Best CBD Oil for Herpes

Would you like to try CBD for viral infections like herpes? CBD Clinicals has gathered all the relevant information about CBD and its therapeutic potential for herpes and its symptoms.

Rating
Highlights

Editor's Choice

Spruce 750mg Lab Grade CBD Oil

4.8 out of 5
  1. Peppermint flavor masks any unpleasant taste
  2. Contains 25mg of CBD per dropper full
  3. Bottle includes a graduated dropper for correct serving measurement

Best CBD Purity

NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil

5.0 out of 5
  1. Natural remedy for various illnesses
  2. Product is full-spectrum whole-plant extract
  3. Contains naturally occurring synergistic cannabinoids and terpenes

Best High Potency

Spruce 2400mg Lab Grade CBD Oil

5.0 out of 5
  1. Maximum possible potency
  2. Each dropper full contains 80mg of CBD
  3. Conveniently fits in a 30mL bottle

Best Value

Avida Full Spectrum CBD Oil Tincture 500mg

4.6 out of 5
  1. Proprietary full-spectrum
  2. Developed using advanced AVIDA CORE Spectrum Technology
  3. Highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3)

Best Value

cbdMD CBD Oil Tincture Natural 1500mg

4.7 out of 5
  1. Made using only CBD sourced from medical hemp
  2. Available in many flavours
  3. Safe for daily use

Best THC Free

CBDistillery THC Free CBD Oil Tinctures

4.4 out of 5
  1. Do not contain THC
  2. Available in different potencies and sizes
  3. Brand has special deals and offers

Best Customer Rated

cbdMD CBD Oil Tincture Natural 750mg

4.4 out of 5
  1. THC-free
  2. Has plenty of flavours to choose from
  3. Totally vegan

Best For Beginners

NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil

4.6 out of 5
  1. Lowest concentration for CBD beginners
  2. Fully organic and lab-tested
  3. Full-spectrum

Best Flavor Range

Hemp Bombs 750mg CBD Oil

3.9 out of 5
  1. Has a wide range of flavours
  2. Safe to intake
  3. Get 20% off when you avail of their subscription
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Compare the Best CBD Oil for Herpes in 2022

ProductPotencyPurityCustomer ServiceTypeExtractionTransparencyAbsorption
Spruce 2400mg Lab Grade CBD Oil
4.8 out of 5
4.5 out of 5
4.5 out of 5
5.0 out of 5
5.0 out of 5
4.5 out of 5
5.0 out of 5
5.0 out of 5
NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
5.0 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
4.0 out of 5
5.0 out of 5
5.0 out of 5
Spruce 2400mg Lab Grade CBD Oil
5.0 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
4.0 out of 5
5.0 out of 5
5.0 out of 5
Avida Full Spectrum CBD Oil Tincture 500mg
4.6 out of 5
5.0 out of 5
3.5 out of 5
3.0 out of 5
5.0 out of 5
4.5 out of 5
4.5 out of 5
5.0 out of 5
cbdMD CBD Oil Tincture Natural 1500mg
4.7 out of 5
5.0 out of 5
3.5 out of 5
5.0 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
4.0 out of 5
CBDistillery THC Free CBD Oil Tinctures
4.4 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
4.5 out of 5
cbdMD CBD Oil Tincture Natural 750mg
4.4 out of 5
4.5 out of 5
3.5 out of 5
5.0 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
4.0 out of 5
NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
4.6 out of 5
2.5 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
4.5 out of 5
5.0 out of 5
5.0 out of 5
Hemp Bombs 750mg CBD Oil
3.9 out of 5
4.5 out of 5
3.5 out of 5
2.5 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
4.0 out of 5

Best CBD Oil for Herpes

1. Spruce 750mg Lab Grade CBD Oil
cbdc overall score

4.8

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

ProsCons

Mid-strength

No other flavors

Natural peppermint flavor

Made from 100% organic and natural ingredients

Overview

Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
cbdc overall score

5.0

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

ProsCons

Pure CBD hemp

No other flavors

All natural

Approximately 300 drops total

Overview

Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

3. Spruce 2400mg Lab Grade CBD Oil
cbdc overall score

5.0

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

ProsCons

Extra Strength

Tastes bitter

No artificial flavoring or colors

No THC-free option

Made from 100% organic and natural ingredients

Overview

The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.

4. Avida Full Spectrum CBD Oil Tincture 500mg
cbdc overall score

4.6

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

ProsCons

Light Spearmint flavor

No other flavor

Non-THC, Non-detected in drug test

Overview

Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.

