Best CBD Oil for Lyme Disease

Are you looking for an alternative to help relieve pain and inflammation caused by tick bites? This article discusses how CBD may help reduce the symptoms of Lyme disease.

Rating
Highlights

Editor's Choice

Spruce 750mg Lab Grade CBD Oil

4.8 out of 5
  1. Peppermint flavor masks any unpleasant taste
  2. Contains 25mg of CBD per dropper full
  3. Bottle includes a graduated dropper for correct serving measurement

Best CBD Purity

NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil

5.0 out of 5
  1. Natural remedy for various illnesses
  2. Product is full-spectrum whole-plant extract
  3. Contains naturally occurring synergistic cannabinoids and terpenes

Best High Potency

Spruce 2400mg Lab Grade CBD Oil

5.0 out of 5
  1. Maximum possible potency
  2. Each dropper full contains 80mg of CBD
  3. Conveniently fits in a 30mL bottle

Best Value

Avida Full Spectrum CBD Oil Tincture 500mg

4.6 out of 5
  1. Proprietary full-spectrum
  2. Developed using advanced AVIDA CORE Spectrum Technology
  3. Highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3)

Best Value

cbdMD CBD Oil Tincture Natural 1500mg

4.7 out of 5
  1. Made using only CBD sourced from medical hemp
  2. Available in many flavours
  3. Safe for daily use

Best THC Free

CBDistillery THC Free CBD Oil Tinctures

4.4 out of 5
  1. Do not contain THC
  2. Available in different potencies and sizes
  3. Brand has special deals and offers

Best Customer Rated

cbdMD CBD Oil Tincture Natural 750mg

4.4 out of 5
  1. THC-free
  2. Has plenty of flavours to choose from
  3. Totally vegan

Best For Beginners

NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil

4.6 out of 5
  1. Lowest concentration for CBD beginners
  2. Fully organic and lab-tested
  3. Full-spectrum

Best Flavor Range

Hemp Bombs 750mg CBD Oil

3.9 out of 5
  1. Has a wide range of flavours
  2. Safe to intake
  3. Get 20% off when you avail of their subscription

Best Allergy Friendly

Sunsoil CBD Oil Drops, Chocolate Mint Flavor

3.6 out of 5
  1. Tastes great
  2. Uses hemp grown organically
  3. Laboratory tests done by a third party

Best CBD Oil for Lyme Disease 2024

  1. Spruce 750mg Lab Grade CBD Oil Editor's Pick
  2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil Best Organic
  3. Spruce 2400mg Lab Grade CBD Oil Editor's Pick
  4. Avida Full Spectrum CBD Oil Tincture 500mg Best Seller
  5. cbdMD CBD Oil Tincture Natural 1500mg Best Natural Alternative
  6. CBDistillery THC Free CBD Oil Tinctures Best THC-Free
  7. cbdMD CBD Oil Tincture Natural 750mg Best Customer Rated
  8. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil Best Starter
  9. Hemp Bombs 750mg CBD Oil Best Flavor Range
  10. Sunsoil CBD Oil Drops, Chocolate Mint Flavor Best Allergy Friendly


