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Best CBD Oil for High Cholesterol

Are you looking for natural alternatives to help with high cholesterol? Check out our list and discover the best cannabidiol (CBD) oils that may improve your cholesterol levels.

Editor's Pick

Spruce 750mg Lab Grade CBD Oil

Best Organic

NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil

Editor's Pick

Spruce 2400mg Lab Grade CBD Oil

Best Seller

Avida Full Spectrum CBD Oil Tincture 500mg

Best Natural Alternative

cbdMD CBD Oil Tincture Natural 1500mg

Best THC-Free

CBDistillery THC Free CBD Oil Tinctures

Best Customer Rated

cbdMD CBD Oil Tincture Natural 750mg

Best Starter

NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil

Hemp Bombs 750mg CBD Oil

Best Allergy Friendly

Sunsoil CBD Oil Drops, Chocolate Mint Flavor

Rating
4.8 out of 5

5.0 out of 5

5.0 out of 5

4.6 out of 5

4.7 out of 5

4.4 out of 5

4.4 out of 5

4.6 out of 5

3.9 out of 5

3.6 out of 5
Highlights
  1. Peppermint flavor masks any unpleasant taste
  2. Contains 25mg of CBD per dropper full
  3. Bottle includes a graduated dropper for correct serving measurement
  1. Natural remedy for various illnesses
  2. Product is full-spectrum whole-plant extract
  3. Contains naturally occurring synergistic cannabinoids and terpenes
  1. Maximum possible potency
  2. Each dropper full contains 80mg of CBD
  3. Conveniently fits in a 30mL bottle
  1. Proprietary full-spectrum
  2. Developed using advanced AVIDA CORE Spectrum Technology
  3. Highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3)
  1. made using only CBD sourced from medical hemp
  2. available in many flavours
  3. safe for daily use
  1. Do not contain THC
  2. Available in different potencies and sizes
  3. Brand has special deals and offers
  1. THC-free
  2. Has plenty of flavours to choose from
  3. Totally vegan
  1. Lowest concentration for CBD beginners
  2. Fully organic and lab-tested
  3. Full-spectrum
  1. Has a wide range of flavours
  2. Safe to intake
  3. Get 20% off when you avail of their subscription
  1. Tastes great
  2. Uses hemp grown organically
  3. Laboratory tests done by a third party

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Compare the Best CBD Oil for High Cholesterol in 2021

Product Potency Purity Customer Service Type Extraction Transparency Absorption
Spruce 2400mg Lab Grade CBD Oil
4.8 out of 5

4.5 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5
NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.0 out of 5

5.0 out of 5

5.0 out of 5
Spruce 2400mg Lab Grade CBD Oil
5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.0 out of 5

5.0 out of 5

5.0 out of 5
Avida Full Spectrum CBD Oil Tincture 500mg
4.6 out of 5

5.0 out of 5

3.5 out of 5

3.0 out of 5

5.0 out of 5

4.5 out of 5

4.5 out of 5

5.0 out of 5
cbdMD CBD Oil Tincture Natural 1500mg
4.7 out of 5

5.0 out of 5

3.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5
CBDistillery THC Free CBD Oil Tinctures
4.4 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.5 out of 5
cbdMD CBD Oil Tincture Natural 750mg
4.4 out of 5

4.5 out of 5

3.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5
NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
4.6 out of 5

2.5 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5
Hemp Bombs 750mg CBD Oil
3.9 out of 5

4.5 out of 5

3.5 out of 5

2.5 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5
Sunsoil CBD Oil Drops, Chocolate Mint Flavor
3.6 out of 5

2.5 out of 5

3.5 out of 5

5.0 out of 5

5.0 out of 5

4.0 out of 5

3.5 out of 5

5.0 out of 5

Best CBD Oil for High Cholesterol

1. Spruce 750mg Lab Grade CBD Oil
cbdc overall score
4.8
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Mid-strength  No other flavors
 Natural peppermint flavor
 Made from 100% organic and natural ingredients
Pro's
 Mid-strength
 Natural peppermint flavor
 Made from 100% organic and natural ingredients
Con's
 No other flavors
Overview

Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
cbdc overall score
5.0
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Pure CBD hemp  No other flavors
 All natural
 Approximately 300 drops total
Pro's
 Pure CBD hemp
 All natural
 Approximately 300 drops total
Con's
 No other flavors
Overview

Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

3. Spruce 2400mg Lab Grade CBD Oil
cbdc overall score
5.0
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Extra Strength  Tastes bitter
 No artificial flavoring or colors  No THC-free option
 Made from 100% organic and natural ingredients
Pro's
 Extra Strength
 No artificial flavoring or colors
 Made from 100% organic and natural ingredients
Con's
 Tastes bitter
 No THC-free option
Overview

The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.

4. Avida Full Spectrum CBD Oil Tincture 500mg
cbdc overall score
4.6
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Light Spearmint flavor  No other flavor
 Non-THC, Non-detected in drug test
Pro's
 Light Spearmint flavor
 Non-THC, Non-detected in drug test
Con's
 No other flavor
Overview

Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.

5. cbdMD CBD Oil Tincture Natural 1500mg
cbdc overall score
4.7
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Various delicious flavors to choose from  cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
 Has vegan, organic, and gluten-free ingredients
 Free shipping for this particular product within USA
 World-class customer service team
Pro's
 Various delicious flavors to choose from
 Has vegan, organic, and gluten-free ingredients
 Free shipping for this particular product within USA
 World-class customer service team
Con's
 cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
Overview

cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

6. CBDistillery THC Free CBD Oil Tinctures
cbdc overall score
4.4
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 60-Day Satisfaction Guarantee  Dropper is a bit shaky
 Various strengths
 Oil extracted from aerial plant parts of US grown industrial hemp
 Sourced from non-GMO industrial hemp grown in the USA through natural farming practices
Pro's
 60-Day Satisfaction Guarantee
 Various strengths
 Oil extracted from aerial plant parts of US grown industrial hemp
 Sourced from non-GMO industrial hemp grown in the USA through natural farming practices
Con's
 Dropper is a bit shaky
Overview

CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.

7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
cbdc overall score
4.6
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Pure CBD hemp  No other flavors
 All natural  A bit pricey compared to competitors
 Approximately 100 drops total
Pro's
 Pure CBD hemp
 All natural
 Approximately 100 drops total
Con's
 No other flavors
 A bit pricey compared to competitors
Overview

This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.

8. cbdMD CBD Oil Tincture Natural 750mg
cbdc overall score
4.4
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Vegan and Gluten free  Does not ship internationally
 Has a third-party lab test
 Wide variety of CBD strengths and sizes
Pro's
 Vegan and Gluten free
 Has a third-party lab test
 Wide variety of CBD strengths and sizes
Con's
 Does not ship internationally
Overview

A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.

9. Hemp Bombs 750mg CBD Oil
cbdc overall score
3.9
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Wide variety of flavors  Incomplete information about the product
 Lab test results are complete  Does not ship to all international countries
 30-day money-back guarantee
Pro's
 Wide variety of flavors
 Lab test results are complete
 30-day money-back guarantee
Con's
 Incomplete information about the product
 Does not ship to all international countries
Overview

Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.

10. Sunsoil CBD Oil Drops, Chocolate Mint Flavor
cbdc overall score
3.6
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Sunsoil CBD is committed to providing high-quality products at an affordable cost.  Product selection is limited.
 The company tests its products thrice before making them available to the public.  The company uses lipid extraction methods.
 From cultivation to packaging, everything is done in Sunsoil CBD grounds.
 Organic and sustainable farming is at the company’s core.
Pro's
 Sunsoil CBD is committed to providing high-quality products at an affordable cost.
 The company tests its products thrice before making them available to the public.
 From cultivation to packaging, everything is done in Sunsoil CBD grounds.
 Organic and sustainable farming is at the company’s core.
Con's
 Product selection is limited.
 The company uses lipid extraction methods.
Overview

The flavor profile is refreshingly sweet, and it balances well with the higher CBD concentration. Promotes the absorption of CBD into your blood circulation.

