Best CBD Skin Care
Planning to add CBD to your skincare routine but unsure of which product to use? Check out the following high-quality CBD skincare products and see which one suits your skin type best!
Best CBD Skin Care 2024
- Spruce 750mg Lab Grade CBD Oil Editor's Pick
- NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil Best Organic
- Spruce 2400mg Lab Grade CBD Oil Editor's Pick
- Avida Full Spectrum CBD Oil Tincture 500mg Best Seller
- cbdMD CBD Oil Tincture Natural 1500mg Best Natural Alternative
- CBDistillery THC Free CBD Oil Tinctures Best THC-Free
- cbdMD CBD Oil Tincture Natural 750mg Best Customer Rated
- NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil Best Starter
- Hemp Bombs 750mg CBD Oil Best Flavor Range
Compare the Best CBD for Skin Care in 2021
Best CBD Skin Care
1. Spruce 750mg Lab Grade CBD Oil
cbdc overall score
4.8
CBDC Evaluation Table/Score
Pros | Cons |
---|---|
Mid-strength |
No other flavors |
Natural peppermint flavor |
|
Made from 100% organic and natural ingredients |
Overview
Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.
2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
cbdc overall score
5.0
CBDC Evaluation Table/Score
Pros | Cons |
---|---|
Pure CBD hemp |
No other flavors |
All natural |
|
Approximately 300 drops total |
Overview
Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.
3. Spruce 2400mg Lab Grade CBD Oil
cbdc overall score
5.0
CBDC Evaluation Table/Score
Pros | Cons |
---|---|
Extra Strength |
Tastes bitter |
No artificial flavoring or colors |
No THC-free option |
Made from 100% organic and natural ingredients |
Overview
The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.
4. Avida Full Spectrum CBD Oil Tincture 500mg
cbdc overall score
4.6
CBDC Evaluation Table/Score
Pros | Cons |
---|---|
Light Spearmint flavor |
No other flavor |
Non-THC, Non-detected in drug test |
Overview
Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.
5. cbdMD CBD Oil Tincture Natural 1500mg
cbdc overall score
4.7
CBDC Evaluation Table/Score
Pros | Cons |
---|---|
Various delicious flavors to choose from |
cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options |
Has vegan, organic, and gluten-free ingredients |
|
Free shipping for this particular product within USA |
|
World-class customer service team |
Overview
cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.
6. CBDistillery THC Free CBD Oil Tinctures
cbdc overall score
4.4
CBDC Evaluation Table/Score
Pros | Cons |
---|---|
60-Day Satisfaction Guarantee |
Dropper is a bit shaky |
Various strengths |
|
Oil extracted from aerial plant parts of US grown industrial hemp |
|
Sourced from non-GMO industrial hemp grown in the USA through natural farming practices |
Overview
CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.
7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
cbdc overall score
4.6
CBDC Evaluation Table/Score
Pros | Cons |
---|---|
Pure CBD hemp |
No other flavors |
All natural |
A bit pricey compared to competitors |
Approximately 100 drops total |
Overview
This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.
8. cbdMD CBD Oil Tincture Natural 750mg
cbdc overall score
4.4
CBDC Evaluation Table/Score
Pros | Cons |
---|---|
Vegan and Gluten free |
Does not ship internationally |
Has a third-party lab test |
|
Wide variety of CBD strengths and sizes |
Overview
A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.
9. Hemp Bombs 750mg CBD Oil
cbdc overall score
3.9
CBDC Evaluation Table/Score
Pros | Cons |
---|---|
Wide variety of flavors |
Incomplete information about the product |
Lab test results are complete |
Does not ship to all international countries |
30-day money-back guarantee |
Overview
Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.
How We Rank
Our Ratings
How Do We Rank Our Reviews?
Value
Benefits of Using CBD for Skin Care
Cannabidiol (CBD), a phytocannabinoid or naturally occurring compound in cannabis plants, is known for its potential therapeutic benefits in different medical conditions, like pain, anxiety, and depression(1).
With the growing research on CBD’s potential benefits, CBD beauty products are also gaining attention in the beauty industry.
