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Best CBD Oil for Alzheimer’s

Are you looking for an alternative solution to manage Alzheimer’s disease? Below are some CBD product recommendations you may consider to help you with this condition.

Editor's Pick

Spruce 750mg Lab Grade CBD Oil

Best Organic

NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil

Editor's Pick

Spruce 2400mg Lab Grade CBD Oil

Best Seller

Avida Full Spectrum CBD Oil Tincture 500mg

Best Natural Alternative

cbdMD CBD Oil Tincture Natural 1500mg

Best THC-Free

CBDistillery THC Free CBD Oil Tinctures

Best Customer Rated

cbdMD CBD Oil Tincture Natural 750mg

Best Starter

NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil

Hemp Bombs 750mg CBD Oil

Best Allergy Friendly

Sunsoil CBD Oil Drops, Chocolate Mint Flavor

Rating
4.8 out of 5

5.0 out of 5

5.0 out of 5

4.6 out of 5

4.7 out of 5

4.4 out of 5

4.4 out of 5

4.6 out of 5

3.9 out of 5

3.6 out of 5
Highlights
  1. Peppermint flavor masks any unpleasant taste
  2. Contains 25mg of CBD per dropper full
  3. Bottle includes a graduated dropper for correct serving measurement
  1. Natural remedy for various illnesses
  2. Product is full-spectrum whole-plant extract
  3. Contains naturally occurring synergistic cannabinoids and terpenes
  1. Maximum possible potency
  2. Each dropper full contains 80mg of CBD
  3. Conveniently fits in a 30mL bottle
  1. Proprietary full-spectrum
  2. Developed using advanced AVIDA CORE Spectrum Technology
  3. Highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3)
  1. made using only CBD sourced from medical hemp
  2. available in many flavours
  3. safe for daily use
  1. Do not contain THC
  2. Available in different potencies and sizes
  3. Brand has special deals and offers
  1. THC-free
  2. Has plenty of flavours to choose from
  3. Totally vegan
  1. Lowest concentration for CBD beginners
  2. Fully organic and lab-tested
  3. Full-spectrum
  1. Has a wide range of flavours
  2. Safe to intake
  3. Get 20% off when you avail of their subscription
  1. Tastes great
  2. Uses hemp grown organically
  3. Laboratory tests done by a third party

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Compare the best CBD Oil for Alzheimer’s in 2021

Product Potency Purity Customer Service Type Extraction Transparency Absorption
Spruce 2400mg Lab Grade CBD Oil
4.8 out of 5

4.5 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5
NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.0 out of 5

5.0 out of 5

5.0 out of 5
Spruce 2400mg Lab Grade CBD Oil
5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.0 out of 5

5.0 out of 5

5.0 out of 5
Avida Full Spectrum CBD Oil Tincture 500mg
4.6 out of 5

5.0 out of 5

3.5 out of 5

3.0 out of 5

5.0 out of 5

4.5 out of 5

4.5 out of 5

5.0 out of 5
cbdMD CBD Oil Tincture Natural 1500mg
4.7 out of 5

5.0 out of 5

3.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5
CBDistillery THC Free CBD Oil Tinctures
4.4 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.5 out of 5
cbdMD CBD Oil Tincture Natural 750mg
4.4 out of 5

4.5 out of 5

3.5 out of 5

5.0 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5
NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
4.6 out of 5

2.5 out of 5

5.0 out of 5

5.0 out of 5

5.0 out of 5

4.5 out of 5

5.0 out of 5

5.0 out of 5
Hemp Bombs 750mg CBD Oil
3.9 out of 5

4.5 out of 5

3.5 out of 5

2.5 out of 5

3.5 out of 5

4.5 out of 5

5.0 out of 5

4.0 out of 5
Sunsoil CBD Oil Drops, Chocolate Mint Flavor
3.6 out of 5

2.5 out of 5

3.5 out of 5

5.0 out of 5

5.0 out of 5

4.0 out of 5

3.5 out of 5

5.0 out of 5

Best CBD Oil for Alzheimer’s

1. Spruce 750mg Lab Grade CBD Oil
cbdc overall score
4.8
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Mid-strength  No other flavors
 Natural peppermint flavor
 Made from 100% organic and natural ingredients
Pro's
 Mid-strength
 Natural peppermint flavor
 Made from 100% organic and natural ingredients
Con's
 No other flavors
Overview

Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
cbdc overall score
5.0
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Pure CBD hemp  No other flavors
 All natural
 Approximately 300 drops total
Pro's
 Pure CBD hemp
 All natural
 Approximately 300 drops total
Con's
 No other flavors
Overview

Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

3. Spruce 2400mg Lab Grade CBD Oil
cbdc overall score
5.0
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Extra Strength  Tastes bitter
 No artificial flavoring or colors  No THC-free option
 Made from 100% organic and natural ingredients
Pro's
 Extra Strength
 No artificial flavoring or colors
 Made from 100% organic and natural ingredients
Con's
 Tastes bitter
 No THC-free option
Overview

The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.

4. Avida Full Spectrum CBD Oil Tincture 500mg
cbdc overall score
4.6
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Light Spearmint flavor  No other flavor
 Non-THC, Non-detected in drug test
Pro's
 Light Spearmint flavor
 Non-THC, Non-detected in drug test
Con's
 No other flavor
Overview

Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.

5. cbdMD CBD Oil Tincture Natural 1500mg
cbdc overall score
4.7
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Various delicious flavors to choose from  cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
 Has vegan, organic, and gluten-free ingredients
 Free shipping for this particular product within USA
 World-class customer service team
Pro's
 Various delicious flavors to choose from
 Has vegan, organic, and gluten-free ingredients
 Free shipping for this particular product within USA
 World-class customer service team
Con's
 cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
Overview

cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

6. CBDistillery THC Free CBD Oil Tinctures
cbdc overall score
4.4
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 60-Day Satisfaction Guarantee  Dropper is a bit shaky
 Various strengths
 Oil extracted from aerial plant parts of US grown industrial hemp
 Sourced from non-GMO industrial hemp grown in the USA through natural farming practices
Pro's
 60-Day Satisfaction Guarantee
 Various strengths
 Oil extracted from aerial plant parts of US grown industrial hemp
 Sourced from non-GMO industrial hemp grown in the USA through natural farming practices
Con's
 Dropper is a bit shaky
Overview

CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.

7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
cbdc overall score
4.6
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Pure CBD hemp  No other flavors
 All natural  A bit pricey compared to competitors
 Approximately 100 drops total
Pro's
 Pure CBD hemp
 All natural
 Approximately 100 drops total
Con's
 No other flavors
 A bit pricey compared to competitors
Overview

This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.

8. cbdMD CBD Oil Tincture Natural 750mg
cbdc overall score
4.4
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Vegan and Gluten free  Does not ship internationally
 Has a third-party lab test
 Wide variety of CBD strengths and sizes
Pro's
 Vegan and Gluten free
 Has a third-party lab test
 Wide variety of CBD strengths and sizes
Con's
 Does not ship internationally
Overview

A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.

9. Hemp Bombs 750mg CBD Oil
cbdc overall score
3.9
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Wide variety of flavors  Incomplete information about the product
 Lab test results are complete  Does not ship to all international countries
 30-day money-back guarantee
Pro's
 Wide variety of flavors
 Lab test results are complete
 30-day money-back guarantee
Con's
 Incomplete information about the product
 Does not ship to all international countries
Overview

Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.

10. Sunsoil CBD Oil Drops, Chocolate Mint Flavor
cbdc overall score
3.6
CBDC Evaluation Table/Score
Potency
Purity
Customer Service
Type
Extraction
Absorption
Transparency
Pro's Con's
 Sunsoil CBD is committed to providing high-quality products at an affordable cost.  Product selection is limited.
 The company tests its products thrice before making them available to the public.  The company uses lipid extraction methods.
 From cultivation to packaging, everything is done in Sunsoil CBD grounds.
 Organic and sustainable farming is at the company’s core.
Pro's
 Sunsoil CBD is committed to providing high-quality products at an affordable cost.
 The company tests its products thrice before making them available to the public.
 From cultivation to packaging, everything is done in Sunsoil CBD grounds.
 Organic and sustainable farming is at the company’s core.
Con's
 Product selection is limited.
 The company uses lipid extraction methods.
Overview

The flavor profile is refreshingly sweet, and it balances well with the higher CBD concentration. Promotes the absorption of CBD into your blood circulation.

