Does CBD oil help with fungus?

  • Researchers of 2011 study published in the British Journal of Pharmacology noted that cannabinoids cannabidiol (CBD), cannabigerol (CBG), and cannabichromene (CBC) might boost the effects of an extremely potent antifungal, caryophyllene oxide(1).
  • Many terpenes have been found to possess antifungal properties in vitro, as a study published in the Cannabis and Cannabinoid Research Journal in 2018 indicated. However, the authors reported that none of the essential oils in the study was as effective as purified CBD(2).
  • The highly lipophilic nature of terpenes makes them capable of disrupting the cell membrane, causing cell death or inhibiting the proliferation of certain fungi, according to authors of a 2017 study published in the Pharmaceuticals Journal(3).
  • Results of a study which was published in Clinical Microbiology Reviews show that both CBG and CBC possess antifungal properties. When these cannabinoids are combined, they produce an entourage effect which can be found in a full spectrum CBD-rich oil, also called whole plant extract(4).
  • Consulting with a trusted medical practitioner experienced with cannabis use is the best course of action for anyone looking to try CBD for the first time or include CBD in their current regimen.

Best CBD Oils for Antifungal

Editor's Pick

Spruce 750mg Lab Grade CBD Oil

Specifically formulated to be more palatable to CBD users
Spruce 750mg Lab Grade CBD Oil Bottle
  • Overall Clinical Score
    99%
    Editor's Pick
  • Score breakdown
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
  • Summary

    Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

    Pros
    Cons
    •  Mid-strength
    •  Natural peppermint flavor
    •  Made from 100% organic and natural ingredients
    •  No other flavors
  • Features
    Discount pricing available? 20% Off Coupon Code: CBDCLINICALS
    Source
    Source of Hemp
    Kentucky, USA & North Carolina, USA
    Form Oil Tincture
    Ingredients Organic Hemp Seed Oil, Full Spectrum CBD Oil
    Type
    Type of CBD
    Full Spectrum
    Extraction
    Extraction Method
    Moonshine extraction method
    How to take it Under tongue
    Potency
    Potency - CBD Per Bottle
    750 mg per bottle
    Carrier Oil Organic Hemp Seed Oil
    Concentration
    CBD Concentration Per Serving
    25mg of CBD per dropper full (1ml)
    Drug Test Contains 0.3% THC but there is a chance you may test positive for marijuana
    Flavours Peppermint
    Price Range $89 ($75.65 for subscriptions, 15% discount from regular price)
    $/mg CBD
    Price ($/mg)
    $0.12/mg ($0.10/mg with subscription)
    Shipping
    Shipping/Time to delivery
    2-4 business days (first class USPS)
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants Organic, Non-GMO, no pesticides, no herbicides, no solvents or chemical fertilizers, No preservatives or sweeteners
    Allergens Vegan, Gluten free
    Refund policy Within 30 days
    Recommended for New CBD users
    Countries served USA only (all 50 states)
Check Latest Prices
Best Organic

NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil

Perfect for anyone who are looking for CBD products that promote a healthy body and mind.
NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
  • Overall Clinical Score
    99%
    Best Organic
  • Score breakdown
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  • Summary

    Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

    Pros
    Cons
    •  Pure CBD hemp
    •  All natural
    •  Approximately 300 drops total
    •  No other flavors
  • Features
    Discount pricing available? 20% Off Coupon Code: CBDCLINICALS20
    Source
    Source of Hemp
    Colorado, USA
    Form Oil Tincture
    Ingredients Full Spectrum Hemp Extract, Organic Virgin Hemp Seed Oil
    Type
    Type of CBD
    Full Spectrum CBD
    Extraction
    Extraction Method
    CO2 Method
    How to take it Under the tongue for approximately 30 seconds before swallowing
    Potency
    Potency - CBD Per Bottle
    900mg per bottle
    Carrier Oil Organic Hemp Oil
    Concentration
    CBD Concentration Per Serving
    60mg per dropper full (1ml)
    Drug Test Contains 0.3% THC but there is a chance you may test positive for marijuana
    Flavours Natural
    Price Range $99 - $434
    $/mg CBD
    Price ($/mg)
    $0.08 - $0.13
    Shipping
    Shipping/Time to delivery
    2-3 Days via USPS
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants No additives or preservatives, Non-GMO, NO herbicides, pesticides, or chemical fertilizers
    Allergens Not specified
    Refund policy Within 30 days
    Recommended for Health-conscious persons
    Countries served USA (all 50 states) and over 40 countries including Australia, Azerbaijan, Beliza, Bosnia & Herzegovina, Brazil, Chile, China, Croatia, Czech Republic, Estonia, France, Hong Kong, Hungary, Ireland, Israel, Japan, Latvia, Lebanon, Lithuania, Macao, Malaysia, Malta, Netherlands, New Zealand, Oman, Paraguay, Poland, Portugal, Saudi Arabia, Serbia, Singapore, South Korea, Sweden, Switzerland, United Arab Emirates, United Kingdom, Uruguay, and many more.
Check Latest Prices
Best Value

