Overall CBDC Brand Rating for Zilis: 5/10

Zilis’ Ultra line prides itself on using UltraCell technology, utilizing most of the active compounds found in hemp, including other cannabinoids, terpenes, fatty acids, and flavonoids.

According to Zilis, UltraCell technology uses liposomes and micelles to increase the bioavailability of CBD. 

Liposomes are particles that house and deliver substances throughout the body(1). Meanwhile, micelles help the body absorb water-insoluble compounds(2)

Zilis CBD products are said to be full-spectrum, containing both cannabidiol (CBD) and tetrahydrocannabinol (THC), the primary psychoactive compounds found in cannabis. These phytocannabinoids are seen to benefit multiple neurological functions(3).

When working together, these cannabinoids and other hemp components produce the entourage effect, the synergy between all active compounds that magnifies the overall health benefits of CBD(4).

Zilis is labeled a multi-level marketing company, which has garnered negative reviews from the Better Business Bureau (BBB). Despite this feedback, the brand continues to work on improving its product line with the help of medical professionals.

Its products have garnered positive reviews from buyers. Comments on third-party seller websites cite UltraCell CBD items as quality products that helped them with pain relief and anxiety. However, the legitimacy of these reviews is questionable.

The brand claims its inventory is made of all-natural products that are certified by the US Hemp Authority.

Looking for something different? See our top CBD Oil for 2022.

Zilis Company Summary

  • Founded in 2015, Zilis is a multi-level marketing company that operates mainly through third-party distributors, also known as ambassadors, with a strong social media presence.
  • It has created an in-company medical advisory board to better communicate with the medical industry and to refine the direction of Zilis products.
  • The brand claims to use organic, non-GMO, industrial hemp plants grown in farms in Colorado.
  • Through its “Pay It Forward” program in partnership with Vitamin Angels, Zilis is said to donate vitamins to expectant mothers and infants to help against malnutrition.
    Zilis also claims to distribute nutrition packs to children from Haiti with the help of a local Haitian NGO.
  • According to the brand, it utilizes the supercritical CO2 extraction method, using pressurized carbon dioxide to obtain its CBD oil’s active ingredients.
  • Aside from CBD oil products, the Zilis Ultra line includes UltraCBG, a full-spectrum oil focusing on CBG (cannabigerol) concentrates.
    Also part of the Ultra line are non-CBD supplements, such as UltraIce for homeostasis, UltraEdge for energy, UltraDream for sleep, and UltraBurn for weight management.

Zilis Pros and Cons

Pros Cons
Updated Certificates of Analysis (COA) available Not priced competitively
High CBD bioavailability Low concentration of CBD
Three flavor options More expensive to buy directly from Zilis
Two sizes available on the main website CBD concentration strength not specified
Not contaminant-free
Additional bottle size only available through resellers
Vague COAs
Negative company reviews from the BBB

Pros of Zilis 

  • Updated third-party lab results for all UltraCell CBD oil flavors are available on the website and accessible through a QR code located in the product label.
  • Zilis claims that its UltraCell products are made with UltraCell technology that creates CBD oil with a 94% bioavailability.
  • Zilis UltraCell Full-Spectrum Hemp CBD Oil is available in raw, berry, and lemon. It is also sweetened with stevia.
  • Customers may choose between the full 30ml bottle or a 15ml travel-size bottle.

Cons of Zilis 

  • A 30ml dropper bottle of Zilis UltraCell CBD oil costs $149.95 if purchased from their main website, which means each milliliter of the product costs $4.99.
  • Outdated COAs with specific data show that each 30ml bottle of UltraCell Hemp CBD Oil in berry contains approximately 127.8mg of CBD. Customers pay $1.17 for every mg of CBD. 
  • Customers may buy Zilis products for less from Zilis independent ambassadors, with some resellers listing Zilis UltraCell CBD for $120 compared to Zilis’ $149.95.
  • The total concentration strength of Zilis UltraCell products’ CBD content is not specified on the website and the packaging label.
  • Third-party lab reports indicate trace amounts of yeast and mold.
  • Some resellers carry a 7ml bottle in their inventory, which is not available on Zilis official shop website.
  • The information presented in the COAs is ambiguous.
  • Reviews left on the Better Business Bureau are negative due to Zilis overall system and lack of transparency.

Review of Zilis Products

Zilis UltraCell Full-Spectrum Hemp CBD Oil 

Zilis UltraCell Full-Spectrum Hemp CBD oils are water-soluble mixtures said to have a bioavailability or absorption rate of 94% due to UltraCell technology.

Research has linked CBD to pain relief(5) and anxiety management(6).

Both lemon and berry-flavored CBD oils are flavored with natural ingredients from plant extracts and contain medium-chain triglyceride (MCT) oil from coconut as the carrier oil.