How CBD Helps with Alzheimer’s Disease

The suggested neuroprotective, anti-inflammatory, and antioxidant properties of cannabidiol (CBD), the non-psychoactive hemp derivative, have been explored and studied for their prospective benefits for Alzheimer’s disease(1).

Alzheimer’s disease (AD) is the most common form of dementia that involves progressive and irreversible damage in memory and cognitive skills(2)

The degenerative cause of Alzheimer’s disease is believed to start in the hippocampus region of the brain that is responsible for memory(3)

Some of the characteristics of the brain of a patient with Alzheimer’s disease include the following(4):

  • Presence of beta-amyloid protein build-up (amyloid plaques)
  • Abnormal accumulation of tau protein (neurofibrillary tangles)
  • Chronic inflammation
  • Hardening of the arteries (atherosclerosis)
  • Beta-amyloid accumulation in the brain arteries

This disease disrupts neurons, resulting in apoptosis (cell death) and loss of neuron function(5)

According to a clinical and scientific review of Alzheimer’s, the disease usually occurs in females over 65(6). The symptoms of Alzheimer’s comes in three stages: the early stage, middle stage, and late-stage(7)

People with Alzheimer’s may exhibit the following symptoms depending on the severity of the disease(8):

  • Memory loss 
  • Mood and personality changes 
  • Increased anxiety or aggression
  • Inability to learn new things
  • Problem recognizing family and friends
  • Hallucinations, paranoia, and delusions
  • Inability to communicate
  • Seizures
  • Increase sleeping
  • Loss of bladder and bowel control

It was reported in a study that endocannabinoids, particularly CBD, may play a vital role in the management of Alzheimer’s disease by offsetting the hyperactivity of amyloid-induced tau protein’s inflammatory and neurochemical consequences(9)

These amyloid-induced tau proteins may accumulate or form an abnormal aggregate that is said to cause Alzheimer’s(10). Endocannabinoids are naturally occurring compounds that may be found in Cannabis sativa.

Another research on the potential functionality and role of the endocannabinoid system (ECS) in the treatment of Alzheimer’s disease reported that cannabinoids showed immunosuppressive effects and neuroprotective, anti-inflammatory, and antioxidant properties(11).

The ECS is responsible for the different inflammatory and immune activities and other central nervous system functions(12)

This neuromodulatory system has two primary receptors: the CB1 receptor, which regulates memory, motor control, and mood, and the CB2 receptor that is accountable for immunomodulatory functions(13)

The psychological deficiencies of Alzheimer’s patients may be linked to the cerebral disturbances in the hippocampus and frontal cortex part of the brain that are known to be abundant in CB1 receptors(14).

It was also noted that CB2 receptors in patients with Alzheimer’s were correlated with beta-amyloid plaques and levels(15)

This receptor demonstrated the potential to assist in beta-amyloid processing and may prevent neuroinflammation in people with Alzheimer’s disease(16).

Tetrahydrocannabinol (THC), the compound found in cannabis that has psychoactive effects, is shown to have a high affinity with the CB1 receptor(17).

Although CBD alone binds weakly with CB1 and CB2 receptors, it was reported in a study that CBD is said to have the capability to antagonize these receptors in the presence of THC(18)

A study also noted the neurogenesis and neuroinflammatory influences of the ECS on Alzheimer’s disease(19).

It was reported that CBD has the potential to promote neurogenesis and lessen the production of the compressed fibrous neuroglia network (gliosis)(20).

However, these promising benefits of cannabinoids in the pharmacology of Alzheimer’s disease requires further clinical trials.