How CBD Helps With High Cholesterol 

Studies suggest that CBD oil helps reduce cholesterol levels and improves heart health with its anti-inflammatory properties. However, results are inconclusive to determine CBD’s effects on the cardiovascular system(1).

According to the Centers for Disease Control and Prevention (CDC), about 29 million American adults have high levels of cholesterol(2)

Cholesterol is a waxy type of lipid or fat found in the blood. High cholesterol levels, particularly bad cholesterol, increase one’s risk of developing cardiovascular diseases(3)

CBD binds with the cannabinoid receptors located in the body’s endocannabinoid system (ECS). This system is responsible for maintaining a state of balance and promoting wellness

The two central ECS receptors, CB1 and CB2, are vital for regulating body functions, including pain perception, mood, memory, and appetite(4)

According to studies, CBD has vascular relaxant properties that relax the arterial walls(5). This mechanism is the result of the interaction between CBD and CB1 receptors

As your arterial walls relax, your heart does not work as hard to pump blood, reducing blood pressure and excess cholesterol. 

Low-density lipoprotein (LDL) and high-density lipoprotein (HDL) are two types of cholesterol.

LDL, referred to as the bad cholesterol, can build up on your blood vessels. This blockage may result in cardiovascular diseases, like stroke and heart attack

Meanwhile, HDL is known as the good cholesterol that carries lipids or fats from other parts of the body to the liver. 

High levels of cholesterol may also be a sign of high triglyceride levels(6). Like cholesterol, triglycerides are also fat-type substances found in the blood. 

Unused calories stored in your body are converted into triglycerides. Similar to cholesterol, high levels of triglycerides may cause heart problems(7)

An increase in HDL or good cholesterol lowers your risk of developing cholesterol-related complications, including high blood pressure, stroke, and type 2 diabetes(8).

In an animal study, CBD has been shown to increase good cholesterol in obese mice models(9). The test subjects received CBD for four weeks. 

According to the results, there was a 55% increase in test subjects’ HDL cholesterol levels and a 25% decrease in their total cholesterol levels. The researchers also noted reduced triglyceride levels in the mice subjects.

Benefits of Using CBD for High Cholesterol

High cholesterol may increase your risk of developing other complications, such as stroke, high blood pressure, and heart attack(10). Multiple studies have demonstrated CBD’s potential in helping with these medical conditions.

CBD for Blood Pressure

Hypertension or high blood pressure may be linked to high cholesterol levels(11). When your arteries are blocked with cholesterol, it gets harder for your heart to pump blood, leading to increased blood pressure. 

A study on healthy volunteer subjects was conducted to see if CBD compounds could reduce blood pressure(12). The study described blood pressure as the body’s response to stress.

The researchers conducted several tests to induce stress in the test subjects and increase their blood pressure. According to results, a single dose of CBD lowered the volunteers’ blood pressure levels during the pre-stress and post-stress tests.

CBD for Stroke

According to a study conducted on ischemic stroke patients, CBD may increase cerebral blood flow, preventing post-ischemic injury(13)

Ischemic stroke is a common type of stroke due to a blockage in the artery that supplies blood to the brain. This blockage reduces the flow of blood and oxygen to the brain, resulting in damage or death of brain cells(14)

CBD, as a neuroprotective agent, may have other therapeutic mechanisms that can help with oxidative disorders(15)

Another study noted that CBD may help reduce inflammatory protein release in cell injury and tissue damage in the early phases of stroke(16)

The researchers tested the effects of CBD compound on ischemic stroke for three days. It was found that CBD had cerebroprotective effects.