Studies showed CBD’s potential anti-inflammatory, antioxidant, antibacterial, antifungal, analgesic, anxiolytic, and moisturizing effects(2–5). With these promising findings, CBD companies are also coming out with more CBD beauty products, like CBD oil tinctures and CBD topicals.
CBD’s Anti-Inflammatory Properties
A 2014 study published in The Journal of Clinical Investigation showed that CBD may have anti-inflammatory actions, reducing excessive oil production(6).
The appearance of blemishes, or small, inflamed bumps on the skin’s surface, is typical among humans, significantly affecting people’s quality of life.
The study also stated that CBD may suppress the proliferation of sebocytes, the cells that create sebum. Sebum plays a role in the formation of pimples.
Thus, CBD may be a promising therapeutic agent for the treatment of acne vulgaris.
A 2018 study published in the Journal of Pharmacology and Experimental Therapeutics examined CBD’s benefits in an experimental model of allergic contact dermatitis(7). This type of dermatitis is a skin inflammatory response to exposure to an allergen, resulting in red, itchy skin.
Results showed that CBD may produce anti-inflammatory effects.
Moreover, a study on cannabinoids in the management of difficult-to-treat pain indicated that CBD may help reduce inflammation by promoting the signaling of the adenosine receptor A2A, which helps suppress immune cells(8).
A 2019 study also investigated CBD ointment’s therapeutic effects on severe skin chronic diseases and their resulting scars(9). Findings indicated that CBD’s topical application may reduce inflammation in patients with skin conditions and promote wellness and improved quality of life.
Furthermore, a 2020 study examined the use of cannabinoids in dermatological inflammatory diseases(10). Results revealed that CBD may suppress the inflammatory reaction of allergic contact dermatitis without cytotoxic effects.
The study also showed that CBD may help treat other skin diseases, like psoriasis, acne, and melanoma.
CBD’s Antibacterial Properties
As early as 1976, CBD’s potential antibacterial properties were already documented(11). The study indicated that the minimum inhibiting concentrations of CBD and tetrahydrocannabinol (THC) for staphylococci and streptococci in broth fall between one and five mμg/ml.
THC is a psychoactive compound found in cannabis plants that causes a euphoric feeling among users.
Staphylococci and streptococci are dangerous human pathogens that may cause minor infections, like boils and localized abscesses(12). More severe conditions may include infections of the bloodstream and the bone and joints.
According to a 2008 study, CBD and other main compounds, like cannabichromene (CBC), cannabigerol (CBG), cannabinol (CBN), and THC, exhibited potent activities against methicillin-resistant Staphylococcus aureus (MRSA)(13).
A 2019 study published in Frontiers in Cellular and Infection Microbiology revealed that CBD may be used with other antibiotics to target certain bacteria to sensitize them to antibiotic treatment and reduce antibiotic resistance(14).
Moreover, a 2020 paper published in Scientific Reports highlighted CBD as a potentially useful compound(15). It may be used in combination with bacitracin to kill Gram-positive bacteria, which contain thick cell walls.
CBD’s Antifungal Properties
A 2011 study from the British Journal of Pharmacology indicated that cannabinoids, like CBD, THC, CBG, and CBC, have moderate antifungal properties(16).
While the study focused on THC’s therapeutic benefits, it indicated that the cannabinoids CBD, CBG, and CBC may boost the effects of an extremely potent antifungal terpenoid: caryophyllene oxide. Caryophyllene oxide is a primary terpene found in cannabis plants, pepper, and basil.
According to a 2018 study from Cannabis and Cannabinoid Research, many terpenes may possess antifungal properties(17). However, the study noted that these terpenes’ essential oils were not as effective as purified CBD.
Another study showed that essential oils containing alpha-pinene and delta-3-carene found in cannabis have potent antifungal properties(18).
While these studies do not focus on CBD, they suggest the antifungal properties of compounds in cannabis plants.
CBD’s Antioxidant Properties
Research from the Proceedings of the National Academy of Sciences of the United States of America showed CBD as a potentially powerful antioxidant(19). The compound may even be 30% to 50% more potent than vitamin C and vitamin E.
Antioxidants help combat oxidative stress, which occurs when there is an imbalance of free radicals (oxidants) and antioxidants(20). Given its antioxidant properties, CBD may help reduce fine lines and wrinkles, nourish the skin, and slow the aging process.