Compare the best CBD Oil for Lyme Disease in 2022

Product Potency Purity Customer Service Type Extraction Transparency Absorption
Spruce 2400mg Lab Grade CBD Oil
4.8 out of 5
4.5 out of 5
4.5 out of 5
5.0 out of 5
5.0 out of 5
4.5 out of 5
5.0 out of 5
5.0 out of 5
NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
5.0 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
4.0 out of 5
5.0 out of 5
5.0 out of 5
Spruce 2400mg Lab Grade CBD Oil
5.0 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
4.0 out of 5
5.0 out of 5
5.0 out of 5
Avida Full Spectrum CBD Oil Tincture 500mg
4.6 out of 5
5.0 out of 5
3.5 out of 5
3.0 out of 5
5.0 out of 5
4.5 out of 5
4.5 out of 5
5.0 out of 5
cbdMD CBD Oil Tincture Natural 1500mg
4.7 out of 5
5.0 out of 5
3.5 out of 5
5.0 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
4.0 out of 5
CBDistillery THC Free CBD Oil Tinctures
4.4 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
4.5 out of 5
cbdMD CBD Oil Tincture Natural 750mg
4.4 out of 5
4.5 out of 5
3.5 out of 5
5.0 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
4.0 out of 5
NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
4.6 out of 5
2.5 out of 5
5.0 out of 5
5.0 out of 5
5.0 out of 5
4.5 out of 5
5.0 out of 5
5.0 out of 5
Hemp Bombs 750mg CBD Oil
3.9 out of 5
4.5 out of 5
3.5 out of 5
2.5 out of 5
3.5 out of 5
4.5 out of 5
5.0 out of 5
4.0 out of 5
Sunsoil CBD Oil Drops, Chocolate Mint Flavor
3.6 out of 5
2.5 out of 5
3.5 out of 5
5.0 out of 5
5.0 out of 5
4.0 out of 5
3.5 out of 5
5.0 out of 5

Best CBD Oil for Lyme Disease

1. Spruce 750mg Lab Grade CBD Oil
cbdc overall score

4.8

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

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Transparency

Pros Cons

Mid-strength

No other flavors

Natural peppermint flavor

Made from 100% organic and natural ingredients

Overview

Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
cbdc overall score

5.0

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Pure CBD hemp

No other flavors

All natural

Approximately 300 drops total

Overview

Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

3. Spruce 2400mg Lab Grade CBD Oil
cbdc overall score

5.0

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Extra Strength

Tastes bitter

No artificial flavoring or colors

No THC-free option

Made from 100% organic and natural ingredients

Overview

The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.

4. Avida Full Spectrum CBD Oil Tincture 500mg
cbdc overall score

4.6

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Light Spearmint flavor

No other flavor

Non-THC, Non-detected in drug test

Overview

Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.

5. cbdMD CBD Oil Tincture Natural 1500mg
cbdc overall score

4.7

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Various delicious flavors to choose from

cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options

Has vegan, organic, and gluten-free ingredients

Free shipping for this particular product within USA

World-class customer service team

Overview

cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

6. CBDistillery THC Free CBD Oil Tinctures
cbdc overall score

4.4

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

60-Day Satisfaction Guarantee

Dropper is a bit shaky

Various strengths

Oil extracted from aerial plant parts of US grown industrial hemp

Sourced from non-GMO industrial hemp grown in the USA through natural farming practices

Overview

CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.

7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
cbdc overall score

4.6

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Pure CBD hemp

No other flavors

All natural

A bit pricey compared to competitors

Approximately 100 drops total

Overview

This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.

8. cbdMD CBD Oil Tincture Natural 750mg
cbdc overall score

4.4

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Vegan and Gluten free

Does not ship internationally

Has a third-party lab test

Wide variety of CBD strengths and sizes

Overview

A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.

9. Hemp Bombs 750mg CBD Oil
cbdc overall score

3.9

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Wide variety of flavors

Incomplete information about the product

Lab test results are complete

Does not ship to all international countries

30-day money-back guarantee

Overview

Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.

10. Sunsoil CBD Oil Drops, Chocolate Mint Flavor
cbdc overall score

3.6

CBDC Evaluation Table/Score
Potency

Purity

Customer Service

Type

Extraction

Absorption

Transparency

Pros Cons

Sunsoil CBD is committed to providing high-quality products at an affordable cost.

Product selection is limited.

The company tests its products thrice before making them available to the public.

The company uses lipid extraction methods.

From cultivation to packaging, everything is done in Sunsoil CBD grounds.

Organic and sustainable farming is at the company’s core.

Overview

The flavor profile is refreshingly sweet, and it balances well with the higher CBD concentration. Promotes the absorption of CBD into your blood circulation.

How We Rank
Our Ratings

How CBD Helps With Lyme Disease

Several studies show that cannabidiol (CBD), a non-psychoactive compound found in the Cannabis sativa plant, may help reduce chronic pain and inflammation(1) and provide antibacterial effects(2).

