• Individuals who need more focus and attention during the daytime may consider taking cannabidiol (CBD) in the morning. CBD may help enhance dopamine levels(1). Dopamine may influence attention, memory, motivation, and mood(2).
  • CBD may help manage anxiety-induced rapid eye movement (REM) sleep and generate an antianxiety effect(3). Thus, individuals with sleeping problems due to anxiety may take CBD in the evening.
  • There is no definitive scientific evidence that taking CBD in the morning has better benefits than taking the compound in the evening and vice versa.
  • Individuals should ask a doctor well versed in cannabis use to determine the appropriate time to take CBD.

Should an Individual Take CBD Oil in the Morning or Night?

Researchers have not conducted definitive studies on the appropriate time of the day to take cannabidiol (CBD). Thus, there is no conclusive scientific proof that taking CBD in the morning has a better effect than taking CBD at night and vice versa.

However, individuals may consider their needs and preferences when deciding the time they need to take CBD oil.

In a 2021 study published in the Journal of Cannabis Research, researchers surveyed 387 individuals on their reasons for using CBD(4). 

Results showed that 70 individuals (18.1%) used CBD in the morning, 99 (25.6%) in the evening, and 92 (23.8%) in the morning and evening.

Meanwhile, 78 (20.2%) respondents mentioned taking CBD when needed.

The same study also showed that individuals taking CBD to help improve sleep were likely to use the product in the evening rather than in the morning(5). Meanwhile, individuals using the compound for self-perceived anxiety were less likely to take the drug in the evening.

Benefits of Taking CBD in the Morning

Individuals who need to improve their focus may consider taking CBD during the daytime. One study suggested that CBD may help activate neurons to enhance dopamine levels(6).

Dopamine is a neurotransmitter that plays a role in movement, learning, and eating(7). Dopamine also influences memory, mood, attention, and motivation(8).

Stress is another factor individuals may consider when taking CBD in the morning. Stress management involves planning ahead of time, deciding the order of tasks, and preparing for possible stressful occasions(9).

One survey showed that stress is among the top reasons individuals take CBD, according to 37% of the 387 respondents(10).

Stress may also be associated with anxiety, such as post-traumatic stress disorder (PTSD) or stress-induced anxiety. 

One scientific review suggested that CBD may have a considerable potential to help with multiple anxiety disorders(11).

Another health benefit that CBD users claim is the compound’s potential to help with exercise and sports.

CBD is purported to have anti-inflammatory, antianxiety, neuroprotective, and analgesic (pain-relieving) properties, which may help recover and manage pain and soreness during sports training or competition(12).

Benefits of Taking CBD in the Evening

Individuals with PTSD may experience sleep cycle disturbances, such as rapid eye movement (REM) sleep abnormality and insomnia(13).

REM sleep is a stage of sleep distinguished by intense dreams and increased brain activity, similar to when one is awake. Thus, sleep at this stage is not considered deep sleep(14).

Insomnia is a sleep disorder wherein an individual has difficulty falling or staying asleep or feels tired after waking up(15).

One study on CBD’s effects on rat subjects showed that the compound may generate an antianxiety effect and manage anxiety-induced REM sleep(16).

Although this study is conducted on animals, researchers may use it as a reference for human studies on CBD’s potential calming effects that may benefit sleep.

How About Taking CBD During Lunch?

No conclusive studies show how CBD may be effective when taken during lunchtime.

However, food may affect CBD’s onset times. In particular, individuals taking oral CBD products may start feeling the effects in about one hour when ingested with an empty stomach or up to three hours when taken with food(17).

Thus, taking CBD while consuming food during lunch may affect how long the compound starts taking effect.

Factors That Determine the Best Time to Take CBD

One of the factors that may influence an individual’s decision when to take CBD is their needs or goals for taking the product.

For example, individuals who need improved focus and memory before going to work during the day may choose to take CBD in the morning.

Meanwhile, CBD users who want to improve their sleep quality may consider taking CBD before going to bed at night.

Individuals who prefer taking CBD oil for their general wellness and health may take the product in the morning or evening.

Still, users should consult a doctor well versed in cannabis use to determine the ideal time to take CBD.

When Should an Individual Take CBD Oil for Insomnia?

Individuals who believe CBD oil may help with insomnia may consider taking the product in the evening before sleeping.

Most adults need around seven to eight hours of sleep every night. However, insomnia may cause an individual to experience insufficient sleep duration or sleepless nights(18).

When Should an Individual Take CBD Oil for Anxiety?