Studies show that MCT oil may aid in weight loss and weight maintenance(7) and offer relief from gastrointestinal issues(8). MCT oil is also observed to enhance energy expenditure(9).

The raw variant uses sunflower lecithin, which is derived from sunflower seed oil. A 2012 study noted that sunflower and other dietary lecithins help decrease cholesterol levels and improve liver health and cognitive functions(10).

The product list also includes xanthan gum and acacia gum. These food stabilizers are said to aid gut health as prebiotics(11).

All Zilis UltraCell Full-Spectrum Hemp CBD Oils are sweetened with stevia and use potassium sorbate as a preservative, extending their shelf life to 18 to 24 months from the manufacturing date indicated on the packaging.

Lab reports state that these CBD oils have trace amounts of yeast and mold.

This product comes in 15ml and 30ml dropper bottles, with 15 and 30 servings per bottle, respectively.

Zilis recommends a dosage of one dropper (1ml) per day or as directed by a healthcare professional. This oil may be taken sublingually or mixed with food and beverages.

Zilis UltraCell Pet

Zilis UltraCell Pet is a full-spectrum oil formulated specifically for cats and dogs. It contains fish oil (salmon) for flavoring and sunflower lecithin as its carrier oil.

According to the Cummings Veterinary Medical Center at Tufts University, the omega-3 found in fish oil may help reduce risks for debilitating symptoms associated with joint, heart, and kidney disease in cats and dogs(12).

Fish oil may also alleviate itchy, flaky skin and promote a healthier, silkier coat for your pets(13).

Its formulation is free from the artificial sweetener xylitol, which, according to the US Food and Drug Administration (FDA), is toxic to dogs(14).

Zilis recommends a dosage of 0.02mg per 1kg of body weight, to be taken orally twice daily.

Zilis UltraCell Full-Spectrum Hemp CBD Topical

Zilis UltraCell Full-Spectrum Hemp CBD Topical is a CBD-infused cream containing aloe leaf and essential oils. It is designed for pain relief while leaving your skin moisturized.

Research has identified cannabinoids to hold analgesic or pain-relieving properties and reduce inflammation to aid with sore joints(15).

Clinical trials on aloe leaf extracts indicated beneficial effects on skin issues, particularly relief from itching and burning sensations associated with psoriasis, dermatitis, and other skin conditions. It is widely used in the cosmetic industry as a base for moisturizing creams and soaps(16).

The main essential oils included are black pepper oil, citronella oil, ginger root oil, and helichrysum flower oil. Studies also found these oils to have anti-inflammatory and antioxidant properties(17-19), while citronella oil is commonly used as a mosquito repellent(20).

Zilis UltraCell Full-Spectrum Hemp CBD Topical is available in two sizes: a 7ml tub and a 2oz tub.

Product Summary

Recommended for Optimizing wellness
Source of Hemp Colorado
Popular Products Zilis UltraCell Full-Spectrum Hemp CBD Oil in berry and Zilis UltraCell Full-Spectrum Hemp CBD Oil in lemon
Types Sold Full-spectrum CBD
Range of Products/Forms Full-spectrum CBD oil, full-spectrum CBG oil, full-spectrum CBD powder, CBD topicals, and CBD pet products
Price Range From $44.95 for the 7ml Zilis UltraCell Full-Spectrum Hemp CBD Topical to $149.95 for the 30ml Zilis UltraCell Full-Spectrum Hemp CBD Oil
Extraction Method CO2 extraction
Lab Testing Transparency & Availability Third-party lab reports available
CBD Concentration per Serving Range Zilis UltraCell Full-Spectrum Hemp CBD Oil (30ml) in berry contains 127.8mg of CBD per unit
Potency Zilis UltraCell Full-Spectrum Hemp CBD Oil (30ml) in berry contains 4.26mg/ml of CBD based on lab results from October 2019
THC Range of Products % Zilis UltraCell Full-Spectrum Hemp CBD Oil (30ml) in berry contains 0.139mg/ml of THC
Flavors Assorted
Tincture Carrier Oil MCT oil and sunflower lecithin
Lab Results Accessible through a QR code and the Zilis website
Shipping/Delivery Ships to the US and Europe
Guarantee High-bioavailability CBD products
Refund Policy Refunds are subject to approval
Contaminants Trace amounts detected in lab results
Vegan and Gluten-Free Not specified
Customer Service [email protected]

+1 (217) 7053702 (US)

+442031292529 (EU)

Country Served US and Europe

Using its UltraCell technology, Zilis promises fast-acting, easily absorbable full-spectrum CBD products for people interested in incorporating CBD into their daily health practices.

Upon absorption, CBD triggers receptors spread throughout the body linked to the endocannabinoid system. This system regulates many essential neurological functions, such as mood, appetite, memory, and sleep(21).