These properties suggest CBD may help alleviate some of the symptoms associated with Lyme disease.

Lyme disease is an infection by several species of the Borrelia bacteria carried by infected black-legged ticks, also known as deer ticks(3).

This disease is most prevalent in the United States and is characterized by common symptoms like fever, fatigue, headache, and skin rashes(4).

Small red bumps similar to mosquito bites appear on the skin during the early stages. Within a month after infection, rashes with a bulls-eye pattern may develop.

Other symptoms of Lyme disease include joint pains and inflammation of the eyes and liver, neurological symptoms, and heart problems(5).

When left untreated, Lyme disease may cause complications like chronic joint inflammation, peripheral neuropathy, heart rhythm irregularities, and cognitive difficulties(6).

Some of these complications may also be associated with fibromyalgia and neuropathic pain.

CBD provides various health benefits that may help address Lyme disease by engaging the body’s endocannabinoid system (ECS).

The ECS modulates essential bodily functions like memory, learning, sleep, temperature regulation, pain control, and inflammatory and immune responses(7). The ECS maintains the body’s wellness and quality of life.

The ECS consists of several cannabinoid receptors, including the CB1 and CB2 receptors. These receptors are found in the immune system and the central nervous system and influence the body’s inflammatory and pain responses(8).

CBD binds with the ECS receptors, helping manage pain and inflammation in medical conditions such as Lyme disease.

Benefits and Uses of Using CBD for Lyme Disease

To date, no study regarding the effects of CBD on individuals with Lyme disease has been conducted.

However, anecdotal information on the effects of CBD mentions that the drug may have anti-inflammatory properties and help relieve pain, fight bacteria, and manage anxiety and depression associated with Lyme disease(9).

CBD is currently unapproved by the Food and Drug Administration (FDA) as a treatment method for Lyme disease. Thus, CBD must not be used to cure the illness.

Consult a doctor or professional health worker regarding Lyme disease and potential antibiotic treatments before taking CBD products.

How Long Does CBD Take to Help Lyme Disease?

Different CBD products have varying onset times depending on the ingestion method(10).

CBD tinctures applied sublingually or under the tongue take a few minutes to take effect because CBD is delivered directly into the bloodstream.

CBD edibles and capsules are administered orally and pass through the digestive system. This method may take one to two hours before CBD takes effect.

CBD topicals like creams, lotions, and balms are applied to the skin and are not absorbed into the bloodstream. Topicals may be more effective for localized skin conditions and joint pains. Onset times may depend on the amount of skin fat.

Inhalants such as vapes deliver CBD directly to the lungs, then into the heart and brain, and finally throughout the body.

The effects of CBD may be felt within seconds to a few minutes after inhalation, giving this method the fastest onset times among other CBD product types.

A negative attribute of vaping is that this method may cause lung disease(11). Consult a physician or healthcare professional before considering vaping as your method to deliver CBD.

How Long Will CBD Help With Lyme Disease?

The duration of the effects of CBD products may depend on the product type, dosage, body weight, and the person’s metabolism(12).

No study has been performed to determine how long CBD may be effective in managing Lyme disease symptoms.

CBD tinctures have short onset times and long-lasting effects, lasting for six to eight hours.

Edibles and capsules usually take longer to work compared to tinctures. However, you may feel the effects for 6 to 12 hours.

CBD topicals may remain effective for five hours or more.

CBD vapes may maintain their effects after about two or three hours.

Risks and Side Effects of Using CBD for Lyme Disease

Side effects of CBD consumption include dry mouth, loss of appetite, drowsiness, fatigue, and diarrhea(13).

CBD products may contain a grapefruit warning, meaning CBD may prevent other medications in the body from breaking down. Drugs that remain unmetabolized may cause further risk in the body(14).

One suggestion to minimize potential risks caused by CBD intake is to start with lower doses first(15). Small amounts may be more effective, especially for individuals new to CBD.

Legality of CBD

The 2018 Farm Bill removed hemp-based CBD products with THC content not exceeding 0.3% from the list of controlled substances of the Drug Enforcement Administration. This law also legalized industrial hemp production in the U.S.(16).