Individuals worrying about anxiety possibly affecting their daytime work and social life may consider taking CBD oil in the morning.

On the other hand, individuals with sleeping difficulties due to anxiety may choose to take CBD in the evening.

Common anxiety symptoms include the following(19):

  • Nervousness or restlessness
  • Sleeping difficulties
  • Increased heart rate
  • Hyperventilation or rapid breathing
  • Trembling
  • Sweating
  • Weakness or tiredness

Anxiety can also cause an individual to worry too much, which may start affecting work or relationships. Work-related stress or financial difficulties can also lead to stress buildup and trigger excessive anxiety(20).

When Should an Individual Take CBD Oil for Pain?

Individuals who feel that pain may disrupt their daytime activities such as work, school, or other social activities may consider taking CBD oil in the morning.

On the other hand, individuals who seek pain relief before going to bed to minimize or prevent sleep disruptions may decide to take CBD at night.

Despite CBD brands and customers claiming that CBD helps manage pain, further studies are needed to substantiate such claims.

However, a 2020 review published in Frontiers in Pharmacology suggested that CBD may have beneficial effects on chronic pain(21). 

Other research shows that CBD may inhibit neuropathic and inflammatory pain(22).

When to Take CBD Oil and Other Products

CBD may inhibit the cytochrome P450 enzymes in the liver, preventing these enzymes from metabolizing or processing certain pharmaceutical drugs(23). This interaction suggests that some medications may have an adverse effect when taken with CBD.

Thus, before taking CBD with other drugs or substances, consult a doctor knowledgeable about cannabis-based products to know about potential drug interactions.

Why Taking CBD Consistently Is Important

Scientists have not conducted conclusive studies on whether consistently taking CBD is beneficial or practical for an individual.

However, some consumers and CBD brands claim that consistent intake of the compound may lead to desired results.

CBD works by interacting with the body’s endocannabinoid system (ECS)(24). The ECS is a regulatory system that controls pain, immune and inflammatory responses, memory, temperature, eating, and sleep(25).

The ECS also maintains homeostasis or a stable internal environment in the body(26). Part of the biological system that contributes to the stability of the body chemistry is the CB1 and CB2 cannabinoid receptors.

CB1 receptors are located in the spinal cord and brain, which may affect memory, emotion, appetite, and pain. Meanwhile, CB2 receptors primarily located in the immune cells, liver, and spleen may help manage inflammation(27).

This interaction suggests that consistently taking CBD may benefit the body’s functions regulated by the ECS. However, additional studies are needed to substantiate this claim.

How Often Should an Individual Take CBD Oil?

There are no set guidelines on how often an individual should take CBD oil. 

The World Health Organization (WHO) noted that CBD has a good safety profile and may be well tolerated among humans(28). The agency also mentioned that the compound does not produce effects indicative of abuse potential.

However, CBD may generally cause fatigue, dry mouth, appetite reduction, and drowsiness(29). Other side effects of CBD include changes in appetite or body weight, tiredness, and diarrhea(30).

How Much CBD Oil Should an Individual Take?

The Food and Drug Administration (FDA) has not provided a standard CBD dosage guide specifically for daytime or nighttime use.

However, one dosing strategy is to start with a low CBD dose and gradually increase the dosage(31).

For example, first-time users may take the drug with an initial serving size of 10 milligrams (mg) of CBD per day(32).

One study mentioned that humans may tolerate high CBD doses of up to 1,500mg per day(33).

Moreover, CBD users may have different dosage needs depending on factors such as diet, exercise, present health conditions, genetics, and stress levels(34).

Some doctors well versed in cannabis may provide recommendations on the usage and daily doses of CBD. Individuals considering taking the product should consult these doctors before deciding on the best CBD dose for the individual’s needs.

To know more about a CBD product’s actual cannabinoid content, individuals should check the product’s certificate of analysis (COA), which are usually accessible publicly on a CBD brand’s website or online store.

COAs come from third-party labs, which test and analyze the product to determine its actual contents, including the amount of CBD and tetrahydrocannabinol (THC) concentrations.

THC, also derived from the cannabis plant, is a cannabinoid known to possess psychoactive effects that may cause an individual to feel “high”(35).

Users may review the COA and compare it to the product label to ensure consistency and safety.

