Best CBD Oil As Mood Stabilizer

Are you considering using CBD to help with mood stability? Read on to know how this non-psychoactive compound may be your natural option. 

Rating
Highlights

Editor's Choice

Spruce 750mg Lab Grade CBD Oil

4.8 out of 5
  1. Peppermint flavor masks any unpleasant taste
  2. Contains 25mg of CBD per dropper full
  3. Bottle includes a graduated dropper for correct serving measurement

Best CBD Purity

NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil

5.0 out of 5
  1. Natural remedy for various illnesses
  2. Product is full-spectrum whole-plant extract
  3. Contains naturally occurring synergistic cannabinoids and terpenes

Best High Potency

Spruce 2400mg Lab Grade CBD Oil

5.0 out of 5
  1. Maximum possible potency
  2. Each dropper full contains 80mg of CBD
  3. Conveniently fits in a 30mL bottle

Best Value

Avida Full Spectrum CBD Oil Tincture 500mg

4.6 out of 5
  1. Proprietary full-spectrum
  2. Developed using advanced AVIDA CORE Spectrum Technology
  3. Highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3)

Best Value

cbdMD CBD Oil Tincture Natural 1500mg

4.7 out of 5
  1. Made using only CBD sourced from medical hemp
  2. Available in many flavours
  3. Safe for daily use

Best THC Free

CBDistillery THC Free CBD Oil Tinctures

4.4 out of 5
  1. Do not contain THC
  2. Available in different potencies and sizes
  3. Brand has special deals and offers

Best Customer Rated

cbdMD CBD Oil Tincture Natural 750mg

4.4 out of 5
  1. THC-free
  2. Has plenty of flavours to choose from
  3. Totally vegan

Best For Beginners

NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil

4.6 out of 5
  1. Lowest concentration for CBD beginners
  2. Fully organic and lab-tested
  3. Full-spectrum

Best Flavor Range

Hemp Bombs 750mg CBD Oil

3.9 out of 5
  1. Has a wide range of flavours
  2. Safe to intake
  3. Get 20% off when you avail of their subscription

Best Allergy Friendly

Royal CBD Full Spectrum CBD Oil

3.7 out of 5
  1. Has three flavors to choose from – Berry, Natural and Vanilla
  2. Vegan and Gluten-Free
  3. Superb customer service

Compare the Best CBD Oil As Mood Stabilizer 2022

Product Potency Purity Customer Service Type Extraction Transparency Absorption
Spruce 750mg Lab Grade CBD Oil
4.8 out of 5
4.5 out of 5
4.5 out of 5
5.0 out of 5
5.0 out of 5
4.5 out of 5
5.0 out of 5
5.0 out of 5
NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
5.0 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
4.0 out of 5
5.0 out of 5
5.0 out of 5
Spruce 2400mg Lab Grade CBD Oil
5.0 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
4.0 out of 5
5.0 out of 5
5.0 out of 5
Avida Full Spectrum CBD Oil Tincture 500mg
4.6 out of 5
5.0 out of 5
3.5 out of 5
3.0 out of 5
5.0 out of 5
4.5 out of 5
4.5 out of 5
5.0 out of 5
cbdMD CBD Oil Tincture Natural 1500mg
4.7 out of 5
5.0 out of 5
3.5 out of 5
5.0 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
4.0 out of 5
CBDistillery THC Free CBD Oil Tinctures
4.4 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
4.5 out of 5
cbdMD CBD Oil Tincture Natural 750mg
4.4 out of 5
4.5 out of 5
3.5 out of 5
5.0 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
4.0 out of 5
NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
4.6 out of 5
2.5 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
4.5 out of 5
5.0 out of 5
5.0 out of 5
Hemp Bombs 750mg CBD Oil
3.9 out of 5
4.5 out of 5
3.5 out of 5
2.5 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
4.0 out of 5
Royal CBD Full Spectrum CBD Oil
3.7 out of 5
2.5 out of 5
3.5 out of 5
5.0 out of 5
5.0 out of 5
4.0 out of 5
1.0 out of 5
5.0 out of 5