A 2019 review published in Antioxidants also emphasized the antioxidant properties of CBD(21). The research discussed how CBD may help treat diseases associated with oxidative stress.
Antioxidants also come in the form of vitamins, minerals, and flavonoids. Full-spectrum CBD for skin care contains a complete range of compounds, including CBD, low THC levels, terpenes, flavonoids, minerals, and fatty acids.
Terpenes are responsible for cannabis plants’ distinct aroma, while flavonoids are the reason for their vivid colors.
Essential fatty acids present in CBD oil products include Omega-3 and Omega-6, which are necessary for both the body and the skin. A 20-week study published in the Journal of Dermatological Treatment showed that dietary hempseed oil may help with atopic dermatitis symptoms(22).
According to the study, hempseed oil is a rich and balanced source of Omega-3 and Omega-6 polyunsaturated fatty acids.
Once all compounds combine, they produce the entourage effect, which means that they are more effective when they work together compared to their individual efficacies(23). Thus, using full-spectrum CBD for skin care allows consumers to maximize the compounds’ benefits.
CBD’s Anxiolytic Effects
To help maintain healthy skin and body, one should get enough sleep and relaxation. CBD’s anxiolytic effects may promote relaxation among users.
A 2019 study from The Permanente Journal measured sleep and anxiety scores in human subjects(24). Results revealed that CBD may have benefits for anxiety-related disorders.
Another study highlighted that CBD may produce anti-anxiety and antidepressant effects(25).
A 2015 review also discussed CBD as a potential treatment for anxiety through its interaction with receptors that regulate fear and anxiety-related behaviors, such as CB1 and 5-HT1A serotonin receptors(26).
Moreover, a 2019 study published in Frontiers in Psychology indicated CBD’s anxiolytic effects for teenagers with social anxiety disorders(27).
CBD may be beneficial for other disorders, including generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder(28).
CBD’s Analgesic Effects
CBD is also known for its potential analgesic or pain-relieving effects. A study highlighted CBD’s therapeutic benefits in different pain types, including neuropathic pain in multiple sclerosis, intractable cancer pain, and rheumatoid arthritis(29).
Moreover, according to a 2020 review, CBD may provide therapeutic benefits in certain forms of epilepsy, cause analgesia in certain conditions, and improve life quality(30).
Consumers may also use topical CBD products for site-specific pain relief. According to a 2018 review, CBD gels that contain CBD and hyaluronic acid may be useful for pain and wound management(31).
Other topical CBD products also contain arnica oil, which may have anti-inflammatory and pain-relieving effects(32).
CBD’s Moisturizing Effects
CBD for skin care may also have hydrating or moisturizing effects. A 2017 review from the Journal of the American Academy of Dermatology indicated that CBD may reduce itch and skin dryness(33).
A 2019 study published in Clinical Therapeutics examined individuals with either psoriasis, eczema, or scarring(34). Results showed that CBD may help hydrate and moisturize dry skin, enhancing skin elasticity.
Other CBD moisturizers and beauty products also contain moisturizing active ingredients, like coconut oil, jojoba oil, argan oil, peppermint oil, aloe, and shea butter, giving the skin moisture glow.
How CBD Helps With Skin Care
To understand CBD’s skincare benefits, one should know how CBD interacts with the endocannabinoid system (ECS). The ECS maintains homeostasis or balance in bodily functions, such as pain perception, immune response, sleep, mood, appetite, and metabolism(35).
Moreover, the ECS consists of two types of receptors: CB1 and CB2 receptors.
CB1 receptors are found in the brain and central nervous system, lungs, liver, and kidneys. These receptors help regulate bodily functions, like memory processing, appetite, pain sensation, mood, and sleep.
CB2 receptors are in cells within the immune system and its associated structures. These receptors elicit a response that helps combat inflammation, thus reducing pain and minimizing damage to tissues.
These anti-inflammatory effects may help treat various skin infections, like psoriasis, acne, and allergic contact dermatitis(36).
CBD also activates TRPV1 and GPR55 receptors, which may help mediate pain perception and inflammation(37–38).