Factors That Affect CBD Absorption

Regardless of the individual’s choice of time to take CBD, they may administer the compound through various administration routes, affecting how CBD is absorbed in the body. These methods include the following:

  • Sublingual administration: Sublingual delivery involves applying CBD oil under the tongue, where the blood vessels absorb the compound. In this method, CBD enters the bloodstream directly and bypasses the digestive tract.

One form of CBD product given sublingually is a tincture. Individuals typically administer this product using a calibrated dropper for accurate dosing.

Other sublingual products include lozenges and oromucosal sprays.

CBD tinctures may have a natural, earthy flavor, which may not appeal to some consumers. One technique to manage this taste is to mix these products with food or drinks(36).

  • Ingestion: Through ingestion, CBD passes through the body’s digestive system before being absorbed into the bloodstream.

Oral CBD products include CBD capsules or edibles such as CBD gummies, candies, and chews.

Oral drug administration is considered a cost-effective and convenient delivery method. One study showed that ingestion may help with infections, inflammations, colorectal and stomach cancers, and bowel diseases(37).

  • Topical application: Applying CBD topically or to the skin may help reduce inflammation, itching, or sunburns in a specific area. CBD topicals have zero bioavailability, meaning the compound does not enter the bloodstream(38).

CBD topicals include creams, salves, lotions, balms, and ointments.

  • Inhalation: Inhaling CBD oil is done by vaporization using CBD vape pens. When a user inhales the compound, it passes through the lungs and brain before spreading throughout the body(39).

Inhalation may have a short onset period, making this method a quick way to administer CBD and find the desired dose. Inhalation may also be suitable for short-term conditions like acute pain or nausea(40).

However, vaping may be associated with lung disease, and thus, individuals must exercise caution when using vapes(41).

Different delivery routes may influence CBD onset time or the optimal time the drug takes to get absorbed into the system before becoming effective. These methods include the following(42):

  • Sublingual administration: 15 to 30 minutes
  • Ingestion: 30 to 90 minutes
  • Topical application: 15 to 30 minutes
  • Inhalation: 2 to 15 minutes

Additionally, there are limited human studies focused on how long CBD’s effects will last after the drug is absorbed into the body. However, estimates of CBD’s duration of effects include the following(43):

  • Sublingual administration: two to four hours
  • Ingestion: six to eight hours
  • Topical application: two to four hours
  • Inhalation: two to four hours

Researchers conducted a study on CBD’s pharmacokinetics in humans and reported that oral CBD products containing 10mg and 20mg of CBD may have half-lives of 1.09 and 1.97 hours, respectively(44).

The study also showed that 10mg CBD capsules may have a half-life between 2.95 and 3.21 hours.

Half-life is the time needed for the drug’s concentration or quantity within the body to decrease by half (50%).

Another factor to consider is the type of CBD product, such as full-spectrum, broad-spectrum, or isolate.

  • Full-spectrum CBD oil: This CBD form typically contains most of the cannabinoids and compounds in the cannabis plant. These compounds include THC, flavonoids, and terpenes(45).

Terpenes are plant compounds often used as essential oil components and give the cannabis plant its distinct aroma(46). On the other hand, flavonoids are plant chemicals that may have antioxidant and antimicrobial benefits(47).

Combining these compounds in full-spectrum CBD oil may produce an “entourage effect.” This phenomenon occurs when the active cannabis compounds and cannabinoids work synergistically to improve their benefits than if they only functioned independently(48).

  • Broad-spectrum CBD oil: This product type is similar to full-spectrum CBD oil. However, broad-spectrum CBD oil is THC-free.
  • CBD isolate: This form is derived from pure CBD only and contains no other cannabinoids and compounds.

Individuals interested in experiencing the “entourage effect” may consider purchasing full-spectrum CBD oil products. Meanwhile, individuals who prefer products without THC or its psychoactive effects may opt for broad-spectrum CBD oil or CBD isolates.

