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Best CBD Oil for Joint Pain

If traditional remedies are not enough to manage persistent joint pain, you may want to look for alternative treatment options. At CBD Clinicals, we can help you find the right cannabidiol (CBD) product that may help with joint pain and improve overall wellness.

Editor's Pick

Spruce 750mg Lab Grade CBD Oil

Best Organic

NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil

Editor's Pick

Spruce 2400mg Lab Grade CBD Oil

Best Seller

Avida Full Spectrum CBD Oil Tincture 500mg

Best Natural Alternative

cbdMD CBD Oil Tincture Natural 1500mg

Best THC-Free

CBDistillery THC Free CBD Oil Tinctures

Best Customer Rated

cbdMD CBD Oil Tincture Natural 750mg

Best Starter

NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil

Hemp Bombs 750mg CBD Oil

Best Allergy Friendly

Sunsoil CBD Oil Drops, Chocolate Mint Flavor

Rating
4.8 out of 5

5.0 out of 5

5.0 out of 5

4.6 out of 5

4.7 out of 5

4.4 out of 5

4.4 out of 5

4.6 out of 5

3.9 out of 5

3.6 out of 5
Highlights
  1. Peppermint flavor masks any unpleasant taste
  2. Contains 25mg of CBD per dropper full
  3. Bottle includes a graduated dropper for correct serving measurement
  1. Natural remedy for various illnesses
  2. Product is full-spectrum whole-plant extract
  3. Contains naturally occurring synergistic cannabinoids and terpenes
  1. Maximum possible potency
  2. Each dropper full contains 80mg of CBD
  3. Conveniently fits in a 30mL bottle
  1. Proprietary full-spectrum
  2. Developed using advanced AVIDA CORE Spectrum Technology
  3. Highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3)
  1. made using only CBD sourced from medical hemp
  2. available in many flavours
  3. safe for daily use
  1. Do not contain THC
  2. Available in different potencies and sizes
  3. Brand has special deals and offers
  1. THC-free
  2. Has plenty of flavours to choose from
  3. Totally vegan
  1. Lowest concentration for CBD beginners
  2. Fully organic and lab-tested
  3. Full-spectrum
  1. Has a wide range of flavours
  2. Safe to intake
  3. Get 20% off when you avail of their subscription
  1. Tastes great
  2. Uses hemp grown organically
  3. Laboratory tests done by a third party

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Compare the best CBD Oil for Joint Pain in 2021

Product Potency Purity Customer Service Type Extraction Transparency Absorption
Spruce 2400mg Lab Grade CBD Oil
4.8 out of 5

4.5 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5
NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.0 out of 5

5.0 out of 5

5.0 out of 5
Spruce 2400mg Lab Grade CBD Oil
5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.0 out of 5

5.0 out of 5

5.0 out of 5
Avida Full Spectrum CBD Oil Tincture 500mg
4.6 out of 5

5.0 out of 5

3.5 out of 5

3.0 out of 5

5.0 out of 5

4.5 out of 5

4.5 out of 5

5.0 out of 5
cbdMD CBD Oil Tincture Natural 1500mg
4.7 out of 5

5.0 out of 5

3.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5
CBDistillery THC Free CBD Oil Tinctures
4.4 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.5 out of 5
cbdMD CBD Oil Tincture Natural 750mg
4.4 out of 5

4.5 out of 5

3.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5
NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
4.6 out of 5

2.5 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5
Hemp Bombs 750mg CBD Oil
3.9 out of 5

4.5 out of 5

3.5 out of 5

2.5 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5
Sunsoil CBD Oil Drops, Chocolate Mint Flavor
3.6 out of 5