Sabaidee Super Good Vibes CBD Oil

4x the strength of a regular cbd oil
Sabaidee Super Good Vibes CBD Oil
  • Overall Clinical Score
    99%
    Best Value
  • Score breakdown
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
  • Summary

    Super Good Vibes CBD Oil provides the purest and highest quality Cannabidiol (CBD) on the market as well as other high quality phytocannabinoids, terpenes, vitamins, omega fatty acids, trace minerals, and other beneficial for your health elements, which all work together to provide benefits.

    Pros
    Cons
    •  Extra strong
    •  Significant benefits with just a few drops
    •  100% Natural ingredients
    •  No other flavors
  • Features
    Discount pricing available? 15% Off Coupon Code: CBDCLINICALS15
    Source
    Source of Hemp
    Colorado, USA
    Form Oil Tincture
    Ingredients Cannabidiol (CBD), Coconut Medium-chain triglycerides (MCT) Oil, Peppermint oil
    Type
    Type of CBD
    Broad Spectrum
    Extraction
    Extraction Method
    CO2-extraction
    How to take it Using 1-3 servings per day as needed is a good start to determine how much you need
    Potency
    Potency - CBD Per Bottle
    1000 mg per bottle
    Carrier Oil Coconut MCT Oil
    Concentration
    CBD Concentration Per Serving
    33.5 mg per dropper (1ml)
    Drug Test Contains 0.3% THC but there is a chance you may test positive for marijuana
    Flavours Peppermint
    Price Range Single Bottle - $119.95, 2-Pack - $109.97 each, 3-Pack - $98.31 each, 6-Pack - $79.99 each
    $/mg CBD
    Price ($/mg)
    Single bottle - $0.010, 2-Pack - $0.011, 3-Pack - $0.009, 6-Pack - $0.007
    Shipping
    Shipping/Time to delivery
    3-5 Business days
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants Contaminant-free
    Allergens Vegan and Gluten-free
    Refund policy Within 30 days
    Recommended for Patients who are looking for serious CBD oil support
    Countries served USA only (all 50 states)
Check Latest Prices
Natural Alternative

cbdMD CBD Oil Tinctures

Uses USA hemp that is grown on non-GMO farms, and is both vegan and gluten-free
cbdMD CBD Oil Tinctures Products
  • Overall Clinical Score
    99%
    Natural Alternative
  • Score breakdown
    Value
    Quality
    Strength
    Customer Service
    Lab Testing Transparency
    Effectiveness
  • Summary

    cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

    Pros
    Cons
    •  Plenty of concentrations to choose from for all people with various kinds of needs
    •  Has vegan, organic, and gluten-free ingredients
    •  Affordable pricing
    •  Affordable pricing
    •  cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options
  • Features
    Discount pricing available? 15% Off Coupon Code: cbdMD15
    Source
    Source of Hemp
    Kentucky, USA
    Form Oil Tincture
    Ingredients Cannabidiol (CBD), MCT Oil, and Flavoring
    Type
    Type of CBD
    Broad Spectrum
    Extraction
    Extraction Method
    CO2 extraction method
    How to take it Under tongue
    Potency
    Potency - CBD Per Bottle
    300 mg - 7500 mg / 30 ml bottle, 1000 mg - 1500 mg / 60 ml bottle
    Carrier Oil Organic Coconut MCT Oil
    Concentration
    CBD Concentration Per Serving
    30 ml: 300 mg - 10 mg per dropper (1ml), 750 mg - 25 mg per dropper (1ml), 1500 mg - 50 mg per dropper (1ml), 3000 mg - 100 mg per dropper (1ml), 5000 mg - 166.6 mg per dropper (1ml), 7500 mg - 250 mg per dropper (1ml), 60 ml: 1000 mg - 16.6 mg per dropper (1ml), 1500 mg - 25 mg per dropper (1ml)
    Drug Test Containing less than 0.3% THC, there are still trace amounts
    Flavours Natural, Berry, Orange and Mint
    Price Range 30 ml Bottles: $29.99 for 300 mg, $69.99 for 750 mg, $99.99 for 1500 mg, $149.99 for 3000 mg, $239.99 for 5000 mg, $339.99 for 7500 mg 60 ml Bottles: $74.99 for 1000 mg, $99.99 for 1500 mg
    $/mg CBD
    Price ($/mg)
    30 ml - $0.05 - $0.10, 60 ml - $0.06 - $0.07
    Shipping
    Shipping/Time to delivery
    2-5 Business days (via Fedex)
    Lab Tests
    Lab Testing Transparency
    Third Party Lab Tested post formulation for safety and potency, available on website
    Contaminants 100% organic, non-GMO, and vegan-certified
    Allergens Vegan, Gluten free
    Refund policy Within 30 days
    Recommended for CBD users with different needs
    Countries served USA only (all 50 states)
Check Latest Prices

Why People are Turning to CBD for Antifungal Treatment

Antifungal medications are known to cause some side effects, especially when administered intravenously or taken orally.

Adverse reactions may include diarrhea, abdominal pain, rashes, skin redness, and itching or burning. These side effects are typically mild and last for a short period of time(5).

Occasionally, antifungal medicines may cause severe side effects, such as swelling of the face, neck or tongue, difficulty breathing, peeling or blistering skin, and liver damage characterized by nausea, loss of appetite, fatigue, and jaundice(6).

To those who seek a safer and more natural remedy, CBD may be able to provide relief from fungal infections without the adverse side effects that typically come with the use of conventional antifungals.

A 2011 study published in the British Journal of Pharmacology showed that certain cannabinoids, such as cannabidiol (CBD), cannabigerol (CBG), and cannabichromene (CBC), have moderate antifungal properties(7).

The study mostly examined the therapeutic benefits of THC, the cannabinoid that induces psychoactive effects on the user, and not CBD.

Still, the researchers noted that the three cannabinoids CBD, CBG, and CBC might boost the effects of an extremely potent antifungal, caryophyllene oxide (a primary terpene found in cannabis, basil, hops etc).

Terpenes, or isoprenoids, which are similar to essential oils, provide cannabis plants their distinctive aromas and flavors. Many of the terpenes have also been found to possess antifungal properties in vitro, as a study published in the Cannabis and Cannabinoid Research Journal in 2018 indicated(8).

In the said study, researchers noted that none of the essential oils was as effective as purified CBD. They also suggested that terpenoids (chemically-modified terpenes) may be used to reduce inflammation.

Meanwhile, research has shown that terpenes help carry major cannabinoids, like CBD, through the bloodstream(9).

Terpenes form the largest group of phytochemicals, according to the authors, and are vital contributors to the pharmacological properties of many medicinal herbs. Some terpenes, such as β-amyrin and cycloartenol, have been shown to possess antibacterial, antifungal, anti-inflammatory and anti-cancer properties in research labs (10).

A 2006 study examined essential oils containing the terpenes, alpha-pinene and delta 3 carene, which are found in the cannabis plant. This study found that both of the terpenes, delta 3 carene in particular, had antifungal benefits(11).

In the said study, which was published in the Applied Microbiology Journal, results supported the theory that essential oils or some of their constituents may be useful in the clinical management of fungal infections.

