana, S., Cavalli, E., Bramanti, P., & Mazzon, E. (2019). Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials. Molecules (Basel, Switzerland), 24(8), 1459. https://doi.org/10.3390/molecules24081459
  4. Johns Hopkins Medicine. Types of Seizures. Retrieved from: https://www.hopkinsmedicine.org/health/conditions-and-diseases/epilepsy/types-of-seizures
  5. ibid.
  6. Reggio PH. Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown. Curr Med Chem. 2010;17(14):1468–1486. DOI:10.2174/092986710790980005.
  7. Zou, S., & Kumar, U. (2018). Cannabinoid receptors and the endocannabinoid system: signaling and function in the central nervous system. International journal of molecular sciences, 19(3), 833.
  8. ibid.
  9. Blair RE, Deshpande LS, DeLorenzo RJ. Cannabinoids: is there a potential treatment role in epilepsy? Expert Opin Pharmacother. 2015;16:1911–4; Friedman D, Devinsky O. Cannabinoids in the treatment of epilepsy. N Engl J Med. 2015;373:1048–58; Bisogno T, Hanus L, De Petrocellis L, et al. Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol. 2001;134:845–52.
  10. Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS. Progress report on new antiepileptic drugs: a summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII) Epilepsia. 2017;58:181–221.
  11. Dragunow, M. (1991). Adenosine and seizure termination. Ann. Neurol. 29:575. doi: 10.1002/ana.410290524; During, M. J., and Spencer, D. D. (1992). Adenosine: a potential mediator of seizure arrest and postictal refractoriness. Ann. Neurol. 32, 618–624. doi: 10.1002/ana.410320504. 
  12. Boison D. Adenosinergic signaling in epilepsy. Neuropharmacology. 2016;104:131‐139. DOI:10.1016/j.neuropharm.2015.08.046. 
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  30. ibid.
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  36. ibid.
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