Benefits of Using CBD Oil for Alzheimer’s Disease

CBD is known to have beneficial effects in psychiatric diseases, like depression, anxiety, and psychosis(21)

A murine model of cerebral malaria showed that adjunct therapy using CBD improved the test subjects’ behavioral and cognitive functions(22).

Several studies reported CBD’s possible neuroprotective, anti-inflammatory, and antioxidant properties(23). The research discussed how CBD may help in the supplemental remedy of people who suffer from neurological disorders. 

In in vitro (test tube experiment done in the laboratory) models of Alzheimer’s disease, researchers examined CBD’s protective role in synaptic plasticity. This ability is defined as the changes in synapses (junctions between neurons), enabling neurons to communicate

It was noted that CBD had protective properties against beta-amyloid peptide’s neurotoxic effects, resulting in neurodegeneration(24).

Neuroprotectant Properties

A study suggested that several cannabinoids showed possible neuroprotective effects by acting on the CB1 and CB2 receptors of the ECS(25).

The neuroprotective properties of CBD were further investigated in a study showing how the treatment of cells with CBD greatly enhanced cell survival. The paper showed that CBD averted beta-amyloid-induced neurotoxicity.

Neuroprotective means the ability to protect brain cells and nerves from impairment and possible death(26).

An animal study showed that CBD demonstrated neuroprotective activities in hypoxia-ischemia (HI)-induced (temporary occlusion of hypoxia and carotid arteries) newborn piglets(27).

It was noted in the study that CBD had exhibited little to no adverse effects when administered.  

Anti-inflammatory properties

Preclinical research on neurodegenerative disorders focused on the neuroprotective properties of CBD along with its antioxidant and anti-inflammatory effects(28).

The researchers observed that CBD had anti-inflammatory properties beneficial for neuroinflammatory diseases, like multiple sclerosis(29).

CBD’s anti-inflammatory effects were also associated with microglial cell migration, including the production of pro-inflammatory mediators targeting CB2 receptors(30).

Antioxidant Properties

Individuals with Alzheimer’s disease exhibited high oxidative stress and damage connected with amyloid plaques and neurofibrillary tangles(31)

A study mentioned that the antioxidant and anti-inflammatory properties of CBD had the potential to protect against oxidative stress and its resulting protein and lipid modification(32).

Another study suggested that the combined use of CBD and THC demonstrated neuroprotective effects in animal models of Parkinson’s disease because of their antioxidant properties(33).

CBD and Neurological Disorders

Alzheimer’s disease is said to comprise 60 to 70% of dementia cases(34).

This condition is followed by other types of dementia, like vascular dementia (caused by impaired blood flow in the brain), Lewy bodies dementia (abnormal protein development in nerve cells), and frontotemporal dementia (deterioration of the brain’s frontal lobe).

The symptoms of dementia are similar to the symptoms of Alzheimer’s. Dementia also starts with memory loss or forgetfulness, behavior changes, and increasing difficulty in communication and walking(35).

According to a study, conventional medications for treating Alzheimer’s disease offer limited therapeutic effects and are associated with adverse effects(36)

Animal studies noted CBD’s effectiveness in treating acute seizures in mice and rat models(37). Seizures are one of the prominent symptoms of Alzheimer’s.

Findings may support CBD’s promise as a potential alternative in helping patients manage Alzheimer’s disease symptoms. However, these studies are limited and inconclusive. 

Other studies examined CBD’s beneficial effects on other neurological diseases. These conditions include Parkinson’s disease, a brain disorder that results in balance and coordination difficulties, stiffness, and shaking, and Huntington’s disease, a progressive brain impairment that causes changes in the central nervous area. 

 Similar to Alzheimer’s, both of these diseases cause memory loss and cognitive disabilities. 

Eight patients with Parkinson’s disease were administered CBD as a supplement to their usual therapy. Results showed that the rating scale in the psychosis questionnaire has significantly decreased(38).

However, a controlled clinical trial of CBD for Huntington’s disease suggested that the administration of 700mg of CBD a day for six weeks did not show any beneficial or adverse effects to patients with the disease(39).