The brand claims to utilize multiple other cannabinoids alongside CBD and THC to induce the entourage effect for a fuller experience of CBD’s health benefits(22)

Prospective users under prescription medication or with diagnosed medical conditions should seek advice from a medical professional before introducing CBD to your daily regimen.

Zilis products are not recommended for use by pregnant women and anyone under the age of 18.

Source of Hemp

Zilis claims to harvest its organic hemp from farms in Colorado, USA.

Two of the Ultra line’s most popular products are UltraCell Full-Spectrum Hemp CBD Oil (30ml) in berry and UltraCell Full-Spectrum Hemp CBD Oil (30ml) in lemon.

Types Sold

All CBD products under the Ultra line are full-spectrum CBD.

Range of Products/Forms

Zilis UltraCell products are available as CBD oils, topicals, powders, and pet products.

Price Range

If purchased through the brand’s official website, UltraCell Full-Spectrum Hemp CBD Oil prices range from $89.95 for the travel-size 15ml bottle to $149.95 for the full-size 30ml bottle.

Other UltraCell CBD products range from $44.95 for a 7ml tub of UltraCell Topical to $149.95 for a 2oz tub of UltraCell Topical.

Extraction Method

According to Zilis, it obtains its high-quality hemp extracts through the supercritical CO2 extraction method. This technique uses pressurized carbon dioxide to extract the needed compounds from hemp plants.

Lab Testing Transparency & Availability

Third-party lab results may be accessed using a QR code located on the product packaging or through the official website. Note that the updated COAs present vague figures.

CBD Concentration per Serving Range

According to a 2019 COA, Zilis’ UltraCell Hemp CBD Oil contains 127.8mg of CBD per 30ml bottle.


A 2019 third-party lab test found Zilis’ UltraCell Hemp CBD Oil contains 4.26mg/ml.

THC Range of Products %

According to its 2019 COA, Zilis UltraCell Hemp CBD Oil (30ml) contains 0.139mg/ml THC.


UltraCell Full-Spectrum Hemp CBD Oil’s flavor selection includes unflavored (raw), berry, and lemon.

UltraCell Pet is salmon-flavored.

Tincture Carrier Oil

UltraCell Full-Spectrum Hemp CBD Oil in berry and lemon are formulated with coconut-derived MCT oil.

UltraCell Full-Spectrum Hemp CBD Oil in raw and UltraCell Pet use sunflower lecithin.

Shipping and Delivery

Zilis ships to the US and European countries. For shipping within the US, deliveries are done Mondays through Fridays.

US postal shipping costs $9.99 and takes up to 12 business days. Ground shipping costs $14.99 and takes up to 7 business days. Meanwhile, express shipping takes three business days for $24.99.

Refund Policy

Customers must send a written request through fax, email, or by support ticket within 30 days of delivery. 

The company sends an RMA (Return Merchandise Authorization) number once the request is approved. All approved returns must be done within seven days, or else refunds are forfeited.

Customers must provide the company with the tracking number of the return shipment, with the RMA number written outside the shipping box.

Zilis does not handle refunds or exchanges for products bought from third parties.


Zilis promises its customers that all UltraCell Full-Spectrum CBD products are made with UltraCell technology and have high bioavailability.


Third-party lab tests detected trace amounts of yeast and mold.

Vegan and Gluten-Free

The brand does not state on its official website if its UltraCell products are vegan and gluten-free.

Zilis UltraCell Pet contains fish oil and is not vegan.

Customer Service

You may email Zilis at [email protected] or call +1 (214) 705-3702 to reach the US office or +442031292529 for its European office.

You may also fill out a customer feedback form on its website.

Country Served

Zilis provides service to the US and Europe.


Zilis claims of UltraCell technology’s effectiveness on increasing CBD oil bioavailability may set Zilis UltraCell Full-Spectrum Hemp CBD Oil apart from other products available on the market.

The brand’s reputation as a multi-level marketing company and its lack of accessible COAs and other information has not dissuaded people from trying its products.

Product prices are hefty, especially when taking into account the product’s low CBD concentration as per outdated COAs. Despite these factors, many customers found the products effective and worth repurchasing. However, a number of CBD users questioned the validity of these reviews.

If you are interested in trying Zilis UltraCell Full-Spectrum Hemp CBD Oil, you may purchase it through their shop’s website at https://shop.zilis.com/, or through its ambassadors.