2.5 out of 5

3.5 out of 5

5.0 out of 5

5.0 out of 5

4.0 out of 5

3.5 out of 5

5.0 out of 5

Best CBD Oil for Joint Pain

1. Spruce 750mg Lab Grade CBD Oil
cbdc overall score
4.8
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Mid-strength  No other flavors
 Natural peppermint flavor
 Made from 100% organic and natural ingredients
Pro's
 Mid-strength
 Natural peppermint flavor
 Made from 100% organic and natural ingredients
Con's
 No other flavors
Overview

Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
cbdc overall score
5.0
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Pure CBD hemp  No other flavors
 All natural
 Approximately 300 drops total
Pro's
 Pure CBD hemp
 All natural
 Approximately 300 drops total
Con's
 No other flavors
Overview

Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

3. Spruce 2400mg Lab Grade CBD Oil
cbdc overall score
5.0
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Extra Strength  Tastes bitter
 No artificial flavoring or colors  No THC-free option
 Made from 100% organic and natural ingredients
Pro's
 Extra Strength
 No artificial flavoring or colors
 Made from 100% organic and natural ingredients
Con's
 Tastes bitter
 No THC-free option
Overview

The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.

4. Avida Full Spectrum CBD Oil Tincture 500mg
cbdc overall score
4.6
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Light Spearmint flavor  No other flavor
 Non-THC, Non-detected in drug test
Pro's
 Light Spearmint flavor
 Non-THC, Non-detected in drug test
Con's
 No other flavor
Overview

Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.

5. cbdMD CBD Oil Tincture Natural 1500mg
cbdc overall score
4.7
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Various delicious flavors to choose from  cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
 Has vegan, organic, and gluten-free ingredients
 Free shipping for this particular product within USA
 World-class customer service team
Pro's
 Various delicious flavors to choose from
 Has vegan, organic, and gluten-free ingredients
 Free shipping for this particular product within USA
 World-class customer service team
Con's
 cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
Overview

cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

6. CBDistillery THC Free CBD Oil Tinctures
cbdc overall score
4.4
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 60-Day Satisfaction Guarantee  Dropper is a bit shaky
 Various strengths
 Oil extracted from aerial plant parts of US grown industrial hemp
 Sourced from non-GMO industrial hemp grown in the USA through natural farming practices
Pro's
 60-Day Satisfaction Guarantee
 Various strengths
 Oil extracted from aerial plant parts of US grown industrial hemp
 Sourced from non-GMO industrial hemp grown in the USA through natural farming practices
Con's
 Dropper is a bit shaky
Overview

CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.

7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
cbdc overall score
4.6
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Pure CBD hemp  No other flavors
 All natural  A bit pricey compared to competitors
 Approximately 100 drops total
Pro's
 Pure CBD hemp
 All natural
 Approximately 100 drops total
Con's
 No other flavors
 A bit pricey compared to competitors
Overview

This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.

8. cbdMD CBD Oil Tincture Natural 750mg
cbdc overall score
4.4
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Vegan and Gluten free  Does not ship internationally
 Has a third-party lab test
 Wide variety of CBD strengths and sizes
Pro's
 Vegan and Gluten free
 Has a third-party lab test
 Wide variety of CBD strengths and sizes
Con's
 Does not ship internationally
Overview

A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.

9. Hemp Bombs 750mg CBD Oil
cbdc overall score
3.9
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Wide variety of flavors  Incomplete information about the product
 Lab test results are complete  Does not ship to all international countries
 30-day money-back guarantee
Pro's
 Wide variety of flavors
 Lab test results are complete
 30-day money-back guarantee
Con's
 Incomplete information about the product
 Does not ship to all international countries
Overview

Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.

