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Best CBD Oil for Liver Disease

Although some liver conditions may be managed with lifestyle modifications, more severe conditions may need a different remedy. If you are considering using cannabidiol (CBD), CBD Clinicals may help you find the right product you need to help maintain a healthier liver.

Editor's Pick

Spruce 750mg Lab Grade CBD Oil

Best Organic

NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil

Editor's Pick

Spruce 2400mg Lab Grade CBD Oil

Best Seller

Avida Full Spectrum CBD Oil Tincture 500mg

Best Natural Alternative

cbdMD CBD Oil Tincture Natural 1500mg

Best THC-Free

CBDistillery THC Free CBD Oil Tinctures

Best Customer Rated

cbdMD CBD Oil Tincture Natural 750mg

Best Starter

NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil

Hemp Bombs 750mg CBD Oil

Best Allergy Friendly

Sunsoil CBD Oil Drops, Chocolate Mint Flavor

Rating
4.8 out of 5

5.0 out of 5

5.0 out of 5

4.6 out of 5

4.7 out of 5

4.4 out of 5

4.4 out of 5

4.6 out of 5

3.9 out of 5

3.6 out of 5
Highlights
  1. Peppermint flavor masks any unpleasant taste
  2. Contains 25mg of CBD per dropper full
  3. Bottle includes a graduated dropper for correct serving measurement
  1. Natural remedy for various illnesses
  2. Product is full-spectrum whole-plant extract
  3. Contains naturally occurring synergistic cannabinoids and terpenes
  1. Maximum possible potency
  2. Each dropper full contains 80mg of CBD
  3. Conveniently fits in a 30mL bottle
  1. Proprietary full-spectrum
  2. Developed using advanced AVIDA CORE Spectrum Technology
  3. Highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3)
  1. made using only CBD sourced from medical hemp
  2. available in many flavours
  3. safe for daily use
  1. Do not contain THC
  2. Available in different potencies and sizes
  3. Brand has special deals and offers
  1. THC-free
  2. Has plenty of flavours to choose from
  3. Totally vegan
  1. Lowest concentration for CBD beginners
  2. Fully organic and lab-tested
  3. Full-spectrum
  1. Has a wide range of flavours
  2. Safe to intake
  3. Get 20% off when you avail of their subscription
  1. Tastes great
  2. Uses hemp grown organically
  3. Laboratory tests done by a third party

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Compare the Best CBD Oil for Liver Disease in 2021

Product Potency Purity Customer Service Type Extraction Transparency Absorption
Spruce 2400mg Lab Grade CBD Oil
4.8 out of 5

4.5 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5
NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.0 out of 5

5.0 out of 5

5.0 out of 5
Spruce 2400mg Lab Grade CBD Oil
5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.0 out of 5

5.0 out of 5

5.0 out of 5
Avida Full Spectrum CBD Oil Tincture 500mg
4.6 out of 5

5.0 out of 5

3.5 out of 5

3.0 out of 5

5.0 out of 5

4.5 out of 5

4.5 out of 5

5.0 out of 5
cbdMD CBD Oil Tincture Natural 1500mg
4.7 out of 5

5.0 out of 5

3.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5
CBDistillery THC Free CBD Oil Tinctures
4.4 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.5 out of 5
cbdMD CBD Oil Tincture Natural 750mg
4.4 out of 5

4.5 out of 5

3.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5
NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
4.6 out of 5

2.5 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5
Hemp Bombs 750mg CBD Oil
3.9 out of 5

4.5 out of 5

3.5 out of 5

2.5 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5
Sunsoil CBD Oil Drops, Chocolate Mint Flavor
3.6 out of 5

2.5 out of 5

3.5 out of 5

5.0 out of 5

5.0 out of 5

4.0 out of 5

3.5 out of 5

5.0 out of 5

Best CBD Oil for Liver Disease

1. Spruce 750mg Lab Grade CBD Oil
cbdc overall score
4.8
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Mid-strength  No other flavors
 Natural peppermint flavor
 Made from 100% organic and natural ingredients
Pro's
 Mid-strength
 Natural peppermint flavor
 Made from 100% organic and natural ingredients
Con's
 No other flavors
Overview

Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
cbdc overall score
5.0
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Pure CBD hemp  No other flavors
 All natural
 Approximately 300 drops total
Pro's
 Pure CBD hemp
 All natural
 Approximately 300 drops total
Con's
 No other flavors
Overview

Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

3. Spruce 2400mg Lab Grade CBD Oil
cbdc overall score
5.0
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Extra Strength  Tastes bitter
 No artificial flavoring or colors  No THC-free option
 Made from 100% organic and natural ingredients
Pro's
 Extra Strength
 No artificial flavoring or colors
 Made from 100% organic and natural ingredients
Con's
 Tastes bitter
 No THC-free option
Overview

The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.

4. Avida Full Spectrum CBD Oil Tincture 500mg
cbdc overall score
4.6
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Light Spearmint flavor  No other flavor
 Non-THC, Non-detected in drug test
Pro's
 Light Spearmint flavor
 Non-THC, Non-detected in drug test
Con's
 No other flavor
Overview

Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.

5. cbdMD CBD Oil Tincture Natural 1500mg
cbdc overall score
4.7
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Various delicious flavors to choose from  cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
 Has vegan, organic, and gluten-free ingredients
 Free shipping for this particular product within USA
 World-class customer service team
Pro's
 Various delicious flavors to choose from
 Has vegan, organic, and gluten-free ingredients
 Free shipping for this particular product within USA
 World-class customer service team
Con's
 cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
Overview

cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

6. CBDistillery THC Free CBD Oil Tinctures
cbdc overall score
4.4
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 60-Day Satisfaction Guarantee  Dropper is a bit shaky
 Various strengths
 Oil extracted from aerial plant parts of US grown industrial hemp
 Sourced from non-GMO industrial hemp grown in the USA through natural farming practices
Pro's
 60-Day Satisfaction Guarantee
 Various strengths
 Oil extracted from aerial plant parts of US grown industrial hemp
 Sourced from non-GMO industrial hemp grown in the USA through natural farming practices
Con's
 Dropper is a bit shaky
Overview

CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.

7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
cbdc overall score
4.6
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Pure CBD hemp  No other flavors
 All natural  A bit pricey compared to competitors
 Approximately 100 drops total
Pro's
 Pure CBD hemp
 All natural
 Approximately 100 drops total
Con's
 No other flavors
 A bit pricey compared to competitors
Overview

This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.

8. cbdMD CBD Oil Tincture Natural 750mg
cbdc overall score
4.4
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Vegan and Gluten free  Does not ship internationally
 Has a third-party lab test
 Wide variety of CBD strengths and sizes
Pro's
 Vegan and Gluten free
 Has a third-party lab test
 Wide variety of CBD strengths and sizes
Con's
 Does not ship internationally
Overview

A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.

9. Hemp Bombs 750mg CBD Oil
cbdc overall score
3.9
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Wide variety of flavors  Incomplete information about the product
 Lab test results are complete  Does not ship to all international countries
 30-day money-back guarantee
Pro's
 Wide variety of flavors
 Lab test results are complete
 30-day money-back guarantee
Con's
 Incomplete information about the product
 Does not ship to all international countries
Overview

Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.

10. Sunsoil CBD Oil Drops, Chocolate Mint Flavor
cbdc overall score
3.6
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Sunsoil CBD is committed to providing high-quality products at an affordable cost.  Product selection is limited.
 The company tests its products thrice before making them available to the public.  The company uses lipid extraction methods.
 From cultivation to packaging, everything is done in Sunsoil CBD grounds.
 Organic and sustainable farming is at the company’s core.
Pro's
 Sunsoil CBD is committed to providing high-quality products at an affordable cost.
 The company tests its products thrice before making them available to the public.
 From cultivation to packaging, everything is done in Sunsoil CBD grounds.
 Organic and sustainable farming is at the company’s core.
Con's
 Product selection is limited.
 The company uses lipid extraction methods.
Overview

The flavor profile is refreshingly sweet, and it balances well with the higher CBD concentration. Promotes the absorption of CBD into your blood circulation.