Best CBD Oil As Mood Stabilizer

1. Spruce 750mg Lab Grade CBD Oil
cbdc overall score

4.8

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

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Transparency

Pros Cons

Mid-strength

No other flavors

Natural peppermint flavor

Made from 100% organic and natural ingredients

Overview

Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
cbdc overall score

5.0

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

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Transparency

Pros Cons

Pure CBD hemp

No other flavors

All natural

Approximately 300 drops total

Overview

Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

3. Spruce 2400mg Lab Grade CBD Oil
cbdc overall score

5.0

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

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Transparency

Pros Cons

Extra Strength

Tastes bitter

No artificial flavoring or colors

No THC-free option

Made from 100% organic and natural ingredients

Overview

The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.

4. Avida Full Spectrum CBD Oil Tincture 500mg
cbdc overall score

4.6

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

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Transparency

Pros Cons

Light Spearmint flavor

No other flavor

Non-THC, Non-detected in drug test

Overview

Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.

5. cbdMD CBD Oil Tincture Natural 1500mg
cbdc overall score

4.7

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Various delicious flavors to choose from

cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options

Has vegan, organic, and gluten-free ingredients

Free shipping for this particular product within USA

World-class customer service team

Overview

cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

6. CBDistillery THC Free CBD Oil Tinctures
cbdc overall score

4.4

CBDC Evaluation Table/Score
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Customer Service

Type

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Transparency

Pros Cons

60-Day Satisfaction Guarantee

Dropper is a bit shaky

Various strengths

Oil extracted from aerial plant parts of US grown industrial hemp

Sourced from non-GMO industrial hemp grown in the USA through natural farming practices

Overview

CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.

7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
cbdc overall score

4.6

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Pure CBD hemp

No other flavors

All natural

A bit pricey compared to competitors

Approximately 100 drops total

Overview

This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.

8. cbdMD CBD Oil Tincture Natural 750mg
cbdc overall score

4.4

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

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Transparency

Pros Cons

Vegan and Gluten free

Does not ship internationally

Has a third-party lab test

Wide variety of CBD strengths and sizes

Overview

A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.

9. Hemp Bombs 750mg CBD Oil
cbdc overall score

3.9

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Wide variety of flavors

Incomplete information about the product

Lab test results are complete

Does not ship to all international countries

30-day money-back guarantee

Overview

Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.

10. Royal CBD Full Spectrum CBD Oil
cbdc overall score

3.7

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Rich in phytochemicals including CBD, CBC, CBG, and a variety of flavorful terpenes

Shipping not specified on website

More flavors to choose from

3rd party lab result is currently not available on website

Extracts contain a whole array of cannabinoids and terpenes from the hemp plant — rather than pure CBD isolate

Overview

Excellent products and superb customer service. Whenever you want to ask them about the dosage, recommended consumption methods, or which CBD oil will work best for you, just give them a call, send them a message, or get in touch with their social media channels. They won’t leave you with any unanswered questions.

How CBD May Help With Mood Stability

Cannabidiol, popularly known as CBD, is a plant-based cannabinoid derived from cannabis plants. Unlike THC (tetrahydrocannabinol), CBD does not have psychoactive activity. 

Most importantly, CBD has purported anti-inflammatory, analgesic, anxiolytic (anti-anxiety), antipsychotic, and neuroprotective properties(1)

Aside from CBD’s therapeutic potential, its activity in the ECS (endocannabinoid system) may further elucidate how the compound may help with mood stability and the medical conditions associated with it. 

The ECS is responsible for maintaining bodily balance. Both CBD and THC interact with the ECScannabinoid receptors (CB1 and CB2) present throughout the body(2)

The cannabinoid receptors are a G-protein coupled receptor family with potential roles in the modulation of signaling pathways linked to numerous medical conditions(3)

A study from the Journal of Neural Transmission linked the depressive period of bipolar disorder, schizophrenia, and major depression with a low density of CB1 receptors in the brain(4)

Bipolar disorder (manic depression) causes extreme mood swings characterized by emotional highs and lows. Meanwhile, schizophrenia is a mental disorder in which individuals have a distorted view of reality. 