10. Sunsoil CBD Oil Drops, Chocolate Mint Flavor
cbdc overall score
3.6
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Sunsoil CBD is committed to providing high-quality products at an affordable cost.  Product selection is limited.
 The company tests its products thrice before making them available to the public.  The company uses lipid extraction methods.
 From cultivation to packaging, everything is done in Sunsoil CBD grounds.
 Organic and sustainable farming is at the company’s core.
Pro's
 Sunsoil CBD is committed to providing high-quality products at an affordable cost.
 The company tests its products thrice before making them available to the public.
 From cultivation to packaging, everything is done in Sunsoil CBD grounds.
 Organic and sustainable farming is at the company’s core.
Con's
 Product selection is limited.
 The company uses lipid extraction methods.
Overview

The flavor profile is refreshingly sweet, and it balances well with the higher CBD concentration. Promotes the absorption of CBD into your blood circulation.

How CBD Works

According to the Mayo Clinic, joint pain is usually associated with other health conditions, including bone cancer, fibromyalgia, osteoarthritis (joint breakdown), and rheumatoid arthritis (inflammatory joint disease)(1).

A 2006 study suggested that rheumatoid arthritis (RA) may lead to joint deformity, destruction, loss of function, and chronic pain. The researchers also warned that RA may result in disability and premature death(2)

Depending on the diagnosis, your doctor may prescribe painkillers, anti-inflammatory drugs, therapy, or surgery, to treat joint pain(3).

However, you may also opt for a natural treatment option, such as CBD.

CBD is a cannabinoid or a naturally occurring compound present in cannabis plants. It is one of the more than 100 cannabinoids in cannabis.

CBD is one of the most well-known cannabinoids, along with tetrahydrocannabinol (THC), the primary psychoactive component of cannabis. Unlike THC and other opioids, CBD is non-psychoactive, meaning that CBD does not get individuals high.

CBD usually comes from the cannabis plant‘s indica strain. However, you may find small traces of CBD in the Cannabis sativa strain.

According to a Journal of Pain Research study, cannabinoids work via interactions with the endocannabinoid system (ECS)(4). CBD interacts with the body’s cannabinoid receptors, which may be found throughout the body, including the central nervous system and immune system.

In a 2006 study, researchers noted that modulating ECS activity may help manage the following health conditions and diseases(5):

  • Neuropathic pain
  • Multiple sclerosis and spinal cord injury
  • Mood and anxiety disorders
  • Movement disorders such as Parkinson’s disease and Huntington’s disease
  • Atherosclerosis or fat buildup on the arterial wall
  • Stroke
  • Hypertension
  • Glaucoma
  • Obesity
  • Osteoporosis

Benefits of Using CBD Oil for Joint Pain

Medical researchers studied the therapeutic effects of CBD in patients with joint pain. 

Medical researchers have conducted animal studies to examine how CBD may help treat arthritis pain and relieve the inflammatory pain linked to the condition.

Researchers of a 2017 animal study published in the Pain journal noted that CBD may prevent the onset of joint neuropathy and osteoarthritis pain(6)

Meanwhile, in a 2011 animal research, scientists observed that CBD may decrease inflammatory pain by controlling the pain receptors’ response to stimuli(7)

A 2014 review of osteoarthritis studies from the European Journal of Neuroscience suggested that CBD may treat osteoarthritis(8).

Medical researchers also published a study in 2016 that demonstrated the efficacy of CBD in treating pain. In the European Journal of Pain animal study, researchers noted that the topical application of CBD may reduce inflammation and pain linked to arthritis symptoms(9)

Scientists have demonstrated that CBD may be a safe treatment option for patients with arthritis. According to a 2017 study, researchers noted that CBD may safely help treat osteoarthritis joint neuropathic pain(10).

Sativex, a cannabis-based drug with THC and CBD, may help in pain management for arthritis patients(11)

In a study published in 2006 in the British Society for Rheumatology journal, medical researchers showed how CBD may help with arthritis.

Sativex was administered to arthritis patients for five weeks. Based on results gathered after the treatment period, the patients experienced an improvement in movement pain and sleep quality(12).

Risks of Using CBD Oil for Joint Pain

Although generally considered safe, CBD may still have side effects, such as drowsiness, lightheadedness, dry mouth, and liver problems(13).