CBD for Heart Attack

CBD has demonstrated its cardioprotective function in a test conducted on rat subjects. CBD has been found to reduce the size of the damaged area where arteries are blocked during a heart attack(17)

The experiment on the same condition was also conducted outside of the test subjects’ body (ex vivo). However, the results were the opposite. 

The reduced size of the artery’s damaged area inside the test subjects (in vivo) may be related to CBD’s anti-inflammatory properties.

In another study conducted on rabbits, the researchers observed that CBD contributed to the restoration of the heart’s left ventricular function and helped reduce the size of acute myocardial infarction (AMI)(18)

AMI, which means “death of heart muscle,” is referred to as heart attack(19)

A review found in the British Journal of Clinical Pharmacology stated that CBD has potential cardioprotective properties. CBD’s purported benefits on the heart include the attenuation of cardiovascular response to different types of stress(20)

According to the researchers, CBD may also have a protective role in reducing damages related to stroke(21)

CBD Dosage and Delivery Methods for High Cholesterol

CBD Dosage

There is no standard dose of CBD for specific health issues, like high cholesterol(22). Dosage is also dependent on several factors, including the severity of the condition, body weight, body chemistry, and CBD concentration of the product. 

If you are taking CBD for the first time, you may start with low amounts to observe how your body reacts to the compound. 

You may gradually increase the dosage if no adverse effects are experienced or your desired results are not achieved. 

According to a study, a CBD dose of up to 1,500mg per day is well-tolerated(23). Still, it is best to consult a healthcare professional on the appropriate CBD dosage or other treatment options for cholesterol management.

CBD Delivery Methods

Due to limited human studies, there are no official recommendations on taking CBD for high cholesterol(24). You may take CBD oil via tinctures, gummies, vape products, or topicals

CBD tincture may be consumed sublingually by putting a few drops of CBD oil under your tongue. The effects of CBD can be felt within 10 to 15 minutes after swallowing, while the effects may last up to several hours(25)

You may ingest CBD oil via gummies or edibles. It takes 30 to 60 minutes for CBD to start working in your system, with the effects lasting up to six hours(26)

Vaping provides a faster way of delivering CBD into your system. As you inhale CBD, it is directly sent to your lungs and absorbed into your bloodstream(27)

Vaped CBD takes effect within minutes and may last for one to four hours(28). However, vape use has been shown to cause various lung problems(29)

You may also apply CBD-infused topical products on your skin for targeted pain relief(30). However, CBD absorption via the topical method is limited(31)

CBD and Other Treatments for High Cholesterol

CBD oil has been widely explored as a substance that may improve cholesterol levels and relieve high cholesterol-related complications. CBD has been found to contain nutrients that potentially lower lipid levels in the body(32)

For instance, CBD oil products that use hempseed oil as the carrier oil contain omega-3 and omega-6 fatty acids. Omega-3 fatty acids are nutrients often found in foods or dietary supplements that may lower triglyceride levels(33)

Lifestyle changes, like daily physical activity and a healthy diet, may also help increase good cholesterol levels and reduce the risks of cardiovascular diseases(34)

However, doctors may prescribe cholesterol medications for cholesterol levels that remain high. 

Cholesterol treatments can remove excess LDL cholesterol or improve general cardiovascular health. Cholesterol medications perform these effects in different ways. 

Your treatment choice depends on the possible side effects, risk factors, age, current health condition, the severity of cholesterol, and risk level. 

Natural Supplements 

Aside from commonly prescribed medications, some people also consider cholesterol-lowering supplements. Some natural products that may reduce total cholesterol and LDL cholesterol include the following(35):

  • Artichoke extract
  • Barley
  • Blond psyllium (found in seed husk)
  • Oat bran (found in whole oats and oatmeal)
  • Plant stanols, lecithin-emulsified (found in some fortified orange juices)
  • Plant sterols (found in some oral supplements and some margarines)

Statins

Statins substantially slow down the cholesterol production in your liver. This prescribed treatment helps the body reabsorb any extra cholesterol from built-up deposits on your artery walls(36).  