How We Rank
Our Ratings

How Do We Rank Our Reviews?

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Value

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Core Technology

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Expandable Packages

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Installation & Set-Up

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Trial Period & Flexible Contracts

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Brand Recognition & Reputation

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How CBD Helps With Liver Disease

There are several types of liver diseases caused by viruses, genes, and substance abuse. The most common liver diseases include cirrhosis, fatty liver disease, hepatitis, and hemochromatosis, a genetic condition that may be inherited(1).

Although some liver problems may be remedied with lifestyle modifications, some conditions may require treatment or surgery(2)

Treatment for autoimmune liver damage often includes corticosteroids or steroid hormones. Another medication for liver damage is prednisone, which may cause side effects, such as weight gain, high blood pressure, glaucoma, and mood swings(3)

A liver transplant is a treatment option for more serious liver diseases. However, a liver transplant also comes with several complications, such as internal bleeding, infection, seizures, liver failure, or rejection of the donated organ(4)

The drawbacks of these liver damage treatments may cause some individuals to search for more natural approaches to treating their livers. Some patients with liver conditions cannot be treated with pharmaceutical drugs, encouraging them to look for other remedies.

CBD has gained popularity because of the cannabinoid’s potential health benefits. Cannabinoids are chemical compounds found in the cannabis plant.

However, there are still questions about whether CBD may help with liver damage or not. 

Although some studies have acknowledged the cannabinoid’s potential ability to stimulate liver regeneration, some studies link CBD to liver damage in animal subjects.

The human endocannabinoid system (ECS) is made up of G-protein-coupled receptors: the cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2). 

G-protein-coupled receptors are receptors in the body that link and transmit signals from compounds to a molecule called a G-protein(5).

You may find CB1 receptors throughout the body. However, the majority of them are in the central nervous system. Meanwhile, CB2 receptors may be found primarily in the immune system(6).

Medical researchers have been studying the ECS for decades to manage various physiological functions and peripheral organs. 

According to a 2006 study, modulating ECS activity may have several therapeutic responses to various health conditions and diseases(7).

The researchers of the 2006 study observed how the ECS may affect weight balance, appetite, energy, and metabolism. They noted that administering a CB1 antagonist decreased food intake and body weight among animal test subjects.

Receptor agonists are medications that bind to receptors and activate them. Meanwhile, antagonists reduce the receptor’s ability to be activated(8)

Another study found in the International Journal of Molecular Sciences noted how CB1 antagonists reduced obesity in mice with diet-induced obesity(9).

Meanwhile, a Hepatology study observed how a CB2 receptor agonist improved fibrogenesis and accelerated liver regeneration(10)

Findings from the British Journal of Pharmacology discussed how CBD may function as a CB2 receptor inverse agonist, producing anti-inflammatory effects(11).

A 2008 study noted that CBD may work as both a cannabinoid receptor agonist and antagonist. The authors stated that CBD in low doses may act as a CB1 antagonist(12)

The 2009 study was supported by a more recent independent study published in the Canadian Journal of Kidney Health and Disease. In the study, the medical researchers used the cannabinoid to block CB1 receptors of insulin-resistant rats, preventing proteinuria (increased protein in the urine) and renal function decline(13).

A recent study highlighted that CBD may function as a CB1 antagonist(14)

Benefits of Using CBD for Liver Disease

According to a 2011 animal study, CBD may restore liver function, normalize 5-HT levels, and improve brain pathology. The researchers observed that the effects of the cannabinoid may be from a combination of CBD’s activities in the liver and brain(15).

Meanwhile, a 2017 study demonstrated that CBD treatment significantly reduced alcohol-induced liver damage in a mouse model. The medical researchers noted that CBD may have therapeutic potential in liver disease linked with inflammation, metabolic dysregulation, oxidative stress, and steatosis (fatty change)(16).

Below are some of the published studies about the effects of CBD on liver diseases.

Hepatitis C

Hepatitis C is a condition caused by the hepatitis C virus (HCV). Symptoms include tiredness, fever, joint pain, loss of appetite, and jaundice (whites of the eyes turning yellow).

