Compare the Best CBD for Hemophilia in 2022

How CBD Helps With Hemophilia 

Hemophilia, or haemophilia, is a genetic bleeding disorder inducing abnormal blood clotting due to a deficiency of blood-clotting proteins⁽¹⁾. 

Platelets, minuscule cell fragments that form blood clots, stop or prevent bleeding⁽²⁾.   

CBD may help relieve the symptoms of hemophilia by interacting with an individual’s endocannabinoid system (ECS). Cannabinoid receptors in the ECS may play a role in producing cytokine proteins related to inflammatory responses^(3-4). 

Cannabis-derived cannabinoids may interact with cannabinoid receptors 1 (CB1 receptors) and cannabinoid receptors 2 (CB2 receptors) for pain management⁽⁵⁾.  

CB1 receptors are mostly located in an individual’s central nervous system (CNS) and the brain. The receptors are related to pain sensation, motor regulation, appetite, sleep, mood, and memory processing. 

CB2 receptors exist within the immune system. These cannabinoid receptors play a role in reducing tissue damage and producing anti-inflammatory effects in tissues. 

A study suggested that CB1 and CB2 receptors may play a role in producing cytokines⁽⁶⁾. These proteins are responsible for inflammatory responses⁽⁷⁾.  

In addition, another study published in the NeuroMolecular Medicine journal hypothesized that the ECS may promote neuroprotective properties⁽⁸⁾. 

An animal study published by the Journal of Pharmacology and Experimental Therapeutics showed that the ECS may regulate the duration and frequency of seizures in rats with epilepsy⁽⁹⁾. 

Furthermore, according to research, cannabinoids may suppress nausea and vomiting by interacting with the CB1 receptors⁽¹⁰⁾. 

Benefits and Uses of CBD for Hemophilia  

Research shows that CBD may interact with the ECS to help reduce acute and chronic pain, higher blood pressure, and vomiting and nausea^(11–13). These symptoms are often associated with hemophilia^(14-15).

The joint pain associated with hemophilia may develop into arthritis if untreated⁽¹⁶⁾. Hemophilia-related bleeding may also lead to complications such as joint damage⁽¹⁷⁾. 

An animal study showed that transdermal CBD applications reduced joint pain in arthritic rats⁽¹⁸⁾. 

Transdermal CBD applications deliver CBD into the bloodstream through the skin. More research is necessitated to determine whether CBD produces similar results in human subjects. 

Another study showed that cannabidiol may reduce acute and chronic pain⁽¹⁹⁾.

The Hemophilia Federation of America reported that individuals with hemophilia may experience hypertension (high blood pressure)⁽²⁰⁾. 

A study published in JCI insight hypothesized that CBD may lower resting blood pressure⁽²¹⁾. 

In addition, head injuries may induce vomiting, nausea, and seizures among individuals with hemophilia⁽²²⁾. 

Researchers hypothesize that chronic administration of cannabidiol may reduce the convulsion episodes among individuals with epilepsy⁽²³⁾. 

Ensure to consult a healthcare professional with extensive experience in CBD for hemophilia before utilizing any CBD product. 

Individuals may consider hemophilia treatment centers and residential caregivers to help with therapy. 

These specialized services may help manage conditions such as viral hepatitis⁽²⁴⁾. A vast majority of individuals with bleeding disorders also have chronic hepatitis C infections,   

How Long Does CBD Take to Help Hemophilia?

There have been no studies on the amount of time required to experience the biological effects of CBD specific for hemophilia. 

However, there are data available on the onset times of CBD when delivered through various methods.

CBD may be administered through CBD topicals, such as CBD creams, CBD lotions, CBD balms, and CBD salves. You may feel localized effects within 10 minutes⁽²⁵⁾ of application.

CBD tinctures require sublingual administration under the tongue for one or two minutes before swallowing. 