According to a recent CBD article published in Harvard Health Publishing, the healthcare field still has no specific conclusion regarding CBD’s efficacy in treating pain since definitive studies are still not available(14).

In addition, the US Food and Drug Administration (FDA) still does not regulate the CBD market. Because of this, you may not be entirely sure about the potency or purity of the CBD products you plan to buy.

Another downside to CBD use is limited research into the cannabinoid’s effects on children or pregnant women.

Moreover, some pain specialists have raised concerns that CBD may alter the body’s natural system of pain regulation. The change may lead to pain tolerance, which could result in the patient needing higher doses of medicine to achieve the same effects(15).

Note that CBD may interact with other medications in the body(16). To know more about drug-to-drug interactions involving CBD, you must first consult with your doctor before using any CBD product.

Your doctor can assess if CBD has the potential to worsen your medical condition.

CBD products may trigger an allergic reaction to those allergic to cannabis or its components. People who have allergies are advised to avoid using CBD products unless they are sure that any compound in the cannabis plant will not trigger their allergy.

To minimize the risks that come with CBD use, you can conduct your own research about CBD. It is also advised to choose reputable products with confirmed third-party testing lab results that confirm the product’s safety and quality.

CBD Dosage and Administration Routes

Dosage

Since CBD use remains unregulated by the FDA, there is no standard CBD dose for joint pain or any other condition. 

Dosing depends on several factors, including your body chemistry, the severity of your joint pain, and the CBD product’s concentration.

You may choose to follow the recommended dosage provided on the product label. Most CBD brands provide a dosing chart for each of their products as a guide. 

To be safe, consult your arthritis doctor to inquire about safe and effective dosing before taking any CBD product.

Methods of Consumption

There are several administration routes for consuming CBD products. Some of the most common routes are:

  • Oral ingestion of CBD edibles or capsules
  • Topical application of CBD balms or balms onto the skin
  • Sublingual method of consumption (dropping the oil under the tongue)
  • Mixing CBD into drinks or meals

One way of administering CBD for joint pain is by applying CBD transdermally on the skin. Some brands mix their topical creams and topical products with other compounds with anti-inflammatory properties and analgesic (pain-relieving) effects, such as cumin, ginger, and rosemary.

According to a 2019 study from the Evidence-Based Complementary and Alternative Medicine journal, cumin possessed analgesic properties ideal for chronic pain treatment(17).

Meanwhile, a 2011 study noted that ginger may reduce inflammation, swelling, and pain(18).

A 2017 study published in the Iranian Journal of Nursing and Midwifery Research suggested that the topical use of rosemary and menthol may reduce musculoskeletal pain intensity in the legs among patients with kidney disease(19).

Another benefit of CBD’s topical application is that it bypasses gastrointestinal administration and first-pass metabolism, leading to more constant plasma levels(20)

The first-pass metabolism effect pertains to the early metabolization (breaking down) of a medication, decreasing the drug’s concentration before it reaches its intended site of action(21).

Another common method of CBD consumption is oral administration. CBD edibles, including capsules, softgels, tablets, brownies, and gummies, are some of the CBD products you may take ingest orally.

You may also take CBD through the sublingual method. CBD oils, CBD tinctures, and CBD extracts may be taken sublingually or dropped under the tongue using a measured dropper

Before swallowing, you must hold the oil in the mouth for 30 seconds to allow CBD into your bloodstream.

The Journal of Clinical Pharmacology published a study in 2002, suggesting that the sublingual method of CBD is an efficient way of introducing CBD in the body. According to the study, CBD oil possessed a sublingual bioavailability of 13% to 19%(22).

Bioavailability means the extent and rate at which a drug is absorbed and becomes available for the body to break down(23)

In a 2015 review, scientists noted that with the sublingual consumption method, peak blood levels of most compounds are reached in 10 to 15 minutes. According to the authors, this is faster than when the same drugs are taken orally(24)

If you do not enjoy the taste of pure CBD hemp extract, some CBD companies offer edibles, like gummies, in delicious flavors. CBD gummies also come in a fixed dose, making the product consistent and convenient to take.