Another study revealed the moderate antibacterial and strong antifungal effects of orange jessamine essential oil containing beta-caryophyllene, a terpene found in some cannabis strains. Researchers also noted that the essential oil acted fast to kill the fungus in a non-clinical setting (12).

While the studies mentioned above are not specific to CBD, the results are an indication that the vast array of compounds contained in cannabis have numerous health benefits, including as a potential fungicide.

Meanwhile, CBD has been shown to possess anti-inflammatory characteristics which may help with symptoms of fungal infections, such as swelling, redness, and heat(13).

CBD’s anti-inflammatory characteristics have been demonstrated in several human and animal studies, like that of a 2014 human study published in the Journal of Clinical Investigation and a 2012 research conducted by authors from Hungary (14).

Another research published in the Free Radical Biology & Medicine Journal showed that CBD, which may interact with the endocannabinoid system, is a promising prototype for anti-inflammatory drug development(15).

The said research corroborates CBD’s potential to help support body movement and healthy joints. The authors’ findings suggest CBD may interact with the immune system, thereby theoretically reducing stress and inflammation.

Studies like these suggest that CBD, as a potent anti-inflammation compound, may also help with fungal diseases.

How CBD Oil Works as an Antifungal

One needs to understand first the mechanism by which antifungals work to comprehend how CBD works as an antifungal.

Fungi and humans have similar intracellular structure, as both are composed of eukaryotic cells, which, unlike bacteria, have a membrane protecting its nuclei.

Also, both humans and fungi are heterotrophic, meaning both species generate energy by feeding on other organisms in the ecosystem instead of producing their own food like plants do(16).

A 2018 study published in the Journal of Fungi shows that the inhibition of ergosterol synthesis is the mode of action of many antifungal drugs(17).

Ergosterol is an immunologically active lipid that induces pyroptosis, according to authors of a 2018 study in a journal published by the American Society for Microbiology(18).

Pyroptosis (from the Greek roots “pyro,” relating to fire or fever, and “ptosis”, denoting falling) is the proinflammatory programmed cell death(19).

Thus, antifungals work by inhibiting the production of ergosterol in fungi, ultimately destroying the cell membranes of the fungi without affecting the human cells in the process, as explained in a 2017 study that examined the mechanistic targets of antifungal agents(20).

Consequently, if the cell membranes are not there to protect the fungus, the fungus is destroyed.

So, how does CBD work as an antifungal?

At their chemical core, nearly all cannabinoids have a single hydroxyl group of one oxygen atom and one hydrogen atom, as researchers of a study published in the Journal of Natural Products in 2016 noted(21).

As explained in the said study, these hydroxyl groups attract other compounds that include oxygen. When these compounds meet and react, they go through a chemical process called oxidation, which binds them, forever changing both molecules.

After the molecules have gone through oxidation with cannabinoids, fungal cells cannot build on themselves and continue multiplying. In their oxidized state, fungal cells are unable to proliferate as they cannot produce ergosterol, which they need to survive.

This mechanism explains how cannabinoids theoretically prevent fungal infections from spreading by blocking them on a molecular level.

Although the said study was conducted on only nine biologically active cannabinoids from Cannabis sativa and did not include CBD, the results illustrate how cannabinoids could work as antifungals.

In another study, researchers explored the antimicrobial and antifungal activities of cannabigerol (CBG) and cannabichromene (CBC)(22). Both of these cannabinoids are present in full-spectrum cannabis oil in varying quantities.

When all the cannabinoids work in synergy, they produce an entourage effect, which can be found only in a full-spectrum CBD-rich oil (also called whole-plant extract).

The Pros and Cons of CBD Oil as an Antifungal

The Pros

  • Studies mentioned previously demonstrate CBD’s anti-inflammatory and antifungal properties, which may help with fungal infections, although this needs further clinical research
  • CBD is non-addictive, says Nora Volkow, director of the National Institute on Drug Abuse (NIDA) in a 2015 article(23). This characteristic makes CBD safe for daily intake.
  • CBD “is generally well tolerated with a good safety profile,” as the World Health Organization (WHO) stated in a critical review(24).
  • CBD oil may be purchased without a prescription in locations where they are legally available.