CB1 receptors are found within the pain pathways of the brain and spinal cord, where they may affect CBD-induced anxiety relief(5)

A study showed that CBD may help with anxiety disorders(6). Anxiety disorders can affect one’s mood and often occur with depression(7)

Aside from possessing an anti-anxiety effect, CBD may interact with the serotonin receptor(8)

The serotonin receptor is activated by serotonin, a neurotransmitter involved in mental health conditions, such as depression and anxiety(9)

Benefits of Using CBD for Mood Stability

A study from the Journal of Clinical Medicine Research mentioned that CBD may be a microglial stabilizer, similar to lithium, which can help with mood stabilization and depression(10)

Microglia refers to a neuronal support cell in the central nervous system that can orchestrate a potent inflammatory response(11)

A 2020 study suggested that inflammation may be a treatment target in mood disorders(12)

Lithium is known for significantly reducing suicidal behavior and is recognized for its anti-inflammatory properties(13)

CBD also has purported anti-inflammatory properties(14). In addition, the non-psychoactive compound is found to be relatively safe(15)

A 2021 preclinical research from the International Journal of Molecular Sciences suggested that CBD may have anxiolytic and antidepressant properties that may help with anxiety and mood disorders(16)

Meanwhile, a comparative study from the Psychological Medicine journal suggested that cannabis use may help improve neurocognitive functioning in bipolar disorder and schizophrenia(17)

According to the NIH (National Center for Complementary and Integrative Health), cannabis involves all products derived from Cannabis sativa plants(18).  

 Although the Psychological Medicine journal study does not focus on CBD, researchers who want to explore CBD’s effect on neurocognition may find the results useful. 

Neurocognition is the process of assessing and linking information. 

Symptoms of bipolar disorder include manic episodes(19).  

A study from the Journal of Psychoactive Drugs hypothesized that cannabis may be a potential mood stabilizer in bipolar disorder(20)

Some individuals with bipolar disorder used cannabis to help with mania, depression, or both and claimed that it is more effective than conventional drugs(21)

Mood disorders are often caused by a chemical imbalance in the brain and stressful life changes(22). CBD has shown promise in improving stress response(23)

Although the results of the studies seem promising, more longitudinal research is recommended to determine the benefits of using CBD for mood stability

How to Use CBD for Mood Stability Safely

CBD is considered a promising agent in treating mood disorders and anxiety(24). Cannabidiol also has a favorable safety profile(25)

If you are considering using CBD for mood stability, below are two commonly used CBD delivery methods you may try:

Inhaling CBD using vape pens is the fastest way to benefit from the effects of the compound(26). The onset time of CBD via the inhalation route is between 2 to 15 minutes(27).  

Nonetheless, the CDC (Centers for Disease Control and Prevention) and the FDA (Food and Drug Administration) warn people against the use of THC-containing e-cigarettes or any vaping products, mainly from informal sources, like dealers, family and friends, and non-commercial sources(28)

Most lung injury cases in the U.S. are associated with vaping(29). Hence, you have to be extra cautious when choosing this delivery method.

The other commonly used CBD delivery method is sublingual (under the tongue) administration. Such a process provides rapid effects without exposing the lungs to tar and heat(30).

The capillaries under the tongue and within the mouth absorb CBD into the bloodstream before the compound is swallowed(31).  

If you choose to take CBD under the tongue, you will feel its effects within 15 to 30 minutes, and they may last from 2 to 4 hours(32)

Most CBD oil products come with calibrated dropper. You can use it to dispense the oil straight to your mouth.  

Still, it is best to talk with a doctor experienced in cannabis use to determine the right CBD delivery method for mood stability.  