Meanwhile, some CBD brands offer unflavored options for their CBD oil product line to attract more customers, even those who do not enjoy the CBD oil’s grassy taste.

You may also infuse CBD oils into your meals. According to a 2018 Frontiers in Pharmacology study, cannabinoid’s highly lipophilic nature (soluble in lipids or oils) makes it easy to dissolve in the fat content of food, which may boost the compound’s solubility and absorption(25).

Vaping is also an efficient way to take CBD since it enters through the lungs’ bloodstream, bypassing the digestive system. 

A 2018 study demonstrated that after smoking CBD through vaping, the cannabinoid reached the peak plasma concentrations within three minutes after dosing(26).

Peak plasma concentration is the highest concentration of medicine in the body after taking it(27).

However, medical researchers caution that vaping can have harmful effects on the lungs. According to a 2020 Cureus study, increased vape use in the United States resulted in a spike in cases of vaping-related pulmonary diseases(28).

Other vaping risks include chemical irritation or allergic reactions to the compounds in the inhaled vapors(29)

A 2018 study reported that the cannabinoid’s half-life is between 1.4 hours and 10.9 hours after dropping CBD on the surface of the mouth. Results showed the half-life of CBD two to five days after an oral administration(30).

Meanwhile, in another study, the half-life of the cannabinoid was reported 24 hours after an intravenous route of consumption and 31 hours after smoking(31)

Half-life is the time needed for one-half of a drug’s concentration to reduce to half of its initial dose in the body(32).

Choosing the Best CBD Product for Joint Pain

Below are some of the relevant factors to keep in mind when looking for high-quality CBD products.

Method of Consumption

Determine the route of administration you plan to use. If you plan on using topical administration of CBD, you may purchase CBD creams, salves, or lotions.

As mentioned above, topical CBD may be ideal for joint pain. Most brands infuse their product with other compounds that possess analgesic properties.

If you opt to use CBD sublingually, you may buy CBD oils, tinctures, or hemp extracts

Some CBD brands offer CBD products for pets suffering from joint pains. However, you must first consult your pet’s veterinarian before giving CBD to your pet.

Extraction Process

CBD brands use various types of extraction methods to remove CBD from the raw plant material. 

One of the most common CBD extraction methods is the CO2 extraction method. This process involves using carbon dioxide, low temperature, and high pressure to produce a pure CBD form. 

Some manufacturers also use an ethanol-based extraction method. This method uses ethanol or other alcohol as a solvent during extraction. 

After the extraction process, most brands mix CBD into carrier oils, such as hemp seed oil and medium-chain triglycerides oil (MCT oil).

Type of CBD

Before buying a CBD product, you must determine the type of CBD you want to consume. There are three types of CBD products currently available on the market: full-spectrum CBD, broad-spectrum CBD, and CBD isolates.

Full-spectrum CBD oil or whole-plant CBD oil contains all cannabinoids from the raw hemp plant., including CBD, terpenes, and traces of THC.

Some customers choose to buy full-spectrum CBD oil tinctures as consuming full-spectrum hemp creates the entourage effect

The entourage effect pertains to the synergy of cannabinoids and terpenes working together(33).

Meanwhile, broad-spectrum CBD also contains all cannabinoids from hemp plants, except THC. Broad-spectrum CBD is ideal for those who want all the health benefits of CBD from a full-spectrum product but want to be THC-free.

Pure CBD or a CBD isolate contains only CBD. CBD isolate products are ideal for you if you need to take a drug test soon. 

Reliability of the Brand

Purchase products only from reliable CBD companies. The most reliable companies provide consumers certificates of analysis (COAs) of their products from third-party laboratories. 

The third-party lab reports confirm the safety and quality of a CBD product.