  1.       Daraee, H., Etemadi, A., Kouhi, M., Alimirzalu, S., Akbarzadeh, A. (2014, Jul. 31). Application of liposomes in medicine and drug delivery. https://doi.org/10.3109/21691401.2014.953633
  2.       Manne, S., Patterson, L. K. (2003). Micelle. Retrieved from https://www.sciencedirect.com/topics/materials-science/micelle
  3.       Maroon, J., & Bost, J. (2018). Review of the neurological benefits of phytocannabinoids. Surgical neurology international, 9, 91. https://doi.org/10.4103/sni.sni_45_18
  4.       Russo E. B. (2011). Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. British journal of pharmacology, 163(7), 1344–1364. https://doi.org/10.1111/j.1476-5381.2011.01238.x
  5.       Russo E. B. (2008). Cannabinoids in the management of difficult to treat pain. Therapeutics and clinical risk management, 4(1), 245–259. https://doi.org/10.2147/tcrm.s1928
  6.       Shannon, S., Lewis, N., Lee, H., & Hughes, S. (2019). Cannabidiol in Anxiety and Sleep: A Large Case Series. The Permanente journal, 23, 18–041. https://doi.org/10.7812/TPP/18-041
  7.       St-Onge, M. P., Bosarge, A., Goree, L. L., & Darnell, B. (2008). Medium chain triglyceride oil consumption as part of a weight loss diet does not lead to an adverse metabolic profile when compared to olive oil. Journal of the American College of Nutrition, 27(5), 547–552. https://doi.org/10.1080/07315724.2008.10719737
  8.       Shah, N. D., Limketkai, B. N. (2017). The Use of Medium-Chain Triglycerides in Gastrointestinal Disorders. Retrieved from https://med.virginia.edu/ginutrition/wp-content/uploads/sites/199/2014/06/Parrish-February-17.pdf
  9.       St. Onge, M. P., Jones, P. J. H. (2002, Mar. 1). Physiological Effects of Medium-Chain Triglycerides: Potential Agents in the Prevention of Obesity. https://doi.org/10.1093/jn/132.3.329
  10.   Küllenberg, D., Taylor, L. A., Schneider, M., & Massing, U. (2012). Health effects of dietary phospholipids. Lipids in health and disease, 11, 3. https://doi.org/10.1186/1476-511X-11-3
  11.   Karlton-Senaye, B. D., Ibrahim, S. A. (2013, Jul.). Impact of gums on the growth of probiotics. Retrieved from https://www.researchgate.net/publication/281787450_Impact_of_gums_on_the_growth_of_probiotics
  12.   Linder, D. E. (2018, Jun. 13). Should I give fish oil to my pet? Retrieved from https://vetnutrition.tufts.edu/2018/06/should-i-give-fish-oil-to-my-pet/
  13.   Arford, K. (2020, May 29). Fish Oil for Dogs. Retrieved from https://www.akc.org/expert-advice/nutrition/fish-oil-for-dogs/
  14.   US Food and Drug Administration (2019, Jul. 7). Paws Off Xylitol; It’s Dangerous for Dogs. Retrieved from https://www.fda.gov/consumers/consumer-updates/paws-xylitol-its-dangerous-dogs
  15.   Russo, E. B. Cannabinoids in the management of difficult to treat pain. Therapeutics and clinical risk management. op. cit.
  16.   Foster, M., Hunter, D., Samman, S. (2011). Evaluation of the Nutritional and Metabolic Effects of Aloe vera. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK92765/
  17.   Kottarapat, J., Liju, V. B., Kuttan, R., Umadevi, N. P. (2014, Mar.). Antioxidant, Anti-inflammatory and Antinociceptive Properties of Black Pepper Essential Oil (Piper nigrum Linn). Retrieved from https://www.researchgate.net/publication/261591338_Antioxidant_Anti-inflammatory_and_Antinociceptive_Properties_of_Black_Pepper_Essential_Oil_Piper_nigrum_Linn
  18.   Funk, J. L., Frye, J. B., Oyarzo, J. N., Chen, J., Zhang, H., & Timmermann, B. N. (2016). Anti-Inflammatory Effects of the Essential Oils of Ginger (Zingiber officinale Roscoe) in Experimental Rheumatoid Arthritis. PharmaNutrition, 4(3), 123–131. https://doi.org/10.1016/j.phanu.2016.02.004
  19.   Viegas, D. A., Palmeira-de-Oliveira, A., Salgueiro, L., Martinez-de-Oliveira, J. (2013, Nov.). Helichrysum italicum: From traditional use to scientific data. Retrieved from https://www.researchgate.net/publication/258635310_Helichrysum_italicum_From_traditional_use_to_scientific_data
  20.   Sharma, R., Rao, R., Kumar, S., Mahant, S., & Khatkar, S. (2019). Therapeutic Potential of Citronella Essential Oil: A Review. Current drug discovery technologies, 16(4), 330–339. https://doi.org/10.2174/1570163815666180718095041
  21.   Chye, Y., Christensen, E., Solowij, N., & Yücel, M. (2019). The Endocannabinoid System and Cannabidiol‘s Promise for the Treatment of Substance Use Disorder. Frontiers in psychiatry, 10, 63. https://doi.org/10.3389/fpsyt.2019.00063
  22.   Russo, E. B. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. British journal of pharmacology. op. cit.
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