According to the World Health Organization (WHO), there were new 1.25 million HCV infections worldwide in 2019(17)

A 2017 study stated that CBD may have bioactivities against HCV. The study noted that CBD’s direct antiviral activity may be effective against non-viral and viral hepatitis (autoimmune hepatitis)(18)

Although the 2017 study highlighted CBD’s potential benefits against HCV, medical researchers also noted that the cannabinoid did not affect the hepatitis B virus. 

You must consult a physician before using CBD for hepatitis C. According to Mayo Clinic, untreated hepatitis C may cause a long-term infection, such as chronic hepatitis C, resulting in severe liver damage(19)

Alcoholic Liver Disease

Alcoholism may result in hepatosteatosis (fatty liver disease), also known as alcoholic liver disease (ALD). 

With early detection and lifestyle modifications, ALD may be treated and reversed. However, if left untreated, ALD may progress to severe liver problems, such as hepatitis and cirrhosis.

Researchers noted that oxidative stress is one of the main factors in inducing steatosis. In a 2014 animal study published in Free Radical Biology and Medicine, medical researchers reported that CBD reduced toxicity and oxidative stress, resulting in reduced ethanol-induced liver injury(20)

In a Frontiers of Pharmacology study, animal studies showed that CBD may reduce liver steatosis and fibrosis caused by chronic and binge ethanol administrations(21).

Non-Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is a medical condition caused by excess fat accumulated in the liver.

The causes of NAFLD may be obesity, insulin resistance, high levels of fat in the body, or high blood sugar.

There has been no prescription treatment approved to manage NAFLD(22). If you have NAFLD, your doctor may recommend a change in lifestyle and diet habits to help you lose weight naturally and reverse the fat deposition.

Several medical researchers have studied CBD’s efficacy in weight loss. A 2020 study posted in the Frontiers in Endocrinology observed the positive effects of CBD on the liver(23)

According to the 2020 study, CBD helped reduce intracellular lipid (fat) content in an in vitro (outside a living organism) hepatosteatosis model. The study also noted that CBD had antioxidant and anti-inflammatory effects(24).

Meanwhile, in a 2017 study published by PLOS One, medical researchers observed a strong connection between cannabis use and reduced NAFLD prevalence(25)

However, further clinical studies are needed to verify the cannabinoid’s efficacy in reducing lipid content in the liver and CBD’s anti-obesity properties. 

Other Benefits of CBD for Liver Disease

According to a 2011 study, CBD may help manage acute liver failure symptoms, thus serving as a potential therapeutic compound for treating human hepatic encephalopathy (brain function decline caused by severe liver disease)(26)

Many health agencies, including the WHO, stated that the non-psychoactive cannabinoid is safe and generally well-tolerated(27)

Prescription is required when buying medications for liver disease. In contrast, some US states allow individuals to purchase hemp-derived CBD products even without a prescription. 

Risks of Using CBD for Liver Disease

The production of CBD remains unregulated. The US Food and Drug Administration (FDA) has only approved Epidiolex, a CBD-derived drug for seizures associated with Lennox-Gastaut Syndrome and Dravet Syndrome(28).

If you plan on buying CBD products, you must research product specifications,  testimonials, reviews, and third-party laboratory tests. According to the FDA, high doses of CBD may lead to liver injury(29)

Meanwhile, in a recent study, medical researchers observed that CBD use may affect liver wellness and result in dose-related liver damage(30)

The study also noted that the use of CBD may increase the risk of liver damage when used with other drugs, such as leflunomide (analgesic), mipomersen (medication for high cholesterol), pexidartinib (giant cell tumor drug), teriflunomide (multiple sclerosis medication), and valproate (epilepsy medication)(31)

If you have severe or moderate liver damage, your doctor may advise slow dose titration, which pertains to the slow adjustment of a medication dose for the maximum benefit without adverse effects(32).

According to Mayo Clinic, there have been no proven alternative medicine therapies for liver disease. Although some studies have indicated possible benefits, further research is still needed(33).