Reliable brands grow their own hemp to ensure the quality of their products. They also adhere to sustainable and ethical farming practices.

Some of the most trusted brands carry gluten-free CBD products with high potency to attract more consumers. 

Money-back guarantees and discounts on bulk purchases are also common offers.

Legality of CBD

Colorado has been at the forefront of the American CBD industry. Known for its favorable CBD regulations, Colorado has made legal since 2012 the use of CBD and other cannabis-derived products(34).

When former President Donald Trump signed the Farm Bill in 2018, the cultivation of hemp became legal in the US. The law removed hemp and hemp-based products from the list of Schedule I controlled substances (substances with high misuse potential)(35)

Under the legislation, hemp farmers may grow and cultivate hemp crops as long as the plants’ THC content is less than 0.3%(36).

Although hemp-derived products are federally legal in the US, state laws have varying levels of restrictions regarding CBD regulations. In some US states, like South Dakota, rules on CBD regulation are still unclear(37).

Most states do not require patients to have a doctor’s recommendation or a prescription when buying CBD. However, patients in other states, like Alabama, still need a prescription to possess or use CBD products(38).

Although the 2018 Farm Bill did not legalize marijuana products, state lawmakers are allowed to introduce their own regulations regarding the legalization of medical marijuana and recreational, over-the-counter marijuana.

Below is a list of US states with Limited Access Marijuana Product Laws. Some states allow the production of high-CBD and low-THC hemp products(39):

  • Alabama
  • Florida
  • Georgia
  • Idaho
  • Iowa
  • Mississippi
  • North Carolina
  • Oklahoma
  • South Carolina
  • Tennessee
  • Utah
  • Virginia
  • Wisconsin
  • Wyoming

Most companies design drug tests to detect psychoactive compounds, like THC. The cannabinoid is present in full-spectrum CBD products, although only in trace amounts.

According to a drug test review published in the Mayo Clinic Proceedings, the detection of trace amounts of THC does not result in a positive test(40). However, the frequent use of CBD products may increase the THC level in your body above the cut-off values set, resulting in a positive drug test.

Currently, the use of CBD alone is not approved for the treatment of pain in the US(41). The FDA has only greenlighted the use of Epidiolex, a CBD-based drug, to treat seizures linked to Dravet syndrome (DS) and Lennox-Gastaut syndrome (LGS), two types of epilepsy(42).

Product Frequently
Asked Questions

  • How can CBD help with joint pain?

    CBD may help provide joint pain relief by interacting with the body’s cannabinoid receptors(43). Through interaction with the body’s ECS, CBD may help prevent the onset of joint neuropathy pain and osteoarthritis pain(44).

  • What research exists that suggests CBD’s benefits in managing joint pain?

    The European Journal of Neuroscience published a review in 2014, stating that CBD may help treat osteoarthritis(45). Researchers for the European Journal of Pain also demonstrated that the topical application of CBD may relieve pain associated with arthritis(46).

  • Can CBD make joint pain worse?

    CreakyJoints, a part of the Global Healthy Living Foundation (GHLF), advises patients to talk to their doctors first before taking CBD, which may interact with other medications they currently take or may worsen a chronic condition(47).  GHLF is a non-profit organization founded to help patients with chronic illnesses.

  • Will CBD interact with other joint pain medications?

    According to Harvard Health Publishing, CBD may interact with other drugs in the body(48). It is recommended to talk to a doctor about potential drug-to-drug interactions before using CBD.

  • Are there other treatments to consider alongside CBD to help with joint pain?

    According to an article from the Mayo Clinic, physical therapy may help treat certain types of arthritis. Exercises may also improve the patient’s range of motion and boost the surrounding joints’ muscle strength(49).

  • Do drug tests detect CBD use?

    Although drug tests detect trace amounts of THC, small amounts of the cannabinoid do not result in a positive drug test(50). However, if you use CBD products frequently enough to increase the THC level in your body above the cut-off values set, you may get a positive test result.