The Cons

  • Studies are too limited to determine whether or not CBD is an effective treatment for conditions other than the ones approved by the U.S. Food and Drug Administration (FDA).
  • As with the use of any natural chemical compound, there are risks involved in using CBD. According to the Mayo Clinic, possible side effects include drowsiness, dry mouth, diarrhea, fatigue, and reduced appetite(25).
  • CBD can alter how the body metabolizes certain medications. Data from a 2019 study published in the Journal of Clinical Medicine indicated that antifungals and anti-inflammatory medicines are among those that may adversely interact with CBD(26).
  • Dr. Doris Trauner, professor of neurosciences and pediatrics at the University of California San Diego School of Medicine and a physician at San Diego’s Rady Children’s Hospital, cautions that CBD products marketed online and in dispensaries are mostly unregulated(27).

The lack of regulation makes it difficult to determine whether the CBD gummies, tinctures, patches, balms, and gelcaps contain what the product label claims.

A 2107 review published in the Journal of the American Medical Association revealed labeling inaccuracies among CBD products. Some products had less CBD than stated, while others had more(28).

How CBD Oil Compares to Alternative Treatments for Fungus

There has been a great interest in using essential oils as possible natural alternatives for conventional synthetic fungicides, according to a 2017 study published in the Pharmaceuticals Journal(29).

Researchers found that essential oils could represent one of the most promising natural products for fungal inhibition. They also noted that a wide variety of essential oils obtained from different plants or herbs exhibited powerful antifungal properties in the laboratory setting.

Another noteworthy finding was that essential oils could also attenuate the microbial growth and biofilm development through specific mechanisms.

Classified as “Generally Recognized as Safe” (GRAS) by the U.S. Food and Drugs Administration (FDA), essential oils are not harmful and may be preferred by consumers over synthetic agents(30).

The antimicrobial or antifungal activity of essential oil may be attributed to the properties of terpenes or terpenoids, as researchers of a study published in the Pharmaceuticals Journal suggest. The terpenes’ highly lipophilic nature makes them capable of disrupting the cell membrane, causing cell death or inhibiting the proliferation of certain fungi(31).

In a study published in the Molecules Journal in 2018, ten essential oils showed outstanding antifungal and cytotoxic (toxic to cells) activities in vitro: Indian, Australian, and Hawaiian sandalwoods, melissa, lemongrass, cilantro, cassia, cinnamon, patchouli, and vetiver(32).

Researchers found that several essential oils showed notable antifungal actions against fungal pathogens in the non-clinical setting. Thus, these oils may theoretically be a viable addition to current antifungal treatment options, as agents themselves or as adjuvant therapies, to combat fungal infections.

So, how does CBD oil compare to essential oils as alternative antifungals?

According to a 2017 study published in the Cannabis and Cannabinoid Research Journal, CBD has a better side effect profile in comparison with other drugs(33). Thus, CBD is generally safe to use.

The authors explained that this safety feature could improve patients’ compliance and adherence to treatment, as CBD is often used as an adjunct therapy.

In an article posted by the American Society for Microbiology (ASM) in June 2019, CBD was described to be a potentially active agent for disrupting biofilms, a physical form of bacteria growth that leads to difficult-to-treat infections(34).

Like essential oils, full-spectrum CBD oil is derived from plants, most of which naturally contain potent terpenes that may prove beneficial in fighting fungus.

CBD oil’s high lipophilicity is another characteristic it shares with essential oils. This lipophilic property is what may help facilitate the diffusion of CBD oil, making it readily absorbed when used in topical or transdermal applications(35).

How to Choose the Right CBD to Help with Fungus

Studies cited previously show that CBD is not the only cannabinoid with antifungal properties. Hence, when choosing a CBD product to help with fungal infections, opt for one that contains full-spectrum CBD oil. Also understand that clinical trials testing these substances are extremely limited or lacking entirely.

Full-spectrum CBD oil contains all phytonutrients from hemp, including trace amounts of THC, terpenes, flavonoids, and essential oils. These compounds may work together to intensify the therapeutic benefits of each individual cannabinoid, resulting in the “entourage effect”.

Those with allergies to THC may opt to use broad-spectrum CBD oil, which is like full-spectrum CBD but without the THC that makes the user high.