Dietary supplements and herbal products may also be harmful to liver health. There are over thousands of medications and herbal products associated with liver damage, including(34):

  • Mistletoe
  • Skullcap, a plant from the mint family
  • Chaparral, a desert shrub
  • Comfrey, a plant used to treat inflammation and chronic pain(35)
  • Kava, a perennial herb
  • Pennyroyal oil, an oil sourced from a plant in the mint genus 
  • Vitamin A
  • Ma-huang, a Chinese herb
  • Germander, a plant from the mint family
  • Valerian, a flowering perennial plant

The list above highlights the importance of seeking medical advice before trying alternative medicine, such as CBD. Consult your doctor on the potential risks of these treatments before you opt for complementary or alternative therapies.

You should also conduct thorough research about CBD. To learn more about CBD‘s potential risks, visit the National Institutes of Health (NIH) website https://www.nih.gov/.

CBD Dosage and Consumption Methods

Dosage

There are various factors to consider to ensure safe CBD dosing. These factors include the product’s CBD potency, CBD concentration, the user’s body weight, and the desired results.

According to a comprehensive review cited in a study from Cannabis and Cannabinoid Research, humans may tolerate a CBD dosage of up to 1,500mg per day(36).

Administration Methods

The most common methods of consuming CBD include:

  • Sublingual (dropping CBD oil under the tongue) method
  • Ingesting CBD tablets, capsules, or other edibles
  • Mixing CBD into food or drinks
  • Applying CBD topicals or balms directly onto the skin

One of the most common methods to take CBD is through vaping. Inhaling CBD serves as a quick way to ingest CBD since the cannabinoid enters the body through the lungs’ bloodstream without going through the digestive system. 

In a 2018 study, medical researchers noted that after vaping CBD, the user may experience the cannabinoid’s highest plasma concentrations three minutes after the dose(37).

However, some studies also noted that vaping may have detrimental effects on the lungs. According to a recent study, the increased vape use in the US resulted in the rise of vaping-related pulmonary problems(38).

Aside from pulmonary health risks, other vaping hazards include allergic reactions or irritation to the chemicals in the inhaled vapors(39)

Meanwhile, in a 2002 study, researchers noted that sublingual administration of CBD was an efficient way of taking the cannabinoid. According to the study, CBD oil had a sublingual bioavailability of 13% to 19%(40).

Bioavailability pertains to the extent and rate at which a medication is absorbed and becomes readily available for the body to process and break down(41)

According to a 2015 review, researchers observed that with the sublingual route of consumption, most compounds’ peak blood levels may be reached in 10 to 15 minutes. The researchers noted that this was faster than when the same drugs are ingested through oral administration. 

If you do not like the taste of hemp oil, some CBD brands provide CBD edibles, like CBD gummies, in delicious flavors. Some companies also offer unflavored options in their CBD oil product line to encourage more individuals to buy.

You may also opt to mix CBD oils into your favorite meals. According to a 2018 study, cannabinoid’s highly lipophilic nature (lipid or oil solubility) allows the compound to dissolve in the fat content of food, which may boost the compound’s absorption and solubility(42).

You may also apply CBD directly to your skin. CBD may be infused in transdermal products, including cream, lotion, balm, or salve. 

One of the major advantages of the transdermal application of CBD is that it avoids the first-pass metabolism, which causes more constant plasma levels(43). The first-pass effect pertains to the early metabolization of a drug, reducing drug concentrations before the substance reaches its intended site of action(44).

In a 2018 study, medical researchers noted that CBD’s half-life is 24 hours after an intravenous administration and 31 hours after pulmonary administration(45). Half-life is the time required for one-half of a drug’s concentration to decrease to half of its initial dose in the body(46).

Meanwhile, researchers noted that the half-life of CBD is between 1.4 hours and 10.9 hours after an oromucosal (surface of the mouth) consumption route. The authors of the research recorded that the half-life of CBD is two to five days after an oral administration(47).

Choosing the Right CBD Oil for Liver Disease

Regardless of the kind of CBD products you want, you must employ careful consideration when hunting for the highest-quality CBD oil for liver problems.