  • What is the CBD dosage for joint pain?

    Although it is unclear how many mg of CBD should be used for joint pain, a 2017 study noted that the chronic use and doses of up to 1,500mg CBD per day are well-tolerated by humans(51).

  • How do I know I am getting a good product?

    The best CBD oils are high-quality CBD products containing organic hemp and non-genetically modified organism (non-GMO) ingredients. These products undergo third-party lab testing and are free from contaminants, such as additives, pesticides, heavy metals, and other harmful substances.

  • If I want to buy CBD oil for arthritis, do I need a doctor’s prescription or recommendation?

    Most states in the country do not require CBD buyers to have a doctor’s recommendation or prescription to buy CBD products. However, like Alabama, some states require individuals to have a prescription to buy and use CBD products(52).


  1. Mayo Clinic. Joint Pain. Retrieved from https://www.mayoclinic.org/symptoms/joint-pain/basics/causes/sym-20050668
  2. Pacher, P., Batkai, S., & Kunos, G. (2006). The Endocannabinoid System as an Emerging Target of Pharmacotherapy. Pharmacological Reviews, 58(3), 389–462. doi:10.1124/pr.58.3.2
  3. Mayo Clinic. Arthritis. Retrieved from https://www.mayoclinic.org/diseases-conditions/arthritis/diagnosis-treatment/drc-20350777
  4. Darkovska-Serafimovska, M., Serafimovska, T., Arsova-Sarafinovska, Z., Stefanoski, S., Keskovski, Z., & Balkanov, T. (2018). Pharmacotherapeutic considerations for use of cannabinoids to relieve pain in patients with malignant diseases. Journal of Pain Research, 11: 837–842. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922297/
  5. P. Pacher, et al. Op cit.
  6. Philpott, H., O’Brien, M., & McDougall., J. (2017). Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. Pain, 158(12): 2442–2451. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690292/
  7. Schuelert, N. & McDougall, J. (2011). The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55. Neuroscience Letters, 500(1):72-6. https://pubmed.ncbi.nlm.nih.gov/21683763/
  8. La Porta, C., Bura, S., Negrete, R., & Maldonado, R. (2014). Involvement of the endocannabinoid system in osteoarthritis pain. European Journal of Neuroscience, 39(3):485-500. https://pubmed.ncbi.nlm.nih.gov/24494687/
  9. Hammell, D., Zhang, L., Abshire, S., McIlwrath, S., Stinchcomb, A., & Westlund, K. (2016). Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. European Journal of Pain, 20(6): 936–948. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851925/
  10. H. Philpott, et al. Op cit.
  11. Blake. D., Robson, P., Ho, M., Jubb, R., & McCabe, C. (2006). Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis. British Society for Rheumatology, 45(1):50-2. https://pubmed.ncbi.nlm.nih.gov/16282192/
  12. Ibid
  13. Shmerling, Robert. (2020) Does CBD help with arthritis pain? Harvard Health Publishing. Retrieved from https://www.health.harvard.edu/blog/does-cbd-help-with-arthritis-pain-2020041019418#
  14. Ibid
  15. Ibid
  16. Ibid
  17. Yimer, E., Tuem, K., Ur-Rehman, N., & Anwar, F. (2019). Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses. Evidence-Based Complementary and Alternative Medicine, 1528635. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535880/
  18. Bode, A. & Dong, Z. (2011). The Amazing and Mighty Ginger. Herbal Medicine: Biomolecular and Clinical Aspects. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK92775/
  19. Keshavarzian, S. & Shahgholian, N. (2017), Comparison of the Effect of Topical Application of Rosemary and Menthol for Musculoskeletal Pain in Hemodialysis Patients.  Iranian Journal of Nursing and Midwifery Research, (6): 436–441. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684790/