5. cbdMD CBD Oil Tincture Natural 1500mg
cbdc overall score

4.7

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

ProsCons

Various delicious flavors to choose from

cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options

Has vegan, organic, and gluten-free ingredients

Free shipping for this particular product within USA

World-class customer service team

Overview

cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

6. CBDistillery THC Free CBD Oil Tinctures
cbdc overall score

4.4

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

ProsCons

60-Day Satisfaction Guarantee

Dropper is a bit shaky

Various strengths

Oil extracted from aerial plant parts of US grown industrial hemp

Sourced from non-GMO industrial hemp grown in the USA through natural farming practices

Overview

CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.

7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
cbdc overall score

4.6

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

ProsCons

Pure CBD hemp

No other flavors

All natural

A bit pricey compared to competitors

Approximately 100 drops total

Overview

This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.

8. cbdMD CBD Oil Tincture Natural 750mg
cbdc overall score

4.4

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

ProsCons

Vegan and Gluten free

Does not ship internationally

Has a third-party lab test

Wide variety of CBD strengths and sizes

Overview

A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.

9. Hemp Bombs 750mg CBD Oil
cbdc overall score

3.9

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

ProsCons

Wide variety of flavors

Incomplete information about the product

Lab test results are complete

Does not ship to all international countries

30-day money-back guarantee

Overview

Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.

How CBD May Help With Herpes

Cannabidiol, popularly known as CBD, is one of the many cannabinoids present in the cannabis plant.  

Research suggests that CBD interacts with the cannabinoid receptors (CB1 and CB2) of the ECS (endocannabinoid system)(1)

CB1 receptors are primarily predominant in the central nervous system. Meanwhile, CB2 receptors, which regulate immune response, are widespread among cells of the immune system(2)

CBD lacks the psychoactivity of THC (tetrahydrocannabinol). THC is responsible for the euphoric effect that most marijuana users feel. 

Although CBD has a low binding affinity for both cannabinoid receptors, the non-psychoactive compound may antagonize them in the presence of THC(3)

A study from the Journal of General Virology hypothesized that the CB1 receptor antagonists may inhibit HCV (hepatitis C virus) production, suggesting their potential as antiviral agents(4).

Since CBD may act as an antagonist at CB1 receptors, the non-psychoactive compound may also help with viral infections, as shown in the research articles from PubMed(5-6). Herpes is a viral infection.  

A study from the Sexually Transmitted Diseases journal suggested that the herpes simplex virus type 2 may increase the susceptibility of the sexual transmission of hepatitis C, a liver infection caused by HCV(7)

Herpes simplex 2 or HSV-2 is a sexually transmitted infection that causes genital herpes(8).  

Meanwhile, herpes simplex 1 or HSV-1 is commonly transmitted orally and can include symptoms like cold sores(9)

In rare cases, HSV-1 or HSV-2 infections may lead to meningitis, an inflammation of the protective layer of membranes that shield the brain and spinal cord(10). CBD has been shown to have anti-inflammatory properties(11), which may be beneficial in these cases.

While these research studies seem promising, no evidence exists directly stating CBD’s effects on herpes

Benefits of Using CBD for Herpes

A study from the International Reviews of Immunology journal indicated that strong cytokine responses are linked to the acute and recurrent phases of HSV (herpes simplex virus) infection(12)

Cytokines are small proteins that are vital in cell signaling. The study also stated that the pro-inflammatory and TH1 type cytokines dominate the cytokine response to HSV infection(13)

Clinical studies suggest that CBD may reduce the level of pro-inflammatory cytokines(14).   

When symptomatic, the common manifestations of HSV-1 or HSV-2 genital infection are clusters of papules and inflamed vesicles (blisters) on the outer surface of the genitals(15)

CBD’s pain-relieving effects(16) may help manage symptoms of certain medical conditions like genital herpes. Symptoms of genital herpes include pain and tenderness in the genital area(17). 

CBD’s potential anti-inflammatory properties(18) may also help with inflammation associated with medical conditions like genital herpes. Gential herpes may lead to rectal inflammation(19)

However, proper assessment in clinical trials is warranted to determine the benefits of using CBD for herpes.

How to Take CBD Oil for Herpes

You may find the topical CBD application helpful during herpes outbreaks.  

Topical CBD products, such as CBD creams, lotions, and balms, allow you to administer the compound directly to the affected area

Inhaling vaporized CBD is another way of administering cannabidiol. However, extra caution is necessary because vaping may damage the lungs(20)

You may also administer CBD sublingually or under the tongue. 

CBD Dosage for Herpes

The FDA (Food and Drug Administration) does not recognize CBD as a form of herpes medication. Therefore, there is no standard CBD dosage for herpes.

Oral herpes spreads from individuals with an active outbreak. A person can catch oral herpes by engaging in oral sex with the infected individual(21)

Treatment plans for oral herpes may involve oral antiviral medications, antiviral topical ointments, or over-the-counter topical anesthetics and anti-inflammatory agents(22)

CBD is believed to have antiviral, analgesic, and anti-inflammatory effects(23). Doses between 10mg and 100mg of CBD per day may help with pain and inflammation(24). Inflammation and pain are common herpes symptoms(25).