Marijuana-based CBD or other plant derivatives that contain more than 0.3% THC are still prohibited under federal law(17).

How to Choose the Best CBD Oil for Lyme Disease

Cannabis oil may be classified by the presence of cannabinoids and other compounds in the product. These forms are full-spectrum, broad-spectrum, and isolates.

Full-spectrum CBD oil contains all the cannabinoids in the hemp plant, like THC, cannabigerol (CBG), and cannabichromene (CDC). All these compounds produce an entourage effect, which enhances CBD’s health benefits(18).

Broad-spectrum CBD is similar to full-spectrum without the THC content. 

CBD isolates only contain cannabidiol, and no other compounds are included. Isolates may appeal to persons who prefer to take only pure CBD.

CBD brands selling cannabis-based products must have their products tested with a third-party lab. This test determines the actual CBD content and the amount of the other ingredients in the product(19).

How to Take CBD Oil for Lyme Disease

CBD tinctures are administered sublingually or under the tongue. Some products applied this way are CBD tinctures in oromucosal sprays or droppers.

Sublingual application allows CBD oil to bypass the digestive tract and enter the bloodstream directly, allowing faster onset times than oral administration.

CBD edibles like cookies, gummies, and candies are consumed orally. CBD is first absorbed and broken down by the digestive system before entering the bloodstream.

Topicals such as creams, balms, and lotions are applied to the skin. Topicals may be effective for skin problems and joint pains.

Vapes are inhaled and absorbed through the lungs. CBD then passes from the lungs to the heart and brain before CBD spreads throughout the body(20).

Vaping can harm the lungs, causing lung damage(21). If you have Lyme disease symptoms, inform a physician or a healthcare worker about your condition before using CBD vapes.

Product Frequently
Asked Questions

  • How can CBD help with Lyme disease?

    Studies show that cannabidiol (CBD) may help provide antimicrobial effects(22). However, bacteria associated with Lyme disease and other gram-negative bacteria may be resistant to CBD(23).

    Although CBD may not completely eliminate all symptoms of Lyme disease, some studies acknowledge that CBD may improve a person’s quality of life(24).

    CBD may help reduce pain and inflammation(25), which are symptoms associated with Lyme disease.

  • What evidence or research exists to say that CBD helps with Lyme disease?

    There are currently no studies on the effects of CBD on individuals with Lyme disease.

    However, CBD has anti-inflammatory properties that may help relieve pain and inflammation(26), common Lyme disease symptoms.

  • Is there any evidence that CBD can make Lyme disease worse?

    To date, there is no evidence that CBD worsens Lyme disease. However, CBD may cause side effects such as appetite loss, dry mouth, fatigue, and diarrhea(27).

  • Will CBD interact with any current medication I may be taking for Lyme disease?

    CBD products may prevent other drugs from being metabolized in the body, causing further risks and side effects to the person.

  • Are there other treatments I should consider alongside CBD to help with Lyme disease?

    Individuals with Lyme disease may take oral or intravenous antibiotics, which may be the only proven treatment to date(28).

    A 2020 study mentioned that combining CBD with antibiotics may be a novel treatment for infections caused by antibiotic-resistant bacteria(29).

  • Can I fail a drug test if I use CBD for Lyme disease?

    Hemp-derived CBD is not a controlled substance(30). However, CBD products with more than 0.3% THC content may cause you to fail a drug test.

    Inquire with your state or local area to determine whether the CBD products you have or planning to purchase are legal to use.

  • What is the dosage for Lyme disease?

    There is no FDA-approved CBD dosage for Lyme disease. Individuals taking CBD for the first time are advised to take small doses initially(31).

  • Is CBD Oil Legal?

    The 2018 Farm Bill removed hemp-based CBD products from the DEA’s list of controlled substances(32). This bill legalizes CBD oil on a federal level.

    However, CBD has not been approved by the FDA for dogs. Results of studies on CBD use on dogs are inconclusive.

  • Can CBD oil help treat Lyme disease?