A 2019 study showed that CBD may reduce anxiety and promote relaxation through 5-HT1A serotonin receptor activation(39). Known as the “happy chemical,” serotonin plays an essential role in helping with mood, anxiety levels, appetite, and cognitive functions.
Another study indicated that CBD may reduce inflammation by promoting adenosine receptor A2A signaling, suppressing immune cells in the process(40).
Thus, CBD’s skincare effects may be due to the substance’s interaction with the endocannabinoid system and other cannabinoid receptors regulating skin and body functions.
How Soon Can CBD’s Effects Be Felt?
CBD for skin care is available in various forms, including CBD oil tinctures and CBD topicals, like creams, lotions, balms, soaps, and salves.
CBD’s potential benefits in skin care may be felt instantly or delayed based on various factors. These include the CBD administration method, its potency, your skin type, body weight, and metabolism.
CBD oil tinctures may be a practical option for those seeking fast results as CBD passes directly through the bloodstream(41). Effects may be evident within 15 to 45 minutes.
Meanwhile, topical CBD beauty products, such as body lotions, eye creams, face creams, and lip balms, may take an hour or two to kick in. CBD is absorbed through the surface of the skin to interact with localized cannabinoid receptors.
Thus, users may apply topical CBD beauty products liberally to overcome the skins’ low cannabinoid absorption rate.
While CBD oil tinctures may provide immediate relief for various skin conditions, effects may last for four to six hours only.
Meanwhile, CBD topicals’ benefits in skin care may last for six hours. Others may last for a few days, depending on different factors, like skin sensitivity and metabolism.
Possible Side effects of Using CBD for Skin Care
While CBD may help treat various skin infections, the compound may also induce some side effects. According to Mayo Clinic, the usual side effects include(42):
- Dry mouth
- Diarrhea
- Drowsiness
- Reduced appetite
- Tiredness
- Fatigue
- Changes in weight
CBD may also interact with some medications, such as blood thinners.
According to a 2011 review, CBD may induce side effects, such as the inhibition of hepatic drug metabolism, decreased fertilization capacity, and decreased activities of p-glycoprotein and other drug transporters(43).
Thus, consumers should consult a dermatologist, especially if they have sensitive skin. This measure ensures that you get advice on proper CBD use according to your skin type.
How to Choose the Best CBD Skin Care Products
Users can choose from a wide range of CBD products for skin care. These include balms, eye creams, face creams, soaps, body lotions, serums, salves, and face masks.
Chic brands, like Sephora, Vertly, and Lord Jones, also offer various CBD-infused beauty products. To purchase the best CBD oil for skin, consumers should follow these tips:
- Seek medical advice, especially if purchasing CBD products for the first time. If you have severe medical conditions or are taking other medications, this step is important to ensure appropriate CBD use.
- Choose CBD products that use organic, GMO-free hemp plants. You should also pick cruelty-free CBD beauty products.
- Select CBD products that use CO2 extraction techniques to maximize the compounds’ benefits.
- Confirm whether the product undergoes third-party lab testing. The certificate of analysis (COA) should be available on the CBD brand’s website. It should determine CBD potency and the product’s absence of pesticides, residual solvents, and other harmful substances.
- Compare product label claims with the COA. Third-party testing of high-quality CBD hemp oil products should show accurate or higher CBD content than the product label claim.
- Choose CBD companies with certifications, memberships to hemp organizations, or accreditations from the Better Business Bureau (BBB). CBD skincare brands that meet these criteria are reliable as they have shown strict compliance, transparency, excellent customer service, and ethical business practices.
- Research on state laws regarding cannabis use to ensure that you can legally use CBD skincare products.
- Know the different CBD types: full-spectrum CBD, broad-spectrum CBD, and CBD isolates.
Full-spectrum CBD products contain all cannabinoids or naturally occurring compounds in cannabis plants, including CBD, THC, terpenes, flavonoids, fatty acids, essential oils, and other minerals.
These compounds combined produce the entourage effect, which may be more efficacious than the isolated cannabis plant elements(44). Users who want to maximize all compounds’ benefits should use full-spectrum CBD products.