  20. D. Hammell, et al. Op cit.
  21. Hermann, T. & Santos, C. (2020). First Pass Effect. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK551679/
  22. Mechoulam R, Parker LA, Gallily R. Cannabidiol: an overview of some pharmacological aspects. J Clin Pharmacol. 2002 Nov;42(S1):11S-19S. DOI: 10.1002/j.1552-4604.2002.tb05998.x
  23. Chow SC. Bioavailability and Bioequivalence in Drug Development. Wiley Interdiscip Rev Comput Stat. 2014;6(4):304–312. DOI:10.1002/wics.1310.
  24. Narang, N. and Sharma, J. (2010, Dec 08). Sublingual Mucosa as A Route for Systemic Drug Delivery. https://innovareacademics.in/journal/ijpps/Vol3Suppl2/1092.pdf
  25. Millar, S., Stone, N., Yates, A., & O’Sullivan, S. (2018). A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans. Frontiers in Pharmacology, 9: 1365. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275223/
  26. Ibid
  27. Clinical Info. Offering Information on HIV/AIDS Treatment, Prevention, and Research. HIV/AIDS Glossary. Cmax. Retrieved from https://clinicalinfo.hiv.gov/en/glossary/cmax
  28. Oriakhi, M. (2020). Vaping: An Emerging Health Hazard. Cureus. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186084/
  29. Shmerling, R. (2019, Dec 10). Can vaping damage your lungs? What we do (and don’t) know. Harvard Health Publishing. Retrieved from https://www.health.harvard.edu/blog/can-vaping-damage-your-lungs-what-we-do-and-dont-know-2019090417734
  30. S. Millar, et al. Op cit.
  31. Ibid
  32. Hallare, J. & Garriets, V. (2020) Half Life. StatPearls. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK554498/#
  33. Ferber, S.G., Namdar, D., Hen-Shoval, D., Eger, G., Koltai, H., Shoval, G., Shbiro, L., Weller, A. (2020). The “Entourage Effect”: Terpenes Coupled with Cannabinoids for the Treatment of Mood Disorders and Anxiety Disorders. PubMed Central (PMC). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324885/
  34. Colorado Official State Web Portal. Amendment 64 Implementation. Retrieved from https://www.colorado.gov/pacific/sites/default/files/13%20Amendment%2064%20LEGIS.pdf
  35. The US Food and Drug Administration (2020, Oct. 1). FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD). Retrieved from https://www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbd
  36. Ibid
  37. Hemppedia. Is CBD legal in all 50 states? – The complete 2020 Guide. Retrieved from https://hemppedia.org/cbd-oil-legal-us/
  38. ProCon.org. States with Legal Cannabidiol (CBD). Retrieved from https://medicalmarijuana.procon.org/states-with-legal-cannabidiol-cbd/
  39. National Conference of State Legislatures. State Medical Marijuana Laws. Retrieved from https://www.ncsl.org/research/health/state-medical-marijuana-laws.aspx
  40. Moeller, K., Kissack, J., Atayee, R., & Lee, K. (2017). Clinical Interpretation of Urine Drug Tests. What Clinicians Need to Know About Urine Drug Screens. Mayo Clinic Proceedings, 774-796. https://www.mayoclinicproceedings.org/article/S0025-6196(16)30825-4/fulltext#sec2.1
  41. Boyaji, S. (2020). CBD for chronic pain: The science doesn’t match the marketing. Harvard Health Publishing. Retrieved from https://www.health.harvard.edu/blog/cbd-for-chronic-pain-the-science-doesnt-match-the-marketing-2020092321003
  42. FDA. FDA Approves New Indication for Drug Containing an Active Ingredient Derived from Cannabis to Treat Seizures in Rare Genetic Disease. Retrieved from https://www.fda.gov/news-events/press-announcements/fda-approves-new-indication-drug-containing-active-ingredient-derived-cannabis-treat-seizures-rare
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