CBD Dosage for Mood Stability

The FDA does not recognize CBD as a form of mood stabilizer. Thus, there is no standard CBD dosage for mood stability

However, in a randomized controlled trial, researchers administered 600 mg of CBD and a placebo to patients with (SAD) social anxiety disorder(33). The participants who received CBD experienced significantly less social anxiety than those given a placebo. 

Meanwhile, a study from Frontiers in Immunology mentioned that CBD may only increase prolactin levels at doses greater than 120mg of CBD per kilogram of body weight(34). This study used a rat model.  

Prolactin modulates anxiety and depressive-like behaviors(35)

Depression is a mood disorder(36). Meanwhile, anxiety disorders can result from severe stress that changes the chemical balance that controls one’s mood(37)

Still, consult a healthcare provider versed in cannabis use to determine the accurate dosage for your condition.  

How Long Does CBD Take to Help With Mood Stability?

How long CBD takes to help with mood stability usually depends on several factors, including the delivery method, individual body weight, and the type of CBD.

For instance, if you take CBD via the inhalation route, you will feel its effects within 2 to 15 minutes(38). However, vaping may damage your lungs(39).

On the other hand, the onset time of CBD via the sublingual route is between 15 and 30 minutes(40).    

How Long Will CBD Help With Mood Stability?

How long CBD’s effects will last after the compound starts to help with mood stability depends on cannabidiol’s bioavailability and half-life.

Bioavailability is the extent to which a particular substance becomes entirely available to its intended biological destinations. 

Meanwhile, half-life refers to the length of time required for the concentration of a specific drug to decrease by 50% of its starting dose. 

About 94% to 97% of a substance will have been eliminated after four to five half-lives(41)

A systematic review mentioned that CBD’s bioavailability following smoking is 31%, with a half-life of 31 hours(42)

Meanwhile, CBD’s bioavailability via the sublingual route is between 6% and 20%(43). In addition, CBD is reported to have a half-life between 1.4 and 10.9 hours following oromucosal spray use(44)

How to Choose CBD for Mood Stability

Various CBD brands in the market promise to offer the best CBD oil for mood stability. Below are a few pertinent factors to consider that may help you sort through products to find the best CBD product for your overall wellness:

1. Hemp Extracts

A full-spectrum CBD oil contains all compounds of the cannabis plant, including CBD and other cannabinoids, essential oils, flavonoids, and terpenes.

This CBD variant also has less than 0.3% THC. Furthermore, full-spectrum CBD oil produces the entourage effect due to the presence of all cannabis compounds.

The entourage effect is a concept where the biologically active compounds of cannabis work better when administered together.

Flavonoids are active compounds present in cannabis that may have antioxidant, anti-inflammatory, and antiviral actions(45).

Meanwhile, terpenes are the components of essential oils responsible for the aroma of cannabis(46).

Broad-spectrum CBD oil also contains all of the natural compounds of cannabis. However, this CBD variant is THC-free. Lastly, CBD isolates are made from pure CBD.

2. Source of Hemp 

For high-quality hemp-derived CBD products, it is necessary to identify the source of hemp. 

Some CBD products may contain pesticides, heavy metals, or genetically modified organisms (GMOs). These substances may put your health at risk. 

Therefore, make sure to choose a CBD brand that provides sufficient information on the hemp used. You should go for organic hemp or non-GMO CBD products manufactured by reputable companies.

Legitimate producers grow hemp in accordance with the United States Department of Agriculture (USDA) regulations, state laws, and tribal plans.

Home-grown hemp is subject to the quality-control procedures of the USDA.

3. Extraction Methods 

Different extraction methods are utilized in manufacturing CBD oil and hemp extracts. These processes include steam distillation, natural solvent extraction, ethanol extraction, and carbon dioxide or CO2 extraction. 

One of the most frequently utilized CBD extraction methods is the CO2 extraction technique, using carbon dioxide as the solvent(47).

4. Third-Party Lab Testing

Consumers must verify whether a CBD brand enlists the services of a third-party laboratory. The company must provide its clients with lab reports or COAs (certificates of analysis) of all their products.