How Soon Can CBD Oil be felt?

CBD oil, which is extracted from hemp, may be in the form of a tincture, vape pen cartridges, topicals, edibles, and patches(40)

It is common practice to take CBD oil tinctures sublingually(41). However, they may also be infused in edibles, like capsules and gummies, or applied topically.

Different forms of CBD oil also have various onset times. These types of CBD may be categorized by delivery systems or according to the routes in which they are taken(42).

CBD administration routes include inhalation, sublingual absorption, ingestion, and transdermal and topical application(43)

Sublingual Absorption

Sublingual delivery is when the CBD oil is dispensed under the tongue through a dropper and held for at least 90 seconds for the mouth’s mucous membrane to absorb the product(44)

Through this method, CBD avoids passing through the stomach and liver and is diffused in the capillaries, eventually penetrating the bloodstream. 

Taken sublingually, CBD’s bioavailability or absorption rate is at 6% to 20%. These figures are higher than the bioavailability of ingested CBD products(45).

Moreover, CBD sublingual absorption has a 15 to 30-minute onset time. Its effects may last from 4 to 6 hours. 

Ingestion

Ingestion of CBD is the most common method of administering CBD oil(46). This approach is also known as the “first-pass effect.”

In this route of delivery, CBD passes through the liver before being absorbed into the bloodstream. 

Onset time ranges from 30 to 90 minutes, depending on your body’s metabolism. This period is relatively long compared to the onset time of other routes of administration(47). However, the duration of the effects of CBD ingestion lasts the longest: 6 to 8 hours at most.  

Edibles, including capsules, gummies, drinks, candies, and others, are the standard CBD products that may be administered through ingestion.

Inhalation

The delivery method that has the fastest onset time is the inhalation method through vaping and smoking(48).

Inhalation has an onset time of 2 to 15 minutes before the user experiences CBD’s effects. This method allows CBD to be absorbed through the lungs and into the bloodstream. 

Vaping or smoking has an absorption rate of 17% to 44%, and its effects may last for 2 to 4 hours(49). However, according to the National Institute on Drug Abuse, some case studies reported that smoking marijuana may increase susceptibility to lung infections(50).

Transdermal Absorption

CBD gels and patches use the transdermal absorption route. This method allows CBD to penetrate the dermis of the skin and go into the bloodstream(51)

Transdermal CBD products have an onset time of 15 to 30 minutes and may last for 4 hours for gels and 8 hours for transdermal patches. Transdermal patches are CBD-infused adhesive products that are normally applied to the wrist or ankle(52).

Topical Absorption

Topical CBD products may be applied directly to the skin for more targeted relief(53). These topicals are generally used to reduce skin inflammation, itchiness, or muscle pain.

This method does not pass through the bloodstream. Instead, it allows CBD to interact with the CB2 receptors of the skin(54)

A 10 to 15 minutes onset time is expected when using CBD topicals. Its effects may last from 2 to 4 hours. 

Risks of Using CBD for Alzheimer’s

A review on the safety and side effects of CBD reported that CBD generally has a safe and better side effect profile compared to other drugs(55).However, treating Alzheimer’s with CBD needs to be handled with caution to avoid adverse effects and further damage to the quality of life of the patient.

Aside from CBD’s benefits, there are also known side effects that need to be considered before administering CBD to individuals with Alzheimer’s

Some of the common adverse effects of CBD include(56):

  • Dry mouth
  • Drowsiness
  • Fatigue
  • Diarrhea
  • Changes in appetite
  • Changes in weight
  • Nausea

Other risks of CBD include its possible drug-to-drug interactions. CBD may reduce or increase another drug’s effect(57).

CBD may induce sleepiness and drowsiness(58). Medications with similar effects should be taken with caution.

CBD and Its Legality

Industrial hemp is the derivative of Cannabis sativa with a low amount of THC and more abundant quantities of CBD. Under the 2018 Farm Bill, it is federally legal to manufacture CBD-rich hemp products in the United States(59).