Some statins boost HDL levels to aid in transporting bad cholesterol from the arteries to your liver(37). This medication may also potentially reverse severe heart diseases

Although statins act as a conventional treatment option for cholesterol, their use may have side effects, like rhabdomyolysis and liver damage(38)

Rhabdomyolysis is a rare condition where the muscle fibers break down rapidly due to muscle injury. This condition may lead to severe complications, such as renal failure or the kidneys’ inability to filter urine and waste(39)

Examples of statins include atorvastatin (Lipitor), simvastatin (Zocor), lovastatin (Altoprev), fluvastatin (Lescol XL), pitavastatin (Livalo), pravastatin (Pravachol), and rosuvastatin (Crestor)(40)

Cholesterol Absorption Inhibitors

One of the primary ways dietary cholesterol enters the body is through your small intestine, where it absorbs the cholesterol and releases it into the bloodstream. 

Cholesterol absorption inhibitors slow down the rate at which the small intestine absorbs cholesterol from food. An example of this drug is ezetimibe (Zetia), which limits the absorption of dietary cholesterol to help reduce blood cholesterol(41)

Ezetimibe and other cholesterol absorption inhibitors may be combined with other drugs, like statins(42)

Bile Acid-Binding Resins

This treatment option seeks to lower the production of cholesterol indirectly. One of the primary uses of cholesterol is to make bile acids, a substance needed to encourage healthy digestion(43)

Bile acid-binding resin is a group of medications that binds themselves to the body’s bile acids and tricks the liver into thinking you do not have enough bile acids. 

Thus, your liver is forced to use up the excess cholesterol out of your blood and reroute it to make more bile acids. Note that this mechanism may induce some digestion troubles. 

Examples of bile acid-binding resins include colesevelam (Welchol), cholestyramine (Prevalite), and colestipol (Colestid). These medications lower cholesterol levels in the blood by binding to bile acids(44)

Injectable Medications

Injectable medications are a newer class of drugs, also known as PCSK9 inhibitors. They are focused on lowering the amount of cholesterol circulating in your blood(45)

These medications encourage the liver to absorb and remove more LDL cholesterol than it usually does. Continuous medical checkups and frequent injections are required to ensure that the treatment is working correctly.

Alirocumab (Praluent) and evolocumab (Repatha) are ideally used by people with a genetic condition that often creates high levels of LDL(46)

These injectable medications may also be used by people with a history of coronary disease and intolerant to statins or other cholesterol drugs.

Risks and Side Effects of CBD for High Cholesterol

CBD is generally well-tolerated with a favorable safety profile(47). However, CBD’s possible side effects may include diarrhea, fatigue, nausea, dry mouth, drowsiness, changes in weight or appetite, gastrointestinal problems, and liver damage(48)

According to a study, CBD has a complex pharmacokinetic profile. This compound may interact with certain drugs or dietary supplements and raise their levels in your bloodstream(49)

It is advisable to avoid taking CBD with medications or supplements with a grapefruit warning. Some examples include statin drugs that lower cholesterol, such as atorvastatin (Lipitor) and simvastatin (Zocor)(50)

These statin drugs are broken down by enzymes. The grapefruit may block the action of these enzymes and result in high concentrations of the substance in the body(51)

The interaction between grapefruit and certain cholesterol medications may cause adverse side effects and increase your risk for muscle or liver damage, eventually leading to kidney failure(52)

The United States Food and Drug Administration (FDA) also advises consumers to be wary of CBD products being marketed with unsubstantiated therapeutic claims and sold as supplements(53)

The FDA does not consider CBD as an ingredient under the Over-the-Counter (OTC) Drug Review(54). Therefore, most CBD products available on the market are not approved by the FDA

Epidiolex is currently the only FDA-approved drug derived from a purified form of CBD. It is used to treat two rare forms of epilepsy, Lennox-Gastaut syndrome (LGS) and Dravet syndrome(55).