    CBD oil may help provide pain relief and reduce inflammation(33). However, CBD has not been approved as a treatment method for Lyme disease.


  1. Cannabidiol (CBD)-what we know and what we don’t
    https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476
  2. The Antimicrobial Activity of Cannabinoids
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400265/
  3. Lyme disease: Symptoms and causes
    https://www.mayoclinic.org/diseases-conditions/lyme-disease/symptoms-causes/syc-20374651
  4. Lyme disease
    https://www.cdc.gov/lyme/index.html
  5. Lyme disease: Symptoms and causes
    https://www.mayoclinic.org/diseases-conditions/lyme-disease/symptoms-causes/syc-20374651
  6. Ibid.
  7. The endocannabinoid system: Essential and mysterious
    https://www.health.harvard.edu/blog/the-endocannabinoid-system-essential-and-mysterious-202108112569
  8. The endocannabinoid system in pain and inflammation: Its relevance to rheumatic disease
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685274/
  9. How my Lyme disease experience led me to start a CBD company
    https://www.lymedisease.org/lyme-cbd-meghan-ward/
  10. Best way to take CBD
    https://www.projectcbd.org/guidance/best-way-take-cbd
  11. Can vaping damage your lungs? What we do (and don’t) know
    https://www.health.harvard.edu/blog/can-vaping-damage-your-lungs-what-we-do-and-dont-know-2019090417734
  12. CBD dosing
    https://www.projectcbd.org/guidance/cbd-dosing
  13. What are the benefits of CBD — and is it safe to use?
    https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/is-cbd-safe-and-effective/faq-20446700
  14. Grapefruit Juice and Some Drugs Don’t Mix
    https://www.fda.gov/consumers/consumer-updates/grapefruit-juice-and-some-drugs-dont-mix
  15. CBD dosing
    https://www.projectcbd.org/guidance/cbd-dosing
  16. Hemp Production and the 2018 Farm Bill
    https://www.fda.gov/news-events/congressional-testimony/hemp-production-and-2018-farm-bill-07252019
  17. CBD & THC: Myths and misconceptions
    https://www.projectcbd.org/cbd-101/cbd-misconceptions
  18. The “Entourage Effect”: Terpenes Coupled with Cannabinoids for the Treatment of Mood Disorders and Anxiety Disorders
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324885/
  19. Cannabis lab testing & safety protocols
    https://www.projectcbd.org/industry/cannabis-lab-testing-safety-protocols
  20. Best way to take CBD
    https://www.projectcbd.org/guidance/best-way-take-cbd
  21. Can vaping damage your lungs? What we do (and don’t) know
    https://www.health.harvard.edu/blog/can-vaping-damage-your-lungs-what-we-do-and-dont-know-2019090417734
  22. The Antimicrobial Activity of Cannabinoids
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400265/
  23. Antibacterial activity of Δ9-tetrahydrocannabinol and cannabidiol
    https://doi.org/10.1007/BF00399444
  24. Cannabidiol in Anxiety and Sleep: A Large Case Series
    https://doi.org/10.7812/TPP/18-041
  25. Cannabidiol (CBD)-what we know and what we don’t
    https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476
  26. Ibid.
  27. What are the benefits of CBD — and is it safe to use?
    https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/is-cbd-safe-and-effective/faq-20446700
  28. Lyme disease: Diagnosis and treatment
    https://www.mayoclinic.org/diseases-conditions/lyme-disease/diagnosis-treatment/drc-20374655
  29. Cannabidiol is an effective helper compound in combination with bacitracin to kill Gram-positive bacteria
    http://dx.doi.org/10.1038/s41598-020-60952-0
  30. Hemp Production and the 2018 Farm Bill
    https://www.fda.gov/news-events/congressional-testimony/hemp-production-and-2018-farm-bill-07252019
  31. CBD dosing
    https://www.projectcbd.org/guidance/cbd-dosing
  32. Hemp
    https://www.usda.gov/topics/hemp
  33. Cannabidiol (CBD)-what we know and what we don’t
    https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476

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