However, the US Food and Drug Administration (US FDA) approved one CBD-infused drug for the treatment of childhood epilepsy only: Epidiolex. The medication aims to help treat rare forms of epilepsy, like Lennox-Gastaut syndrome and Dravet syndrome(60).

CBD Dosage

There is no universally accepted and approved CBD dosage for wellness or possible treatment of a condition. You should consult a doctor to avoid overdose or unwanted drug-to-drug adverse effects.

For firsttime users, it is advisable to start low and go slow when it comes to CBD. Starting with a low dosage of CBD may allow users to adjust their dose more efficiently and carefully.

Things to Consider When Buying CBD Products for Alzheimer’s

Although CBD has promising benefits in managing Alzheimer’s disease symptoms, you must evaluate the following before picking the best CBD oil product for this disorder.

  • Type of CBD Extract

CBD and THC are found in the Cannabis plant. Their significant difference lies in their ability to induce euphoria. 

CBD is the non-addictive and non-psychoactive cannabinoid normally found in hemp or cannabis strains that contain 0.3% THC. Contrastingly, THC is the psychoactive component of marijuana that has the ability to produce a high in users(61).

CBD products are categorized into three types based on the content of the extract. Broad-spectrum CBD and CBD isolates do not have any traces of THC. 

Moreover, broad-spectrum CBD has some cannabinoids present in the hemp plant (except THC), while CBD isolates have pure CBD only(62).

Meanwhile, the whole-plant extract or full-spectrum CBD contains all the phytocannabinoids found in the hemp plant, including traces of THC, terpene profiles, and flavonoids. These phytocompounds and cannabinoids are believed to produce a synergistic effect known as the entourage effect(63).

  • Source of Hemp 

Knowing the source of hemp oil or CBD extract used in a product, the quality of hemp, farming methods used, and the company’s protocols and regulations help when picking the right CBD product.

Most CBD brands claim that they use organic, US-grown hemp. Oregon, Colorado, North Carolina, and Kentucky are a few states that are part of the hemp pilot program(64)

These states follow the US Department of Agriculture’s (USDA) procedures in researching and cultivating industrial hemp(65).

  • Certificate of Analysis

It is a prudent choice to examine the certification of analysis (COA) of each CBD product before deciding to buy it. 

The COA shows the information on the CBD concentration and potency of the product and the laboratory results for microbials, chemicals, solvents, and pesticides. 

Laboratory tests may be conducted by the brand (an in-house lab test) or by a third-party laboratory.

  • Amount of CBD Concentration and Potency

The CBD concentration and potency indicated in the COA features the amount of CBD per container and the amount of CBD per serving. These details may be useful when deciding on the dosing and administration of CBD products.

  • Extraction Method

The CBD extraction method is the process in which the hemp extract is obtained. It determines the purity and quality of the CBD extract.

Ethanol and CO2  extraction methods are the most commonly used approaches in obtaining CBD extracts(66).

  • Ingredients

It is best to check the CBD product’s ingredients to be aware of the possible allergic reactions you may have to its components. This practice also avoids the occurrence of adverse effects upon CBD intake.

CBD products often contain carrier oils that may contribute to the beneficial effects of CBD. Two of the most common carrier oils are medium-chain triglyceride (MCT) coconut oil and hempseed oil. 

Hempseed oil is known for being a source of healthy digestible proteins and dietary nutrients(67). Moreover, MCT oil is commonly derived from coconuts and has omega-3 suitable for cardiovascular diseases(68).

Product Frequently
Asked Questions


  1. Watt, G., and Karl, T., (February 2017), In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer’s Disease, Behavioural Neuroscience, Western Sydney University, retrieved from https://www.frontiersin.org/articles/10.3389/fphar.2017.00020/full
  2. NIH National Institute on Aging, (n.d.), What Is Alzheimer’s Disease?, retrieved from https://www.nia.nih.gov/health/what-alzheimers-disease#:~:text=Alzheimer’s%20disease%20is%20an%20irreversible,appear%20in%20their%20mid%2D60s
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