Below are some tips to remember before buying CBD products:

  • Seek medical advice before using CBD. Learn about possible drug-to-drug interactions and adverse effects of CBD use for liver disease.
  • Look for brands certified by the US Hemp Authority or other accrediting organizations.
  • Compare the information on the product label to the data from the third-party lab reports.
  • Research the state CBD laws applicable in your area.
  • Read the reviews of past buyers before purchasing a CBD product.

Legality of CBD

The then President Donald Trump legalized hemp production at the federal level in 2018 when he signed the Farm Bill into law. The Farm Bill removed hemp and hemp-derived products with less than 0.3% of tetrahydrocannabinol (THC) from the list of Schedule I controlled substances(48).

Although the Farm Bill did not legalize marijuana and marijuana-derived products, state lawmakers can implement their own laws regarding medical and recreational marijuana legalization.

Although CBD is federally legal, you must first research state CBD laws before purchasing CBD products. As of December 2020, the FDA still has not regulated the production and the marketing of CBD(49).

You should also note that state laws have varying levels of restrictions regarding CBD regulations. In some places, like South Dakota, state laws about CBD remain unclear(50).

Product Frequently
Asked Questions

  • How can CBD help with liver disease?

    In a 2008 study, the authors suggested that CBD may work as a cannabinoid receptor agonist and antagonist(51). Another study demonstrated that a CB2 receptor agonist may improve fibrogenesis and accelerated liver regeneration(52)

  • What research exists that suggests CBD’s benefits in patients with liver disease?

    The researchers of a study published in the British Journal of Pharmacology observed that CBD  improved acute liver failure symptoms on animal subjects(53). Another study published in Pharmacognosy Research noted that CBD may help treat HCV(54).

  • Can CBD make liver disease worse?

    According to a recent StatPearls article, CBD may cause dose-related liver damage(55). StatPearls is a database of short review articles for health professionals in nursing, medicine, and allied health.

  • Will CBD interact with other liver disease medications?

    In a study published in the Medical Cannabis Cannabinoids journal, researchers stated that cannabinoids may affect liver activity, specifically the cytochrome P450 (CYP450) enzymes’ metabolic processes. The activation of these liver enzymes may have significant effects on other medications(56).

  • Are there other treatments to consider alongside CBD to help with liver disease?

    Since the liver metabolizes several medications in the body, you must practice caution when taking CBD with other drugs. Instead of using CBD with other liver disease medications, you may choose to live a healthier lifestyle, which involves less alcohol intake, a more nutritious diet, and exercise.

  • Do drug tests detect CBD use?

    Although ingesting trace amounts of THC may not result in a positive drug test, frequent use of CBD products may increase THC levels in the body. Drug tests can detect high concentrations of THC in the body(57).

  • What is the CBD dosage for liver disease?

    According to a Cannabis and Cannabinoid Research study, humans can tolerate CBD doses of up to 1,500mg per day(58).

  • What is a high-quality CBD product?

    An excellent CBD product is made up of organic ingredients and hemp-derived CBD. CBD users must also look for products free from contaminants, including herbicides, additives, pesticides, residual solvents, heavy metals, and other harmful substances.

  • Can you buy CBD oil online?

    Most CBD brands have online shops where you may purchase CBD products. Customers need to provide their payment information only at the checkout page and wait for their purchase to arrive at their door.