How to Choose the Right CBD Oil for High Cholesterol

When choosing the best CBD product to use for cholesterol, it helps to know the components of each type of CBD oil. You may select from full-spectrum, broad-spectrum, or CBD isolates.

Full-spectrum CBD oil has all the compounds present in the Cannabis sativa plant, including tetrahydrocannabinol (THC), terpenes, flavonoids, essential oils, and fatty acids

These compounds produce a synergy, called the entourage effect, to provide maximum health benefits

Broad-spectrum is a type of CBD oil that uses most phytocompounds from the cannabis plant. However, the psychoactive compound THC is removed from the extract.

CBD isolate is pure CBD that does not have all the components of the cannabis plant. This type of CBD oil is made from isolated cannabidiol

Other things to consider before buying any CBD product include the following. 

  • Find out the CBD product’s hemp source, like Colorado, Oregon, or Kentucky. 
  • Opt for CBD oil products derived from non-GMO, organic hemp.
  • Know which extraction method is used in the CBD product. Some of the most common methods include carbon dioxide (CO2) and ethanol extraction. 
  • Look for the CBD product’s third-party lab reports. They must be easily accessible on the CBD brand’s website. 
  • When purchasing online, check brand or product reviews from other customers.
  • When purchasing from a dispensary or retailer, make sure that CBD is legal in your state. 

Legality of CBD

The Farm Bill of 2018 made CBD readily accessible in many parts of the United States. CBD products are legal as long as they are derived from hemp containing less than 0.3% THC(56).

Under the 2018 Farm Bill, the growth, production, and manufacturing of hemp plants are also legal on the federal level. Thus, industrial hemp was removed as a Schedule I drug from the federal Controlled Substance List. 

Controlled substances are drugs or prescription medications regulated by the government, as they may cause addiction(57)

State laws may have varying levels of restriction regarding CBD. Many states allow CBD-rich oils with high concentrations of THC(58)

Medical marijuana may also be legally accessible to patients with a qualifying condition. Before purchasing medical cannabis, patients may need to provide a prescription from their physician(59)