The waiting period allows the mucus membrane to absorb the cannabinoid. You may experience the effects within 15 to 30 minutes after the application⁽²⁶⁾. 

CBD edibles like CBD gummies, CBD brownies, and CBD candies are CBD products that help conceal the earthy taste of cannabidiol. 

You may experience the biological effects of CBD edibles within 30 minutes to two hours⁽²⁷⁾.  CBD in these products must pass through an individual’s digestive system before the purported therapeutic effects can be experienced.

Meanwhile, CBD vape oil may produce biological effects within two minutes⁽²⁸⁾. However, note that vaping may worsen existing lung conditions⁽²⁹⁾. 

Inhaling vapor or smoke may also cause chemical irritation and allergic reactions⁽³⁰⁾.  

How Long Will CBD Help With Hemophilia?

Researchers have not conducted any studies specifically on the efficacy duration of CBD products for hemophilia. 

However, a 2018 review determined that the half-life of cannabidiol was two to five days after the test subjects took a daily oral dose⁽³¹⁾.  

Half-life refers to the amount of time necessitated for a substance’s amount to reduce to half of its original value⁽³²⁾.

Meanwhile, past human and animal studies suggested that the bioavailability of cannabidiol ranges from 13% to 19%⁽³³⁾. 

Bioavailability denotes the degree and rate at which an active drug ingredient is absorbed and becomes available at the location of drug action⁽³⁴⁾.  

Is CBD Safe for People With Hemophilia?

The World Health Organization (WHO) surmised that CBD has a good safety profile⁽³⁵⁾. In its report, WHO noted research results suggesting that cannabidiol does not cause drug dependence. 

Meanwhile, desmopressin is used to treat hemophilia’s clotting disorders⁽³⁶⁾. The medicine may cause side effects, including increased heart rate, nausea, headaches, blood clots, and seizures. 

Individuals may also take over-the-counter (OTC) medicines to provide pain relief associated with hemophilia⁽³⁷⁾. 

OTC pain relievers such as Advil and Motrin may reduce inflammation and pain. However, these drugs may interfere with blood clotting⁽³⁸⁾. 

To avoid such potential side effects from prescription and OTC medicines, individuals may opt to use CBD as a natural alternative to reduce the symptoms of hemophilia. 

However, drug interactions between CBD and other medications may occur. Individuals interested in trying CBD should consult a hematologist before using CBD oil or other products for hemophilia. 

Risks and Side Effects of Using CBD for Hemophilia

Using cannabidiol products may cause side effects such as dry mouth, fatigue, drowsiness, appetite loss, and diarrhea⁽³⁹⁾.

Using CBD products may also induce problems with the liver’s drug metabolism⁽⁴⁰⁾. 

Before using CBD for hemophilia, ask a doctor for advice on dosing and possible drug interactions.

How to Choose CBD Oil for Hemophilia 

Here are guidelines for selecting the best CBD products for hemophilia.

Types of CBD

CBD oil may come in different types: full-spectrum CBD oil, broad-spectrum CBD oil, and CBD isolates. 

Full-spectrum CBD oil possesses all the naturally occurring compounds in the Cannabis sativa plant, including cannabinoids, flavonoids, terpenes, fatty acids, and essential oils. 

Flavonoids are water-soluble pigments extensively represented in plants. Terpenes are aromatic compounds that characterize plants’ distinct smells. 

A high-quality full-spectrum hemp extract contains higher cannabidiol levels than other cannabinoids. To improve the body’s absorption of CBD, manufacturers combine pure CBD oil with a carrier oil like hempseed oil or medium-chain triglyceride (MCT) oil. 

Delta-9-tetrahydrocannabinol (THC) is among the cannabinoids present in full-spectrum CBD oil. THC is a psychoactive plant-based phytocannabinoid. 

The combination of cannabis plant compounds in full-spectrum CBD oil creates the entourage effect, producing synergy among the natural components.