However, regardless of the form of CBD product of choice, careful consideration must still be employed in selecting the best CBD oil to help with inflammation, fungal infection, and itchiness.

The following factors are essential to ensure the safety and reliability of the CBD products purchased:

  1. Research on the exact legal stipulations applicable to CBD in the area where it would be purchased and used.
  2. Purchase only high-quality CBD products from legitimate and reliable brands. The majority of companies that manufacture the best CBD oil products grow their hemp from their farm, or they purchase from licensed hemp producers.
  3. Research product reviews before buying from an online store. When buying from a physical store or dispensary, check whether the store is authorized by the government to sell CBD.
  4. One important thing to look for in CBD products is certification codes. Several certification authorities approve certain products only after some thorough screening tests.
  5. Compare company claims about their products’ potency with that of the third-party lab reports.
  6. Consulting with a trusted medical professional who is experienced in CBD use is ideal before one purchases his or her first bottle of CBD.

Antifungal CBD Dosage

There is no recommended CBD dosage specific for fighting fungus or any type of fungal infections as prospective clinical research has yet to be undertaken.

According to an article written by Peter Grinspoon, MD, on Harvard Health in August 2019, experts do not know the most effective therapeutic dose of CBD for any particular medical condition(36).

Without sufficient high-quality evidence in human studies, effective doses cannot be determined. Also, Grinspoon says that given that CBD is currently mostly available as an unregulated supplement, it is difficult to know what the consumers are getting.

Grinspoon’s advice to those looking to try and purchase CBD products is to talk with their doctor to make sure that taking CBD would not cause adverse interactions with other medications that are currently taken.

In a 2017 study, researchers said that chronic CBD use and large doses of up to 1500 mg a day had been repeatedly shown to be well tolerated by humans(37).

While CBD is considered generally safe, as the 2011 review in the Current Drug Safety Journal suggests, the long-term effects are yet to be determined(38).

How to Take Antifungal CBD Oil

There are different types of fungal diseases, says the Centers for Disease Control and Prevention (CDC). The treatment varies with each type, depending on the particular area of the body that was affected(39).

Fungal nail infections are among the most common fungal diseases. The toenail fungus can cause a nail infection where the infected nail becomes discolored, thick, and more likely to break and crack.

Other types of fungal disease are vaginal candidiasis and Candida infections of the mouth, throat, and esophagus.

For CBD to be effective, it must go where it is needed. Thus, it is essential to know the location of the CBD’s target.

A consultation with a doctor can help determine the type of fungal infection that one has, and this information can help an individual set a specific target for the CBD.

Full-spectrum CBD oil may be the best option in fighting fungal infections as it contains all phytonutrients from hemp, including trace amounts of THC, terpenes, flavonoids, and essential oils.

One of the fastest ways to feel the effects of CBD is to vape it. However, if vaping is not an option, there are still other methods.

If the target is close to the skin or a mucous membrane, like the vagina, one could first try a localized CBD product, such as a topical or suppository. These products deliver the highest concentration of CBD in a specific area.

Topicals like CBD creams, lotions, and patches may also be applied to a target area on the skin.

In cases of inflammation, CBD needs to travel through the bloodstream to reach its target. Oral CBD products like tinctures are best for this purpose. Sublingual (under the tongue) absorption is an efficient method of taking CBD oil.

In a 2010 review, published in the International Journal of Pharmacy and Pharmaceutical Sciences, researchers found that peak blood levels of most substances given sublingually are achieved in 10 to 15 minutes, which is faster than when those same drugs are ingested orally(40).

Gummies and gelcaps containing full-spectrum CBD oil may also be taken orally.

Conclusion

Pharmaceutical antifungal options, while useful, can be dangerous for some people and lead to undesirable effects on the human body.

Sought by those who prefer a safer and more natural remedy, CBD may provide relief from fungal infections without the adverse side effects that typically come with the use of conventional antifungals.

Medical cannabis, also called medical marijuana, is a term for derivatives of the Cannabis sativa plant used to relieve severe and chronic symptoms(41).