Broad-spectrum CBD is like full-spectrum CBD, except that it has no THC. These types of CBD products suit those who want to avoid the euphoric effects of THC.
Meanwhile, CBD isolates are pure CBD hemp extracts that allow users to maximize CBD’s benefits.
How to Use CBD for Skin Care
CBD for skin care is available in various forms, including CBD oil tinctures and topical CBD products, like creams, cleansers, body lotions, lip balms, soaps, and salves.
The most common way to use CBD for skin care is through topical CBD beauty products. Depending on your needs, you can apply lip balms, eye creams, face creams, and body lotions directly to your skin.
Those who want to reduce under-eye puffiness can use CBD eye creams. Moreover, those who wish to maintain moisturized skin can use CBD soaps, CBD cleansers, and CBD lotions.
Effects of topical CBD products may be felt after an hour or two and may last for six hours or even several days.
As CBD topicals are absorbed through the skin’s surface, users may apply a more significant amount of CBD to their skin. However, they should start low and slow to observe the skin’s reaction to CBD.
They may increase the dosage once they see positive effects after several days of use.
CBD oil tinctures allow CBD to be absorbed directly into the bloodstream(45). Users can take CBD tinctures sublingually or under the tongue and let CBD stay in place for 30 to 60 seconds before swallowing.
Tinctures may take effect within 15 to 45 minutes(46). However, results may vary per person, depending on the CBD administration method and potency, user skin type, body weight, and metabolism.
Legality of CBD
Under the 2018 Farm Bill, hemp-derived CBD products with 0.3% THC or less are legal at the federal level(47).
Tetrahydrocannabinol (THC) is a psychoactive compound that causes a euphoric high among users. While hemp-derived CBD products are no longer part of the Controlled Substances Act (CSA), marijuana remains a Schedule 1 controlled drug(48).
Marijuana has a high potential for abuse, which can be attributed to THC’s psychoactive effects(49).
The 2018 Farm Bill highlighted the authority of the US Food and Drug Administration (FDA) to regulate products with cannabis or cannabis-derived compounds(50).
The FDA does not allow products containing CBD or THC to be sold legally as dietary supplements(51). The agency approves the use of cannabis drugs Epidiolex, Marinol, and Syndros only.
Epidiolex is a purified form of CBD derived from cannabis. This CBD product is approved to help treat seizures associated with Lennox-Gastaut syndrome and Dravet syndrome, two rare cases of epilepsy in children.
Marinol and Syndros are approved to treat anorexia associated with weight loss in patients with acquired immunodeficiency syndrome (AIDS).
As no other FDA-approved CBD products are available, users should purchase CBD in states that allow recreational or medical marijuana use.
Product Frequently
Asked Questions
-
How can CBD help with skin care?
CBD may help with skin care through its interaction with the endocannabinoid system, which maintains balance in different bodily functions, like pain perception, sleep, and immune response(52).
-
Is there evidence that CBD helps with skin care?
Studies showed that CBD may help with skin care through the compound’s antibacterial, anti-inflammatory, antibacterial, antifungal, antioxidant, anxiolytic, analgesic, and moisturizing effects(53–56).
-
Is there any evidence that CBD can make my skin worse?
While research about CBD’s effectiveness in the skin is inconclusive, no study showed that CBD could worsen the skin. However, CBD may induce some side effects, like drowsiness, diarrhea, and fatigue(57).
You should consult a dermatologist knowledgeable about CBD for proper CBD use.
-
Will CBD interact with medications I may be taking for skin care?
CBD may interact with other medications, altering how the body breaks down such medications(58). Thus, you should talk to a dermatologist before taking CBD for skin care.
-
Are there other treatments I should consider alongside CBD to help with skin care?
You can also wear sunscreen, drink more water, and maintain a healthy diet while using CBD beauty products. You should consult your dermatologist to avoid possible allergies or drug interactions when taking other medications.
-
Can I fail a drug test if I use CBD for skin care?
CBD is a non-psychoactive compound that does not make users feel high or fail in a drug test. However, other CBD products contain trace amounts of the psychoactive compound THC.
Frequent usage of full-spectrum products, even those with low THC contents, may still result in a false-positive drug test.
-
What is the dosage for skin care?