Broad-spectrum CBD oil also includes all the chemical compounds in hemp. However, it is typically THC-free, making it non-psychoactive. Broad-spectrum CBD allows individuals to avoid the side effects of THC.   

A study hypothesized that cannabinoids in the Cannabis sativa plant, particularly THC and cannabinol (CBN), may produce an anticoagulation effect⁽⁴¹⁾. 

Coagulation denotes the formation of blood clots. An anticoagulant reduces the risk of the formation of blood clots.     

Some individuals may search for a CBD oil that does not interfere with blood clots. Thus, CBD isolates may be a good choice as the pure CBD contains no other cannabinoids that may induce anticoagulation, such as THC⁽⁴²⁾. 

CBD isolates contain pure CBD extracts and typically contain no other cannabinoids present in hemp.

Tips to Select CBD Oil

Here are some guidelines for selecting the best CBD oil:

• Ensure a CBD product is manufactured from organic hemp free of genetically modified organisms (non-GMO). Cannabidiol products derived from organic hemp contain less than 0.3% THC, the federal legal limit. 
• Avoid CBD products manufactured from stalks and seeds of hemp plants. Stalks have a minimum amount of cannabidiol, while hempseeds contain no CBD. 
• Locate the CBD product’s certificate of analysis (COA). The COA contains the third-party lab results to prove a CBD item has undergone independent and comprehensive lab testing. 
• Examine whether the CBD product’s COA specifications, including CBD concentration and potency, match the specifications on the product label 

The COA verifies the CBD products do not have harmful contaminants, such as heavy metals, pesticides, residual solvents, and chemical additives. 

• Seek a medical consultation from a doctor with experience in utilizing CBD products and medical marijuana before purchasing CBD products.

Legality of CBD

While most US states have legalized medical cannabis, the remaining states have legalized cannabidiol extracts⁽⁴³⁾. However, state restrictions may apply, depending on the form of CBD or the amount of THC allowed. 

The 2018 Farm Bill permits the use and distribution of hemp-derived cannabidiol products containing less than 3% of THC⁽⁴⁴⁾.  

In addition, the US Drug Enforcement Administration (DEA) has reduced CBD research requirements for human clinical trials⁽⁴⁵⁾.  

Meanwhile, the FDA recommends that CBD brands include a disclaimer label on CBD products, stating that the item is not a dietary supplement⁽⁴⁶⁾. 

The Farm Bill removed hemp from the federal government’s list of Schedule I drugs⁽⁴⁷⁾. However, the FDA noted that marijuana remains a Schedule I drug. 

Substances listed under the Schedule I category contain addictive or abusive properties without clinically-based medical benefits. 

Before using or traveling with CBD, check applicable state laws regarding CBD use for medical purposes. 

What Is Hemophilia?

The US Centers for Disease Control and Prevention (CDC) defines hemophilia as an inherited blood disorder characterized by abnormal blood clotting⁽⁴⁸⁾. 

Hemophilia can be categorized as mild hemophilia, moderate hemophilia, or severe hemophilia.  

Hemophilia may cause bleeding episodes in the mouth, head, and joints, and nose bleeds. Bleeding can occur externally or internally. 

In addition, those with a family history of hemophilia may be susceptible to developing the condition⁽⁴⁹⁾. Hemophilia is passed down through the X chromosome.

The National Hemophilia Foundation (NHF) reported that two types of hemophilia exist dependent on the blood-clotting protein deficiency⁽⁵⁰⁾. They include Hemophilia A and Hemophilia B.

Hemophilia A results from a defective or missing factor VIII protein⁽⁵¹⁾. Symptoms may include spontaneous bleeding or excessive bleeding.   

Meanwhile, Hemophilia B results from a missing or defective factor IX protein⁽⁵²⁾.

Individuals with Hemophilia A or B may develop antibodies known as inhibitors⁽⁵³⁾. Inhibitors are protective proteins.