The documents mentioned should be readily accessible on the brand’s official website. When all pertinent information is posted online, customers can compare the values specified on the laboratory report with the figures on the product label. 

Comparing reports allows consumers to verify a brand’s claims regarding the concentration, potency, and effects of CBD.

5. Types of CBD Products 

Most CBD-derived products available in the market are:

  • CBD vapes
  • CBD oils and CBD tinctures 
  • Edibles, like CBD gummies and capsules
  • Topicals, like CBD creams, salves, and lotions

 

The type of CBD products you choose will depend on your lifestyle preferences, specific conditions, and expected effects.

6. Carrier Oils   

Usually, coconut oil and hempseed oil are used as carrier oils. 

The terms hempseed oil and hemp oil are often used interchangeably. However, they are not the same. 

CBD oil, sometimes called hemp oil, is a form of essential oil obtained from the flowers and leaves of hemp plants. Hempseed oil, meanwhile, is extracted from the pressed seeds of hemp plants. 

Hempseed oil does not have CBD. However, it is rich in nutrients and fatty acids(48).

7. Brand Reputation

Although many CBD brands are dedicated to offering only high-quality CBD products to their customers, researching the CBD company to verify if it is a trusted brand is crucial. 

Therefore, read customer reviews to get more insights into the manufacturer and its products. 

Since most people have different opinions and experiences of a product, understanding the overall impression given by other customers may help you with your decision-making. 

Risks and Side Effects of Using CBD for Mood Stability

Generally, commonly reported side effects of using CBD include(49):

  • Drowsiness
  • Low blood pressure
  • Dry mouth 

Another cause for concern is possible drug interactions. Antidepressants and mood stabilizers are recommended for moderate to severe depression(50)

CBD is a potent inhibitor of CYP2D6, an enzyme that metabolizes various antidepressants(51). Hence, CBD may increase serum concentrations of antidepressants like SSRIs (selective serotonin reuptake inhibitors)(52).  

Is CBD Safe for Mood Stability?

Aside from potential risks and side effects, another cause for concern is the lack of regulation of CBD products marketed as supplements(53)

The FDA only has limited scientific data about CBD’s safety(54). Still, the agency is committed to constantly updating the public as it learns more about the compound.

CBD’s safety profile has been established in numerous ways(55). Nevertheless, further clinical trials are needed to ensure that the pharmaceutical compound is well-tested

Legality of CBD

Under federal law, cannabis (sometimes called marijuana) remains a Schedule I substance under the Controlled Substances Act(56)

The United States Drug Enforcement Administration or DEA said that substances listed in the Schedule I drugs category have a high abuse potential with no accepted medical use(57)

Meanwhile, most states with medical marijuana laws have a patient registry to protect individuals against arrest for having a certain amount of cannabis-derived products for personal medicinal use(58)

Still, rules and regulations regarding medical cannabis may be confusing. Hence, consumers should familiarize themselves with various state laws. 

For instance, Colorado permits recreational and medical marijuana use. The local government decriminalized the use of marijuana by passing Amendment 64 to the Colorado Constitution in November 2012(59).

In Texas, the local government passed laws in June 2019 to create an industrial hemp program(60)

Under House Bill 1325, the Texas Department of State Health Services is in charge of issuing licenses to people who want to manufacture or sell consumable hemp-derived products in the Lone Star State. 

Meanwhile, in October 2021, California Governor Gavin Newsom signed Assembly Bill No. 45 into law(61)

The bill allowed the inclusion of hemp and cannabinoids, extracts, or hemp derivatives in dietary supplements, food and beverages, cosmetics, and processed pet food provided that they contain less than 0.3% THC(62).

On the other hand, in Indiana, Gov. Eric Holcomb signed Senate Enrolled Act No. 52. The bill allowed the distribution and retail sale of “low-THC hemp extract,” defined as a product derived from Cannabis sativa L. that meets industrial hemp’s definition(63)

The Farm Bill indicates that Cannabis sativa L. and other derivatives of cannabis with less than 0.3% THC content on a dry weight basis are deemed legal under federal law(64).