To fight fungal infections, choose a full-spectrum or broad-spectrum CBD oil product that contains all the beneficial terpenes and other cannabinoids and discuss this option with a physician.

Exploring medical cannabis means becoming a highly educated consumer. Consulting with a trusted medical practitioner experienced with cannabis use is the best course of action for anyone looking to try CBD for the first time or include CBD in their current regimen.


  1. Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 2011;163(7):1344–1364. doi:10.1111/j.1476-5381.2011.01238.x.
  2. Gallily R, Yekhtin Z, Hanuš LO. The Anti-Inflammatory Properties of Terpenoids from Cannabis. Cannabis Cannabinoid Res. 2018;3(1):282–290. Published 2018 Dec 26. doi:10.1089/can.2018.0014.
  3. Nazzaro F, Fratianni F, Coppola R, Feo V. Essential Oils and Antifungal Activity. Pharmaceuticals (Basel). 2017;10(4):86. Published 2017 Nov 2. doi:10.3390/ph10040086.
  4. Ghannoum MA, Rice LB. Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. Clin Microbiol Rev. 1999;12(4):501–517.
  5. NHS Choices. (2020, Feb 3). Antifungal medicines. Retrieved from https://www.nhs.uk/conditions/antifungal-medicines/.
  6. Ibid.
  7. Russo EB. op. cit.
  8. Gallily R, Yekhtin Z, Hanuš LO. The Anti-Inflammatory Properties of Terpenoids from Cannabis. Cannabis Cannabinoid Res. 2018;3(1):282–290. Published 2018 Dec 26. doi:10.1089/can.2018.0014.
  9. Andre CM, Hausman JF, Guerriero G. Cannabis sativa: The Plant of the Thousand and One Molecules. Front Plant Sci. 2016;7:19. Published 2016 Feb 4. doi:10.3389/fpls.2016.00019.
  10. Ibid.
  11. Cavaleiro C, Pinto E, Gonçalves MJ, Salgueiro L. 21 April 2006. Antifungal activity of Juniperus essential oils against dermatophyte, Aspergillus and Candida strains. https://doi.org/10.1111/j.1365-2672.2006.02862.x.
  12. Neta MCS, Vittorazzi C, […], and Scherer R. Effects of β-caryophyllene and Murraya paniculata essential oil in the murine hepatoma cells and in the bacteria and fungi 24-h time–kill curve studies. https://doi.org/10.1080/13880209.2016.1254251.
  13. InformedHealth.org [Internet]. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-. What is an inflammation? 2010 Nov 23 [Updated 2018 Feb 22]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK279298/.
  14. Oláh A, Tóth BI, Borbíró I, et al. Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes. J Clin Invest. 2014;124(9):3713–3724. doi:10.1172/JCI64628; Ribeiro A, Ferraz-de-Paula V, […], and Palermo-Neto J. Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor. Eur J Pharmacol. 2012 Mar 5;678(1-3):78-85. doi: 10.1016/j.ejphar.2011.12.043. Epub 2012 Jan 12.
  15. Booz GW. Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. Free Radic Biol Med. 2011;51(5):1054–1061. doi:10.1016/j.freeradbiomed.2011.01.007.
  16. Detoni M. (2015, Sept. 20). What do humans and fungi have in common? Retrieved from https://socratic.org/questions/what-do-humans-and-fungi-have-in-common.
  17. Pan, Jiao & Hu, Cuiting & Yu, Jae-Hyuk. (2018). Lipid Biosynthesis as an Antifungal Target. Journal of fungi (Basel, Switzerland). 4. 10.3390/jof4020050.
  18. Rodrigues ML. The Multifunctional Fungal Ergosterol. mBio. 2018;9(5):e01755-18. Published 2018 Sep 18. doi:10.1128/mBio.01755-18.
  19. Cookson, B. T., and M. A. Brennan. 2001. Pro-inflammatory programmed cell death. Trends Microbiol. 9:113-114.
  20. Mazu TK, Bricker BA, Flores-Rozas H, Ablordeppey SY. The Mechanistic Targets of Antifungal Agents: An Overview. Mini Rev Med Chem. 2016;16(7):555–578. doi:10.2174/1389557516666160118112103.
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