  1. MedLinePlus. Liver Diseases. Retrieved from https://medlineplus.gov/liverdiseases.html
  2. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Corticosteroids. [Updated 2014 May 30]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK548400/
  3. The Mayo Clinic. Corticosteroids Overview. Retrieved from https://www.mayoclinic.org/steroids/art-20045692
  4. The Mayor Clinic. Liver Transplant Overview. Retrieved from https://www.mayoclinic.org/tests-procedures/liver-transplant/about/pac-20384842
  5. Britannica. G protein-coupled receptor. Biochemistry. Retrieved from https://www.britannica.com/science/G-protein-coupled-receptor
  6. Alswat K. A. (2013). The role of endocannabinoids system in fatty liver disease and therapeutic potentials. Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association, 19(4), 144–151. https://doi.org/10.4103/1319-3767.114505
  7. Pacher, P., Bátkai, S., & Kunos, G. (2006). The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacological reviews, 58(3), 389–462. https://doi.org/10.1124/pr.58.3.2
  8. Berg. K. & Clarke, W. (2018). Making Sense of Pharmacology: Inverse Agonism and Functional Selectivity. International Journal of Neuropsychopharmacology, v.21(10). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165953/#
  9. Rossi, F., Punzo, F., Umano, G. R., Argenziano, M., & Miraglia Del Giudice, E. (2018). Role of Cannabinoids in Obesity. International journal of molecular sciences, 19(9), 2690. https://doi.org/10.3390/ijms19092690
  10. Teixeira-Clerc, F., Belot, M. P., Manin, S., Deveaux, V., Cadoudal, T., Chobert, M. N., Louvet, A., Zimmer, A., Tordjmann, T., Mallat, A., & Lotersztajn, S. (2010). Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration. Hepatology (Baltimore, Md.), 52(3), 1046–1059. https://doi.org/10.1002/hep.23779
  11. Thomas, A., Baillie, G. L., Phillips, A. M., Razdan, R. K., Ross, R. A., & Pertwee, R. G. (2007). Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. British Journal of Pharmacology, 150(5), 613–623. https://doi.org/10.1038/sj.bjp.0707133
  12. Pertwee R. G. (2008). The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. British journal of pharmacology, 153(2), 199–215. https://doi.org/10.1038/sj.bjp.0707442
  13. Ho, C., Martinusen, D., & Lo, C. (2019). A Review of Cannabis in Chronic Kidney Disease Symptom Management. Canadian Journal of Kidney Health and Disease, 6, 2054358119828391. https://doi.org/10.1177/2054358119828391
  14. Ibid
  15. Avraham, Y., Grigoriadis, N., Poutahidis, T., Vorobiev, L., Magen, I., Ilan, Y., Mechoulam, R., & Berry, E. (2011). Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice. British journal of pharmacology, 162(7), 1650–1658. https://doi.org/10.1111/j.1476-5381.2010.01179.x
  16. Wang, Y., Mukhopadhyay, P., Cao, Z., Wang, H., Feng, D., Haskó, G., Mechoulam, R., Gao, B., & Pacher, P. (2011). Cannabidiol attenuates alcohol-induced liver steatosis, metabolic dysregulation, inflammation and neutrophil-mediated injury. Scientific Reports, 7: 12064. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608708/
  17. The World Health Organization. Hepatitis C overview. Retrieved from https://www.who.int/news-room/fact-sheets/detail/hepatitis-c
  18. Lowe, H. I., Toyang, N. J., & McLaughlin, W. (2017). Potential of Cannabidiol for the Treatment of Viral Hepatitis. Pharmacognosy research, 9(1), 116–118. https://doi.org/10.4103/0974-8490.199780
  19. The Mayo Clinic. Hepatitis C Overview. https://www.mayoclinic.org/diseases-conditions/hepatitis-c/symptoms-causes/syc-20354278#
  20. Yang, L., Rozenfeld, R., Wu, D., Devi, L. A., Zhang, Z., & Cederbaum, A. (2014). Cannabidiol protects the liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy. Free radical biology & medicine, 68, 260–267.
  21. Ternay, J., Naassila, M., Nourredine, M., Louvet, A., Bailly, A., Sescousse, G., Maurage, P., Cottencin, O., Carrieri, P., & Rolland, B. (2019). Therapeutic Prospects of Cannabidiol for Alcohol Use Disorder and Alcohol-Related Damages on the Liver and the Brain. Frontiers of Pharmacology. https://www.frontiersin.org/articles/10.3389/fphar.2019.00627/full
  22. K. Alswat. Op cit.