Product Frequently
Asked Questions

  • How can CBD help with mood stability?

    CBD has purported anti-anxiety and antidepressant effects that may help with anxiety and mood disorders(65). The putative therapeutic properties of CBD make the compound a potential mood stabilizer.   

  • What evidence or research exists to say that CBD helps with mood stability?

    Research regarding the effect of CBD on mood stability is limited. However, a study suggested that cannabis may be an effective mood stabilizer for bipolar disorder(66)

    Cannabis refers to all items or products derived from Cannabis sativa plants(67). These include CBD and THC products.  

  • Is there any evidence that CBD can make mood stability worse?

    No evidence suggests that CBD can make mood stability worse. A study mentioned that 600mg of CBD, when taken for schizophrenia, was well tolerated and did not worsen suicidality or mood(68).  

  • Will CBD interact with any current medication I may be taking for mood stability?

    The most frequently used mood stabilizer is lithium(69). However, a study from Child Neurology Open indicated that lithium is excreted renally. Thus, any substance that impairs renal function may increase lithium levels(70).  

    Cannabidiol may interact with lithium due to CBD-induced renal dysfunction, as reflected by elevated creatinine levels(71)

    Creatinine refers to a waste product produced by the muscles as part of everyday activity. 

  • Are there other treatments I should consider alongside CBD to help with mood stability?

    Mood-stabilizing medicines, such as lithium, lamotrigine, divalproex, and carbamazepine, are used to treat mood problems(72). However, mood stabilizers can make individuals dizzy or sick to their stomach. 

    Meanwhile, the FDA states that CBD may cause minor side effects like gastrointestinal distress, including diarrhea or decreased appetite(73)

    Since mood stabilizers can make some people sick to their stomach, talking with a doctor before using CBD alongside these medications is necessary to avoid adverse reactions.

  • Can I fail a drug test if I use CBD for mood stability?

    CBD does not cause a euphoric high(74). However, some CBD products have small amounts of THC that may build up in the body when taken regularly, in a span of four to six days(75)

    An increased THC level in the bloodstream may result in a positive drug test.  

  • What is the dosage for mood stability? How often should you take CBD for mood stability?

    There is no standard CBD dosage for mood stability. Nevertheless, microdoses in the range of 0.5mg to 20mg of CBD a day may help with mood disorders(76)

  • Does CBD for mood stability cause adverse effects?

    Generally, typical side effects of CBD include gastrointestinal distress and changes in alertness and mood(77).

    Hence, it is best to talk with a doctor experienced in cannabis use to learn more about CBD and its potential adverse effects when taken for mood stability.

  • Is CBD oil legal to use for mood stability?

    The legality of CBD depends on the rules and regulations of the state you are in. Hence, make sure to learn about your state laws regarding the use of CBD oil to avoid legal repercussions. 