There are no official guidelines regarding CBD dosage for skin care. However, users should start at low doses and increase dosage gradually once results are evident after days or weeks of CBD use.
-
Is CBD anti-aging?
CBD may help fight aging through its antioxidant properties that combat oxidative stress or imbalance between free radicals and antioxidants(59).
-
Where do I buy CBD for skin care?
CBD beauty products are available in various CBD retailers and dispensaries across the United States. Most CBD brands also allow users to purchase directly from their website. Other companies also accept international orders.
- Corroon, J., & Phillips, J. A. (2018). A Cross-Sectional Study of Cannabidiol Users. Cannabis and cannabinoid research, 3(1), 152–161. doi.org/10.1089/can.2018.0006.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043845/#:~:text=Results%3A%20Almost%2062%25%20of%20CBD,reported%20%E2%80%9Cnot%20very%20well.%E2%80%9D
- Corroon, J. (2018). Op Cit.
- Appendino, G., Gibbons, S., Giana, A., Pagani, A., Grassi, G., Stavri, M., Smith, E., & Rahman, M. M. (2008). Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. Journal of natural products, 71(8), 1427–1430. doi.org/10.1021/np8002673. https://pubmed.ncbi.nlm.nih.gov/18681481/
- Russo E. B. (2011). Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. British journal of pharmacology, 163(7), 1344–1364. doi.org/10.1111/j.1476-5381.2011.01238.x. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165946/
- Mounessa, J. S., Siegel, J. A., Dunnick, C. A., & Dellavalle, R. P. (2017). The role of cannabinoids in dermatology. Journal of the American Academy of Dermatology, 77(1), 188–190. doi.org/10.1016/j.jaad.2017.02.056. https://www.jaad.org/article/S0190-9622(17)30308-0/fulltext
- Oláh, A., Tóth, B. I., Borbíró, I., Sugawara, K., Szöllõsi, A. G., Czifra, G., Pál, B., Ambrus, L., Kloepper, J., Camera, E., Ludovici, M., Picardo, M., Voets, T., Zouboulis, C. C., Paus, R., & Bíró, T. (2014). Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes. The Journal of clinical investigation, 124(9), 3713–3724. doi.org/10.1172/JCI64628. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151231/
- Petrosino, S., Verde, R., Vaia, M., Allarà, M., Iuvone, T., & Di Marzo, V. (2018). Anti-inflammatory Properties of Cannabidiol, a Nonpsychotropic Cannabinoid, in Experimental Allergic Contact Dermatitis. The Journal of pharmacology and experimental therapeutics, 365(3), 652–663. doi.org/10.1124/jpet.117.244368. https://pubmed.ncbi.nlm.nih.gov/29632236/
- Russo E. B. (2008). Cannabinoids in the management of difficult to treat pain. Therapeutics and clinical risk management, 4(1), 245–259. doi.org/10.2147/tcrm.s1928. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/#b26
- Palmieri, B., Laurino, C., & Vadalà, M. (2019). A therapeutic effect of cbd-enriched ointment in inflammatory skin diseases and cutaneous scars. La Clinica terapeutica, 170(2), e93–e99. doi.org/10.7417/CT.2019.2116. https://pubmed.ncbi.nlm.nih.gov/30993303/
- Scheau, C., Badarau, I. A., Mihai, L. G., Scheau, A. E., Costache, D. O., Constantin, C., Calina, D., Caruntu, C., Costache, R. S., & Caruntu, A. (2020). Cannabinoids in the Pathophysiology of Skin Inflammation. Molecules (Basel, Switzerland), 25(3), 652. doi.org/10.3390/molecules25030652. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037408/
- Van Klingeren, B., & Ten Ham, M. (1976). Antibacterial activity of delta9-tetrahydrocannabinol and cannabidiol. Antonie van Leeuwenhoek, 42(1-2), 9–12. doi.org/10.1007/BF00399444. https://pubmed.ncbi.nlm.nih.gov/1085130/
- Foster T. Staphylococcus. In: Baron S, editor. Medical Microbiology. 4th edition. Galveston (TX): University of Texas Medical Branch at Galveston; 1996. Chapter 12. Available from: https://www.ncbi.nlm.nih.gov/books/NBK8448/
- Appendino, G. (2008). Op Cit.