  1. Potential Effects of Cannabidiol as a Wake-Promoting Agent
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023456/
  2. Dopamine
    https://my.clevelandclinic.org/health/articles/22581-dopamine
  3. Effect of Cannabidiol on Sleep Disruption Induced by the Repeated Combination Tests Consisting of Open Field and Elevated Plus-Maze in Rats
    https://pubmed.ncbi.nlm.nih.gov/21867717/
  4. Reasons for Cannabidiol Use: A Cross-Sectional Study of CBD Users, Focusing on Self-Perceived Stress, Anxiety, and Sleep Problems
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893882/
  5. Ibid.
  6. Potential Effects of Cannabidiol as a Wake-Promoting Agent
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023456/
  7. Explainer: What Is Dopamine?
    https://www.sciencenewsforstudents.org/article/explainer-what-dopamine
  8. Dopamine
    https://my.clevelandclinic.org/health/articles/22581-dopamine
  9. Manage Stress
    https://health.gov/myhealthfinder/topics/health-conditions/heart-health/manage-stress
  10. Reasons for Cannabidiol Use: A Cross-Sectional Study of CBD Users, Focusing on Self-Perceived Stress, Anxiety, and Sleep Problems
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893882/
  11. Cannabidiol as a Potential Treatment for Anxiety Disorders
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604171/
  12. Potential Role of Cannabidiol on Sports Recovery: A Narrative Review
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369499/
  13. Effect of Cannabidiol on Sleep Disruption Induced by the Repeated Combination Tests Consisting of Open Field and Elevated Plus-Maze in Rats
    https://pubmed.ncbi.nlm.nih.gov/21867717/
  14. Sleep Basics
    https://my.clevelandclinic.org/health/articles/12148-sleep-basics
  15. Insomnia: Symptoms & Causes
    https://www.mayoclinic.org/diseases-conditions/insomnia/symptoms-causes/syc-20355167
  16. Effect of Cannabidiol on Sleep Disruption Induced by the Repeated Combination Tests Consisting of Open Field and Elevated Plus-Maze in Rats
    https://pubmed.ncbi.nlm.nih.gov/21867717/
  17. Best Way to Take CBD
    https://www.projectcbd.org/guidance/best-way-take-cbd
  18. Insomnia: Symptoms & Causes
    https://www.mayoclinic.org/diseases-conditions/insomnia/symptoms-causes/syc-20355167
  19. Anxiety Disorders: Symptoms & Causes
    https://www.mayoclinic.org/diseases-conditions/anxiety/symptoms-causes/syc-20350961
  20. Ibid.
  21. A Balanced Approach for Cannabidiol Use in Chronic Pain
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204604/
  22. Cannabidiol (CBD)-What We Know and What We Don’t
    https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476
  23. Page 114-115 of Healing With CBD
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  24. Cannabidiol Primer for Healthcare Professionals
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340472/
  25. The Endocannabinoid System: Essential and Mysterious
    https://www.health.harvard.edu/blog/the-endocannabinoid-system-essential-and-mysterious-202108112569
  26. Page 58 of Healing With CBD
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  27. Cannabidiol Primer for Healthcare Professionals
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340472/
  28. WHO Expert Committee on Drug Dependence
    https://apps.who.int/iris/bitstream/handle/10665/279948/9789241210225-eng.pdf
  29. What Are the Benefits of CBD — And Is It Safe to Use?
    https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/is-cbd-safe-and-effective/faq-20446700
  30. Dosage, Efficacy and Safety of Cannabidiol Administration in Adults: A Systematic Review of Human Trials
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092763/
  31. CBD Dosing
    https://www.projectcbd.org/guidance/cbd-dosing
  32. Page 218 of Healing With CBD
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  33. Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent
    https://pubmed.ncbi.nlm.nih.gov/22129319/
  34. CBD dosing
    https://www.projectcbd.org/guidance/cbd-dosing
  35. Tetrahydrocannabinol
    https://www.sciencedirect.com/topics/neuroscience/tetrahydrocannabinol
  36. Page 208 of Healing With CBD
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  37. Advances in Oral Drug Delivery
    https://www.frontiersin.org/articles/10.3389/fphar.2021.618411/full
  38. Page 210 of Healing With CBD
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  39. Best Way to Take CBD
    https://www.projectcbd.org/guidance/best-way-take-cbd
  40. Ibid.
  41. Can vaping damage your lungs? What we do (and don’t) know
    https://www.health.harvard.edu/blog/can-vaping-damage-your-lungs-what-we-do-and-dont-know-2019090417734
  42. Page 190-193 of Healing With CBD
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  43. Ibid.
  44. A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans
    https://doi.org/10.3389/fphar.2018.01365
  45. Cannabidiol Primer for Healthcare Professionals
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340472/
  46. The Cannabis Terpenes
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763918/
  47. Flavonoids as Antioxidants
    https://pubmed.ncbi.nlm.nih.gov/10924197/
  48. Page 92 of Healing With CBD
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
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Written by 

Stanley Clark

Stanley Clark is a community development volunteer and writer. He had worked on several commercials, events, and campaigns before writing full-time in the area of natural health and wellness. He has a particular interest in reviewing CBD brands for their...

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