  1. Cannabidiol
    https://pubchem.ncbi.nlm.nih.gov/compound/Cannabidiol
  2. Ibid.
  3. Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877694/
  4. Expression of CB1 Cannabinoid Receptor in the Anterior Cingulate Cortex in Schizophrenia, Bipolar Disorder, and Major Depression
    https://link.springer.com/article/10.1007/s00702-007-0660-5
  5. Cannabidiol
    https://pubchem.ncbi.nlm.nih.gov/compound/Cannabidiol
  6. Cannabidiol as a Potential Treatment for Anxiety Disorders
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604171/
  7. Mood Disorders
    https://www.mayoclinic.org/diseases-conditions/mood-disorders/symptoms-causes/syc-20365057
  8. Cannabidiol Modulates Serotonergic Transmission and Reverses Both Allodynia and Anxiety-Like Behavior in a Model of Neuropathic Pain
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319597/
  9. Ibid.
  10. The Impact of Cannabidiol on Psychiatric and Medical Conditions
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331870/
  11. Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response
    https://www.frontiersin.org/articles/10.3389/fncel.2018.00488/full
  12. Inflammation as a Treatment Target in Mood Disorders: Review
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345526/
  13. Inflammation and lithium: clues to mechanisms contributing to suicide-linked traits
    https://www.nature.com/articles/tp2014129
  14. Antioxidative and Anti-Inflammatory Properties of Cannabidiol
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023045/
  15. An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569602/
  16. Cannabidiol as a Potential Treatment for Anxiety and Mood Disorders: Molecular Targets and Epigenetic Insights from Preclinical Research
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917759/
  17. Opposite Relationships Between Cannabis Use and Neurocognitive Functioning in Bipolar Disorder and Schizophrenia
    https://pubmed.ncbi.nlm.nih.gov/19891810/
  18. Cannabis (Marijuana) and Cannabinoids: What You Need To Know
    https://www.nccih.nih.gov/health/cannabis-marijuana-and-cannabinoids-what-you-need-to-know
  19. What Is Bipolar Disorder?
    https://www.psychiatry.org/patients-families/bipolar-disorders/what-are-bipolar-disorders
  20. The Use of Cannabis as a Mood Stabilizer in Bipolar Disorder: Anecdotal Evidence and the Need for Clinical Research
    https://pubmed.ncbi.nlm.nih.gov/9692379/
  21. Ibid.
  22. Mood Disorders
    https://www.hopkinsmedicine.org/health/conditions-and-diseases/mood-disorders
  23. Enhancing Endocannabinoid Control of Stress with Cannabidiol
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704602/
  24. Cannabidiol as a Potential Treatment for Anxiety and Mood Disorders: Molecular Targets and Epigenetic Insights from Preclinical Research
    https://pubmed.ncbi.nlm.nih.gov/33668469/
  25. An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569602/
  26. How to Safely Use CBD: Should You Inhale, Spray, Apply, or Eat It?
    https://www.consumerreports.org/cbd/how-to-use-cbd-inhale-spray-apply-eat/
  27. Healing With CBD, page 190.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  28. Outbreak of Lung Injury Associated with the Use of E-Cigarette, or Vaping, Products
    https://www.cdc.gov/tobacco/basic_information/e-cigarettes/severe-lung-disease.html
  29. Ibid.
  30. CBD: A Patient’s Guide to Medicinal Cannabis, page 105.
    https://drive.google.com/file/d/1MILU_6ZjYkII-XMUPHLFPiPQbrz__5Sh/view
  31. Healing With CBD, page 207.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  32. Healing With CBD, page 192.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  33. Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients
    https://pubmed.ncbi.nlm.nih.gov/21307846/
  34. Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161644/
  35. Actions of Prolactin in the Brain: From Physiological Adaptations to Stress and Neurogenesis to Psychopathology
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811943/
  36. Depression (Major Depressive Disorder)
    https://www.mayoclinic.org/diseases-conditions/depression/symptoms-causes/syc-20356007
  37. Anxiety Disorders
    https://my.clevelandclinic.org/health/diseases/9536-anxiety-disorders
  38. Healing With CBD, page 190.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  39. Is It Safe to Vape CBD?
    https://www.consumerreports.org/cbd/is-it-safe-to-vape-cbd/
  40. Healing With CBD, page 192.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  41. Half-Life
    https://www.ncbi.nlm.nih.gov/books/NBK554498/