- Kosgodage, U. S., Matewele, P., Awamaria, B., Kraev, I., Warde, P., Mastroianni, G., Nunn, A. V., Guy, G. W., Bell, J. D., Inal, J. M., & Lange, S. (2019). Cannabidiol Is a Novel Modulator of Bacterial Membrane Vesicles. Frontiers in cellular and infection microbiology, 9, 324. doi.org/10.3389/fcimb.2019.00324. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747004/
- Wassmann, C. S., Højrup, P., & Klitgaard, J. K. (2020). Cannabidiol is an effective helper compound in combination with bacitracin to kill Gram-positive bacteria. Scientific reports, 10(1), 4112. doi.org/10.1038/s41598-020-60952-0. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057955/
- Russo E. B. (2011). Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Op Cit.
- Gallily, R., Yekhtin, Z., & Hanuš, L. O. (2018). The Anti-Inflammatory Properties of Terpenoids from Cannabis. Cannabis and cannabinoid research, 3(1), 282–290. doi.org/10.1089/can.2018.0014. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308289/
- Cavaleiro, C., Pinto, E., Gonçalves, M. J., & Salgueiro, L. (2006). Antifungal activity of Juniperus essential oils against dermatophyte, Aspergillus and Candida strains. Journal of applied microbiology, 100(6), 1333–1338. doi.org/10.1111/j.1365-2672.2006.02862.x. https://pubmed.ncbi.nlm.nih.gov/16696681/
- Hampson, A. J., Grimaldi, M., Axelrod, J., & Wink, D. (1998). Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proceedings of the National Academy of Sciences of the United States of America, 95(14), 8268–8273. doi.org/10.1073/pnas.95.14.8268. https://www.pnas.org/content/95/14/8268
- Whiteley, N. (2016, Nov. 22). Cannabinoids & Oxidation [Book Excerpt]. Retrieved from https://www.projectcbd.org/medicine/cannabinoids-oxidation-book-excerpt
- Atalay, S., Jarocka-Karpowicz, I., & Skrzydlewska, E. (2019). Antioxidative and Anti-Inflammatory Properties of Cannabidiol. Antioxidants (Basel, Switzerland), 9(1), 21. doi.org/10.3390/antiox9010021. https://pubmed.ncbi.nlm.nih.gov/31881765/
- Callaway, J., Schwab, U., Harvima, I., Halonen, P., Mykkänen, O., Hyvönen, P., & Järvinen, T. (2005). Efficacy of dietary hempseed oil in patients with atopic dermatitis. The Journal of dermatological treatment, 16(2), 87–94. doi.org/10.1080/09546630510035832. https://pubmed.ncbi.nlm.nih.gov/16019622/
- Russo E. B. (2019). The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No “Strain,” No Gain. Frontiers in plant science, 9, 1969. doi.org/10.3389/fpls.2018.01969. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334252/
- Shannon, S., Lewis, N., Lee, H., & Hughes, S. (2019). Cannabidiol in Anxiety and Sleep: A Large Case Series. The Permanente journal, 23, 18–041. doi.org/10.7812/TPP/18-041. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326553/
- de Mello Schier, A. R., de Oliveira Ribeiro, N. P., Coutinho, D. S., Machado, S., Arias-Carrión, O., Crippa, J. A., Zuardi, A. W., Nardi, A. E., & Silva, A. C. (2014). Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa. CNS & neurological disorders drug targets, 13(6), 953–960. doi.org/10.2174/1871527313666140612114838. https://pubmed.ncbi.nlm.nih.gov/24923339/
- Blessing, E. M., Steenkamp, M. M., Manzanares, J., & Marmar, C. R. (2015). Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics: the journal of the American Society for Experimental NeuroTherapeutics, 12(4), 825–836. doi.org/10.1007/s13311-015-0387-1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604171/
- Masataka N. (2019). Anxiolytic Effects of Repeated Cannabidiol Treatment in Teenagers With Social Anxiety Disorders. Frontiers in psychology, 10, 2466. doi.org/10.3389/fpsyg.2019.02466. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856203/
- Blessing, E. M. (2015). Op Cit.