Product Frequently
Asked Questions


  1. Stanley, C. P., Hind, W. H., & O’Sullivan, S. E. (2013). Is the cardiovascular system a therapeutic target for cannabidiol?. British journal of clinical pharmacology, 75(2), 313–322. https://doi.org/10.1111/j.1365-2125.2012.04351.x
  2. Centers for Disease Control and Prevention. (2020, April 2). High Cholesterol Facts. https://www.cdc.gov/cholesterol/facts.htm
  3. ClevelandClinic.org. Cholesterol: High Cholesterol Diseases. Retrieved from: https://my.clevelandclinic.org/health/articles/11918-cholesterol-high-cholesterol-diseases
  4. Manzanares, J., Julian, M., & Carrascosa, A. (2006). Role of the cannabinoid system in pain control and therapeutic implications for the management of acute and chronic pain episodes. Current Neuropharmacology, 4(3), 239–257. https://doi.org/10.2174/157015906778019527
  5. Stanley, C. et.al. op. cit.
  6. Bitzur, R., Cohen, H., Kamari, Y., Shaish, A., & Harats, D. (2009). Triglycerides and HDL cholesterol: stars or second leads in diabetes?. Diabetes care, 32 Suppl 2(Suppl 2), S373–S377. https://doi.org/10.2337/dc09-S343
  7. Ibid.
  8. High Cholesterol. (n.d.). Retrieved from https://strokefoundation.org.au/About-Stroke/Prevent-Stroke/High%20cholesterol
  9. Jadoon, K. A., Ratcliffe, S. H., Barrett, D. A., Thomas, E. L., Stott, C., Bell, J. D., O’Sullivan, S. E., & Tan, G. D. (2016). Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study. Diabetes care, 39(10), 1777–1786. https://doi.org/10.2337/dc16-0650
  10. Avci, E., Dolapoglu, A., & Akgun, D. E. (2018). Role of Cholesterol as a Risk Factor in Cardiovascular Diseases. Cholesterol – Good, Bad and the Heart, N/D. https://doi.org/10.5772/intechopen.76357
  11. Sakurai, M., Stamler, J., Miura, K., Brown, I. J., Nakagawa, H., Elliott, P., Ueshima, H., Chan, Q., Tzoulaki, I., Dyer, A. R., Okayama, A., Zhao, L., & INTERMAP Research Group (2011). Relationship of dietary cholesterol to blood pressure: the INTERMAP study. Journal of hypertension, 29(2), 222–228. https://doi.org/10.1097/HJH.0b013e32834069a5
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  13. Hayakawa, K., Mishima, K., & Fujiwara, M. (2010). Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke. Pharmaceuticals (Basel, Switzerland), 3(7), 2197–2212. https://doi.org/10.3390/ph3072197
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  16. Hayakawa, K., Irie, K., Sano, K., Watanabe, T., Higuchi, S., Enoki, M., Nakano, T., Harada, K., Ishikane, S., Ikeda, T., Fujioka, M., Orito, K., Iwasaki, K., Mishima, K., & Fujiwara, M. (2009). Therapeutic Time Window of Cannabidiol Treatment on Delayed Ischemic Damage via High-Mobility Group Box1-Inhibiting Mechanism. Biological & Pharmaceutical Bulletin, 32(9), 1538–1544. https://doi.org/10.1248/bpb.32.1538
  17. Jadoon, K. A., Tan, G. D., & O’Sullivan, S. E. (2017). A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study. JCI insight, 2(12), e93760. https://doi.org/10.1172/jci.insight.93760
  18. Feng, Y., Chen, F., Yin, T., Xia, Q., Liu, Y., Huang, G., Zhang, J., Oyen, R., & Ni, Y. (2015). Pharmacologic Effects of Cannabidiol on Acute Reperfused Myocardial Infarction in Rabbits. Journal of Cardiovascular Pharmacology, 66(4), 354–363. https://doi.org/10.1097/fjc.0000000000000287
  19. Heart attack. (2020, June 16). Retrieved July 22, 2020, from https://www.mayoclinic.org/diseases-conditions/heart-attack/symptoms-causes/syc-20373106
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  21. Ibid.
  22. Iffland, K., & Grotenhermen, F. (2017). An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis and cannabinoid research, 2(1), 139–154. https://doi.org/10.1089/can.2016.0034
  23. Bergamaschi MM, Queiroz RH, Zuardi AW, et al. . Safety and side effects of cannabidiol, a Cannabis sativa constituent. Curr Drug Saf. 2011;6:237–249
  24. Iffland, K. op. cit.
  25. Huestis, M. A. (2007). Human cannabinoid pharmacokinetics. Chemistry & biodiversity, 4(8), 1770.
  26. Borodovsky, J. T., Crosier, B. S., Lee, D. C., Sargent, J. D., & Budney, A. J. (2016). Smoking, vaping, eating: Is legalization impacting the way people use cannabis?. The International journal on drug policy, 36, 141–147. https://doi.org/10.1016/j.drugpo.2016.02.022
  27. ibid.
  28. ibid.
  29. Broderick, S. (2020). What Does Vaping Do to Your Lungs? Johns Hopkins Medicine. https://www.hopkinsmedicine.org/health/wellness-and-prevention/what-does-vaping-do-to-your-lungs