  42. A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275223/
  43. Healing With CBD, page 192.
    https://drive.google.com/file/d/1AGlxnhS2SoFeOXEuysv75bd_C9pEnwsU/view
  44. A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275223/
  45. Flavonoids As Antioxidants
    https://pubmed.ncbi.nlm.nih.gov/10924197/
  46. The Cannabis Terpenes
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763918/
  47. Understanding Dabs: Contamination Concerns of Cannabis Concentrates and Cannabinoid Transfer During the Act of Dabbing
    https://www.jstage.jst.go.jp/article/jts/40/6/40_797/_pdf/-char/en
  48. Hemp Seed Oil Properties
    https://extension.okstate.edu/fact-sheets/hemp-seed-oil-properties.html
  49. CBD: What You Need to Know Before You Try
    https://www.cedars-sinai.org/blog/cbd-safe.html
  50. Antidepressants and Mood Stabilizers: Novel Research Avenues and Clinical Insights for Bipolar Depression
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713374/
  51. Medical Cannabis: Adverse Effects & Drug Interactions, page 11.
    https://doh.dc.gov/sites/default/files/dc/sites/doh/publication/attachments/Medical%20Cannabis%20Adverse%20Effects%20and%20Drug%20Interactions_0.pdf
  52. Ibid.
  53. CBD: What You Need to Know Before You Try
    https://www.cedars-sinai.org/blog/cbd-safe.html
  54. What You Need to Know (And What We’re Working to Find Out) About Products Containing Cannabis or Cannabis-derived Compounds, Including CBD
    https://www.fda.gov/consumers/consumer-updates/what-you-need-know-and-what-were-working-find-out-about-products-containing-cannabis-or-cannabis
  55. An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569602/
  56. State Medical Cannabis Laws
    https://www.ncsl.org/research/health/state-medical-marijuana-laws.aspx
  57. Drug Scheduling
    https://www.dea.gov/drug-information/drug-scheduling
  58. State Medical Cannabis Laws
    https://www.ncsl.org/research/health/state-medical-marijuana-laws.aspx
  59. Legal Marijuana Use in Colorado
    https://cannabis.colorado.gov/legal-marijuana-use-in-colorado
  60. Cannabis and the Law
    https://guides.sll.texas.gov/cannabis/cbd
  61. Assembly Bill No. 45
    https://leginfo.legislature.ca.gov/faces/billTextClient.xhtml?bill_id=202120220AB45
  62. Ibid.
  63. Senate Enrolled Act No. 52
    https://medicalmarijuana.procon.org/wp-content/uploads/sites/37/indiana-sb52.pdf
  64. FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD)
    https://www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbd
  65. Cannabidiol as a Potential Treatment for Anxiety and Mood Disorders: Molecular Targets and Epigenetic Insights from Preclinical Research
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917759/
  66. The Use of Cannabis as a Mood Stabilizer in Bipolar Disorder: Anecdotal Evidence and the Need for Clinical Research
    https://pubmed.ncbi.nlm.nih.gov/9692379/
  67. Cannabis (Marijuana) and Cannabinoids: What You Need To Know
    https://www.nccih.nih.gov/health/cannabis-marijuana-and-cannabinoids-what-you-need-to-know
  68. The Impact of Cannabidiol on Psychiatric and Medical Conditions
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331870/
  69. Facts About Mood Stabilizers
    https://www.mirecc.va.gov/visn22/Facts_about_Mood_Stabilizers_Veteran_and_Family_Handout.pdf
  70. Drug-Drug Interactions Between Cannabidiol and Lithium
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427002/
  71. Ibid.
  72. Mood-Stabilizing Medicines
    https://www.uofmhealth.org/health-library/pl1025
  73. What You Need to Know (And What We’re Working to Find Out) About Products Containing Cannabis or Cannabis-derived Compounds, Including CBD
    https://www.fda.gov/consumers/consumer-updates/what-you-need-know-and-what-were-working-find-out-about-products-containing-cannabis-or-cannabis
  74. Cannabidiol (CBD)-What We Know and What We Don’t
    https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476
  75. Can You Take CBD and Pass a Drug Test?
    https://www.consumerreports.org/cbd/can-you-take-cbd-and-pass-a-drug-test/
  76. CBD: A Patient’s Guide to Medicinal Cannabis, page 129.
    https://drive.google.com/file/d/1MILU_6ZjYkII-XMUPHLFPiPQbrz__5Sh/view
  77. What You Need to Know (And What We’re Working to Find Out) About Products Containing Cannabis or Cannabis-derived Compounds, Including CBD
    https://www.fda.gov/consumers/consumer-updates/what-you-need-know-and-what-were-working-find-out-about-products-containing-cannabis-or-cannabis

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