- Russo E. B. (2008). Cannabinoids in the management of difficult to treat pain. Op Cit.
- Argueta, D. A., Ventura, C. M., Kiven, S., Sagi, V., & Gupta, K. (2020). A Balanced Approach for Cannabidiol Use in Chronic Pain. Frontiers in pharmacology, 11, 561. doi.org/10.3389/fphar.2020.00561. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204604/
- Bruni, N., Della Pepa, C., Oliaro-Bosso, S., Pessione, E., Gastaldi, D., & Dosio, F. (2018). Cannabinoid Delivery Systems for Pain and Inflammation Treatment. Molecules (Basel, Switzerland), 23(10), 2478. doi.org/10.3390/molecules23102478. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222489/
- Iannitti, T., Morales-Medina, J. C., Bellavite, P., Rottigni, V., & Palmieri, B. (2016). Effectiveness and Safety of Arnica montana in Post-Surgical Setting, Pain and Inflammation. American journal of therapeutics, 23(1), e184–e197. doi.org/10.1097/MJT.0000000000000036. https://pubmed.ncbi.nlm.nih.gov/25171757/
- Mounessa, J. S. (2017). Op Cit.
- Palmieri, B. (2019). Op Cit.
- Education Collaboration Hope. (2017, Apr. 18). A Look at the Endocannabinoid System’s CB1 and CB2 Receptors. Retrieved from https://echoconnection.org/look-endocannabinoid-systems-cb1-cb2-receptors/
- Scheau, C. (2020). Op Cit.
- Costa, B., Giagnoni, G., Franke, C., Trovato, A. E., & Colleoni, M. (2004). Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation. British journal of pharmacology, 143(2), 247–250. doi.org/10.1038/sj.bjp.0705920. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1575333/
- Sharir, H., & Abood, M. E. (2010). Pharmacological characterization of GPR55, a putative cannabinoid receptor. Pharmacology & therapeutics, 126(3), 301–313. doi.org/10.1016/j.pharmthera.2010.02.004. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874616/
- De Gregorio, D., McLaughlin, R. J., Posa, L., Ochoa-Sanchez, R., Enns, J., Lopez-Canul, M., Aboud, M., Maione, S., Comai, S., & Gobbi, G. (2019). Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain. Pain, 160(1), 136–150. doi.org/10.1097/j.pain.0000000000001386. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319597/
- Russo E. B. (2008). Cannabinoids in the management of difficult to treat pain. Op Cit.
- Arthritis Foundation. CBD for Arthritis Pain: What You Should Know. Retrieved from https://www.arthritis.org/health-wellness/healthy-living/managing-pain/pain-relief-solutions/cbd-for-arthritis-pain
- Bauer, B. A. (2018, Dec. 20). What are the benefits of CBD — and is it safe to use? Retrieved from https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/is-cbd-safe-and-effective/faq-20446700
- Bergamaschi, M. M., Queiroz, R. H., Zuardi, A. W., & Crippa, J. A. (2011). Safety and side effects of cannabidiol, a Cannabis sativa constituent. Current drug safety, 6(4), 237–249. doi.org/10.2174/157488611798280924. https://pubmed.ncbi.nlm.nih.gov/22129319/
- Russo E. B. (2019). The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No “Strain,” No Gain. Op Cit.
- Arthritis Foundation. Op Cit.
- Ibid.
- U.S. Food and Drug Administration. (2020, Oct. 1). FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD). Retrieved from https://www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbd
- U.S. Food and Drug Administration. (2020, Oct. 1). FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD). Op Cit.
- Ibid.
- Ibid.
- Ibid.
- Education Collaboration Hope. (2017, Apr. 18). Op Cit.
- Corroon, J. (2018). Op Cit.
- Appendino, G. (2008). Op Cit.
- Russo E. B. (2011). Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Op Cit.
- Mounessa, J. S. (2017). Op Cit.
- Bauer, B. A. (2018, Dec. 20).Op Cit.
- Iffland, K., & Grotenhermen, F. (2017). An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis and cannabinoid research, 2(1), 139–154. doi.org/10.1089/can.2016.0034. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569602/
- Hampson, A. J. (1998). Op Cit.