  30. Palmieri, B., Laurino, C., & Vadalà, M. (2019). A therapeutic effect of cbd-enriched ointment in inflammatory skin diseases and cutaneous scars. Clin Ter, 170(2), e93-e99.
  31. ibid.
  32. Leizer, Cary & Ribnicky, David & Poulev, Alexander & Dushenkov, Vyacheslav & Raskin, Ilya. (2000). The Composition of Hemp Seed Oil and Its Potential as an Important Source of Nutrition. Journal of Nutraceuticals, Functional & Medical Foods. 2. 35-53. 10.1300/J133v02n04_04.
  33. Skulas-Ray, A. C., Wilson, P. W. F., Harris, W. S., Brinton, E. A., Kris-Etherton, P. M., Richter, C. K., Jacobson, T. A., Engler, M. B., Miller, M., Robinson, J. G., Blum, C. B., Rodriguez-Leyva, D., de Ferranti, S. D., & Welty, F. K. (2019). Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association. Circulation, 140(12), N/D. https://doi.org/10.1161/cir.0000000000000709
  34. Mann, S., Beedie, C., & Jimenez, A. (2014). Differential effects of aerobic exercise, resistance training and combined exercise modalities on cholesterol and the lipid profile: review, synthesis and recommendations. Sports medicine (Auckland, N.Z.), 44(2), 211–221. https://doi.org/10.1007/s40279-013-0110-5
  35. MayoClinic.org. Cholesterol-lowering supplements may be helpful. Retrieved from: https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/cholesterol-lowering-supplements/art-20050980
  36. MayoClinic.org. High cholesterol. Retrieved from: https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/diagnosis-treatment/drc-20350806
  37. Mayo Clinic Staff. (2018, October 24). HDL cholesterol: How to boost your ‘good’ cholesterol. Retrieved from https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/hdl-cholesterol/art-20046388
  38. Golomb, B. A., & Evans, M. A. (2008). Statin adverse effects : a review of the literature and evidence for a mitochondrial mechanism. American journal of cardiovascular drugs : drugs, devices, and other interventions, 8(6), 373–418. https://doi.org/10.2165/0129784-200808060-00004
  39. NWANKWO, C., & OBASI, S. C. (2015). Renal Failure: Implication For Health Education. International Journal of Research, 9(1).
  40. High cholesterol. op. cit.
  41. Ibid.
  42. Ibid.
  43. Ibid.
  44. Ibid.
  45. Ibid.
  46. Ibid.
  47. World Health Organization (WHO). (2018). Cannabidiol (CBD) Critical Review Report. https://www.who.int/medicines/access/controlled-substances/CannabidiolCriticalReview.pdf
  48. Machado Bergamaschi, M., Helena Costa Queiroz, R., Waldo Zuardi, A., & Crippa, A. S. (2011). Safety and side effects of cannabidiol, a Cannabis sativa constituent. Current drug safety, 6(4), 237-249.
  49. Brown, J. D., & Winterstein, A. G. (2019). Potential Adverse Drug Events and Drug-Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use. Journal of clinical medicine, 8(7), 989. https://doi.org/10.3390/jcm8070989. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/
  50. FDA.gov. (July 2017). Grapefruit Juice and Some Drugs Don’t Mix. Retrieved from: https://www.fda.gov/consumers/consumer-updates/grapefruit-juice-and-some-drugs-dont-mix
  51. Ibid.
  52. Ibid.
  53. FDA.gov. (October 2020). FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD). Retrieved from: https://www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbd
  54. ibid.
  55. ibid.
  56. Farm Bill. U.S. Department of Agriculture. Retrieved from: https://www.usda.gov/farmbill
  57. National Cancer Institute. Definition of Controlled Substance. Retrieved from: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/controlled-substance
  58. ProCon.org. (2019, July 24). Legal Medical Marijuana States and DC Laws, Fees, and Possession Limits. Retrieved from https://medicalmarijuana.procon.org/legal-medical-marijuana-states-and-dc/
  59. National Conference of State Legislatures. (October 2020). State Medical Marijuana Laws. Retrieved from: https://www.ncsl.org/research/health/state-medical-marijuana-laws.aspx
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  65. FDA.gov. op. cit.
  66. ibid. 
  67. Gill, L. (2019, May 15). Can You Take CBD and Pass a Drug Test? Retrieved from https://www.consumerreports.org/cbd/can-you-take-cbd-and-pass-a-drug-test/.
  68. Machado Bergamaschi, M., et.al. op. cit.
  69. Brown, J. D., & Winterstein, A. G. op. cit.
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