How Long Does CBD Take to Help With Herpes?

CBD in topicals usually takes effect within 15 to 30 minutes(26). Meanwhile, the onset time of CBD via the inhalation route is between 2 to 15 minutes(27)

Although inhaling CBD using vape pens is the fastest way to benefit from CBD, vaping may damage the lungs(28-29)

How Long Will CBD Help With Herpes?

How long CBD will last after it starts to take effect depends on its bioavailability, which is the extent to which a particular drug becomes entirely available to one’s system. 

The bioavailability of CBD after smoking is 31%(30). On the other hand, CBD in topicals has zero bioavailability(31). The bioavailability of CBD via the sublingual route is between 6% and 20%(32)

How to Choose the Right CBD for Herpes

You can choose between full-spectrum CBD, broad-spectrum CBD, and CBD isolates. 

The full-spectrum and broad-spectrum variants contain all compounds of the cannabis plant. Their only difference is that the broad-spectrum CBD is nearly THC-free. Meanwhile, CBD isolates are made of pure CBD.

When purchasing from online stores, make sure to be aware of any disclaimers

Also, search for the lab reports provided by a third-party lab. These documents are vital in checking the labeling accuracy of CBD products like tinctures

Lab reports like the COA (certificate of analysis) ensure that the products are free from pesticides and other harmful substances. 

Risks and Side Effects of Using CBD for Herpes

Generally, CBD may induce some risks and minor side effects like fatigue and dry mouth(33)

Legality of CBD

The 2018 Farm Bill states that Cannabis sativa L. and other derivatives of cannabis with less than 0.3% THC content on a dry weight basis are considered federally legal(34)

Colorado is one of the states that permit recreational and medical marijuana use(35)

You may check government reports and journals, which are located online using a digital object identifier (DOI) to know more about various state laws.

Product Frequently
Asked Questions

  • How can CBD help with herpes?

    CBD has anti-inflammatory and antiviral effects that may help with viral infections(36) like shingles, chickenpox, and herpes.  

    Herpes simplex viruses cause sores on mucous membranes or skin. These sores occur when the infected cell tissues are not adequately eliminated by immunoregulatory white blood cells of the immune system

    CBD may combat the inflammation induced by active HSV outbreak and fight against viruses(37)

  • What evidence or research exists to say that CBD helps with herpes?

    Herpes symptoms include ulcers or painful blisters at the site of infection(38). CBD has the potential to provide pain relief(39).

  • Is there any evidence that CBD can make herpes worse?

    No evidence suggests that CBD can make herpes worse. However, herpes may cause fatigue(40), and one of the common side effects of CBD is fatigue(41).

  • Will CBD interact with any current medication I may be taking for herpes?

    CBD has the potential for pharmacodynamic and pharmacokinetic drug-to-drug interactions(42). Always ask your doctor before using CBD simultaneously with any drugs like immune-suppressant medications. 

  • Are there other treatments I should consider alongside CBD to help with herpes?

    There is no cure for herpes infection. You cannot get rid of it permanently. However, antiviral medicines may be the closest and probably the strongest treatment you can use to shorten outbreaks and relieve discomfort during breakouts(43)

    Your healthcare provider may prescribe antiviral medications like acyclovir (Zovirax) for herpes(44). Still, you should ask your doctor regarding CBD supplementations with other medications.

  • Can I fail a drug test if I use CBD for herpes?

    Full-spectrum CBD products contain small amounts of THC, which may build up in the body when taken frequently and regularly(45). An increased THC level in the bloodstream may result in a positive drug test.  

  • What is the dosage for herpes?

    Doses between 10mg and 100mg may help with pain(46). Herpes is associated with painful blisters.

  • Are there side effects to using CBD for herpes?

    Generally, CBD may induce minor side effects such as drowsiness and fatigue(47).