  23. Bielawiec, P., Harasim-Symbor, E., & Chabowski, A. (2020). Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on Cannabidiol. Frontiers in endocrinology, 11, 114. https://doi.org/10.3389/fendo.2020.00114
  24. Ibid
  25. Adejumo AC, Alliu S, Ajayi TO, Adejumo KL, Adegbala OM, et al. (2017) Cannabis use is associated with reduced prevalence of non-alcoholic fatty liver disease: A cross-sectional study. PLOS ONE 12(4): e0176416. https://doi.org/10.1371/journal.pone.0176416
  26. Y. Avraham, et al. Op cit.
  27. WHO. Expert Committee on Drug Dependence. (2017, Nov 6-10). Cannabidiol (CBD). Retrieved from https://www.who.int/medicines/access/controlled-substances/5.2_CBD.pdf
  28. U.S. Food and Drug Administration. (2020, Jan 15). FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD). Retrieved from https://www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbd
  29. U.S. Food and Drug Administration. What you need to know (And What We’re Working to Find Out) About Products Containing Cannabis or Cannabis-derived Compounds, Including CBD., Retrieved from https://www.fda.gov/consumers/consumer-updates/what-you-need-know-and-what-were-working-find-out-about-products-containing-cannabis-or-cannabis#
  30. Meissner, H. & Cascella, M. (2020) Cannabidiol (CBD). Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK556048/
  31. Ibid
  32. Cleveland Clinic. What Does ‘Titration’ Mean? (2019, November). Retrieved from https://health.clevelandclinic.org/what-does-titration-mean/
  33. Mayo Clinic. Liver Disease. Retrieved from https://www.mayoclinic.org/diseases-conditions/liver-problems/diagnosis-treatment/drc-20374507
  34. Ibid
  35. National Center for Biotechnology Information. Comfrey. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK548370/
  36. Iffland K, Grotenhermen F. An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis Cannabinoid Res. 2017;2(1):139–154. Published 2017 Jun 1. DOI:10.1089/can.2016.0034
  37. Millar, S., Stone, N., Yates, A., & O’Sullivan, S. (2018). A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans. Frontiers in Pharmacology, 9: 1365. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275223/
  38. Oriakhi, M. (2020). Vaping: An Emerging Health Hazard. Cureus. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186084/
  39. Shmerling, R. (2019, Dec 10). Can vaping damage your lungs? What we do (and don’t) know. https://www.health.harvard.edu/blog/can-vaping-damage-your-lungs-what-we-do-and-dont-know-2019090417734
  40. Mechoulam R, Parker LA, Gallily R. Cannabidiol: an overview of some pharmacological aspects. J Clin Pharmacol. 2002 Nov;42(S1):11S-19S. DOI: 10.1002/j.1552-4604.2002.tb05998.x
  41. Chow SC. Bioavailability and Bioequivalence in Drug Development. Wiley Interdiscip Rev Comput Stat. 2014;6(4):304–312. DOI:10.1002/wics.1310
  42. S. Millar, et al. Op cit. 
  43. Hammell, D., Zhang, L., Ma., F., McIlwrath, S., Stinchcomb, A., & Westlund, K. (2016). Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. European Journal of Pain, (6): 936–948. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851925/
  44. Hermann, T. & Santos, C. (2020). First Pass Effect. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK551679/
  45. S. Millar, et al. Op cit.
  46. Hallare, J. & Garriets, V. (2020) Half Life. StatPearls. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK554498/#
  47. Ibid
  48. The US Food and Drug Administration (2020, Oct. 1). FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD). Retrieved from https://www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbd
  49. Ibid
  50. Hemppedia. Is CBD legal in all 50 states? – The complete 2020 Guide. Retrieved from https://hemppedia.org/cbd-oil-legal-us/
  51. R. G. Pertwee, (2008). Op cit.
  52. F. Teixeira-Clerc, et al. Op cit.
  53. Y. Avraham, et al. Op cit.
  54. H. Lowe, et al. Op cit.
  55. H. Meissner, et al. Op cit.
  56. K. Iffland, et al. Op cit.
  57. Moeller, K., Kissack, J., Atayee, R., & Lee, K. (2017). Clinical Interpretation of Urine Drug Tests. What Clinicians Need to Know About Urine Drug Screens. Mayo Clinic Proceedings, 774-796. https://www.mayoclinicproceedings.org/article/S0025-6196(16)30825-4/fulltext#sec2.1
  58. K. Iffland, et al. Op cit.
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