  1. The Diverse CB1 and CB2 Receptor Pharmacology of Three Plant Cannabinoids: Δ9-Tetrahydrocannabinol, Cannabidiol, and Δ9-Tetrahydrocannabivarin
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219532/
  2. The CB2 receptor and its role as a regulator of inflammation
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075023/
  3. Cannabinoids and Pain: New Insights From Old Molecules
    https://www.frontiersin.org/articles/10.3389/fphar.2018.01259/full 
  4. Endocannabinoid CB1 Antagonists Inhibit Hepatitis C Virus Production, Providing a Novel Class of Antiviral Host-Targeting Agents
    https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.067231-0
  5. Cannabidiol Is a Negative Allosteric Modulator of the Cannabinoid CB1 Receptor
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621983
  6. Cannabidiol for Viral Diseases: Hype or Hope?
    https://www.liebertpub.com/doi/10.1089/can.2019.0060
  7. Herpes Simplex Virus-2 May Increase the Susceptibility of the Sexual Transmission of Hepatitis C
    https://pubmed.ncbi.nlm.nih.gov/7482102
  8. Herpes Simplex Virus
    https://www.who.int/news-room/fact-sheets/detail/herpes-simplex-virus
  9. Ibid.
  10. Herpes: HSV-1 and HSV-2
    https://www.hopkinsmedicine.org/health/conditions-and-diseases/herpes-hsv1-and-hsv2
  11. Antioxidative and Anti-Inflammatory Properties of Cannabidiol
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023045/
  12. Cytokines in Experimental Herpes Simplex Virus Infection
    https://pubmed.ncbi.nlm.nih.gov/12486819/
  13. Ibid.
  14. Antioxidative and Anti-Inflammatory Properties of Cannabidiol
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023045/
  15. Herpes Virus, Oral Clinical Signs and QoL: Systematic Review of Recent Data
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563194/
  16. Research Shows Pain-Relieving Effects of CBD
    https://www.sciencedaily.com/releases/2021/04/210423130221.htm
  17. Genital Herpes
    https://www.mayoclinic.org/diseases-conditions/genital-herpes/symptoms-causes/syc-20356161
  18. Antioxidative and Anti-Inflammatory Properties of Cannabidiol
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023045/
  19. Genital Herpes
    https://www.mayoclinic.org/diseases-conditions/genital-herpes/symptoms-causes/syc-20356161
  20. Is It Safe to Vape CBD?
    https://www.consumerreports.org/cbd/is-it-safe-to-vape-cbd/
  21. Oral Herpes
    https://www.hopkinsmedicine.org/health/conditions-and-diseases/herpes-hsv1-and-hsv2/oral-herpes
  22. Ibid.
  23. Cannabidiol for Viral Diseases: Hype or Hope?
    https://www.liebertpub.com/doi/10.1089/can.2019.0060
  24. CBD: A Patient’s Guide to Medicinal Cannabis, page 129.
    https://drive.google.com/file/d/1MILU_6ZjYkII-XMUPHLFPiPQbrz__5Sh/view
  25. Cannabidiol for Viral Diseases: Hype or Hope?
    https://www.liebertpub.com/doi/10.1089/can.2019.0060
  26. Healing With CBD, page 193.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  27. Healing With CBD, page 190.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  28. How to Safely Use CBD: Should You Inhale, Spray, Apply, or Eat It?
    https://www.consumerreports.org/cbd/how-to-use-cbd-inhale-spray-apply-eat/
  29.  Is It Safe to Vape CBD?
    https://www.consumerreports.org/cbd/is-it-safe-to-vape-cbd/
  30. A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275223/
  31. Healing With CBD, page 193.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  32. Healing With CBD, page 192.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  33. What Are the Benefits of CBD — And Is It Safe to Use?
    https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/is-cbd-safe-and-effective/faq-20446700
  34. FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD)
    https://www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbd
  35. Legal Marijuana Use in Colorado
    https://cannabis.colorado.gov/legal-marijuana-use-in-colorado
  36. Cannabidiol for Viral Diseases: Hype or Hope?
    https://www.liebertpub.com/doi/10.1089/can.2019.0060
  37. Ibid. 
  38. Herpes Simplex Virus
    https://www.who.int/news-room/fact-sheets/detail/herpes-simplex-virus
  39. Research Shows Pain-Relieving Effects of CBD
    https://www.sciencedaily.com/releases/2021/04/210423130221.htm
  40. Human herpesvirus 6 and chronic fatigue syndrome
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250792/
  41. What Are the Benefits of CBD – and Is It Safe to Use?
    https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/is-cbd-safe-and-effective/faq-20446700
  42. Potential Adverse Drug Events and Drug-Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use
    https://www.mdpi.com/2077-0383/8/7/989
  43. Genital Herpes Symptoms & Treatment
    https://www.avert.org/sex-stis/sexually-transmitted-infections/herpes
  44. Acyclovir (Oral Route, Intravenous Route)
    https://www.mayoclinic.org/drugs-supplements/acyclovir-oral-route-intravenous-route/proper-use/drg-20068393
  45. Can You Take CBD and Pass a Drug Test?
    https://www.consumerreports.org/cbd/can-you-take-cbd-and-pass-a-drug-test/
  46. CBD: A Patient’s Guide to Medicinal Cannabis, page 129.
    https://drive.google.com/file/d/1MILU_6ZjYkII-XMUPHLFPiPQbrz__5Sh/view
  47. What Are the Benefits of CBD — And Is It Safe to Use?
    https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/is-cbd-safe-and-effective/faq-20446700

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